Q54VC1 (ABCCF_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ABC transporter C family member 15

Alternative name(s):
ABC transporter ABCC.15

Gene names

Name:	abcC15
ORF Names:	DDB_G0280459

Organism

Dictyostelium discoideum (Slime mold)

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	1436 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification] Contains 2 ABC transmembrane type-1 domains. Contains 2 ABC transporter domains.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Domain	Repeat Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of substances Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1436	1436	ABC transporter C family member 15		PRO_0000363859
Regions
	Transmembrane	8 – 28	21	Helical; Potential
	Transmembrane	129 – 149	21	Helical; Potential
	Transmembrane	165 – 185	21	Helical; Potential
	Transmembrane	238 – 258	21	Helical; Potential
	Transmembrane	261 – 281	21	Helical; Potential
	Transmembrane	349 – 369	21	Helical; Potential
	Transmembrane	373 – 393	21	Helical; Potential
	Transmembrane	873 – 893	21	Helical; Potential
	Transmembrane	919 – 939	21	Helical; Potential
	Transmembrane	985 – 1005	21	Helical; Potential
	Transmembrane	1017 – 1039	23	Helical; Potential
	Transmembrane	1101 – 1121	21	Helical; Potential
	Transmembrane	1127 – 1147	21	Helical; Potential
	Domain	128 – 412	285	ABC transmembrane type-1 1
	Domain	543 – 766	224	ABC transporter 1
	Domain	865 – 1155	291	ABC transmembrane type-1 2
	Domain	1193 – 1426	234	ABC transporter 2
	Nucleotide binding	575 – 582	8	ATP Potential
	Nucleotide binding	1227 – 1234	8	ATP Potential
	Compositional bias	437 – 472	36	Asn-rich
	Compositional bias	516 – 519	4	Poly-Glu
	Compositional bias	539 – 542	4	Poly-Gln
	Compositional bias	795 – 815	21	Poly-Asn

Sequences

	Sequence		Length	Mass (Da)
	Q54VC1 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 9CC96CFA69AD9325	FASTA	1,436	164,683
	10 20 30 40 50 60 MIKKIKNIIN KIINFFSTIY ILCKIYLYYN IKNRYEAYNI LSVYGDDDFF NKPCPEDSSN 70 80 90 100 110 120 WKDKLTFKWV ERIIFVGFFR APLNLNDISD LPSSLKVENT APLLKDIIFN DSTIPLIKHI 130 140 150 160 170 180 YSKFLPRNYI ATGLFVFVSV FSFITPLILK NFLSYVEKID EQKHIYIGII QCFLLFLSSF 190 200 210 220 230 240 INMASQQYSY WFGFKTSLEV KGALETIIFE KMTKLSNLSK KNYNIGSMLN LMSVDTDFFQ 250 260 270 280 290 300 YFFCHYYIEI FLFPIQILSL LGFLIYVIGI AGFVGFLVML ITIPLSSFLG TQISKNLSTS 310 320 330 340 350 360 MGYADTRISL TGELINGIKF LKQYAWEKMF CERIEEQRKL QLKYLYIRII YWVLVQIVTQ 370 380 390 400 410 420 ASSGLVLVST FTTYTLLGYE VSLEIAFTSI TILQNLRRPI ESLPDCLHKF ISLIASAKRI 430 440 450 460 470 480 ETFLQSSELQ NQPFIHNQSG LNDILIRNIN FNWNEHNLKL KNNKNNQNNN QNKRSIILSS 490 500 510 520 530 540 GEQFEITNDF TFDGIDIQDD NYDYEKEYKI NYNNNEEEEN FMTDCLLKIK PLIKDRRLQQ 550 560 570 580 590 600 QQADYQDLLS INLPPPPSEN VDFKAPKGLL TIISGGVRSG KTSLASGLLG EICKAVDKSS 610 620 630 640 650 660 PDSVNSILST IQQPFLQSTS FRENILFGKP MNMERYIKVI EACCLAPDLL AMGEGKDLTE 670 680 690 700 710 720 IGERGINLSN GLKHRIQLAR ALYADSDCYI LDEILSSVDP EIANYIFQHC IKGMMKGKTV 730 740 750 760 770 780 ILVTHQIQFI SSADHVVVVD NGVLIQGTYL ELLRMGIDFE MILKEKENRI EKQIVQLQED 790 800 810 820 830 840 EDYYEEVEIL DFTMNNNNNN NNNNNNNNSN FNGNNKLKRS SISLPKGISI ESIISKDFDQ 850 860 870 880 890 900 TTIEKAKLFV QEDRNKGDPG WIIYKKYIRM GSSISFFIFT CIIYLTSQII LLLSDYWLQS 910 920 930 940 950 960 WASHDRLNVS EPTDVHYLLI YLAYIGGFVF TLGVRYLLIA KITFGSAETL HRSLLKSIIR 970 980 990 1000 1010 1020 APLTFFEQNP VGRILNRFGK DISDIDILLL DCFSDVLYCG ACLVTSIGII IYISPYIAIP 1030 1040 1050 1060 1070 1080 FVILIAINYI FQLFYNYSVL ELKRIQSISR SPVYSLLSEV YNGLTTIRSF GQQERFFNMM 1090 1100 1110 1120 1130 1140 KDNININLRV FFYNFAVSRW IGIRVEFLSA IVVLMSALFS IFNDNPGLSA LGVTTALGIT 1150 1160 1170 1180 1190 1200 FNLNWFMRQF GELESRINSV ERVQSYISIP KEKETNEDEF IQTGFIWPSR GEIEFKNVEI 1210 1220 1230 1240 1250 1260 RYRPNSIATL RNFSMKINAQ ERIGIIGRSG SGKSTIGMSL FRMIECSSGS ILIDGDDISQ 1270 1280 1290 1300 1310 1320 IDLKRLRSSI GIVPQDPFIF SGSIRLNLDP FDQFTDNEIW EALSKVKLKK MVSTMPMKLE 1330 1340 1350 1360 1370 1380 SLVQGGDGLT IGNKQLLCLC RAILRNSKIV LFDEATNSID FQTTRLIKQT IEENFKDCTI 1390 1400 1410 1420 1430 LTIAHNIDTI LDSDKIAIID EGELIEFDTP LNLIKDSTSR FSKLIKLNNN QKNKLN

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000036 Genomic DNA. Translation: EAL67208.1.
RefSeq	XP_641188.1. XM_636096.1.
3D structure databases
HSSP	HSSP built from PDB template 2CBZ based on UniProtKB P33527.
ProteinModelPortal	Q54VC1.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0216384; DDB0216384; DDB_G0280459.
GeneID	8622569.
GenomeReviews	Gene locus abcC15 in contig CM000152_GR.
KEGG	ddi:DDB_G0280459.
Organism-specific databases
dictyBase	DDB_G0280459. abcC15.
Phylogenomic databases
eggNOG	KOG0054.
GeneTree	EPrGT00050000000398.
HOGENOM	HBG758042.
InParanoid	Q54VC1.
OMA	LISSHEF.
PhylomeDB	Q54VC1.
ProtClustDB	CLSZ2430599.
Family and domain databases
InterPro	IPR003439. ABC_transporter-like. IPR017940. ABC_transporter_type1. IPR001140. ABC_transptr_TM_dom. IPR011527. ABC_transptrTM_dom_typ1. IPR003593. ATPase_AAA+_core. [Graphical view]
Pfam	PF00664. ABC_membrane. 2 hits. PF00005. ABC_tran. 2 hits. [Graphical view]
SMART	SM00382. AAA. 2 hits. [Graphical view]
SUPFAM	SSF90123. ABC_TM_1. 2 hits.
PROSITE	PS50929. ABC_TM1F. 2 hits. PS00211. ABC_TRANSPORTER_1. False negative. PS50893. ABC_TRANSPORTER_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ABCCF_DICDI

Accession

Primary (citable) accession number: Q54VC1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	May 24, 2005
Last modified:	September 21, 2011
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)