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Q54X15

- HDA21_DICDI

UniProt

Q54X15 - HDA21_DICDI

Protein

Type-2 histone deacetylase 1

Gene

hdaD

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.By similarity

    Catalytic activityi

    Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei1232 – 12321Proton acceptorBy similarity

    GO - Molecular functioni

    1. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
    2. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
    3. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
    4. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator, Hydrolase, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Type-2 histone deacetylase 1 (EC:3.5.1.98)
    Short name:
    DdHdaD
    Gene namesi
    Name:hdaD
    ORF Names:DDB_G0279267
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 3, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0279267. hdaD.

    Subcellular locationi

    Nucleus By similarity. Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14891489Type-2 histone deacetylase 1PRO_0000331371Add
    BLAST

    Expressioni

    Developmental stagei

    Down-regulated during terminal differentiation of cells into spores and stalk.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi44689.DDBDRAFT_0205687.

    Structurei

    3D structure databases

    ProteinModelPortaliQ54X15.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi135 – 14612Poly-AsnAdd
    BLAST
    Compositional biasi191 – 21323Poly-AsnAdd
    BLAST
    Compositional biasi222 – 2276Poly-Asn
    Compositional biasi232 – 24413Poly-SerAdd
    BLAST
    Compositional biasi272 – 28110Poly-Asn
    Compositional biasi284 – 29613Poly-AsnAdd
    BLAST
    Compositional biasi334 – 3374Poly-Ser
    Compositional biasi357 – 3604Poly-Asn
    Compositional biasi364 – 3685Poly-Asn
    Compositional biasi371 – 39929Poly-AsnAdd
    BLAST
    Compositional biasi438 – 4447Poly-Asn
    Compositional biasi486 – 55368Poly-AsnAdd
    BLAST
    Compositional biasi913 – 92917Poly-AsnAdd
    BLAST
    Compositional biasi959 – 99032Poly-AsnAdd
    BLAST
    Compositional biasi1001 – 10099Poly-Asn
    Compositional biasi1328 – 13336Poly-Asp
    Compositional biasi1339 – 136729Poly-AsnAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0123.
    OMAiCPRIEDV.

    Family and domain databases

    Gene3Di3.40.800.20. 2 hits.
    InterProiIPR023801. His_deacetylse_dom.
    [Graphical view]
    PfamiPF00850. Hist_deacetyl. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q54X15-1 [UniParc]FASTAAdd to Basket

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    MSTIHQVNEM NSRVGEKPAC CIGAARGHCT AHCPRIEDVL YSQRKGKTNK     50
    GAQRWRCKAC GTKWTSKGII IQPPVVPDTI VNSIGFGNGP EEISMEQLRA 100
    NARPYKKTKT GDNILQTSPF PSLFGNSIGM GLGGNNNNIN NNNNSNGSNS 150
    SNNSHNGGSS PSGSPIPSPP SPVSFLQRNS NVFVPILPQS NGNNINNNNN 200
    NNSNSNSNNI NSNSSNSMQL QNNNNNNGQL RSSSSSLSLS SSSSQLNSSS 250
    NGNGSSRNLL TSQKSAQSLI GNINNNNNNN NIINNNSNNN TNNNNNIMNG 300
    TTTSTTKPVV VGGPMQILNS VVNNSPTSSK PILSSSSQNL LYNSSGSIPQ 350
    PSQSPQNNNN TTINNNNNTT NNNNNNNNSN NNNNSNNNNN NSNNNNINNV 400
    ANGTPRPSLQ TSRLQGKLPS PQQYNTSPSH QQYPSPKNNN NSNNIIPIQS 450
    TYGQPTPPPT KPPVSSKAPA VYHNVRVPSP NTTVDNNNNN NNNNNNNNNN 500
    NNNNNNNNNN NNSNNNNNSN NNNNNINNNN NNNNNSNNNN NGNSNNNNNN 550
    NSNYQQQHQY FSPNQNYIQQ QVQAVQTQQA QHILAQQQAQ AQQQYIQQLQ 600
    LQQQTLAHAQ SQAAHQAQTL THSRHNDLLS PIDSQIWAPI QYSWIQTHYN 650
    PSSSLLECLK RLINSVVVFS NELPVDQRLK MINFLTTLSS PSSESQYNTN 700
    ASKQMLNCID NSVFNITKHY QMLYQSISKH YSMMEDSFIP LTEVYFDENE 750
    INKFIHFSDQ FKIIEEQFEF ILRELSSIRD TLIIKRENIE KNIIESSKFL 800
    NNSSNNDNGI EEIGLEQAKQ DTTRLLESLA PLETTLNSME IKFKSIQKEI 850
    SMVIRVFSFF ELLYNIHINC HQTIVEKHSR QLSTYMIDVI QQSLYNCDVI 900
    SVAYNRLKTG LFNSNNNNNN NNNNNNNNNE EDDQLIDTTN PFINKLSDLL 950
    SKYENISKNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNRN RDRDREFERD 1000
    NNSNNNNNNI EKERNRNNRI RDRDNMDIDN ISSFISNNQQ QHIGQSQSVQ 1050
    QSSQLPKERK VMALYHTTCL DHLVPDDHPE SPKRLSSVIK AINDFSRQSD 1100
    RLIIKNDPEE INDKWILTVH SPEYLRLLED LTEKLDANEI RPLNVNNDGA 1150
    STGINQFSTS TPITTTGTAT VTPGSTTSST NGEQCEDGDT FVSKLSLHAA 1200
    KRSAGATCQA IDNVMKGNVT SAFVAARPPG HHAGRDGLTS GTSSQGFCLL 1250
    NHVCIGAKYA QLKYNLDKIA IIDFDVHHGN GTEEILSNDQ GFYFLSIHMF 1300
    EEGFYPGSGG GVGSIGVVNL NEFNEQNDYD DDDNNNDVNN NNNNNNNNNN 1350
    NNNNNNNNKN NNNNNSNSIT QQSTITNNSN CKGNIVNIPL DPKSSASSFL 1400
    KAFSIIIDKL NDYQPELILI SCGFDAHMED HLASLCLLEE NYVEITRSLR 1450
    RVADRWCKGR LVSILEGGYN INALRQCTIA HLSALSEDD 1489
    Length:1,489
    Mass (Da):165,561
    Last modified:May 24, 2005 - v1
    Checksum:i8587B045FDC673B5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000030 Genomic DNA. Translation: EAL67782.1.
    RefSeqiXP_641762.1. XM_636670.1.

    Genome annotation databases

    EnsemblProtistsiDDB0237655; DDB0237655; DDB_G0279267.
    GeneIDi8621960.
    KEGGiddi:DDB_G0279267.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000030 Genomic DNA. Translation: EAL67782.1 .
    RefSeqi XP_641762.1. XM_636670.1.

    3D structure databases

    ProteinModelPortali Q54X15.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDBDRAFT_0205687.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0237655 ; DDB0237655 ; DDB_G0279267 .
    GeneIDi 8621960.
    KEGGi ddi:DDB_G0279267.

    Organism-specific databases

    dictyBasei DDB_G0279267. hdaD.

    Phylogenomic databases

    eggNOGi COG0123.
    OMAi CPRIEDV.

    Family and domain databases

    Gene3Di 3.40.800.20. 2 hits.
    InterProi IPR023801. His_deacetylse_dom.
    [Graphical view ]
    Pfami PF00850. Hist_deacetyl. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.
    2. "Histone deacetylases regulate multicellular development in the social amoeba Dictyostelium discoideum."
      Sawarkar R., Visweswariah S.S., Nellen W., Nanjundiah V.
      J. Mol. Biol. 391:833-848(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiHDA21_DICDI
    AccessioniPrimary (citable) accession number: Q54X15
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3