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Q54VG0 (DHTK1_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial

EC=1.2.4.2
Alternative name(s):
Oxoglutarate dehydrogenase A
Gene names
Name:odhA
ORF Names:DDB_G0280353
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length900 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.

Catalytic activity

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactor

Thiamine pyrophosphate By similarity.

Subcellular location

Mitochondrion Potential.

Sequence similarities

Belongs to the alpha-ketoglutarate dehydrogenase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentMitochondrion
   DomainTransit peptide
   LigandThiamine pyrophosphate
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-KW

tricarboxylic acid cycle

Inferred from electronic annotation. Source: InterPro

   Cellular_componentmitochondrion

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionoxoglutarate dehydrogenase (succinyl-transferring) activity

Inferred by curator. Source: dictyBase

thiamine pyrophosphate binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 900Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrialPRO_0000388782

Regions

Compositional bias25 – 317Poly-Ser

Sequences

Sequence LengthMass (Da)Tools
Q54VG0 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: F2F2A86C9191EF98

FASTA900101,831
        10         20         30         40         50         60 
MIGLRSISKN KQTINSISKS FYCTSSPSSS SVKLSVTRLI DGYRAHGHLA ANIDPLARME 

        70         80         90        100        110        120 
RIRSQLLDLD RYNLVKGQSI PSTIDLINQD LTNLDQVVSF LENAYCNDVT AQFDHIESIE 

       130        140        150        160        170        180 
EKAWLYEKFE QLQHQNPSKS EKINILKNLI KSEIFDQFMQ KKFPTFKRYG LEGNESMMVS 

       190        200        210        220        230        240 
CDSIFRESAK NQLKNVVIGM PHRGRLNLLV QMCNYPAKDF FWKVKGNSEF SEGILGVGDV 

       250        260        270        280        290        300 
TSHIAVSTDL QFNNNKESVH VSLIHNPSHL EAVDPVAAGK TRAKQFYEKN EGGSESLCLM 

       310        320        330        340        350        360 
LHGDAAVAGQ GVVTETLQLS QLSGFNIGGC VHVIVNNQIG FTTVPTNGRS NRYSSDIGKF 

       370        380        390        400        410        420 
IGAPIIVVNS QSPEQVEKVS RLAVEYRQKF KKDIIIDLIG WRKFGHNEVD EPSFTQPTMY 

       430        440        450        460        470        480 
QNIRKRQSIP QKYATQIISQ GIFSEQELLE FTQKEQAILE EQFQLSTPEN FKYSPMDHLQ 

       490        500        510        520        530        540 
GKWSGLIQSK HIADDSKLDT GYSVEELSEI ANDSVKVPSD FQVHQRLLRS FSNARLEKLK 

       550        560        570        580        590        600 
QNQADWATAE SMAVGSLMKQ GYNVRISGQD VGRGTFSQRH FNLTEQNSDR IYQPLNNMGA 

       610        620        630        640        650        660 
KGELDVVNSN LSEFAVLCYE YGYSLESPDT LPIWEAQFGD FINGAQIAID QFVTSGESKW 

       670        680        690        700        710        720 
LRQSGIVILL PHGFDGAGPE HSSCRIERFL QLSDTEAVNV KDDTLINQET NFYFINPSTP 

       730        740        750        760        770        780 
ANYFHALRRQ MIRNYRKPLI VAGPKVLLRH PNCFSTLNEM APGTHFQTVL SDPDTINNAS 

       790        800        810        820        830        840 
TIKRVIFCSG KVFYDLQEER KAKNFNDVAI IRLEQIAPFP YQRIQEEINR YSNATKFAWV 

       850        860        870        880        890        900 
QEEQQNGGCW SFVEPRFKQR YPQTSQIKYI GRPPLAASAI GISSIHKKEV SQLLIDAFNF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000035 Genomic DNA. Translation: EAL67403.1.
RefSeqXP_641395.1. XM_636303.1.

3D structure databases

ProteinModelPortalQ54VG0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDB_0230197.

Proteomic databases

PRIDEQ54VG0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0230197; DDB0230197; DDB_G0280353.
GeneID8622529.
KEGGddi:DDB_G0280353.

Organism-specific databases

dictyBaseDDB_G0280353. odhA.

Phylogenomic databases

eggNOGCOG0567.
InParanoidQ54VG0.
OMALCSGKHY.
PhylomeDBQ54VG0.

Family and domain databases

Gene3D3.40.50.970. 2 hits.
InterProIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERPTHR23152. PTHR23152. 1 hit.
PfamPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMSSF52518. SSF52518. 2 hits.
TIGRFAMsTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetSearch...

Other

PROQ54VG0.

Entry information

Entry nameDHTK1_DICDI
AccessionPrimary (citable) accession number: Q54VG0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: May 24, 2005
Last modified: July 9, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase