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Q54VG0

- DHTK1_DICDI

UniProt

Q54VG0 - DHTK1_DICDI

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Protein
Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial
Gene
odhA, DDB_G0280353
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactori

Thiamine pyrophosphate By similarity.

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: dictyBase
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial (EC:1.2.4.2)
Alternative name(s):
Oxoglutarate dehydrogenase A
Gene namesi
Name:odhA
ORF Names:DDB_G0280353
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 3, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0280353. odhA.

Subcellular locationi

Mitochondrion Reviewed prediction

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 900Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrialPRO_0000388782
Transit peptidei1 – ?Mitochondrion Reviewed prediction

Proteomic databases

PRIDEiQ54VG0.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0230197.

Structurei

3D structure databases

ProteinModelPortaliQ54VG0.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi25 – 317Poly-Ser

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0567.
InParanoidiQ54VG0.
KOiK15791.
OMAiLCSGKHY.
PhylomeDBiQ54VG0.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q54VG0-1 [UniParc]FASTAAdd to Basket

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MIGLRSISKN KQTINSISKS FYCTSSPSSS SVKLSVTRLI DGYRAHGHLA    50
ANIDPLARME RIRSQLLDLD RYNLVKGQSI PSTIDLINQD LTNLDQVVSF 100
LENAYCNDVT AQFDHIESIE EKAWLYEKFE QLQHQNPSKS EKINILKNLI 150
KSEIFDQFMQ KKFPTFKRYG LEGNESMMVS CDSIFRESAK NQLKNVVIGM 200
PHRGRLNLLV QMCNYPAKDF FWKVKGNSEF SEGILGVGDV TSHIAVSTDL 250
QFNNNKESVH VSLIHNPSHL EAVDPVAAGK TRAKQFYEKN EGGSESLCLM 300
LHGDAAVAGQ GVVTETLQLS QLSGFNIGGC VHVIVNNQIG FTTVPTNGRS 350
NRYSSDIGKF IGAPIIVVNS QSPEQVEKVS RLAVEYRQKF KKDIIIDLIG 400
WRKFGHNEVD EPSFTQPTMY QNIRKRQSIP QKYATQIISQ GIFSEQELLE 450
FTQKEQAILE EQFQLSTPEN FKYSPMDHLQ GKWSGLIQSK HIADDSKLDT 500
GYSVEELSEI ANDSVKVPSD FQVHQRLLRS FSNARLEKLK QNQADWATAE 550
SMAVGSLMKQ GYNVRISGQD VGRGTFSQRH FNLTEQNSDR IYQPLNNMGA 600
KGELDVVNSN LSEFAVLCYE YGYSLESPDT LPIWEAQFGD FINGAQIAID 650
QFVTSGESKW LRQSGIVILL PHGFDGAGPE HSSCRIERFL QLSDTEAVNV 700
KDDTLINQET NFYFINPSTP ANYFHALRRQ MIRNYRKPLI VAGPKVLLRH 750
PNCFSTLNEM APGTHFQTVL SDPDTINNAS TIKRVIFCSG KVFYDLQEER 800
KAKNFNDVAI IRLEQIAPFP YQRIQEEINR YSNATKFAWV QEEQQNGGCW 850
SFVEPRFKQR YPQTSQIKYI GRPPLAASAI GISSIHKKEV SQLLIDAFNF 900
Length:900
Mass (Da):101,831
Last modified:May 24, 2005 - v1
Checksum:iF2F2A86C9191EF98
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000035 Genomic DNA. Translation: EAL67403.1.
RefSeqiXP_641395.1. XM_636303.1.

Genome annotation databases

EnsemblProtistsiDDB0230197; DDB0230197; DDB_G0280353.
GeneIDi8622529.
KEGGiddi:DDB_G0280353.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000035 Genomic DNA. Translation: EAL67403.1 .
RefSeqi XP_641395.1. XM_636303.1.

3D structure databases

ProteinModelPortali Q54VG0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0230197.

Proteomic databases

PRIDEi Q54VG0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0230197 ; DDB0230197 ; DDB_G0280353 .
GeneIDi 8622529.
KEGGi ddi:DDB_G0280353.

Organism-specific databases

dictyBasei DDB_G0280353. odhA.

Phylogenomic databases

eggNOGi COG0567.
InParanoidi Q54VG0.
KOi K15791.
OMAi LCSGKHY.
PhylomeDBi Q54VG0.

Miscellaneous databases

PROi Q54VG0.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiDHTK1_DICDI
AccessioniPrimary (citable) accession number: Q54VG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: May 24, 2005
Last modified: September 3, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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