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Q54X03 (PMM1_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphomannomutase 1

Short name=PMM 1
EC=5.4.2.8
Gene names
Name:pmmA
ORF Names:DDB_G0279289
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length249 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions By similarity.

Catalytic activity

Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

Pathway

Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the eukaryotic PMM family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processGDP-mannose biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

mannose biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionphosphomannomutase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 249249Phosphomannomutase 1
PRO_0000327516

Sites

Active site121Nucleophile By similarity
Active site141Proton donor/acceptor Potential
Binding site211Substrate By similarity
Binding site1231Substrate By similarity
Binding site1341Substrate By similarity
Binding site1411Substrate By similarity
Binding site1791Substrate By similarity
Binding site1811Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q54X03 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 1490BEAA64356233

FASTA24928,558
        10         20         30         40         50         60 
MSLVPNTICL FDVDGTLTKP RNVITPEMKD FLAGLRTKVE LGVVGGSDIN KIKEQLGENC 

        70         80         90        100        110        120 
INEFHYLFAE NGLLSFKDGS LLATQDIKKF LGEENIKKFI NFVLHYIADL DIPIKRGTFV 

       130        140        150        160        170        180 
EFRNGMINIS PIGRNCSQQE REEFEKYDLE HKIRPTMVSI LKEKFQSLGL QYSIGGQISF 

       190        200        210        220        230        240 
DVFPIGWDKT YCLRHLPEDK YKTIYFFGDK TFVGGNDYEI ANDPRITKSF TVTSPTDTKN 


FLSELFYKQ 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000030 Genomic DNA. Translation: EAL67793.1.
RefSeqXP_641774.1. XM_636682.1.

3D structure databases

ProteinModelPortalQ54X03.
SMRQ54X03. Positions 7-245.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDB_0231660.

Proteomic databases

PRIDEQ54X03.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0231660; DDB0231660; DDB_G0279289.
GeneID8621971.
KEGGddi:DDB_G0279289.

Organism-specific databases

dictyBaseDDB_G0279289. pmmA.

Phylogenomic databases

eggNOGCOG0561.
OMAPNTICLF.
PhylomeDBQ54X03.

Enzyme and pathway databases

UniPathwayUPA00126; UER00424.

Family and domain databases

Gene3D3.40.50.1000. 2 hits.
InterProIPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR005002. PMM.
[Graphical view]
PANTHERPTHR10466. PTHR10466. 1 hit.
PfamPF03332. PMM. 1 hit.
[Graphical view]
SUPFAMSSF56784. SSF56784. 1 hit.
TIGRFAMsTIGR01484. HAD-SF-IIB. 1 hit.
ProtoNetSearch...

Entry information

Entry namePMM1_DICDI
AccessionPrimary (citable) accession number: Q54X03
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: July 9, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase