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Protein

Phosphomannomutase 1

Gene

pmmA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.By similarity

Catalytic activityi

Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

Pathwayi: GDP-alpha-D-mannose biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Probable mannose-6-phosphate isomerase (mpi)
  2. Phosphomannomutase 1 (pmmA), Phosphomannomutase 2 (pmmB)
This subpathway is part of the pathway GDP-alpha-D-mannose biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate, the pathway GDP-alpha-D-mannose biosynthesis and in Nucleotide-sugar biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei12NucleophileBy similarity1
Active sitei14Proton donor/acceptorSequence analysis1
Binding sitei21SubstrateBy similarity1
Binding sitei123SubstrateBy similarity1
Binding sitei134SubstrateBy similarity1
Binding sitei141SubstrateBy similarity1
Binding sitei179SubstrateBy similarity1
Binding sitei181SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase

Enzyme and pathway databases

ReactomeiR-DDI-446205. Synthesis of GDP-mannose.
UniPathwayiUPA00126; UER00424.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphomannomutase 1 (EC:5.4.2.8)
Short name:
PMM 1
Gene namesi
Name:pmmA
ORF Names:DDB_G0279289
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0279289. pmmA.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003275161 – 249Phosphomannomutase 1Add BLAST249

Proteomic databases

PaxDbiQ54X03.
PRIDEiQ54X03.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi44689.DDB0231660.

Structurei

3D structure databases

ProteinModelPortaliQ54X03.
SMRiQ54X03.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic PMM family.Curated

Phylogenomic databases

eggNOGiKOG3189. Eukaryota.
COG0561. LUCA.
InParanoidiQ54X03.
KOiK17497.
OMAiFDYCFSE.
PhylomeDBiQ54X03.

Family and domain databases

CDDicd02585. HAD_PMM. 1 hit.
Gene3Di3.40.50.1000. 2 hits.
InterProiView protein in InterPro
IPR036412. HAD-like_sf.
IPR006379. HAD-SF_hydro_IIB.
IPR023214. HAD_sf.
IPR005002. PMM.
PANTHERiPTHR10466. PTHR10466. 1 hit.
PfamiView protein in Pfam
PF03332. PMM. 1 hit.
SFLDiSFLDG01143. C2.B.3:_Phosphomannomutase_Lik. 1 hit.
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01484. HAD-SF-IIB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q54X03-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLVPNTICL FDVDGTLTKP RNVITPEMKD FLAGLRTKVE LGVVGGSDIN
60 70 80 90 100
KIKEQLGENC INEFHYLFAE NGLLSFKDGS LLATQDIKKF LGEENIKKFI
110 120 130 140 150
NFVLHYIADL DIPIKRGTFV EFRNGMINIS PIGRNCSQQE REEFEKYDLE
160 170 180 190 200
HKIRPTMVSI LKEKFQSLGL QYSIGGQISF DVFPIGWDKT YCLRHLPEDK
210 220 230 240
YKTIYFFGDK TFVGGNDYEI ANDPRITKSF TVTSPTDTKN FLSELFYKQ
Length:249
Mass (Da):28,558
Last modified:May 24, 2005 - v1
Checksum:i1490BEAA64356233
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000030 Genomic DNA. Translation: EAL67793.1.
RefSeqiXP_641774.1. XM_636682.1.

Genome annotation databases

EnsemblProtistsiEAL67793; EAL67793; DDB_G0279289.
GeneIDi8621971.
KEGGiddi:DDB_G0279289.

Similar proteinsi

Entry informationi

Entry nameiPMM1_DICDI
AccessioniPrimary (citable) accession number: Q54X03
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: October 25, 2017
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families