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Protein

Probable protein phosphatase DDB_G0279461

Gene

DDB_G0279461

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi784 – 7841Manganese 1By similarity
Metal bindingi784 – 7841Manganese 2By similarity
Metal bindingi785 – 7851Manganese 1; via carbonyl oxygenBy similarity
Metal bindingi956 – 9561Manganese 2By similarity
Metal bindingi996 – 9961Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase DDB_G0279461 (EC:3.1.3.16)
Gene namesi
ORF Names:DDB_G0279461
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195 Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0279461.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10061006Probable protein phosphatase DDB_G0279461PRO_0000369245Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi44689.DDBDRAFT_0205778.

Structurei

3D structure databases

ProteinModelPortaliQ54WS9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini744 – 1005262PPM-type phosphatasePROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili65 – 12258Sequence AnalysisAdd
BLAST
Coiled coili450 – 51667Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi223 – 23412Poly-AsnAdd
BLAST
Compositional biasi244 – 25613Poly-AsnAdd
BLAST
Compositional biasi291 – 2966Poly-Gln
Compositional biasi316 – 35237Poly-AsnAdd
BLAST
Compositional biasi372 – 38110Poly-Asn
Compositional biasi554 – 5607Poly-Asn
Compositional biasi613 – 6219Poly-Asn
Compositional biasi622 – 63918Poly-ThrAdd
BLAST

Sequence similaritiesi

In the C-terminal section; belongs to the PP2C family.Curated
Contains 1 PPM-type phosphatase domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG0631.
InParanoidiQ54WS9.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS51746. PPM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54WS9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMVPSLSTSI SSPALFKNRE GGEEGNDGGL EQLQNQVNDL GDLNFNEEGD
60 70 80 90 100
YNNDQQPTNE EEGTADNELE SLMSLVNDNN NNNNNTSGID DDNNNDIDDN
110 120 130 140 150
NNNNNNNNNN NNNNNNNKEG LNDLFISSIN VSTLLNDLDQ LSDTHSHASV
160 170 180 190 200
SNQSSNGSVR RGYDIKTQRS VGTKGQGGSS GSSPRSNSLR VYRTFPYRGD
210 220 230 240 250
HHFSWLNNIR DVDSSEDPNS CHNSNNNNKN NKNNQPSSTH DQTNINNNNN
260 270 280 290 300
NNCNDNEKPI KPNSTNGIRH SRKYKGLQQL DFLGSNIILP QQQQPQPIED
310 320 330 340 350
NQQVVPQPFQ VDAESNYNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNDNE
360 370 380 390 400
NNQHPINPVN TQNTQQNVTH SNNNNNNNNN NTAPPNQWSE LIESLGYGSQ
410 420 430 440 450
SDEQKTFGST LDDLNNANSC SDLKDLIVDG ISINNETSPS QSQEITDFSK
460 470 480 490 500
IDNLNKNINI NNNNNTDSQQ PLPSIDVNFS HNNNNNNNDN DNNNNNNNNN
510 520 530 540 550
NNNNNNNNNN NIQDIQIPYH QNDQDYNIQE GNDINNDNYE IRVSNNDDDN
560 570 580 590 600
DSSNNNNNNN SKFQENLNLL NTGMGGRICK TDQKKQLSRT ITFADPSSIL
610 620 630 640 650
SFFGSIPTDE DQNNNNNKNK NTTTTTTTTN TTTTTTTTTS ASAAAQNKLD
660 670 680 690 700
LLSSLSAGQS SGGVGGGNNV LNSSSTPAIK VNHQHKVTEQ NRTSSKISLS
710 720 730 740 750
TIFPKLPPFT NQQSPPTLSP SKYYYPLLQP EPTTLIRGFS SAADINKRGL
760 770 780 790 800
KRAKKPMEME DVYLTQYPLG DDQDSQIALF AIFDGHSGKG CAVAAKEIFP
810 820 830 840 850
NILLKYIKST KNENGGKPIY DMRGVFLNAF KEVDAQLSKF EYEGATATVC
860 870 880 890 900
LVWRAGHQRF VQSANVGDST AFLSYGNETL FLSKDHRATD PEEIQRIKND
910 920 930 940 950
GITLTEGQTR INGLMVSRAL GDHFIKHLNC GLSGEPYVSP PISITPFHSH
960 970 980 990 1000
LIVASDGLWD VISGNRAMEI VKVQQTEEKM SNSLLQCAIG SIKAKDNISI

IVVTLQ
Length:1,006
Mass (Da):111,161
Last modified:April 14, 2009 - v2
Checksum:i173B5733030E9B62
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000031 Genomic DNA. Translation: EAL67669.2.
RefSeqiXP_641638.2. XM_636546.2.

Genome annotation databases

EnsemblProtistsiDDB0304651; DDB0304651; DDB_G0279461.
GeneIDi8622044.
KEGGiddi:DDB_G0279461.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000031 Genomic DNA. Translation: EAL67669.2.
RefSeqiXP_641638.2. XM_636546.2.

3D structure databases

ProteinModelPortaliQ54WS9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDBDRAFT_0205778.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0304651; DDB0304651; DDB_G0279461.
GeneIDi8622044.
KEGGiddi:DDB_G0279461.

Organism-specific databases

dictyBaseiDDB_G0279461.

Phylogenomic databases

eggNOGiCOG0631.
InParanoidiQ54WS9.

Miscellaneous databases

PROiQ54WS9.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS51746. PPM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiY9461_DICDI
AccessioniPrimary (citable) accession number: Q54WS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 14, 2009
Last modified: April 29, 2015
This is version 54 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.