Q54W19 (ABCD1_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ABC transporter D family member 1

Alternative name(s):
ABC transporter ABCD.1

Gene names

Name:	abcD1
ORF Names:	DDB_G0279917

Organism

Dictyostelium discoideum (Slime mold)

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	734 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily. [View classification] Contains 1 ABC transmembrane type-1 domain. Contains 1 ABC transporter domain.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Domain	Coiled coil Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	peroxisomal long-chain fatty acid import Inferred from sequence or structural similarity. Source: dictyBase
Cellular component	ATP-binding cassette (ABC) transporter complex Inferred from sequence or structural similarity. Source: dictyBase integral to peroxisomal membrane Inferred from sequence or structural similarity. Source: dictyBase
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of substances Inferred from sequence or structural similarity. Source: dictyBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 734	734	ABC transporter D family member 1		PRO_0000370849
Regions
	Transmembrane	52 – 72	21	Helical; Potential
	Transmembrane	112 – 132	21	Helical; Potential
	Transmembrane	177 – 197	21	Helical; Potential
	Transmembrane	204 – 224	21	Helical; Potential
	Transmembrane	374 – 394	21	Helical; Potential
	Domain	63 – 351	289	ABC transmembrane type-1
	Domain	492 – 729	238	ABC transporter
	Nucleotide binding	525 – 532	8	ATP Potential
	Coiled coil	332 – 359	28	Potential
	Compositional bias	8 – 15	8	Poly-Asn

Sequences

	Sequence		Length	Mass (Da)
	Q54W19 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: DAFAE2F1D3270CD8	FASTA	734	84,377
	10 20 30 40 50 60 MKTTNVKNNN NNINNTDEEI KIKNNYNQND ERLKKIKENK FDWALFKRFI NIIKILYAKP 70 80 90 100 110 120 VIPLTLFLIL FGNGFAQTYV SKFTGILLAD IYASFTSGDK VFFLSSVLKA GFAIGGSALL 130 140 150 160 170 180 AAIINFIVSI MAWNWRKTLC LYIQNVYFKK SLFYKILAFD DRIDNPDQRI TSDIDNFTTL 190 200 210 220 230 240 LASIVSQCIT GPMVVVYYTY LCYTTIDWYA PLIVYGFFFL GYLINKLVMS PMVSINYLQD 250 260 270 280 290 300 KLEGDFRSLH QRIRNFSESI ALYSLSKEKQ HPEKRFDNND YDHGYESDDS DQSCDESTTI 310 320 330 340 350 360 INRKKNKGSQ YYKNKNSTSK KINDFIDKLS GDSNDQKEEL LVEEEQAKIQ FEALLKNKKR 370 380 390 400 410 420 VIFWQLGLNT TSDLFTYLSP IANYFIIAIP VFFLNNKSVL QPGDVTVQSY NCIMLASGFS 430 440 450 460 470 480 QYINVSQSIS DLSGYISRIS SMIEVCKKIM EDVSLDADIT KLNEKVAQTH NNDAIINTGS 490 500 510 520 530 540 SGNISLNNGD SITLDDVTYF TPKGNQLYSK ISINVKRGNN LLIMGPSGSG KSSLIRIING 550 560 570 580 590 600 LWPFFKGSID RPENGDMFFL PQQPYLIFGT LEEQILYPFS KKQKRIPKSI MRELFQRFEI 610 620 630 640 650 660 DYLLDRERFI KKSAQVNDLT HNWLNQLSPG EQQLIAIIRL IYHKPKFALM DESTSSIPQS 670 680 690 700 710 720 LEERVYYVAK ELGITIISVG HRISLLKYHS TLLRFDKDKN WYLEDIINQN NQSNNINNNN 730 NNNTNKIAED SVFD

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

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Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000035 Genomic DNA. Translation: EAL67430.1.
RefSeq	XP_641431.1. XM_636339.1.
3D structure databases
ProteinModelPortal	Q54W19.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0215371; DDB0215371; DDB_G0279917.
GeneID	8622316.
GenomeReviews	Gene locus abcD1 in contig CM000152_GR.
KEGG	ddi:DDB_G0279917.
Organism-specific databases
dictyBase	DDB_G0279917. abcD1.
Phylogenomic databases
eggNOG	KOG0060.
HOGENOM	HBG077969.
InParanoid	Q54W19.
OMA	INIELHA.
PhylomeDB	Q54W19.
ProtClustDB	CLSZ2430652.
Family and domain databases
InterPro	IPR010509. ABC_Ald_N. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR017940. ABC_transporter_type1. IPR011527. ABC_transptrTM_dom_typ1. IPR003593. ATPase_AAA+_core. [Graphical view]
Pfam	PF06472. ABC_membrane_2. 1 hit. PF00005. ABC_tran. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
SUPFAM	SSF90123. ABC_TM_1. 1 hit.
PROSITE	PS50929. ABC_TM1F. 1 hit. PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ABCD1_DICDI

Accession

Primary (citable) accession number: Q54W19

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 5, 2009
Last sequence update:	May 24, 2005
Last modified:	September 21, 2011
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)