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Protein

Type-3 glutamine synthetase

Gene

glnA3

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate-ammonia ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. nitrogen compound metabolic process Source: InterPro
  2. response to bacterium Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Type-3 glutamine synthetase (EC:6.3.1.2)
Alternative name(s):
Type-3 glutamate--ammonia ligase
Short name:
Type-3 GS
Gene namesi
Name:glnA3
Synonyms:glnB
ORF Names:DDB_G0279591
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 3, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0279591. glnA3.

Subcellular locationi

GO - Cellular componenti

  1. phagocytic vesicle Source: dictyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 735735Type-3 glutamine synthetasePRO_0000330468Add
BLAST

Proteomic databases

PRIDEiQ54WR9.

Interactioni

Subunit structurei

Homohexamer.By similarity

Protein-protein interaction databases

STRINGi44689.DDB_0231551.

Structurei

3D structure databases

ProteinModelPortaliQ54WR9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3968.
InParanoidiQ54WR9.
KOiK01915.
OMAiFDDHYFG.
PhylomeDBiQ54WR9.

Family and domain databases

Gene3Di3.30.590.10. 2 hits.
InterProiIPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR022147. GSIII_N.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF12437. GSIII_N. 1 hit.
[Graphical view]
PROSITEiPS00181. GLNA_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54WR9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSNRRREFIE YIDSREPVEA DIDISDKADR LTDIYDSDTY GLNAMRETLP
60 70 80 90 100
SHCYKKIREV MQTGSALDPE IADMVANGMK EWAIKQGATH YCHWFLPLNG
110 120 130 140 150
LAAEKHDSFI SIFPGDDKVL LEFSGMQLIK GEPDASSFPS GGIRSTWEAR
160 170 180 190 200
GYTVWDATSP AFIRREKNGA ILCIPTAFCS WTGEALDQKT PLLRSMEYVS
210 220 230 240 250
NESIITLSSL FNEKHKRISP TLGIEQEFFL IDRKFYLARP DLVNCGRTLI
260 270 280 290 300
GAKPPKGQEM EDHYFGTMNS RIISCIQEVE WKMWRLGMPL KTRHNEVAPG
310 320 330 340 350
QYEVAPIFER ANIAADHNMM LMDILKNVST KHGLVCLFHE KPFAGVNGSG
360 370 380 390 400
KHNNWSLSTD GGSNLLEPGH TPSQNARFIL FLTAIIRAVD IHADLLRASV
410 420 430 440 450
AVPGNEHRLG ANEAPPAIIS IYLGKELDTV INNIINNTDI QAPGSDDMDL
460 470 480 490 500
GVVGFPPLPK DSTDRNRTSP FAFTGNKFEF RAVGSSQVVN FPCIVLNTIV
510 520 530 540 550
AESLRFIREE ILREMKVSSR QTAFNKIIKD TLIQHVRVVF NGDGYSGDWK
560 570 580 590 600
ELAKSRGLAN LPSTPEALTN INSEKNIKLF SESNILSPVE LESRQEILFE
610 620 630 640 650
IYNKSIKIEA NSLYDLVSTL VLPACFAHQK NIAESVNSIM PFIQSQKSFS
660 670 680 690 700
QPNHQYSHLS EVVESVNLLI EANQKLLALI KQTKDFNSEH SLATFLNQSV
710 720 730
IPQMNEVRKF SDHLEGIVED KSWPVPKYSE ILFLR
Length:735
Mass (Da):82,616
Last modified:May 24, 2005 - v1
Checksum:i9B2B44F894566A08
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000031 Genomic DNA. Translation: EAL67734.1.
RefSeqiXP_641648.1. XM_636556.1.

Genome annotation databases

EnsemblProtistsiDDB0231551; DDB0231551; DDB_G0279591.
GeneIDi8622055.
KEGGiddi:DDB_G0279591.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000031 Genomic DNA. Translation: EAL67734.1.
RefSeqiXP_641648.1. XM_636556.1.

3D structure databases

ProteinModelPortaliQ54WR9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB_0231551.

Proteomic databases

PRIDEiQ54WR9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0231551; DDB0231551; DDB_G0279591.
GeneIDi8622055.
KEGGiddi:DDB_G0279591.

Organism-specific databases

dictyBaseiDDB_G0279591. glnA3.

Phylogenomic databases

eggNOGiCOG3968.
InParanoidiQ54WR9.
KOiK01915.
OMAiFDDHYFG.
PhylomeDBiQ54WR9.

Family and domain databases

Gene3Di3.30.590.10. 2 hits.
InterProiIPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR022147. GSIII_N.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF12437. GSIII_N. 1 hit.
[Graphical view]
PROSITEiPS00181. GLNA_ATP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "Proteomics fingerprinting of phagosome maturation and evidence for the role of a Galpha during uptake."
    Gotthardt D., Blancheteau V., Bosserhoff A., Ruppert T., Delorenzi M., Soldati T.
    Mol. Cell. Proteomics 5:2228-2243(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: AX2.

Entry informationi

Entry nameiGLNA3_DICDI
AccessioniPrimary (citable) accession number: Q54WR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: January 7, 2015
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.