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Q54VG0

- DHTK1_DICDI

UniProt

Q54VG0 - DHTK1_DICDI

Protein

Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial

Gene

odhA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.By similarity

    Catalytic activityi

    2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

    Cofactori

    Thiamine pyrophosphate.By similarity

    GO - Molecular functioni

    1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: dictyBase
    2. thiamine pyrophosphate binding Source: InterPro

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Thiamine pyrophosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial (EC:1.2.4.2)
    Alternative name(s):
    Oxoglutarate dehydrogenase A
    Gene namesi
    Name:odhA
    ORF Names:DDB_G0280353
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 3, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0280353. odhA.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 900Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrialPRO_0000388782
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Proteomic databases

    PRIDEiQ54VG0.

    Interactioni

    Protein-protein interaction databases

    STRINGi44689.DDB_0230197.

    Structurei

    3D structure databases

    ProteinModelPortaliQ54VG0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi25 – 317Poly-Ser

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0567.
    InParanoidiQ54VG0.
    KOiK15791.
    OMAiLCSGKHY.
    PhylomeDBiQ54VG0.

    Family and domain databases

    Gene3Di3.40.50.970. 2 hits.
    InterProiIPR011603. 2oxoglutarate_DH_E1.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view]
    PANTHERiPTHR23152. PTHR23152. 1 hit.
    PfamiPF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTiSM00861. Transket_pyr. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 2 hits.
    TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q54VG0-1 [UniParc]FASTAAdd to Basket

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    MIGLRSISKN KQTINSISKS FYCTSSPSSS SVKLSVTRLI DGYRAHGHLA    50
    ANIDPLARME RIRSQLLDLD RYNLVKGQSI PSTIDLINQD LTNLDQVVSF 100
    LENAYCNDVT AQFDHIESIE EKAWLYEKFE QLQHQNPSKS EKINILKNLI 150
    KSEIFDQFMQ KKFPTFKRYG LEGNESMMVS CDSIFRESAK NQLKNVVIGM 200
    PHRGRLNLLV QMCNYPAKDF FWKVKGNSEF SEGILGVGDV TSHIAVSTDL 250
    QFNNNKESVH VSLIHNPSHL EAVDPVAAGK TRAKQFYEKN EGGSESLCLM 300
    LHGDAAVAGQ GVVTETLQLS QLSGFNIGGC VHVIVNNQIG FTTVPTNGRS 350
    NRYSSDIGKF IGAPIIVVNS QSPEQVEKVS RLAVEYRQKF KKDIIIDLIG 400
    WRKFGHNEVD EPSFTQPTMY QNIRKRQSIP QKYATQIISQ GIFSEQELLE 450
    FTQKEQAILE EQFQLSTPEN FKYSPMDHLQ GKWSGLIQSK HIADDSKLDT 500
    GYSVEELSEI ANDSVKVPSD FQVHQRLLRS FSNARLEKLK QNQADWATAE 550
    SMAVGSLMKQ GYNVRISGQD VGRGTFSQRH FNLTEQNSDR IYQPLNNMGA 600
    KGELDVVNSN LSEFAVLCYE YGYSLESPDT LPIWEAQFGD FINGAQIAID 650
    QFVTSGESKW LRQSGIVILL PHGFDGAGPE HSSCRIERFL QLSDTEAVNV 700
    KDDTLINQET NFYFINPSTP ANYFHALRRQ MIRNYRKPLI VAGPKVLLRH 750
    PNCFSTLNEM APGTHFQTVL SDPDTINNAS TIKRVIFCSG KVFYDLQEER 800
    KAKNFNDVAI IRLEQIAPFP YQRIQEEINR YSNATKFAWV QEEQQNGGCW 850
    SFVEPRFKQR YPQTSQIKYI GRPPLAASAI GISSIHKKEV SQLLIDAFNF 900
    Length:900
    Mass (Da):101,831
    Last modified:May 24, 2005 - v1
    Checksum:iF2F2A86C9191EF98
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000035 Genomic DNA. Translation: EAL67403.1.
    RefSeqiXP_641395.1. XM_636303.1.

    Genome annotation databases

    EnsemblProtistsiDDB0230197; DDB0230197; DDB_G0280353.
    GeneIDi8622529.
    KEGGiddi:DDB_G0280353.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000035 Genomic DNA. Translation: EAL67403.1 .
    RefSeqi XP_641395.1. XM_636303.1.

    3D structure databases

    ProteinModelPortali Q54VG0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDB_0230197.

    Proteomic databases

    PRIDEi Q54VG0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0230197 ; DDB0230197 ; DDB_G0280353 .
    GeneIDi 8622529.
    KEGGi ddi:DDB_G0280353.

    Organism-specific databases

    dictyBasei DDB_G0280353. odhA.

    Phylogenomic databases

    eggNOGi COG0567.
    InParanoidi Q54VG0.
    KOi K15791.
    OMAi LCSGKHY.
    PhylomeDBi Q54VG0.

    Miscellaneous databases

    PROi Q54VG0.

    Family and domain databases

    Gene3Di 3.40.50.970. 2 hits.
    InterProi IPR011603. 2oxoglutarate_DH_E1.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view ]
    PANTHERi PTHR23152. PTHR23152. 1 hit.
    Pfami PF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTi SM00861. Transket_pyr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 2 hits.
    TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiDHTK1_DICDI
    AccessioniPrimary (citable) accession number: Q54VG0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 24, 2009
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3