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Q54VG0

- DHTK1_DICDI

UniProt

Q54VG0 - DHTK1_DICDI

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Protein

Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial

Gene

odhA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactori

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: dictyBase
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial (EC:1.2.4.2)
Alternative name(s):
Oxoglutarate dehydrogenase A
Gene namesi
Name:odhA
ORF Names:DDB_G0280353
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 3, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0280353. odhA.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 900Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrialPRO_0000388782
Transit peptidei1 – ?MitochondrionSequence Analysis

Proteomic databases

PRIDEiQ54VG0.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0230197.

Structurei

3D structure databases

ProteinModelPortaliQ54VG0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi25 – 317Poly-Ser

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0567.
InParanoidiQ54VG0.
KOiK15791.
OMAiLCSGKHY.
PhylomeDBiQ54VG0.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q54VG0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIGLRSISKN KQTINSISKS FYCTSSPSSS SVKLSVTRLI DGYRAHGHLA
60 70 80 90 100
ANIDPLARME RIRSQLLDLD RYNLVKGQSI PSTIDLINQD LTNLDQVVSF
110 120 130 140 150
LENAYCNDVT AQFDHIESIE EKAWLYEKFE QLQHQNPSKS EKINILKNLI
160 170 180 190 200
KSEIFDQFMQ KKFPTFKRYG LEGNESMMVS CDSIFRESAK NQLKNVVIGM
210 220 230 240 250
PHRGRLNLLV QMCNYPAKDF FWKVKGNSEF SEGILGVGDV TSHIAVSTDL
260 270 280 290 300
QFNNNKESVH VSLIHNPSHL EAVDPVAAGK TRAKQFYEKN EGGSESLCLM
310 320 330 340 350
LHGDAAVAGQ GVVTETLQLS QLSGFNIGGC VHVIVNNQIG FTTVPTNGRS
360 370 380 390 400
NRYSSDIGKF IGAPIIVVNS QSPEQVEKVS RLAVEYRQKF KKDIIIDLIG
410 420 430 440 450
WRKFGHNEVD EPSFTQPTMY QNIRKRQSIP QKYATQIISQ GIFSEQELLE
460 470 480 490 500
FTQKEQAILE EQFQLSTPEN FKYSPMDHLQ GKWSGLIQSK HIADDSKLDT
510 520 530 540 550
GYSVEELSEI ANDSVKVPSD FQVHQRLLRS FSNARLEKLK QNQADWATAE
560 570 580 590 600
SMAVGSLMKQ GYNVRISGQD VGRGTFSQRH FNLTEQNSDR IYQPLNNMGA
610 620 630 640 650
KGELDVVNSN LSEFAVLCYE YGYSLESPDT LPIWEAQFGD FINGAQIAID
660 670 680 690 700
QFVTSGESKW LRQSGIVILL PHGFDGAGPE HSSCRIERFL QLSDTEAVNV
710 720 730 740 750
KDDTLINQET NFYFINPSTP ANYFHALRRQ MIRNYRKPLI VAGPKVLLRH
760 770 780 790 800
PNCFSTLNEM APGTHFQTVL SDPDTINNAS TIKRVIFCSG KVFYDLQEER
810 820 830 840 850
KAKNFNDVAI IRLEQIAPFP YQRIQEEINR YSNATKFAWV QEEQQNGGCW
860 870 880 890 900
SFVEPRFKQR YPQTSQIKYI GRPPLAASAI GISSIHKKEV SQLLIDAFNF
Length:900
Mass (Da):101,831
Last modified:May 24, 2005 - v1
Checksum:iF2F2A86C9191EF98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000035 Genomic DNA. Translation: EAL67403.1.
RefSeqiXP_641395.1. XM_636303.1.

Genome annotation databases

EnsemblProtistsiDDB0230197; DDB0230197; DDB_G0280353.
GeneIDi8622529.
KEGGiddi:DDB_G0280353.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000035 Genomic DNA. Translation: EAL67403.1 .
RefSeqi XP_641395.1. XM_636303.1.

3D structure databases

ProteinModelPortali Q54VG0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0230197.

Proteomic databases

PRIDEi Q54VG0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0230197 ; DDB0230197 ; DDB_G0280353 .
GeneIDi 8622529.
KEGGi ddi:DDB_G0280353.

Organism-specific databases

dictyBasei DDB_G0280353. odhA.

Phylogenomic databases

eggNOGi COG0567.
InParanoidi Q54VG0.
KOi K15791.
OMAi LCSGKHY.
PhylomeDBi Q54VG0.

Miscellaneous databases

PROi Q54VG0.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiDHTK1_DICDI
AccessioniPrimary (citable) accession number: Q54VG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: May 24, 2005
Last modified: November 26, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3