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Protein

Thioredoxin reductase

Gene

trrA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Thioredoxin + NADP+ = thioredoxin disulfide + NADPH.

Cofactori

FADBy similarityNote: Binds 1 FAD per subunit.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi36 – 4813FADBy similarityAdd
BLAST
Nucleotide bindingi289 – 29810FADBy similarity

GO - Molecular functioni

  • thioredoxin-disulfide reductase activity Source: dictyBase

GO - Biological processi

  • cell redox homeostasis Source: dictyBase
  • culmination involved in sorocarp development Source: dictyBase
  • phagocytosis Source: dictyBase
  • removal of superoxide radicals Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin reductase (EC:1.8.1.9)
Gene namesi
Name:trrA
ORF Names:DDB_G0280815
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0280815. trrA.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 319319Thioredoxin reductasePRO_0000318657Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi144 ↔ 147Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ54UU8.
PRIDEiQ54UU8.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi44689.DDB0231235.

Structurei

3D structure databases

ProteinModelPortaliQ54UU8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiKOG0404. Eukaryota.
COG0492. LUCA.
InParanoidiQ54UU8.
KOiK00384.
OMAiKQEDNSM.
PhylomeDBiQ54UU8.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR008255. Pyr_nucl-diS_OxRdtase_2_AS.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
IPR005982. Thioredox_Rdtase.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PRINTSiPR00469. PNDRDTASEII.
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR01292. TRX_reduct. 1 hit.
PROSITEiPS00573. PYRIDINE_REDOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54UU8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTEKIQKVV IIGSGPAGHT AGIYAGRARL EPLMFEGFMA GGVAAGGQLT
60 70 80 90 100
TTTEIENFPG FPIDISGSEL MDKMREQNIK CGTTIETKTI SKVDLKQRPF
110 120 130 140 150
TIYVEDEEDK PIKAQSIIIA TGATAKRMGV PGETEFWSKG VSACAVCDGA
160 170 180 190 200
LPIYRNKHLV VVGGGDTAAE EATFLTHFAS KVTLLVRRNV MRASKAMQQK
210 220 230 240 250
VFSNPKIEVL WDTTLVEIKG EKSVTSVGIY NSETKVSSNL DAQGLFYAIG
260 270 280 290 300
HTPNSAFLNG QLNTDETGYI ITQPGSTKTN VEGVFACGDV QDKVYRQAIT
310
AAGNGCMAAL DCERFLSSL
Length:319
Mass (Da):34,208
Last modified:May 24, 2005 - v1
Checksum:iA03B2A592B189957
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000038 Genomic DNA. Translation: EAL67065.1.
RefSeqiXP_641039.1. XM_635947.1.

Genome annotation databases

EnsemblProtistsiDDB0231235; DDB0231235; DDB_G0280815.
GeneIDi8622741.
KEGGiddi:DDB_G0280815.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000038 Genomic DNA. Translation: EAL67065.1.
RefSeqiXP_641039.1. XM_635947.1.

3D structure databases

ProteinModelPortaliQ54UU8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0231235.

Proteomic databases

PaxDbiQ54UU8.
PRIDEiQ54UU8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0231235; DDB0231235; DDB_G0280815.
GeneIDi8622741.
KEGGiddi:DDB_G0280815.

Organism-specific databases

dictyBaseiDDB_G0280815. trrA.

Phylogenomic databases

eggNOGiKOG0404. Eukaryota.
COG0492. LUCA.
InParanoidiQ54UU8.
KOiK00384.
OMAiKQEDNSM.
PhylomeDBiQ54UU8.

Miscellaneous databases

PROiQ54UU8.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR008255. Pyr_nucl-diS_OxRdtase_2_AS.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
IPR005982. Thioredox_Rdtase.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PRINTSiPR00469. PNDRDTASEII.
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR01292. TRX_reduct. 1 hit.
PROSITEiPS00573. PYRIDINE_REDOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRXB_DICDI
AccessioniPrimary (citable) accession number: Q54UU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 24, 2005
Last modified: September 7, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Miscellaneous

The active site is a redox-active disulfide bond.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.