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Q54UU8 (TRXB_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Thioredoxin reductase

EC=1.8.1.9
Gene names
Name:trrA
ORF Names:DDB_G0280815
OrganismDictyostelium discoideum (Slime mold)
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length319 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Thioredoxin + NADP+ = thioredoxin disulfide + NADPH.

Cofactor

Binds 1 FAD per subunit By similarity.

Miscellaneous

The active site is a redox-active disulfide bond.

Sequence similarities

Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 319319Thioredoxin reductase
PRO_0000318657

Regions

Nucleotide binding36 – 4813FAD By similarity
Nucleotide binding289 – 29810FAD By similarity

Amino acid modifications

Disulfide bond144 ↔ 147Redox-active By similarity

Sequences

Sequence LengthMass (Da)Tools
Q54UU8 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: A03B2A592B189957

FASTA31934,208
        10         20         30         40         50         60 
MSTEKIQKVV IIGSGPAGHT AGIYAGRARL EPLMFEGFMA GGVAAGGQLT TTTEIENFPG 

        70         80         90        100        110        120 
FPIDISGSEL MDKMREQNIK CGTTIETKTI SKVDLKQRPF TIYVEDEEDK PIKAQSIIIA 

       130        140        150        160        170        180 
TGATAKRMGV PGETEFWSKG VSACAVCDGA LPIYRNKHLV VVGGGDTAAE EATFLTHFAS 

       190        200        210        220        230        240 
KVTLLVRRNV MRASKAMQQK VFSNPKIEVL WDTTLVEIKG EKSVTSVGIY NSETKVSSNL 

       250        260        270        280        290        300 
DAQGLFYAIG HTPNSAFLNG QLNTDETGYI ITQPGSTKTN VEGVFACGDV QDKVYRQAIT 

       310 
AAGNGCMAAL DCERFLSSL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000038 Genomic DNA. Translation: EAL67065.1.
RefSeqXP_641039.1. XM_635947.1.

3D structure databases

HSSPHSSP built from PDB template 1VDC based on UniProtKB Q39243.
ProteinModelPortalQ54UU8.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ54UU8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0231235; DDB0231235; DDB_G0280815.
GeneID8622741.
GenomeReviewsGene locus trrA in contig CM000152_GR.
KEGGddi:DDB_G0280815.

Organism-specific databases

dictyBaseDDB_G0280815. trrA.

Phylogenomic databases

eggNOGKOG0404.
GeneTreeEPrGT00050000005240.
HOGENOMHBG669726.
OMAFFRDRDI.
PhylomeDBQ54UU8.
ProtClustDBCLSZ2430598.

Family and domain databases

InterProIPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR008255. Pyr_nucl-diS_OxRdtase_2_AS.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR001327. Pyr_OxRdtase_NAD-bd_dom.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
IPR005982. Thioredox_Rdtase.
[Graphical view]
KOK00384.
PfamPF00070. Pyr_redox. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PRINTSPR00368. FADPNR.
PR00469. PNDRDTASEII.
TIGRFAMsTIGR01292. TRX_reduct. 1 hit.
PROSITEPS00573. PYRIDINE_REDOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTRXB_DICDI
AccessionPrimary (citable) accession number: Q54UU8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 24, 2005
Last modified: November 16, 2011
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase

SIMILARITY comments

Index of protein domains and families