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Protein

Eukaryotic translation initiation factor 3 subunit C

Gene

eif3C

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Enzyme and pathway databases

ReactomeiR-DDI-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-DDI-72689. Formation of a pool of free 40S subunits.
R-DDI-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-DDI-72702. Ribosomal scanning and start codon recognition.

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit CUniRule annotation
Short name:
eIF3cUniRule annotation
Alternative name(s):
Eukaryotic translation initiation factor 3 subunit 8UniRule annotation
Gene namesi
Name:eif3C
Synonyms:eif3s8
ORF Names:DDB_G0279109
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0279109. eif3C.

Subcellular locationi

Q54X97:
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003303301 – 936Eukaryotic translation initiation factor 3 subunit CAdd BLAST936

Proteomic databases

PaxDbiQ54X97.

Interactioni

Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

STRINGi44689.DDB0233926.

Structurei

3D structure databases

ProteinModelPortaliQ54X97.
SMRiQ54X97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini643 – 814PCIPROSITE-ProRule annotationAdd BLAST172

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi172 – 177Poly-Asp6
Compositional biasi247 – 270Asp-richAdd BLAST24
Compositional biasi861 – 921Gln-richAdd BLAST61
Compositional biasi862 – 900His-richAdd BLAST39

Sequence similaritiesi

Belongs to the eIF-3 subunit C family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1076. Eukaryota.
ENOG410XRU3. LUCA.
InParanoidiQ54X97.
KOiK03252.
OMAiVVMHRSE.
PhylomeDBiQ54X97.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.80.10.10. 1 hit.
HAMAPiMF_03002. eIF3c. 1 hit.
InterProiView protein in InterPro
IPR027516. EIF3C.
IPR008905. EIF3C_N_dom.
IPR032675. L_dom-like.
IPR000717. PCI_dom.
IPR036388. WH-like_DNA-bd_sf.
IPR036390. WH_DNA-bd_sf.
PfamiView protein in Pfam
PF05470. eIF-3c_N. 1 hit.
PF01399. PCI. 1 hit.
SMARTiView protein in SMART
SM00088. PINT. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiView protein in PROSITE
PS50250. PCI. 1 hit.

Sequencei

Sequence statusi: Complete.

Q54X97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRFYRQGSS SESSSESSSD SDVQVKKPTR YVSSSEDEIE EKRIVLSAKD
60 70 80 90 100
KIWQQFDESL KKVRNALKTN DWVSTTSEFD NMTKLITNGK TTRIIEKEGF
110 120 130 140 150
PPSFIKALFI IQTSHRDLTT EQKKKLHANN NKSYNSIKQK LKKTCDLYAK
160 170 180 190 200
ELKPYHDNPA LVNEQENKAN SDDDDDDLSE SESEESESSD DDKGKGKGKA
210 220 230 240 250
AFGKKPATKA VVAKKPLTKK GDDDSESESE ESESESEELI SESWSSDSDD
260 270 280 290 300
DSDSDSDDDS GDNKWMIKDD KKVVAKASVT TVRKTDKDKL DRRNAVVSPL
310 320 330 340 350
SGSGSAVPTA GEGEGEKLTQ DQIMKKVKEV ISNRGKLKTD PMKQIQQLEY
360 370 380 390 400
FYSLIQGDKE TFIVLYELIA AQFDTASVKV ALSIPVWQKV ADGIKKLLEI
410 420 430 440 450
LETNTNFVLV LEHQEPTISK GQVAVTGNLL ALFEMLDDEF SKSLQSINYP
460 470 480 490 500
TKEYLDRLQD EQIILDLGES LQKYYESAGN NGAAAKIAIR RIEHIYYKSS
510 520 530 540 550
NLKNNIIPST MPLSEQITLM SKLSSFVYKF GDERLNARTI LCNIYFNAIN
560 570 580 590 600
NKFHEARDMM LMSHLQDNPT LMDVSTQILF NRAMVQLGLC AFRCGYIQEA
610 620 630 640 650
QNCVVEFSGL RKDLLAQGLS VQSKTAEKDT VREVEETTRI LPAHMWIPID
660 670 680 690 700
LIETVNLISG MLIAVPQNAY RPFDNKFKTC KFYQRHMDSV DRQIFIAPSE
710 720 730 740 750
TSKDIIYQAS KALSAGDWQQ CLEHVNTLRF WSLIPDIDSV REKLTRIVQE
760 770 780 790 800
VSLKTFLFTY STSYDSILLS ELADRFHLPK SQVHSIVAKM MNNHEISASM
810 820 830 840 850
EHSTESITFR AEQTKLQYLA LHYSESLVDF VEQNERIYDV KFGTSYRKKG
860 870 880 890 900
DNDHLPIAGG QHHGHQHHGH QHHGHHHHNQ QQQQHHQQQQ QTTQHHHHHH
910 920 930
QNQNQGNQQY QNKKHHNSNQ QKSHKKRQNN SLVVNN
Length:936
Mass (Da):106,690
Last modified:May 24, 2005 - v1
Checksum:i9E15FC9BFC89F9BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000027 Genomic DNA. Translation: EAL67893.1.
RefSeqiXP_641870.1. XM_636778.1.

Genome annotation databases

EnsemblProtistsiEAL67893; EAL67893; DDB_G0279109.
GeneIDi8621876.
KEGGiddi:DDB_G0279109.

Similar proteinsi

Entry informationi

Entry nameiEIF3C_DICDI
AccessioniPrimary (citable) accession number: Q54X97
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: October 25, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. Translation initiation factors
    List of translation initiation factor entries
  3. SIMILARITY comments
    Index of protein domains and families