Q54X73 (ACOC_DICDI) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 56.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Probable cytoplasmic aconitate hydratase Short name=Aconitase EC=4.2.1.3 Alternative name(s): Citrate hydro-lyase | ||||||
| Gene names |
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| Organism | Dictyostelium discoideum (Slime mold) [Reference proteome] | ||||||
| Taxonomic identifier | 44689 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium |
Protein attributes
| Sequence length | 894 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Catalyzes the isomerization of citrate to isocitrate via cis-aconitate By similarity. |
| Catalytic activity | Citrate = isocitrate. |
| Cofactor | Binds 1 4Fe-4S cluster per subunit By similarity. |
| Subcellular location | Cytoplasm By similarity. |
| Sequence similarities | Belongs to the aconitase/IPM isomerase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Tricarboxylic acid cycle |
| Cellular component | Cytoplasm |
| Ligand | 4Fe-4S Iron Iron-sulfur Metal-binding |
| Molecular function | Lyase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular_component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular_function | 4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW citrate hydro-lyase (cis-aconitate-forming) activityInferred from electronic annotation. Source: EC isocitrate hydro-lyase (cis-aconitate-forming) activityInferred from electronic annotation. Source: EC metal ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 894 | 894 | Probable cytoplasmic aconitate hydratase | PRO_0000328573 | |||||
Regions | |||||||||
| Region | 207 – 209 | 3 | Substrate binding By similarity | ||||||
| Region | 781 – 782 | 2 | Substrate binding By similarity | ||||||
Sites | |||||||||
| Metal binding | 438 | 1 | Iron-sulfur (4Fe-4S) By similarity | ||||||
| Metal binding | 504 | 1 | Iron-sulfur (4Fe-4S) By similarity | ||||||
| Metal binding | 507 | 1 | Iron-sulfur (4Fe-4S) By similarity | ||||||
| Binding site | 87 | 1 | Substrate By similarity | ||||||
| Binding site | 537 | 1 | Substrate By similarity | ||||||
| Binding site | 542 | 1 | Substrate By similarity | ||||||
Sequences
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References
| [1] | "The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.  Kuspa A.Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AAFI02000028 Genomic DNA. Translation: EAL67861.1. |
| RefSeq | XP_641837.1. XM_636745.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 2B3Y based on UniProtKB P21399. |
| ProteinModelPortal | Q54X73. |
| SMR | Q54X73. Positions 4-892. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 44689.DDB_0229908. |
Proteomic databases | |
| PRIDE | Q54X73. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblProtists | DDB0229908; DDB0229908; DDB_G0279159. |
| GeneID | 8621900. |
| KEGG | ddi:DDB_G0279159. |
Organism-specific databases | |
| dictyBase | DDB_G0279159. aco1. |
Phylogenomic databases | |
| eggNOG | COG1048. |
| KO | K01681. |
| OMA | TEVFDIA. |
| ProtClustDB | PTZ00092. |
Family and domain databases | |
| Gene3D | 3.20.19.10. 1 hit. 3.30.499.10. 3 hits. 3.40.1060.10. 1 hit. |
| InterPro | IPR015931. Acnase/IPM_dHydase_lsu_aba_1/3. IPR015937. Acoase/IPM_deHydtase. IPR001030. Acoase/IPM_deHydtase_lsu_aba. IPR015928. Aconitase/3IPM_dehydase_swvl. IPR006249. Aconitase/Fe_reg_prot_2. IPR015934. Aconitase/Fe_reg_prot_2/AcnD. IPR015932. Aconitase/IPMdHydase_lsu_aba_2. IPR018136. Aconitase_4Fe-4S_BS. IPR000573. AconitaseA/IPMdHydase_ssu_swvl. [Graphical view] |
| PANTHER | PTHR11670. PTHR11670. 1 hit. PTHR11670:SF1. PTHR11670:SF1. 1 hit. |
| Pfam | PF00330. Aconitase. 1 hit. PF00694. Aconitase_C. 1 hit. [Graphical view] |
| PRINTS | PR00415. ACONITASE. |
| SUPFAM | SSF52016. Aconitase/3IPM_dehydase_swvl. 1 hit. SSF53732. Aconitase_N. 1 hit. |
| TIGRFAMs | TIGR01341. aconitase_1. 1 hit. |
| PROSITE | PS00450. ACONITASE_1. 1 hit. PS01244. ACONITASE_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ACOC_DICDI | ||||||||
| Accession | Primary (citable) accession number: Q54X73 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
Relevant documents
| Dictyostelium discoideum Dictyostelium discoideum: entries, gene names and cross-references to dictyBase |
| SIMILARITY comments Index of protein domains and families |