Reviewed, UniProtKB/Swiss-Prot Q54VL5 (ALLC_DICDI)

Names and origin

Protein names

Recommended name:
    Allantoicase
    EC=3.5.3.4
Alternative name(s):
    Allantoate amidinohydrolase

Gene names

Name:	allC
ORF Names:	DDB_G0280267

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	369 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Utilization of purines as secondary nitrogen sources, when primary sources are limiting By similarity.
Catalytic activity	Allantoate + H2O = (S)-ureidoglycolate + urea.
Pathway	Nitrogen metabolism; (S)-allantoin degradation; (S)-ureidoglycolate from allantoate (aminidohydrolase route): step 1/1.
Sequence similarities	Belongs to the allantoicase family.
Sequence caution	The sequence AAX18646.1 differs from that shown. Reason: Frameshift at several positions.

Ontologies

Keywords
Biological process	Purine metabolism
Molecular function	Hydrolase
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	purine base metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	allantoicase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 369	369	Allantoicase		PRO_0000328153
Regions
	Compositional bias	345 – 357	13	Poly-Asn
Experimental info
	Sequence conflict	83	1	K → N in AAX18646. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q54VL5-1 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: CAEB56829C1B44B7	FASTA	369	41,778
	10 20 30 40 50 60 MVYANNNIDP NAPCYVSECA ELLSDKVGGV VLGCTDQWFA ECVNLIKHSA PVWDAEKYVD 70 80 90 100 110 120 TGKWMDGWET KRHNPDHDWC IIKLGIPGVI YGFEIDTAYF TGNYPPHASI EALCDDSDPN 130 140 150 160 170 180 FNTLKESNNW EVILNKSDLG SSCKKYFECK VEKRFTHIKF RIYPDGGVAR LRAYGRVVKD 190 200 210 220 230 240 WTLVIPGELV DLAAIENGGL VTQVSDHFYG NKNNIIMPGR SVNMGDGWET KRRRGPGNDW 250 260 270 280 290 300 LTVKLAKEGI VKRIEVDTNW FKGNFPTSCS IDAIHSSSAP DETHLQDYEW TNILPNSPLC 310 320 330 340 350 360 GHRRHFFQNE LVNNDKPFTH IRLNIFPDGG VSRLRINCSL PDSKNNNNNN NNNNNNNTSN SFKTSDRQQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
[2]	Hou L.S., Ma N.S. Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 61-238.
[3]	Bienvenut W.V., Ura S., Insall R.H. Submitted (JUL-2009) to UniProtKB Cited for: PROTEIN SEQUENCE OF 126-136; 235-244; 253-262 AND 305-333, MASS SPECTROMETRY. Strain: AX2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AAFI02000035 Genomic DNA. Translation: EAL67360.1. AY894718 mRNA. Translation: AAX18646.1. Frameshift.
RefSeq	XP_641340.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q54VL5.
Genome annotation databases
GeneID	3392421.
GenomeReviews	Gene locus allC in contig CM000152_GR.
KEGG	ddi:DDB_0231471.
Organism-specific databases
dictyBase	DDB_G0280267. allC.
Phylogenomic databases
OMA	MANPILD.
Enzyme and pathway databases
BRENDA	3.5.3.4. 424.
Family and domain databases
InterPro	IPR005164. Allantoicase. IPR015908. Allantoicase_region. [Graphical view]
PANTHER	PTHR12045. Allantoicase. 1 hit.
Pfam	PF03561. Allantoicase. 2 hits. [Graphical view]
PIRSF	PIRSF016516. Allantoicase. 1 hit.
TIGRFAMs	TIGR02961. allantoicase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ALLC_DICDI

Accession

Primary (citable) accession number: Q54VL5
Secondary accession number(s): Q5D6A3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	May 24, 2005
Last modified:	November 3, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)