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Q54VM2 (MDHC_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable malate dehydrogenase 3

EC=1.1.1.37
Gene names
Name:mdhC
ORF Names:DDB_G0280255
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length333 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity. HAMAP-Rule MF_01517

Catalytic activity

(S)-malate + NAD+ = oxaloacetate + NADH. HAMAP-Rule MF_01517

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01517

Sequence similarities

Belongs to the LDH/MDH superfamily. MDH type 2 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 333333Probable malate dehydrogenase 3 HAMAP-Rule MF_01517
PRO_0000312366

Regions

Nucleotide binding12 – 187NAD By similarity
Nucleotide binding130 – 1323NAD By similarity

Sites

Active site1881Proton acceptor By similarity
Binding site931Substrate By similarity
Binding site991Substrate By similarity
Binding site1061NAD By similarity
Binding site1131NAD By similarity
Binding site1321Substrate By similarity
Binding site1631Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q54VM2 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: B98891A299AB53FF

FASTA33335,986
        10         20         30         40         50         60 
MSNEVINVLI TGAAGQIAYS LIFNVCKGDM FGLDQRIKLH LLDIPQMVDS LKGIVMEIQD 

        70         80         90        100        110        120 
GAYPLIADTV ITADVKEAFT GVHYAILVGA MPRREGMERA DLLKANAAIF KVQGKALAEH 

       130        140        150        160        170        180 
ANKNVKVLVV GNPANTNALI AQVSANGIPK ENFTCLTRLD QNRAKSQIAL KAGVNVKDVH 

       190        200        210        220        230        240 
NVIIWGNHSS TQYPDYRCGY INLSTGKTPI STAIKDEKWL QGEFISTVQK RGAAVIAARK 

       250        260        270        280        290        300 
LSSAASAAKA ITDHMHDWVL GTAEGEYVSM GVYSDGSYGV PEGLIFSFPV KCANGKYTIV 

       310        320        330 
QGLQMDDLSK NLINLTTEEL VAEKTTALQF LSE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000035 Genomic DNA. Translation: EAL67354.1.

3D structure databases

ProteinModelPortalQ54VM2.
SMRQ54VM2. Positions 5-332.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDB_0230187.

Proteomic databases

PRIDEQ54VM2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0230187; DDB0230187; DDB_G0280255.
KEGGddi:DDB_G0280255.

Organism-specific databases

dictyBaseDDB_G0280255. mdhC.

Phylogenomic databases

eggNOGCOG0039.
KOK00025.
OMADVHHCKV.
PhylomeDBQ54VM2.
ProtClustDBCLSZ2437838.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPMF_01517. Malate_dehydrog_2.
InterProIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR011274. Malate_DH_NAD-dep_euk.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR23382. PTHR23382. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMSSF56327. SSF56327. 1 hit.
TIGRFAMsTIGR01759. MalateDH-SF1. 1 hit.
TIGR01758. MDH_euk_cyt. 1 hit.
PROSITEPS00068. MDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMDHC_DICDI
AccessionPrimary (citable) accession number: Q54VM2
Entry history
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: May 24, 2005
Last modified: April 16, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase