Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial

Gene

odhA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactori

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGlycolysis
LigandThiamine pyrophosphate

Enzyme and pathway databases

ReactomeiR-DDI-389661 Glyoxylate metabolism and glycine degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial (EC:1.2.4.2)
Alternative name(s):
Oxoglutarate dehydrogenase A
Gene namesi
Name:odhA
ORF Names:DDB_G0280353
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0280353 odhA

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000388782? – 900Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

PaxDbiQ54VG0

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0230197

Structurei

3D structure databases

ProteinModelPortaliQ54VG0
SMRiQ54VG0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi25 – 31Poly-Ser7

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0451 Eukaryota
COG0567 LUCA
InParanoidiQ54VG0
KOiK15791
OMAiLCSGKHY
PhylomeDBiQ54VG0

Family and domain databases

InterProiView protein in InterPro
IPR011603 2oxoglutarate_DH_E1
IPR001017 DH_E1
IPR031717 KGD_C
IPR029061 THDP-binding
IPR005475 Transketolase-like_Pyr-bd
PANTHERiPTHR23152 PTHR23152, 1 hit
PfamiView protein in Pfam
PF00676 E1_dh, 1 hit
PF16870 OxoGdeHyase_C, 1 hit
PF02779 Transket_pyr, 1 hit
PIRSFiPIRSF000157 Oxoglu_dh_E1, 1 hit
SMARTiView protein in SMART
SM00861 Transket_pyr, 1 hit
SUPFAMiSSF52518 SSF52518, 2 hits
TIGRFAMsiTIGR00239 2oxo_dh_E1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q54VG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIGLRSISKN KQTINSISKS FYCTSSPSSS SVKLSVTRLI DGYRAHGHLA
60 70 80 90 100
ANIDPLARME RIRSQLLDLD RYNLVKGQSI PSTIDLINQD LTNLDQVVSF
110 120 130 140 150
LENAYCNDVT AQFDHIESIE EKAWLYEKFE QLQHQNPSKS EKINILKNLI
160 170 180 190 200
KSEIFDQFMQ KKFPTFKRYG LEGNESMMVS CDSIFRESAK NQLKNVVIGM
210 220 230 240 250
PHRGRLNLLV QMCNYPAKDF FWKVKGNSEF SEGILGVGDV TSHIAVSTDL
260 270 280 290 300
QFNNNKESVH VSLIHNPSHL EAVDPVAAGK TRAKQFYEKN EGGSESLCLM
310 320 330 340 350
LHGDAAVAGQ GVVTETLQLS QLSGFNIGGC VHVIVNNQIG FTTVPTNGRS
360 370 380 390 400
NRYSSDIGKF IGAPIIVVNS QSPEQVEKVS RLAVEYRQKF KKDIIIDLIG
410 420 430 440 450
WRKFGHNEVD EPSFTQPTMY QNIRKRQSIP QKYATQIISQ GIFSEQELLE
460 470 480 490 500
FTQKEQAILE EQFQLSTPEN FKYSPMDHLQ GKWSGLIQSK HIADDSKLDT
510 520 530 540 550
GYSVEELSEI ANDSVKVPSD FQVHQRLLRS FSNARLEKLK QNQADWATAE
560 570 580 590 600
SMAVGSLMKQ GYNVRISGQD VGRGTFSQRH FNLTEQNSDR IYQPLNNMGA
610 620 630 640 650
KGELDVVNSN LSEFAVLCYE YGYSLESPDT LPIWEAQFGD FINGAQIAID
660 670 680 690 700
QFVTSGESKW LRQSGIVILL PHGFDGAGPE HSSCRIERFL QLSDTEAVNV
710 720 730 740 750
KDDTLINQET NFYFINPSTP ANYFHALRRQ MIRNYRKPLI VAGPKVLLRH
760 770 780 790 800
PNCFSTLNEM APGTHFQTVL SDPDTINNAS TIKRVIFCSG KVFYDLQEER
810 820 830 840 850
KAKNFNDVAI IRLEQIAPFP YQRIQEEINR YSNATKFAWV QEEQQNGGCW
860 870 880 890 900
SFVEPRFKQR YPQTSQIKYI GRPPLAASAI GISSIHKKEV SQLLIDAFNF
Length:900
Mass (Da):101,831
Last modified:May 24, 2005 - v1
Checksum:iF2F2A86C9191EF98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000035 Genomic DNA Translation: EAL67403.1
RefSeqiXP_641395.1, XM_636303.1

Genome annotation databases

EnsemblProtistsiEAL67403; EAL67403; DDB_G0280353
GeneIDi8622529
KEGGiddi:DDB_G0280353

Similar proteinsi

Entry informationi

Entry nameiDHTK1_DICDI
AccessioniPrimary (citable) accession number: Q54VG0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: May 24, 2005
Last modified: March 28, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome