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Reviewed, UniProtKB/Swiss-Prot Q54X15 (HDA21_DICDI)

Last modified February 9, 2010. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Type-2 histone deacetylase 1
      Short name=DdHdaD
    EC=3.5.1.98
Gene names
Name: hdaD
ORF Names: DDB_G0279267
OrganismDictyostelium discoideum (Slime mold) [Complete proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

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Protein attributes

Sequence length1489 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.

Catalytic activity

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Subcellular location

Nucleus By similarity. Cytoplasm By similarity.

Developmental stage

Down-regulated during terminal differentiation of cells into spores and stalk. Ref.2

Sequence similarities

Belongs to the histone deacetylase family. Type 2 subfamily.

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Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentCytoplasm
Nucleus
   Molecular functionChromatin regulator
Hydrolase
Repressor
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processchromatin modification

Inferred from electronic annotation. Source: UniProtKB-KW

regulation of transcription

Inferred from electronic annotation. Source: UniProtKB-KW

transcription

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionhydrolase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 14891489Type-2 histone deacetylase 1
PRO_0000331371

Regions

Compositional bias135 – 14612Poly-Asn
Compositional bias191 – 21323Poly-Asn
Compositional bias222 – 2276Poly-Asn
Compositional bias232 – 24413Poly-Ser
Compositional bias272 – 28110Poly-Asn
Compositional bias284 – 29613Poly-Asn
Compositional bias334 – 3374Poly-Ser
Compositional bias357 – 3604Poly-Asn
Compositional bias364 – 3685Poly-Asn
Compositional bias371 – 39929Poly-Asn
Compositional bias438 – 4447Poly-Asn
Compositional bias486 – 55368Poly-Asn
Compositional bias913 – 92917Poly-Asn
Compositional bias959 – 99032Poly-Asn
Compositional bias1001 – 10099Poly-Asn
Compositional bias1328 – 13336Poly-Asp
Compositional bias1339 – 136729Poly-Asn

Sites

Active site12321Proton acceptor By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q54X15-1 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 8587B045FDC673B5

FASTA1,489165,561
        10         20         30         40         50         60 
MSTIHQVNEM NSRVGEKPAC CIGAARGHCT AHCPRIEDVL YSQRKGKTNK GAQRWRCKAC 

        70         80         90        100        110        120 
GTKWTSKGII IQPPVVPDTI VNSIGFGNGP EEISMEQLRA NARPYKKTKT GDNILQTSPF 

       130        140        150        160        170        180 
PSLFGNSIGM GLGGNNNNIN NNNNSNGSNS SNNSHNGGSS PSGSPIPSPP SPVSFLQRNS 

       190        200        210        220        230        240 
NVFVPILPQS NGNNINNNNN NNSNSNSNNI NSNSSNSMQL QNNNNNNGQL RSSSSSLSLS 

       250        260        270        280        290        300 
SSSSQLNSSS NGNGSSRNLL TSQKSAQSLI GNINNNNNNN NIINNNSNNN TNNNNNIMNG 

       310        320        330        340        350        360 
TTTSTTKPVV VGGPMQILNS VVNNSPTSSK PILSSSSQNL LYNSSGSIPQ PSQSPQNNNN 

       370        380        390        400        410        420 
TTINNNNNTT NNNNNNNNSN NNNNSNNNNN NSNNNNINNV ANGTPRPSLQ TSRLQGKLPS 

       430        440        450        460        470        480 
PQQYNTSPSH QQYPSPKNNN NSNNIIPIQS TYGQPTPPPT KPPVSSKAPA VYHNVRVPSP 

       490        500        510        520        530        540 
NTTVDNNNNN NNNNNNNNNN NNNNNNNNNN NNSNNNNNSN NNNNNINNNN NNNNNSNNNN 

       550        560        570        580        590        600 
NGNSNNNNNN NSNYQQQHQY FSPNQNYIQQ QVQAVQTQQA QHILAQQQAQ AQQQYIQQLQ 

       610        620        630        640        650        660 
LQQQTLAHAQ SQAAHQAQTL THSRHNDLLS PIDSQIWAPI QYSWIQTHYN PSSSLLECLK 

       670        680        690        700        710        720 
RLINSVVVFS NELPVDQRLK MINFLTTLSS PSSESQYNTN ASKQMLNCID NSVFNITKHY 

       730        740        750        760        770        780 
QMLYQSISKH YSMMEDSFIP LTEVYFDENE INKFIHFSDQ FKIIEEQFEF ILRELSSIRD 

       790        800        810        820        830        840 
TLIIKRENIE KNIIESSKFL NNSSNNDNGI EEIGLEQAKQ DTTRLLESLA PLETTLNSME 

       850        860        870        880        890        900 
IKFKSIQKEI SMVIRVFSFF ELLYNIHINC HQTIVEKHSR QLSTYMIDVI QQSLYNCDVI 

       910        920        930        940        950        960 
SVAYNRLKTG LFNSNNNNNN NNNNNNNNNE EDDQLIDTTN PFINKLSDLL SKYENISKNN 

       970        980        990       1000       1010       1020 
NNNNNNNNNN NNNNNNNNNN NNNNNNNNRN RDRDREFERD NNSNNNNNNI EKERNRNNRI 

      1030       1040       1050       1060       1070       1080 
RDRDNMDIDN ISSFISNNQQ QHIGQSQSVQ QSSQLPKERK VMALYHTTCL DHLVPDDHPE 

      1090       1100       1110       1120       1130       1140 
SPKRLSSVIK AINDFSRQSD RLIIKNDPEE INDKWILTVH SPEYLRLLED LTEKLDANEI 

      1150       1160       1170       1180       1190       1200 
RPLNVNNDGA STGINQFSTS TPITTTGTAT VTPGSTTSST NGEQCEDGDT FVSKLSLHAA 

      1210       1220       1230       1240       1250       1260 
KRSAGATCQA IDNVMKGNVT SAFVAARPPG HHAGRDGLTS GTSSQGFCLL NHVCIGAKYA 

      1270       1280       1290       1300       1310       1320 
QLKYNLDKIA IIDFDVHHGN GTEEILSNDQ GFYFLSIHMF EEGFYPGSGG GVGSIGVVNL 

      1330       1340       1350       1360       1370       1380 
NEFNEQNDYD DDDNNNDVNN NNNNNNNNNN NNNNNNNNKN NNNNNSNSIT QQSTITNNSN 

      1390       1400       1410       1420       1430       1440 
CKGNIVNIPL DPKSSASSFL KAFSIIIDKL NDYQPELILI SCGFDAHMED HLASLCLLEE 

      1450       1460       1470       1480 
NYVEITRSLR RVADRWCKGR LVSILEGGYN INALRQCTIA HLSALSEDD

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References

« Hide 'large scale' references
[1]"The genome of the social amoeba Dictyostelium discoideum."
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. expand/collapse author list , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
Nature 435:43-57(2005) [PubMed: 15875012] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.
[2]"Histone deacetylases regulate multicellular development in the social amoeba Dictyostelium discoideum."
Sawarkar R., Visweswariah S.S., Nellen W., Nanjundiah V.
J. Mol. Biol. 391:833-848(2009) [PubMed: 19576222] [Abstract]
Cited for: DEVELOPMENTAL STAGE.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AAFI02000030 Genomic DNA. Translation: EAL67782.1.
RefSeqXP_641762.1.

3D structure databases

SMRQ54X15. Positions 1060-1487.
ModBaseSearch...

Genome annotation databases

GeneID8621960.
KEGGddi:DDB_0237655.

Organism-specific databases

dictyBaseDDB_G0279267. hdaD.

Phylogenomic databases

eggNOGKOG1343.
PhylomeDBQ54X15.

Family and domain databases

InterProIPR000286. His_deacetylse.
[Graphical view]
Gene3DG3DSA:3.40.800.20. His_deacetylse. 1 hit.
PfamPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameHDA21_DICDI
AccessionPrimary (citable) accession number: Q54X15
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: February 9, 2010
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

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Relevant documents

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents