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Q54VU7

- MAP12_DICDI

UniProt

Q54VU7 - MAP12_DICDI

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Protein
Methionine aminopeptidase 1D, mitochondrial
Gene
metap1d, map1d, DDB_G0280127
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) By similarity.UniRule annotation

Catalytic activityi

Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.UniRule annotation

Cofactori

Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe2+-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei232 – 2321Substrate By similarity
Metal bindingi249 – 2491Divalent metal cation 1 By similarity
Metal bindingi260 – 2601Divalent metal cation 1 By similarity
Metal bindingi260 – 2601Divalent metal cation 2; catalytic By similarity
Metal bindingi323 – 3231Divalent metal cation 2; catalytic; via tele nitrogen By similarity
Binding sitei330 – 3301Substrate By similarity
Metal bindingi355 – 3551Divalent metal cation 2; catalytic By similarity
Metal bindingi389 – 3891Divalent metal cation 1 By similarity
Metal bindingi389 – 3891Divalent metal cation 2; catalytic By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-HAMAP
  2. metalloaminopeptidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. protein initiator methionine removal Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease

Keywords - Ligandi

Metal-binding

Protein family/group databases

MEROPSiM24.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine aminopeptidase 1D, mitochondrial (EC:3.4.11.18)
Short name:
MAP 1D
Short name:
MetAP 1D
Alternative name(s):
Methionyl aminopeptidase type 1D, mitochondrial
Peptidase M 1D
Gene namesi
Name:metap1d
Synonyms:map1d
ORF Names:DDB_G0280127
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 3, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0280127. map1d.

Subcellular locationi

Mitochondrion By similarity UniRule annotation

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 5858Mitochondrion Reviewed prediction
Add
BLAST
Chaini59 – 404346Methionine aminopeptidase 1D, mitochondrialUniRule annotation
PRO_0000328514Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi44689.DDBDRAFT_0206394.

Structurei

3D structure databases

ProteinModelPortaliQ54VU7.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi27 – 359Poly-SerUniRule annotation
Compositional biasi38 – 425Poly-AsnUniRule annotation

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0024.
KOiK01265.
OMAiCANEFDS.
PhylomeDBiQ54VU7.

Family and domain databases

Gene3Di3.90.230.10. 1 hit.
HAMAPiMF_01974. MetAP_1.
InterProiIPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002467. Pept_M24A_MAP1.
[Graphical view]
PfamiPF00557. Peptidase_M24. 1 hit.
[Graphical view]
PRINTSiPR00599. MAPEPTIDASE.
SUPFAMiSSF55920. SSF55920. 1 hit.
TIGRFAMsiTIGR00500. met_pdase_I. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q54VU7-1 [UniParc]FASTAAdd to Basket

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MNKILKNIIN KSSINNVFKT SFNGGISSSS SSSSSYLNNN NNIIKSYNVQ    50
QKQQQRYYSS FEDDLSPKKL KEKILENETE EIRDFVRSQR LTKKTASPLE 100
GMNRKERRKM TTKLYRNPDN LIRGGIVSPQ PLIPAHIKKP KYVLGEPVID 150
FEIDDPIEIH TAESIEHMRV VGKMAKEVLE YAGTLVRPGI TTDEIDKLVH 200
QNIIDRGAYP SPLGYKGFPK SICTSINEVL CHGIPDDRPL EFGDIVKIDV 250
TLYYNGYHGD TCATFPVGEI DSSSKRLIEA TEKALYAAIG EVKDGALFNK 300
IGKKIQLVAN KYSLSVTPEF TGHGIGQLFH TAPFVFQCAN EFDSVMKEGM 350
IFTIEPVLVE STSPYAEWKM WDDKWTVSSR EGGWSAQFEH TILVTKDGYE 400
ILTK 404
Length:404
Mass (Da):45,549
Last modified:May 24, 2005 - v1
Checksum:iAC369296B3E58FD4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000035 Genomic DNA. Translation: EAL67290.1.
RefSeqiXP_641258.1. XM_636166.1.

Genome annotation databases

EnsemblProtistsiDDB0235404; DDB0235404; DDB_G0280127.
GeneIDi8622390.
KEGGiddi:DDB_G0280127.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000035 Genomic DNA. Translation: EAL67290.1 .
RefSeqi XP_641258.1. XM_636166.1.

3D structure databases

ProteinModelPortali Q54VU7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDBDRAFT_0206394.

Protein family/group databases

MEROPSi M24.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0235404 ; DDB0235404 ; DDB_G0280127 .
GeneIDi 8622390.
KEGGi ddi:DDB_G0280127.

Organism-specific databases

dictyBasei DDB_G0280127. map1d.

Phylogenomic databases

eggNOGi COG0024.
KOi K01265.
OMAi CANEFDS.
PhylomeDBi Q54VU7.

Miscellaneous databases

PROi Q54VU7.

Family and domain databases

Gene3Di 3.90.230.10. 1 hit.
HAMAPi MF_01974. MetAP_1.
InterProi IPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002467. Pept_M24A_MAP1.
[Graphical view ]
Pfami PF00557. Peptidase_M24. 1 hit.
[Graphical view ]
PRINTSi PR00599. MAPEPTIDASE.
SUPFAMi SSF55920. SSF55920. 1 hit.
TIGRFAMsi TIGR00500. met_pdase_I. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiMAP12_DICDI
AccessioniPrimary (citable) accession number: Q54VU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: September 3, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi