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Q54UT2

- DGK_DICDI

UniProt

Q54UT2 - DGK_DICDI

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Protein
Deoxyguanosine kinase
Gene
dgk, DDB_G0280843
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Purine-specific deoxyribonuleoside kinase that phosphorylates preferentially deoxyguanosine, as part of the deoxyribonucleotide salvage pathway.

Catalytic activityi

ATP + deoxyguanosine = ADP + dGMP.1 Publication

Kineticsi

  1. KM=1.4 µM for deoxyguanosine1 Publication
  2. KM=206 µM for deoxyadenosine

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei63 – 631Substrate By similarity
Binding sitei75 – 751Substrate By similarity
Binding sitei86 – 861Substrate By similarity
Active sitei114 – 1141Proton acceptor Reviewed prediction
Binding sitei115 – 1151Substrate By similarity
Binding sitei120 – 1201Substrate By similarity
Binding sitei180 – 1801Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi39 – 479ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. deoxyguanosine kinase activity Source: dictyBase
  3. phosphotransferase activity, alcohol group as acceptor Source: InterPro

GO - Biological processi

  1. deoxyguanosine salvage Source: dictyBase
  2. deoxyribonucleoside monophosphate biosynthetic process Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SABIO-RKQ54UT2.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyguanosine kinase (EC:2.7.1.113)
Short name:
dGK
Alternative name(s):
DddGK
Gene namesi
Name:dgk
ORF Names:DDB_G0280843
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 3, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0280843. dgk.

Subcellular locationi

Cytoplasm Inferred

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 285285Deoxyguanosine kinase
PRO_0000327522Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi44689.DDBDRAFT_0218264.

Structurei

3D structure databases

ProteinModelPortaliQ54UT2.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi272 – 2798Poly-Asn

Sequence similaritiesi

Belongs to the DCK/DGK family.

Phylogenomic databases

eggNOGiCOG1428.
KOiK03954.
OMAiWVFAENC.
PhylomeDBiQ54UT2.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR002624. DNK.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10513. PTHR10513. 1 hit.
PfamiPF01712. dNK. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q54UT2-1 [UniParc]FASTAAdd to Basket

« Hide

MFRRSLMFMI SNNKNTNMVS SINTTNKVNN FSKIIILEGN ISAGKTYLSS    50
KLGDLLGYKV FLEPTATNPY LSLFYKEPSK YALIMQKWLL NQRYNTFLNA 100
LQYSLENEQG VILDRSVYSD WVFAENCRSE GLISAEGFKE YNSIRDRFLS 150
NIPIPNVTLF LDVDPKQCLQ RIQNRKRDCE QSIPLSYLSG LDNCYKKFLI 200
EMKSKGSNVI ILDWNNFGDI NLVLNEINND NFNNFNNSNN SKFNDVNYKK 250
QQLISDIENE KNNLKEMKFF LNENNNNNNQ EKIKS 285
Length:285
Mass (Da):33,193
Last modified:March 18, 2008 - v2
Checksum:i1857E13F82E733C5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY669384 mRNA. Translation: AAV85947.1.
AAFI02000025 Genomic DNA. Translation: EAL67033.2.
RefSeqiXP_641009.2. XM_635917.2.

Genome annotation databases

EnsemblProtistsiDDB0233982; DDB0233982; DDB_G0280843.
GeneIDi8621793.
KEGGiddi:DDB_G0280843.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY669384 mRNA. Translation: AAV85947.1 .
AAFI02000025 Genomic DNA. Translation: EAL67033.2 .
RefSeqi XP_641009.2. XM_635917.2.

3D structure databases

ProteinModelPortali Q54UT2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDBDRAFT_0218264.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0233982 ; DDB0233982 ; DDB_G0280843 .
GeneIDi 8621793.
KEGGi ddi:DDB_G0280843.

Organism-specific databases

dictyBasei DDB_G0280843. dgk.

Phylogenomic databases

eggNOGi COG1428.
KOi K03954.
OMAi WVFAENC.
PhylomeDBi Q54UT2.

Enzyme and pathway databases

SABIO-RK Q54UT2.

Miscellaneous databases

PROi Q54UT2.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR002624. DNK.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR10513. PTHR10513. 1 hit.
Pfami PF01712. dNK. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Dictyostelium discoideum salvages purine deoxyribonucleosides by highly specific bacterial-like deoxyribonucleoside kinases."
    Sandrini M.P.B., Soederbom F., Mikkelsen N.E., Piskur J.
    J. Mol. Biol. 369:653-664(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES.
    Strain: AX4.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiDGK_DICDI
AccessioniPrimary (citable) accession number: Q54UT2
Secondary accession number(s): Q14EL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: March 18, 2008
Last modified: September 3, 2014
This is version 53 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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