SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q54VQ7

- HDA22_DICDI

UniProt

Q54VQ7 - HDA22_DICDI

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Type-2 histone deacetylase 2
Gene
hdaC, DDB_G0280195
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1165 – 11651Substrate By similarity
Binding sitei1227 – 12271Substrate; via carbonyl oxygen By similarity
Metal bindingi1256 – 12561Divalent metal cation By similarity
Metal bindingi1258 – 12581Divalent metal cation By similarity
Metal bindingi1350 – 13501Divalent metal cation By similarity

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  3. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  5. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC
  6. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Type-2 histone deacetylase 2 (EC:3.5.1.98)
Short name:
DdHdaC
Gene namesi
Name:hdaC
ORF Names:DDB_G0280195
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 3, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0280195. hdaC.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 17041704Type-2 histone deacetylase 2
PRO_0000331372Add
BLAST

Proteomic databases

PRIDEiQ54VQ7.

Expressioni

Developmental stagei

Expressed after cells enter the multicellular phase upon starvation.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi44689.DDBDRAFT_0206434.

Structurei

3D structure databases

ProteinModelPortaliQ54VQ7.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi25 – 306Poly-Asn
Compositional biasi45 – 5511Poly-Asn
Add
BLAST
Compositional biasi58 – 6811Poly-Asn
Add
BLAST
Compositional biasi225 – 23713Poly-Asn
Add
BLAST
Compositional biasi246 – 28641Poly-Asn
Add
BLAST
Compositional biasi360 – 3678Poly-Glu
Compositional biasi543 – 5497Poly-Gln
Compositional biasi561 – 57919Poly-Asn
Add
BLAST
Compositional biasi673 – 6808Poly-Gln
Compositional biasi1037 – 10404Poly-Thr
Compositional biasi1489 – 150618Poly-Gln
Add
BLAST
Compositional biasi1513 – 153422Thr-rich
Add
BLAST
Compositional biasi1540 – 15489Poly-Asn
Compositional biasi1551 – 156818Poly-Asn
Add
BLAST
Compositional biasi1585 – 161632Poly-Asn
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0123.
OMAiNSEFETH.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
3.40.800.20. 1 hit.
InterProiIPR017956. AT_hook_DNA-bd_motif.
IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PRINTSiPR01270. HDASUPER.
SMARTiSM00384. AT_hook. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.

Sequencei

Sequence statusi: Complete.

Q54VQ7-1 [UniParc]FASTAAdd to Basket

« Hide

MSTNNIIEGD EDTKTTITNE SNTDNNNNNN DDNKNNTENT TSPTNNNNTN     50
DNDNNSDNNN NKNNNNNNSQ VTEEQQVTLE DSGSEDDINF EEHELSDSAE 100
EDEDEMEDDD EDADGRQNQN PNSAGGKRRG RPSKVQQSTN THLSQTTPES 150
PTIFTPDGKV PKRISTSTNN TPNTQSALKT NKRPRLTSDE EKDLMLSEES 200
DGGVGEDDDS IMSTNDKPQD ENQSNQNQNN NNNNNNNTTT TTTTTNNSNN 250
NNQNLNQNNN NNNNNNNINN NNNNNNSNND NNNNNNRPAR GRPKTNGSRS 300
EERKRIQLQQ YIQATQGSST TTSDPNNQNN QINQINQNNQ NNQNNQNNQN 350
NSLGEEEFGE EFEEEEEDMG QPKKKTKYKT SKKSVPNHLD IRPCWFVGCV 400
KADRSLKILR PCLIPTCKTH AIKSEVRISE ALRRGDFVND ESSGVKDKVC 450
GICGDKKDLH HCGNNGCAFG FCNDCVEIAA MKHNNHPNGN KWICWVCQFV 500
RTKAKEKERT RWVKEQLNPG LTSISRKFRR GPELDMAQAQ FLQQQQQQQT 550
SPNEKRSSQF NSNNSNNNNN NNSNNNNNNS GFDPSGSPNN QQNQKRLRKK 600
INASSDIYET RKYTKKRNDE DSAPPSPTSI IGNSVMVGSS GAAGGGIIKN 650
TTVVVEQQGY SATPPSPNTL MVQQQQQLQQ THQQARLSQQ QAQLQQLKAL 700
QQQHQHQQQN NGNFNNLIES VLSPNREPLN PIDNFVDQTF TAVKFFSTLS 750
QNPPDEIKER IDNFVDLMMR IKTVRWASDY GLVWRMIEEL SNLIKRNLLS 800
SQSVVEMYSE LKSLEEGALE NMTTNARNVP LERAITMVFE NHETAGLIGK 850
ECCSTRNALI YSIEVALRAI ADYQHDLEDN LMEESLRSNK VSTEIEQIEH 900
QIKANLDEIH KFKYQEVELL DSLSKVRGAI AAHESIRDTL QKKSSELKVD 950
MLLIKNGISD KEKETKSQQA TLENEIYALK LLITMVESIY WIHDYFYESR 1000
VGECEKLINN KLSQLQNKLE TQIPHPPNAL DNAIPNTTTT VMGEDGQPVI 1050
VPTTVDIKNK FKTIAIYHKI CMQHKVPNFH LEKPDRIQVA VSCINEFASN 1100
PLVDIFDNPP EVDMRYVMAV HDANYIKKLE TSLPPENSEF ETHLESDKSG 1150
AMVTVASHKD FEGDDDNIYD TFVSHRSIKA ALRASGSVCA AVDSVSRSGY 1200
TRAFCAIRPP GHHAGRYGRT SDAPSQGYCL INNVAIGAKY ASLTAGYSRI 1250
AVVDFDVHHG NGTQEILSGD DNFLFISIHV CDEKRYFYPG TGQDVGDIDE 1300
VSGQFDGNIL NIGLKRNTGS AVFLQQWMNK IIPRLEAYKP QLIFLSAGFD 1350
GHKDDPTNGL KLNEEDYFVI TKMIKTVAFK YCKGRIISVL EGGYGIEKTN 1400
SLQRCVNSHL KALIEDTDEE IHLANISYGH FSETQETAIP KFNINNFISN 1450
PNKRGKKNNL NTINFINNNM NNINNNITNS LSNKQLERQK QLQQQQQQAQ 1500
QAQQQQSPQQ SQTIENTSIT TTTTTTSTTT TLSTSDSESN NNINNNNNDY 1550
NNNNNNNSNN NNNNSNNNQP TNFNSSTSSP ILSGNNNNNN NNNNNNNNNN 1600
INNNNNNNSN NNNNMNTSNP TNQQSSVIIS DDMDDVQTNS NPPNPQYPLS 1650
PNSVNRGNNP SNISMSGAQR SAPLIISPKP SNSPNSPSTS NNNGTPQNIN 1700
NSDN 1704
Length:1,704
Mass (Da):190,816
Last modified:May 24, 2005 - v1
Checksum:i84E83B42FB36896E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000035 Genomic DNA. Translation: EAL67324.1.
RefSeqiXP_641298.1. XM_636206.1.

Genome annotation databases

EnsemblProtistsiDDB0237658; DDB0237658; DDB_G0280195.
GeneIDi8622431.
KEGGiddi:DDB_G0280195.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000035 Genomic DNA. Translation: EAL67324.1 .
RefSeqi XP_641298.1. XM_636206.1.

3D structure databases

ProteinModelPortali Q54VQ7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDBDRAFT_0206434.

Proteomic databases

PRIDEi Q54VQ7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0237658 ; DDB0237658 ; DDB_G0280195 .
GeneIDi 8622431.
KEGGi ddi:DDB_G0280195.

Organism-specific databases

dictyBasei DDB_G0280195. hdaC.

Phylogenomic databases

eggNOGi COG0123.
OMAi NSEFETH.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
3.40.800.20. 1 hit.
InterProi IPR017956. AT_hook_DNA-bd_motif.
IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF00850. Hist_deacetyl. 1 hit.
[Graphical view ]
PRINTSi PR01270. HDASUPER.
SMARTi SM00384. AT_hook. 1 hit.
[Graphical view ]
SUPFAMi SSF57903. SSF57903. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "Histone deacetylases regulate multicellular development in the social amoeba Dictyostelium discoideum."
    Sawarkar R., Visweswariah S.S., Nellen W., Nanjundiah V.
    J. Mol. Biol. 391:833-848(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiHDA22_DICDI
AccessioniPrimary (citable) accession number: Q54VQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3