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Q54UT2

- DGK_DICDI

UniProt

Q54UT2 - DGK_DICDI

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Protein

Deoxyguanosine kinase

Gene

dgk

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Purine-specific deoxyribonuleoside kinase that phosphorylates preferentially deoxyguanosine, as part of the deoxyribonucleotide salvage pathway.

Catalytic activityi

ATP + deoxyguanosine = ADP + dGMP.1 Publication

Kineticsi

  1. KM=1.4 µM for deoxyguanosine1 Publication
  2. KM=206 µM for deoxyadenosine1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei63 – 631SubstrateBy similarity
Binding sitei75 – 751SubstrateBy similarity
Binding sitei86 – 861SubstrateBy similarity
Active sitei114 – 1141Proton acceptorSequence Analysis
Binding sitei115 – 1151SubstrateBy similarity
Binding sitei120 – 1201SubstrateBy similarity
Binding sitei180 – 1801SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi39 – 479ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. deoxyguanosine kinase activity Source: dictyBase

GO - Biological processi

  1. deoxyguanosine salvage Source: dictyBase
  2. deoxyribonucleoside monophosphate biosynthetic process Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SABIO-RKQ54UT2.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyguanosine kinase (EC:2.7.1.113)
Short name:
dGK
Alternative name(s):
DddGK
Gene namesi
Name:dgk
ORF Names:DDB_G0280843
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 3, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0280843. dgk.

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 285285Deoxyguanosine kinasePRO_0000327522Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi44689.DDBDRAFT_0218264.

Structurei

3D structure databases

ProteinModelPortaliQ54UT2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi272 – 2798Poly-Asn

Sequence similaritiesi

Belongs to the DCK/DGK family.Curated

Phylogenomic databases

eggNOGiCOG1428.
InParanoidiQ54UT2.
KOiK03954.
OMAiWVFAENC.
PhylomeDBiQ54UT2.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR002624. DNK.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10513. PTHR10513. 1 hit.
PfamiPF01712. dNK. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q54UT2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFRRSLMFMI SNNKNTNMVS SINTTNKVNN FSKIIILEGN ISAGKTYLSS
60 70 80 90 100
KLGDLLGYKV FLEPTATNPY LSLFYKEPSK YALIMQKWLL NQRYNTFLNA
110 120 130 140 150
LQYSLENEQG VILDRSVYSD WVFAENCRSE GLISAEGFKE YNSIRDRFLS
160 170 180 190 200
NIPIPNVTLF LDVDPKQCLQ RIQNRKRDCE QSIPLSYLSG LDNCYKKFLI
210 220 230 240 250
EMKSKGSNVI ILDWNNFGDI NLVLNEINND NFNNFNNSNN SKFNDVNYKK
260 270 280
QQLISDIENE KNNLKEMKFF LNENNNNNNQ EKIKS
Length:285
Mass (Da):33,193
Last modified:March 18, 2008 - v2
Checksum:i1857E13F82E733C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY669384 mRNA. Translation: AAV85947.1.
AAFI02000025 Genomic DNA. Translation: EAL67033.2.
RefSeqiXP_641009.2. XM_635917.2.

Genome annotation databases

EnsemblProtistsiDDB0233982; DDB0233982; DDB_G0280843.
GeneIDi8621793.
KEGGiddi:DDB_G0280843.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY669384 mRNA. Translation: AAV85947.1 .
AAFI02000025 Genomic DNA. Translation: EAL67033.2 .
RefSeqi XP_641009.2. XM_635917.2.

3D structure databases

ProteinModelPortali Q54UT2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDBDRAFT_0218264.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0233982 ; DDB0233982 ; DDB_G0280843 .
GeneIDi 8621793.
KEGGi ddi:DDB_G0280843.

Organism-specific databases

dictyBasei DDB_G0280843. dgk.

Phylogenomic databases

eggNOGi COG1428.
InParanoidi Q54UT2.
KOi K03954.
OMAi WVFAENC.
PhylomeDBi Q54UT2.

Enzyme and pathway databases

SABIO-RK Q54UT2.

Miscellaneous databases

PROi Q54UT2.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR002624. DNK.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR10513. PTHR10513. 1 hit.
Pfami PF01712. dNK. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Dictyostelium discoideum salvages purine deoxyribonucleosides by highly specific bacterial-like deoxyribonucleoside kinases."
    Sandrini M.P.B., Soederbom F., Mikkelsen N.E., Piskur J.
    J. Mol. Biol. 369:653-664(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES.
    Strain: AX4.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiDGK_DICDI
AccessioniPrimary (citable) accession number: Q54UT2
Secondary accession number(s): Q14EL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: March 18, 2008
Last modified: October 29, 2014
This is version 55 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3