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Q54VQ7 (HDA22_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Type-2 histone deacetylase 2

Short name=DdHdaC
EC=3.5.1.98
Gene names
Name:hdaC
ORF Names:DDB_G0280195
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length1704 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.

Catalytic activity

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Subcellular location

Nucleus By similarity. Cytoplasm By similarity.

Developmental stage

Expressed after cells enter the multicellular phase upon starvation. Ref.2

Sequence similarities

Belongs to the histone deacetylase family. HD type 2 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 17041704Type-2 histone deacetylase 2
PRO_0000331372

Regions

Compositional bias25 – 306Poly-Asn
Compositional bias45 – 5511Poly-Asn
Compositional bias58 – 6811Poly-Asn
Compositional bias225 – 23713Poly-Asn
Compositional bias246 – 28641Poly-Asn
Compositional bias360 – 3678Poly-Glu
Compositional bias543 – 5497Poly-Gln
Compositional bias561 – 57919Poly-Asn
Compositional bias673 – 6808Poly-Gln
Compositional bias1037 – 10404Poly-Thr
Compositional bias1489 – 150618Poly-Gln
Compositional bias1513 – 153422Thr-rich
Compositional bias1540 – 15489Poly-Asn
Compositional bias1551 – 156818Poly-Asn
Compositional bias1585 – 161632Poly-Asn

Sites

Metal binding12561Divalent metal cation By similarity
Metal binding12581Divalent metal cation By similarity
Metal binding13501Divalent metal cation By similarity
Binding site11651Substrate By similarity
Binding site12271Substrate; via carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q54VQ7 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 84E83B42FB36896E

FASTA1,704190,816
        10         20         30         40         50         60 
MSTNNIIEGD EDTKTTITNE SNTDNNNNNN DDNKNNTENT TSPTNNNNTN DNDNNSDNNN 

        70         80         90        100        110        120 
NKNNNNNNSQ VTEEQQVTLE DSGSEDDINF EEHELSDSAE EDEDEMEDDD EDADGRQNQN 

       130        140        150        160        170        180 
PNSAGGKRRG RPSKVQQSTN THLSQTTPES PTIFTPDGKV PKRISTSTNN TPNTQSALKT 

       190        200        210        220        230        240 
NKRPRLTSDE EKDLMLSEES DGGVGEDDDS IMSTNDKPQD ENQSNQNQNN NNNNNNNTTT 

       250        260        270        280        290        300 
TTTTTNNSNN NNQNLNQNNN NNNNNNNINN NNNNNNSNND NNNNNNRPAR GRPKTNGSRS 

       310        320        330        340        350        360 
EERKRIQLQQ YIQATQGSST TTSDPNNQNN QINQINQNNQ NNQNNQNNQN NSLGEEEFGE 

       370        380        390        400        410        420 
EFEEEEEDMG QPKKKTKYKT SKKSVPNHLD IRPCWFVGCV KADRSLKILR PCLIPTCKTH 

       430        440        450        460        470        480 
AIKSEVRISE ALRRGDFVND ESSGVKDKVC GICGDKKDLH HCGNNGCAFG FCNDCVEIAA 

       490        500        510        520        530        540 
MKHNNHPNGN KWICWVCQFV RTKAKEKERT RWVKEQLNPG LTSISRKFRR GPELDMAQAQ 

       550        560        570        580        590        600 
FLQQQQQQQT SPNEKRSSQF NSNNSNNNNN NNSNNNNNNS GFDPSGSPNN QQNQKRLRKK 

       610        620        630        640        650        660 
INASSDIYET RKYTKKRNDE DSAPPSPTSI IGNSVMVGSS GAAGGGIIKN TTVVVEQQGY 

       670        680        690        700        710        720 
SATPPSPNTL MVQQQQQLQQ THQQARLSQQ QAQLQQLKAL QQQHQHQQQN NGNFNNLIES 

       730        740        750        760        770        780 
VLSPNREPLN PIDNFVDQTF TAVKFFSTLS QNPPDEIKER IDNFVDLMMR IKTVRWASDY 

       790        800        810        820        830        840 
GLVWRMIEEL SNLIKRNLLS SQSVVEMYSE LKSLEEGALE NMTTNARNVP LERAITMVFE 

       850        860        870        880        890        900 
NHETAGLIGK ECCSTRNALI YSIEVALRAI ADYQHDLEDN LMEESLRSNK VSTEIEQIEH 

       910        920        930        940        950        960 
QIKANLDEIH KFKYQEVELL DSLSKVRGAI AAHESIRDTL QKKSSELKVD MLLIKNGISD 

       970        980        990       1000       1010       1020 
KEKETKSQQA TLENEIYALK LLITMVESIY WIHDYFYESR VGECEKLINN KLSQLQNKLE 

      1030       1040       1050       1060       1070       1080 
TQIPHPPNAL DNAIPNTTTT VMGEDGQPVI VPTTVDIKNK FKTIAIYHKI CMQHKVPNFH 

      1090       1100       1110       1120       1130       1140 
LEKPDRIQVA VSCINEFASN PLVDIFDNPP EVDMRYVMAV HDANYIKKLE TSLPPENSEF 

      1150       1160       1170       1180       1190       1200 
ETHLESDKSG AMVTVASHKD FEGDDDNIYD TFVSHRSIKA ALRASGSVCA AVDSVSRSGY 

      1210       1220       1230       1240       1250       1260 
TRAFCAIRPP GHHAGRYGRT SDAPSQGYCL INNVAIGAKY ASLTAGYSRI AVVDFDVHHG 

      1270       1280       1290       1300       1310       1320 
NGTQEILSGD DNFLFISIHV CDEKRYFYPG TGQDVGDIDE VSGQFDGNIL NIGLKRNTGS 

      1330       1340       1350       1360       1370       1380 
AVFLQQWMNK IIPRLEAYKP QLIFLSAGFD GHKDDPTNGL KLNEEDYFVI TKMIKTVAFK 

      1390       1400       1410       1420       1430       1440 
YCKGRIISVL EGGYGIEKTN SLQRCVNSHL KALIEDTDEE IHLANISYGH FSETQETAIP 

      1450       1460       1470       1480       1490       1500 
KFNINNFISN PNKRGKKNNL NTINFINNNM NNINNNITNS LSNKQLERQK QLQQQQQQAQ 

      1510       1520       1530       1540       1550       1560 
QAQQQQSPQQ SQTIENTSIT TTTTTTSTTT TLSTSDSESN NNINNNNNDY NNNNNNNSNN 

      1570       1580       1590       1600       1610       1620 
NNNNSNNNQP TNFNSSTSSP ILSGNNNNNN NNNNNNNNNN INNNNNNNSN NNNNMNTSNP 

      1630       1640       1650       1660       1670       1680 
TNQQSSVIIS DDMDDVQTNS NPPNPQYPLS PNSVNRGNNP SNISMSGAQR SAPLIISPKP 

      1690       1700 
SNSPNSPSTS NNNGTPQNIN NSDN 

« Hide

References

« Hide 'large scale' references
[1]"The genome of the social amoeba Dictyostelium discoideum."
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. expand/collapse author list , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.
[2]"Histone deacetylases regulate multicellular development in the social amoeba Dictyostelium discoideum."
Sawarkar R., Visweswariah S.S., Nellen W., Nanjundiah V.
J. Mol. Biol. 391:833-848(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: DEVELOPMENTAL STAGE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000035 Genomic DNA. Translation: EAL67324.1.
RefSeqXP_641298.1. XM_636206.1.

3D structure databases

ProteinModelPortalQ54VQ7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDBDRAFT_0206434.

Proteomic databases

PRIDEQ54VQ7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0237658; DDB0237658; DDB_G0280195.
GeneID8622431.
KEGGddi:DDB_G0280195.

Organism-specific databases

dictyBaseDDB_G0280195. hdaC.

Phylogenomic databases

eggNOGCOG0123.
OMANSEFETH.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
3.40.800.20. 1 hit.
InterProIPR017956. AT_hook_DNA-bd_motif.
IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERPTHR10625. PTHR10625. 1 hit.
PfamPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PRINTSPR01270. HDASUPER.
SMARTSM00384. AT_hook. 1 hit.
[Graphical view]
SUPFAMSSF57903. SSF57903. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHDA22_DICDI
AccessionPrimary (citable) accession number: Q54VQ7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase