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Q54X15

- HDA21_DICDI

UniProt

Q54X15 - HDA21_DICDI

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Protein

Type-2 histone deacetylase 1

Gene
hdaD, DDB_G0279267
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1232 – 12321Proton acceptor By similarity

GO - Molecular functioni

  1. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  2. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  3. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Type-2 histone deacetylase 1 (EC:3.5.1.98)
Short name:
DdHdaD
Gene namesi
Name:hdaD
ORF Names:DDB_G0279267
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 3, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0279267. hdaD.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14891489Type-2 histone deacetylase 1PRO_0000331371Add
BLAST

Expressioni

Developmental stagei

Down-regulated during terminal differentiation of cells into spores and stalk.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi44689.DDBDRAFT_0205687.

Structurei

3D structure databases

ProteinModelPortaliQ54X15.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi135 – 14612Poly-AsnAdd
BLAST
Compositional biasi191 – 21323Poly-AsnAdd
BLAST
Compositional biasi222 – 2276Poly-Asn
Compositional biasi232 – 24413Poly-SerAdd
BLAST
Compositional biasi272 – 28110Poly-Asn
Compositional biasi284 – 29613Poly-AsnAdd
BLAST
Compositional biasi334 – 3374Poly-Ser
Compositional biasi357 – 3604Poly-Asn
Compositional biasi364 – 3685Poly-Asn
Compositional biasi371 – 39929Poly-AsnAdd
BLAST
Compositional biasi438 – 4447Poly-Asn
Compositional biasi486 – 55368Poly-AsnAdd
BLAST
Compositional biasi913 – 92917Poly-AsnAdd
BLAST
Compositional biasi959 – 99032Poly-AsnAdd
BLAST
Compositional biasi1001 – 10099Poly-Asn
Compositional biasi1328 – 13336Poly-Asp
Compositional biasi1339 – 136729Poly-AsnAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0123.
OMAiCPRIEDV.

Family and domain databases

Gene3Di3.40.800.20. 2 hits.
InterProiIPR023801. His_deacetylse_dom.
[Graphical view]
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54X15-1 [UniParc]FASTAAdd to Basket

« Hide

MSTIHQVNEM NSRVGEKPAC CIGAARGHCT AHCPRIEDVL YSQRKGKTNK     50
GAQRWRCKAC GTKWTSKGII IQPPVVPDTI VNSIGFGNGP EEISMEQLRA 100
NARPYKKTKT GDNILQTSPF PSLFGNSIGM GLGGNNNNIN NNNNSNGSNS 150
SNNSHNGGSS PSGSPIPSPP SPVSFLQRNS NVFVPILPQS NGNNINNNNN 200
NNSNSNSNNI NSNSSNSMQL QNNNNNNGQL RSSSSSLSLS SSSSQLNSSS 250
NGNGSSRNLL TSQKSAQSLI GNINNNNNNN NIINNNSNNN TNNNNNIMNG 300
TTTSTTKPVV VGGPMQILNS VVNNSPTSSK PILSSSSQNL LYNSSGSIPQ 350
PSQSPQNNNN TTINNNNNTT NNNNNNNNSN NNNNSNNNNN NSNNNNINNV 400
ANGTPRPSLQ TSRLQGKLPS PQQYNTSPSH QQYPSPKNNN NSNNIIPIQS 450
TYGQPTPPPT KPPVSSKAPA VYHNVRVPSP NTTVDNNNNN NNNNNNNNNN 500
NNNNNNNNNN NNSNNNNNSN NNNNNINNNN NNNNNSNNNN NGNSNNNNNN 550
NSNYQQQHQY FSPNQNYIQQ QVQAVQTQQA QHILAQQQAQ AQQQYIQQLQ 600
LQQQTLAHAQ SQAAHQAQTL THSRHNDLLS PIDSQIWAPI QYSWIQTHYN 650
PSSSLLECLK RLINSVVVFS NELPVDQRLK MINFLTTLSS PSSESQYNTN 700
ASKQMLNCID NSVFNITKHY QMLYQSISKH YSMMEDSFIP LTEVYFDENE 750
INKFIHFSDQ FKIIEEQFEF ILRELSSIRD TLIIKRENIE KNIIESSKFL 800
NNSSNNDNGI EEIGLEQAKQ DTTRLLESLA PLETTLNSME IKFKSIQKEI 850
SMVIRVFSFF ELLYNIHINC HQTIVEKHSR QLSTYMIDVI QQSLYNCDVI 900
SVAYNRLKTG LFNSNNNNNN NNNNNNNNNE EDDQLIDTTN PFINKLSDLL 950
SKYENISKNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNRN RDRDREFERD 1000
NNSNNNNNNI EKERNRNNRI RDRDNMDIDN ISSFISNNQQ QHIGQSQSVQ 1050
QSSQLPKERK VMALYHTTCL DHLVPDDHPE SPKRLSSVIK AINDFSRQSD 1100
RLIIKNDPEE INDKWILTVH SPEYLRLLED LTEKLDANEI RPLNVNNDGA 1150
STGINQFSTS TPITTTGTAT VTPGSTTSST NGEQCEDGDT FVSKLSLHAA 1200
KRSAGATCQA IDNVMKGNVT SAFVAARPPG HHAGRDGLTS GTSSQGFCLL 1250
NHVCIGAKYA QLKYNLDKIA IIDFDVHHGN GTEEILSNDQ GFYFLSIHMF 1300
EEGFYPGSGG GVGSIGVVNL NEFNEQNDYD DDDNNNDVNN NNNNNNNNNN 1350
NNNNNNNNKN NNNNNSNSIT QQSTITNNSN CKGNIVNIPL DPKSSASSFL 1400
KAFSIIIDKL NDYQPELILI SCGFDAHMED HLASLCLLEE NYVEITRSLR 1450
RVADRWCKGR LVSILEGGYN INALRQCTIA HLSALSEDD 1489
Length:1,489
Mass (Da):165,561
Last modified:May 24, 2005 - v1
Checksum:i8587B045FDC673B5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000030 Genomic DNA. Translation: EAL67782.1.
RefSeqiXP_641762.1. XM_636670.1.

Genome annotation databases

EnsemblProtistsiDDB0237655; DDB0237655; DDB_G0279267.
GeneIDi8621960.
KEGGiddi:DDB_G0279267.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000030 Genomic DNA. Translation: EAL67782.1 .
RefSeqi XP_641762.1. XM_636670.1.

3D structure databases

ProteinModelPortali Q54X15.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDBDRAFT_0205687.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0237655 ; DDB0237655 ; DDB_G0279267 .
GeneIDi 8621960.
KEGGi ddi:DDB_G0279267.

Organism-specific databases

dictyBasei DDB_G0279267. hdaD.

Phylogenomic databases

eggNOGi COG0123.
OMAi CPRIEDV.

Family and domain databases

Gene3Di 3.40.800.20. 2 hits.
InterProi IPR023801. His_deacetylse_dom.
[Graphical view ]
Pfami PF00850. Hist_deacetyl. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "Histone deacetylases regulate multicellular development in the social amoeba Dictyostelium discoideum."
    Sawarkar R., Visweswariah S.S., Nellen W., Nanjundiah V.
    J. Mol. Biol. 391:833-848(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiHDA21_DICDI
AccessioniPrimary (citable) accession number: Q54X15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: May 14, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3