Q54X15 (HDA21_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Type-2 histone deacetylase 1
Short name=DdHdaD
EC=3.5.1.98

Gene names

Name:	hdaD
ORF Names:	DDB_G0279267

Organism

Dictyostelium discoideum (Slime mold) [Reference proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	1489 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.
Catalytic activity	Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
Subcellular location	Nucleus By similarity. Cytoplasm By similarity.
Developmental stage	Down-regulated during terminal differentiation of cells into spores and stalk. Ref.2
Sequence similarities	Belongs to the histone deacetylase family. HD type 2 subfamily.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Molecular function	Chromatin regulator Hydrolase Repressor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	histone H3 deacetylation Inferred from electronic annotation. Source: GOC histone H4 deacetylation Inferred from electronic annotation. Source: GOC regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	NAD-dependent histone deacetylase activity (H3-K14 specific) Inferred from electronic annotation. Source: EC NAD-dependent histone deacetylase activity (H3-K18 specific) Inferred from electronic annotation. Source: EC NAD-dependent histone deacetylase activity (H3-K9 specific) Inferred from electronic annotation. Source: EC NAD-dependent histone deacetylase activity (H4-K16 specific) Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1489	1489	Type-2 histone deacetylase 1		PRO_0000331371
Regions
	Compositional bias	135 – 146	12	Poly-Asn
	Compositional bias	191 – 213	23	Poly-Asn
	Compositional bias	222 – 227	6	Poly-Asn
	Compositional bias	232 – 244	13	Poly-Ser
	Compositional bias	272 – 281	10	Poly-Asn
	Compositional bias	284 – 296	13	Poly-Asn
	Compositional bias	334 – 337	4	Poly-Ser
	Compositional bias	357 – 360	4	Poly-Asn
	Compositional bias	364 – 368	5	Poly-Asn
	Compositional bias	371 – 399	29	Poly-Asn
	Compositional bias	438 – 444	7	Poly-Asn
	Compositional bias	486 – 553	68	Poly-Asn
	Compositional bias	913 – 929	17	Poly-Asn
	Compositional bias	959 – 990	32	Poly-Asn
	Compositional bias	1001 – 1009	9	Poly-Asn
	Compositional bias	1328 – 1333	6	Poly-Asp
	Compositional bias	1339 – 1367	29	Poly-Asn
Sites
	Active site	1232	1	Proton acceptor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q54X15 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 8587B045FDC673B5	FASTA	1,489	165,561
	10 20 30 40 50 60 MSTIHQVNEM NSRVGEKPAC CIGAARGHCT AHCPRIEDVL YSQRKGKTNK GAQRWRCKAC 70 80 90 100 110 120 GTKWTSKGII IQPPVVPDTI VNSIGFGNGP EEISMEQLRA NARPYKKTKT GDNILQTSPF 130 140 150 160 170 180 PSLFGNSIGM GLGGNNNNIN NNNNSNGSNS SNNSHNGGSS PSGSPIPSPP SPVSFLQRNS 190 200 210 220 230 240 NVFVPILPQS NGNNINNNNN NNSNSNSNNI NSNSSNSMQL QNNNNNNGQL RSSSSSLSLS 250 260 270 280 290 300 SSSSQLNSSS NGNGSSRNLL TSQKSAQSLI GNINNNNNNN NIINNNSNNN TNNNNNIMNG 310 320 330 340 350 360 TTTSTTKPVV VGGPMQILNS VVNNSPTSSK PILSSSSQNL LYNSSGSIPQ PSQSPQNNNN 370 380 390 400 410 420 TTINNNNNTT NNNNNNNNSN NNNNSNNNNN NSNNNNINNV ANGTPRPSLQ TSRLQGKLPS 430 440 450 460 470 480 PQQYNTSPSH QQYPSPKNNN NSNNIIPIQS TYGQPTPPPT KPPVSSKAPA VYHNVRVPSP 490 500 510 520 530 540 NTTVDNNNNN NNNNNNNNNN NNNNNNNNNN NNSNNNNNSN NNNNNINNNN NNNNNSNNNN 550 560 570 580 590 600 NGNSNNNNNN NSNYQQQHQY FSPNQNYIQQ QVQAVQTQQA QHILAQQQAQ AQQQYIQQLQ 610 620 630 640 650 660 LQQQTLAHAQ SQAAHQAQTL THSRHNDLLS PIDSQIWAPI QYSWIQTHYN PSSSLLECLK 670 680 690 700 710 720 RLINSVVVFS NELPVDQRLK MINFLTTLSS PSSESQYNTN ASKQMLNCID NSVFNITKHY 730 740 750 760 770 780 QMLYQSISKH YSMMEDSFIP LTEVYFDENE INKFIHFSDQ FKIIEEQFEF ILRELSSIRD 790 800 810 820 830 840 TLIIKRENIE KNIIESSKFL NNSSNNDNGI EEIGLEQAKQ DTTRLLESLA PLETTLNSME 850 860 870 880 890 900 IKFKSIQKEI SMVIRVFSFF ELLYNIHINC HQTIVEKHSR QLSTYMIDVI QQSLYNCDVI 910 920 930 940 950 960 SVAYNRLKTG LFNSNNNNNN NNNNNNNNNE EDDQLIDTTN PFINKLSDLL SKYENISKNN 970 980 990 1000 1010 1020 NNNNNNNNNN NNNNNNNNNN NNNNNNNNRN RDRDREFERD NNSNNNNNNI EKERNRNNRI 1030 1040 1050 1060 1070 1080 RDRDNMDIDN ISSFISNNQQ QHIGQSQSVQ QSSQLPKERK VMALYHTTCL DHLVPDDHPE 1090 1100 1110 1120 1130 1140 SPKRLSSVIK AINDFSRQSD RLIIKNDPEE INDKWILTVH SPEYLRLLED LTEKLDANEI 1150 1160 1170 1180 1190 1200 RPLNVNNDGA STGINQFSTS TPITTTGTAT VTPGSTTSST NGEQCEDGDT FVSKLSLHAA 1210 1220 1230 1240 1250 1260 KRSAGATCQA IDNVMKGNVT SAFVAARPPG HHAGRDGLTS GTSSQGFCLL NHVCIGAKYA 1270 1280 1290 1300 1310 1320 QLKYNLDKIA IIDFDVHHGN GTEEILSNDQ GFYFLSIHMF EEGFYPGSGG GVGSIGVVNL 1330 1340 1350 1360 1370 1380 NEFNEQNDYD DDDNNNDVNN NNNNNNNNNN NNNNNNNNKN NNNNNSNSIT QQSTITNNSN 1390 1400 1410 1420 1430 1440 CKGNIVNIPL DPKSSASSFL KAFSIIIDKL NDYQPELILI SCGFDAHMED HLASLCLLEE 1450 1460 1470 1480 NYVEITRSLR RVADRWCKGR LVSILEGGYN INALRQCTIA HLSALSEDD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
[2]	"Histone deacetylases regulate multicellular development in the social amoeba Dictyostelium discoideum." Sawarkar R., Visweswariah S.S., Nellen W., Nanjundiah V. J. Mol. Biol. 391:833-848(2009) [PubMed] [Europe PMC] [Abstract] Cited for: DEVELOPMENTAL STAGE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000030 Genomic DNA. Translation: EAL67782.1.
RefSeq	XP_641762.1. XM_636670.1.
3D structure databases
ProteinModelPortal	Q54X15.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0237655; DDB0237655; DDB_G0279267.
GeneID	8621960.
KEGG	ddi:DDB_G0279267.
Organism-specific databases
dictyBase	DDB_G0279267. hdaD.
Phylogenomic databases
eggNOG	COG0123.
OMA	ELILISC.
Family and domain databases
Gene3D	3.40.800.20. 2 hits.
InterPro	IPR023801. His_deacetylse_dom. [Graphical view]
Pfam	PF00850. Hist_deacetyl. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HDA21_DICDI

Accession

Primary (citable) accession number: Q54X15

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	May 24, 2005
Last modified:	May 1, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)