Q54VJ0 (ABCC2_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ABC transporter C family member 2

Alternative name(s):
ABC transporter ABCC.2

Gene names

Name:	abcC2
ORF Names:	DDB_G0280055

Organism

Dictyostelium discoideum (Slime mold)

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	1384 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification] Contains 2 ABC transmembrane type-1 domains. Contains 2 ABC transporter domains.
Sequence caution	The sequence AAL85705.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Domain	Repeat Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of substances Inferred from sequence or structural similarity Ref.1. Source: dictyBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1384	1384	ABC transporter C family member 2		PRO_0000363848
Regions
	Transmembrane	112 – 132	21	Helical; Potential
	Transmembrane	140 – 160	21	Helical; Potential
	Transmembrane	226 – 246	21	Helical; Potential
	Transmembrane	247 – 267	21	Helical; Potential
	Transmembrane	333 – 353	21	Helical; Potential
	Transmembrane	813 – 833	21	Helical; Potential
	Transmembrane	852 – 872	21	Helical; Potential
	Transmembrane	941 – 961	21	Helical; Potential
	Transmembrane	1036 – 1056	21	Helical; Potential
	Transmembrane	1061 – 1081	21	Helical; Potential
	Domain	104 – 388	285	ABC transmembrane type-1 1
	Domain	505 – 724	220	ABC transporter 1
	Domain	814 – 1093	280	ABC transmembrane type-1 2
	Domain	1137 – 1371	235	ABC transporter 2
	Nucleotide binding	537 – 544	8	ATP Potential
	Nucleotide binding	1171 – 1178	8	ATP Potential
	Compositional bias	423 – 430	8	Poly-Asn
	Compositional bias	744 – 751	8	Poly-Ser

Sequences

	Sequence		Length	Mass (Da)
	Q54VJ0 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 11EADB8B2DC421AE	FASTA	1,384	157,060
	10 20 30 40 50 60 MIKNLKQKIK NRFSYSLLSE DDNTDYFSKP CPEDNATLWQ RFTFGWTERM LMTGYFNGPL 70 80 90 100 110 120 EMKDVSDLPD RNKVNITAPF LDTIDYNSKY PLIKQIYKEF VSRNKISVAT KIFVAIVSIL 130 140 150 160 170 180 SPLCLKYFIY YIKLDESQKT FKFGFLLCVL LFLSSLSLTL SQQYGYWFGL QTSLHARGAI 190 200 210 220 230 240 TQKIFEKTLR LSNQAKRLYN SGTIMNIISV DVGTFSDFFW NNHIEIFVFP FQILALLILL 250 260 270 280 290 300 CWIVGLSGLV GFGVMVVSIP LCTFLSTKIA KNLRISLGYA DTRCNLTSEF INGIRFLKLY 310 320 330 340 350 360 AWEQLFLDRI EEQRTLQLKY LYRRAIYWIL DRMITQVTSA LVLVATFSTY ALTGNQMTLE 370 380 390 400 410 420 VAFTAMTIFV NLRRPLEMLP EAIHRALSLI PSSKRIENFL QSPEIQDQPF LEQYSNNKLS 430 440 450 460 470 480 IRNNNNNNNN VSSTSSIASS ASSNELFDVK INNGTFDWNE IDDLDSGMII NDVRGFAISS 490 500 510 520 530 540 DINDMDEMIL GDEKVGKSND TNNGIEYDGA VQPSSSSYVL NNINFIAPAG KLTVICGIVG 550 560 570 580 590 600 SGKTSLVSGL IGEIYRVSGS VNIPNNISFT TQQPFLLSTS LRDNILFGKP MNMERYKKVI 610 620 630 640 650 660 DACCLTPDLL QLAAKDLTEI GERGINLSGG QKQRISLARA LYSDSDCFIL DEPLSAVDPE 670 680 690 700 710 720 VASHLFDHCI QGMMKDKTRI LVTHQLQFIP SADHIIVVDN GVLTQGTYSE LKEKGIDFES 730 740 750 760 770 780 IMKTKKLNID ENDQSSTSTT DKKSSTSSSS SELKKSTSLL NSTKELDINT IISEKNDPNL 790 800 810 820 830 840 IEKAKLLVKE DRNEGEVGFE VYRQYFRHGS LNLFFLTCAL YFISQIIFQL SDFWLTIWTN 850 860 870 880 890 900 DETNQHDDKY YILYYCIFIG AFIVFLVVRY FMMASITFAA SKKLHSELLN SVAFASCQFF 910 920 930 940 950 960 DTNPSGRILN RFSKDISDID LILMENFSDV LQCGSTVVVA LFMMIYITPL ISIPFAILVV 970 980 990 1000 1010 1020 VYYVIQKLYR ASSVELKRME SITRSPVFSL LAEAYNGLVT IRCYQQQKRF IEMMQNHINI 1030 1040 1050 1060 1070 1080 NLRLFFYSFS VHRWVGIRLE FITALIVFFT AFSSLFSSNT GFSVLAVTTA LGICSYLNWT 1090 1100 1110 1120 1130 1140 IRQMTELEVK MNSVERVESY IKTPREGIRH TSEFEDEIDI DGEIEMDFTK WPSRGEVEFK 1150 1160 1170 1180 1190 1200 NVEIKYRPTA DPSLKNISFK INAKDHIGVV GRTGAGKSTV GISLFRMVEC SKGSIFIDGV 1210 1220 1230 1240 1250 1260 DISKVGLHEL RDALGIVPQD PFIFSGSIRM NIDPFNKYTD DEIWTALEKV KLKDAISSMP 1270 1280 1290 1300 1310 1320 LKLESGVQEN GDGLSFGQKQ LLCLSRTILK NSKVVLMDEA TSGIDYVTAA LLKQTIDENF 1330 1340 1350 1360 1370 1380 NDCTMLTIAH RLDTIIDSTK IAVIDKGELV EYDTPMNLIK TEGSRFKKLV KYQTDFYEES QKKF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Evolutionary analyses of ABC transporters of Dictyostelium discoideum." Anjard C., Loomis W.F. Eukaryot. Cell 1:643-652(2002) [PubMed: 12456012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], NOMENCLATURE. Strain: AX4.
[2]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF474334 Genomic DNA. Translation: AAL85705.1. Sequence problems. AAFI02000035 Genomic DNA. Translation: EAL67254.1.
RefSeq	XP_641365.1. XM_636273.1.
3D structure databases
HSSP	HSSP built from PDB template 2CBZ based on UniProtKB P33527.
ProteinModelPortal	Q54VJ0.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0220024; DDB0220024; DDB_G0280055.
GeneID	8622499.
GenomeReviews	Gene locus abcC2 in contig CM000152_GR.
KEGG	ddi:DDB_G0280055.
Organism-specific databases
dictyBase	DDB_G0280055. abcC2.
Phylogenomic databases
eggNOG	KOG0054.
GeneTree	EPrGT00050000000398.
HOGENOM	HBG758042.
InParanoid	Q54VJ0.
OMA	HAREKEM.
PhylomeDB	Q54VJ0.
ProtClustDB	CLSZ2430599.
Family and domain databases
InterPro	IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR017940. ABC_transporter_type1. IPR001140. ABC_transptr_TM_dom. IPR011527. ABC_transptrTM_dom_typ1. IPR003593. ATPase_AAA+_core. [Graphical view]
Pfam	PF00664. ABC_membrane. 2 hits. PF00005. ABC_tran. 2 hits. [Graphical view]
SMART	SM00382. AAA. 2 hits. [Graphical view]
SUPFAM	SSF90123. ABC_TM_1. 2 hits.
PROSITE	PS50929. ABC_TM1F. 2 hits. PS00211. ABC_TRANSPORTER_1. 2 hits. PS50893. ABC_TRANSPORTER_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ABCC2_DICDI

Accession

Primary (citable) accession number: Q54VJ0
Secondary accession number(s): Q8T6H7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	May 24, 2005
Last modified:	September 21, 2011
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)