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Q54VQ7

- HDA22_DICDI

UniProt

Q54VQ7 - HDA22_DICDI

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Protein

Type-2 histone deacetylase 2

Gene

hdaC

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).By similarity

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1165 – 11651SubstrateBy similarity
Binding sitei1227 – 12271Substrate; via carbonyl oxygenBy similarity
Metal bindingi1256 – 12561Divalent metal cationBy similarity
Metal bindingi1258 – 12581Divalent metal cationBy similarity
Metal bindingi1350 – 13501Divalent metal cationBy similarity

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. metal ion binding Source: UniProtKB-KW
  3. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  5. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  6. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Type-2 histone deacetylase 2 (EC:3.5.1.98)
Short name:
DdHdaC
Gene namesi
Name:hdaC
ORF Names:DDB_G0280195
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 3, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0280195. hdaC.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 17041704Type-2 histone deacetylase 2PRO_0000331372Add
BLAST

Proteomic databases

PRIDEiQ54VQ7.

Expressioni

Developmental stagei

Expressed after cells enter the multicellular phase upon starvation.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi44689.DDBDRAFT_0206434.

Structurei

3D structure databases

ProteinModelPortaliQ54VQ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi25 – 306Poly-Asn
Compositional biasi45 – 5511Poly-AsnAdd
BLAST
Compositional biasi58 – 6811Poly-AsnAdd
BLAST
Compositional biasi225 – 23713Poly-AsnAdd
BLAST
Compositional biasi246 – 28641Poly-AsnAdd
BLAST
Compositional biasi360 – 3678Poly-Glu
Compositional biasi543 – 5497Poly-Gln
Compositional biasi561 – 57919Poly-AsnAdd
BLAST
Compositional biasi673 – 6808Poly-Gln
Compositional biasi1037 – 10404Poly-Thr
Compositional biasi1489 – 150618Poly-GlnAdd
BLAST
Compositional biasi1513 – 153422Thr-richAdd
BLAST
Compositional biasi1540 – 15489Poly-Asn
Compositional biasi1551 – 156818Poly-AsnAdd
BLAST
Compositional biasi1585 – 161632Poly-AsnAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0123.
InParanoidiQ54VQ7.
OMAiNSEFETH.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
3.40.800.20. 1 hit.
InterProiIPR017956. AT_hook_DNA-bd_motif.
IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PRINTSiPR01270. HDASUPER.
SMARTiSM00384. AT_hook. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.

Sequencei

Sequence statusi: Complete.

Q54VQ7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTNNIIEGD EDTKTTITNE SNTDNNNNNN DDNKNNTENT TSPTNNNNTN
60 70 80 90 100
DNDNNSDNNN NKNNNNNNSQ VTEEQQVTLE DSGSEDDINF EEHELSDSAE
110 120 130 140 150
EDEDEMEDDD EDADGRQNQN PNSAGGKRRG RPSKVQQSTN THLSQTTPES
160 170 180 190 200
PTIFTPDGKV PKRISTSTNN TPNTQSALKT NKRPRLTSDE EKDLMLSEES
210 220 230 240 250
DGGVGEDDDS IMSTNDKPQD ENQSNQNQNN NNNNNNNTTT TTTTTNNSNN
260 270 280 290 300
NNQNLNQNNN NNNNNNNINN NNNNNNSNND NNNNNNRPAR GRPKTNGSRS
310 320 330 340 350
EERKRIQLQQ YIQATQGSST TTSDPNNQNN QINQINQNNQ NNQNNQNNQN
360 370 380 390 400
NSLGEEEFGE EFEEEEEDMG QPKKKTKYKT SKKSVPNHLD IRPCWFVGCV
410 420 430 440 450
KADRSLKILR PCLIPTCKTH AIKSEVRISE ALRRGDFVND ESSGVKDKVC
460 470 480 490 500
GICGDKKDLH HCGNNGCAFG FCNDCVEIAA MKHNNHPNGN KWICWVCQFV
510 520 530 540 550
RTKAKEKERT RWVKEQLNPG LTSISRKFRR GPELDMAQAQ FLQQQQQQQT
560 570 580 590 600
SPNEKRSSQF NSNNSNNNNN NNSNNNNNNS GFDPSGSPNN QQNQKRLRKK
610 620 630 640 650
INASSDIYET RKYTKKRNDE DSAPPSPTSI IGNSVMVGSS GAAGGGIIKN
660 670 680 690 700
TTVVVEQQGY SATPPSPNTL MVQQQQQLQQ THQQARLSQQ QAQLQQLKAL
710 720 730 740 750
QQQHQHQQQN NGNFNNLIES VLSPNREPLN PIDNFVDQTF TAVKFFSTLS
760 770 780 790 800
QNPPDEIKER IDNFVDLMMR IKTVRWASDY GLVWRMIEEL SNLIKRNLLS
810 820 830 840 850
SQSVVEMYSE LKSLEEGALE NMTTNARNVP LERAITMVFE NHETAGLIGK
860 870 880 890 900
ECCSTRNALI YSIEVALRAI ADYQHDLEDN LMEESLRSNK VSTEIEQIEH
910 920 930 940 950
QIKANLDEIH KFKYQEVELL DSLSKVRGAI AAHESIRDTL QKKSSELKVD
960 970 980 990 1000
MLLIKNGISD KEKETKSQQA TLENEIYALK LLITMVESIY WIHDYFYESR
1010 1020 1030 1040 1050
VGECEKLINN KLSQLQNKLE TQIPHPPNAL DNAIPNTTTT VMGEDGQPVI
1060 1070 1080 1090 1100
VPTTVDIKNK FKTIAIYHKI CMQHKVPNFH LEKPDRIQVA VSCINEFASN
1110 1120 1130 1140 1150
PLVDIFDNPP EVDMRYVMAV HDANYIKKLE TSLPPENSEF ETHLESDKSG
1160 1170 1180 1190 1200
AMVTVASHKD FEGDDDNIYD TFVSHRSIKA ALRASGSVCA AVDSVSRSGY
1210 1220 1230 1240 1250
TRAFCAIRPP GHHAGRYGRT SDAPSQGYCL INNVAIGAKY ASLTAGYSRI
1260 1270 1280 1290 1300
AVVDFDVHHG NGTQEILSGD DNFLFISIHV CDEKRYFYPG TGQDVGDIDE
1310 1320 1330 1340 1350
VSGQFDGNIL NIGLKRNTGS AVFLQQWMNK IIPRLEAYKP QLIFLSAGFD
1360 1370 1380 1390 1400
GHKDDPTNGL KLNEEDYFVI TKMIKTVAFK YCKGRIISVL EGGYGIEKTN
1410 1420 1430 1440 1450
SLQRCVNSHL KALIEDTDEE IHLANISYGH FSETQETAIP KFNINNFISN
1460 1470 1480 1490 1500
PNKRGKKNNL NTINFINNNM NNINNNITNS LSNKQLERQK QLQQQQQQAQ
1510 1520 1530 1540 1550
QAQQQQSPQQ SQTIENTSIT TTTTTTSTTT TLSTSDSESN NNINNNNNDY
1560 1570 1580 1590 1600
NNNNNNNSNN NNNNSNNNQP TNFNSSTSSP ILSGNNNNNN NNNNNNNNNN
1610 1620 1630 1640 1650
INNNNNNNSN NNNNMNTSNP TNQQSSVIIS DDMDDVQTNS NPPNPQYPLS
1660 1670 1680 1690 1700
PNSVNRGNNP SNISMSGAQR SAPLIISPKP SNSPNSPSTS NNNGTPQNIN

NSDN
Length:1,704
Mass (Da):190,816
Last modified:May 24, 2005 - v1
Checksum:i84E83B42FB36896E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000035 Genomic DNA. Translation: EAL67324.1.
RefSeqiXP_641298.1. XM_636206.1.

Genome annotation databases

EnsemblProtistsiDDB0237658; DDB0237658; DDB_G0280195.
GeneIDi8622431.
KEGGiddi:DDB_G0280195.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000035 Genomic DNA. Translation: EAL67324.1 .
RefSeqi XP_641298.1. XM_636206.1.

3D structure databases

ProteinModelPortali Q54VQ7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDBDRAFT_0206434.

Proteomic databases

PRIDEi Q54VQ7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0237658 ; DDB0237658 ; DDB_G0280195 .
GeneIDi 8622431.
KEGGi ddi:DDB_G0280195.

Organism-specific databases

dictyBasei DDB_G0280195. hdaC.

Phylogenomic databases

eggNOGi COG0123.
InParanoidi Q54VQ7.
OMAi NSEFETH.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
3.40.800.20. 1 hit.
InterProi IPR017956. AT_hook_DNA-bd_motif.
IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF00850. Hist_deacetyl. 1 hit.
[Graphical view ]
PRINTSi PR01270. HDASUPER.
SMARTi SM00384. AT_hook. 1 hit.
[Graphical view ]
SUPFAMi SSF57903. SSF57903. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "Histone deacetylases regulate multicellular development in the social amoeba Dictyostelium discoideum."
    Sawarkar R., Visweswariah S.S., Nellen W., Nanjundiah V.
    J. Mol. Biol. 391:833-848(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiHDA22_DICDI
AccessioniPrimary (citable) accession number: Q54VQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: October 29, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3