Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phospholipase D A

Gene

pldA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role in cell growth. Hydrolyzes membrane phospholipids, such as PtdCho free headgroup and PtdOH (phosphatidic acid; signaling molecule on its own). Involved in the inhibition of actin-based motility and endocytosis. Its inhibition causes complete collapse of F-actin organization.3 Publications

Catalytic activityi

A phosphatidylcholine + H2O = choline + a phosphatidate.

Enzyme regulationi

Inhibited by butan-1-ol.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei440PROSITE-ProRule annotation1
Active sitei442PROSITE-ProRule annotation1
Active sitei447PROSITE-ProRule annotation1
Active sitei709PROSITE-ProRule annotation1
Active sitei711PROSITE-ProRule annotation1
Active sitei716PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Enzyme and pathway databases

BRENDAi3.1.4.4 1939
ReactomeiR-DDI-1483166 Synthesis of PA
R-DDI-2029485 Role of phospholipids in phagocytosis
R-DDI-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipase D A (EC:3.1.4.4)
Alternative name(s):
Phosphatase D1
Short name:
PLD 1
Gene namesi
Name:pldA
Synonyms:pld1
ORF Names:DDB_G0281031
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0281031 pldA

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003674701 – 1269Phospholipase D AAdd BLAST1269

Proteomic databases

PaxDbiQ54UK0

Expressioni

Developmental stagei

Expressed consistently in both vegetative and developing cells.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0231506

Structurei

3D structure databases

ProteinModelPortaliQ54UK0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini435 – 462PLD phosphodiesterase 1PROSITE-ProRule annotationAdd BLAST28
Domaini704 – 731PLD phosphodiesterase 2PROSITE-ProRule annotationAdd BLAST28

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili131 – 192Sequence analysisAdd BLAST62
Coiled coili803 – 835Sequence analysisAdd BLAST33
Coiled coili1059 – 1096Sequence analysisAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi90 – 93Poly-Gly4
Compositional biasi101 – 114Poly-AsnAdd BLAST14
Compositional biasi239 – 242Poly-Asn4
Compositional biasi256 – 268Poly-SerAdd BLAST13
Compositional biasi801 – 819Poly-AsnAdd BLAST19
Compositional biasi822 – 834Poly-AsnAdd BLAST13
Compositional biasi837 – 840Poly-Asn4
Compositional biasi878 – 881Poly-Thr4
Compositional biasi882 – 886Poly-Ala5
Compositional biasi887 – 899Poly-ThrAdd BLAST13
Compositional biasi988 – 991Poly-Pro4
Compositional biasi996 – 1002Poly-Pro7
Compositional biasi1054 – 1060Poly-Thr7
Compositional biasi1062 – 1096Poly-GlnAdd BLAST35
Compositional biasi1099 – 1107Poly-Gln9
Compositional biasi1110 – 1115Poly-Gln6

Sequence similaritiesi

Belongs to the phospholipase D family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG1329 Eukaryota
COG1502 LUCA
InParanoidiQ54UK0
KOiK01115
OMAiEVFITAW

Family and domain databases

InterProiView protein in InterPro
IPR025202 PLD-like_dom
IPR001736 PLipase_D/transphosphatidylase
IPR015679 PLipase_D_fam
PANTHERiPTHR18896 PTHR18896, 1 hit
PfamiView protein in Pfam
PF00614 PLDc, 1 hit
PF13091 PLDc_2, 1 hit
SMARTiView protein in SMART
SM00155 PLDc, 2 hits
PROSITEiView protein in PROSITE
PS50035 PLD, 2 hits

Sequencei

Sequence statusi: Complete.

Q54UK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNNSKSPPN EQHQQQPHPP DVLVQLTESF QHFFQSLSPQ YQSMTSLPSI
60 70 80 90 100
NKDSYTSVGS APTTNNNSNS NSNSNSSNRS LNNSGSSNSG GGGSNSNKKV
110 120 130 140 150
NNNNNNNNNN NNNNLQSPTQ SQFPYHYQYS SKALHDFEEK RKLLIEQLKS
160 170 180 190 200
VKINLDTQCD DDPISFIKIR MELTKVKTSL ETELKSLDEL LHTTSEVEEP
210 220 230 240 250
NPTPIDSITS LLTMIMPSSI SNSVTNNTPS SATPLTLSNN NNYTSSSLAT
260 270 280 290 300
SPTTNSSSSS SSSSSSSSTH YYNSSISSNS LSSNLPPSSI PILNTSNNKN
310 320 330 340 350
SYPNSIIPQG TPLDNPDPNL PRFPQRDHIS VKLYVDCDDY FAASAQAIEN
360 370 380 390 400
ATREVFITAW FLSPEVYLIR FPSLDERYRL DNLLKRKAMQ GVKIFIILWD
410 420 430 440 450
ETKIATFKGS KRAKDKLEEL HTNIKVIKHP PIIPIYWSHH QKTLIIDQEI
460 470 480 490 500
AFVGGVDFCF GRFDTWCHHL IDVNSTLWKG KDYYNPILGD MGDILVPFED
510 520 530 540 550
SVDRKKIPRM PWHDVMAGVN GLAARDVALN FILRWNHHKD DYYPQLYFDT
560 570 580 590 600
TPLSPVGTSQ CQLLRSMDEW SGGGRIERSI HTAYVQAIED ANHYIYIENQ
610 620 630 640 650
NFVSTHAPNV WNQISFEIVK RIKRAIRKKE VFRVFIVIPC QQDGKVEETQ
660 670 680 690 700
IKGLMHWQYS TIIRGENTIM KLLRRDCPDV DLTEYICFLS LRTHAFLEGT
710 720 730 740 750
FVTEQIYVHS KLMIVDDRTI IVGSANINDR SLIGERDSEL AFIIRDEIDT
760 770 780 790 800
IQTKMNGQDY IASRLVFNFR LRLWKEHLGL LPQINYPPHD QINNDINNIV
810 820 830 840 850
NLNNNNNSNI NNNINNNNNE INNNNNNNNN NNSNEINNNN SDGILNNSNS
860 870 880 890 900
FHHGSVSDNL PPLNPSSNLN SSNKKLPTTT TAAAAATTTT TTTTTTTTTN
910 920 930 940 950
GTGTTNKQKT SHHRSNSFQG LVLQSPGSNR SNLSSPQDSP QDSPRLKNLA
960 970 980 990 1000
EEISPPPTEQ HQHQSPITDI NLILENVDTI IHSNEQLPPP PSSTTPPPPP
1010 1020 1030 1040 1050
PPLTTTDSVI IEDYKSDGGN LNIENNNSNN TILTNAATSM NNSTSSLSST
1060 1070 1080 1090 1100
SLPTTTTTTT AQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQPSQQ
1110 1120 1130 1140 1150
QQQQQQQLSQ QQQLQIKKKR SSISPSTSSN KLLLSGNGSG DSIRVVTDSG
1160 1170 1180 1190 1200
SSPRGQPRSM SSLHDHADSS YCQKSNIDLI DPTCSDFYFG VWIATAASNT
1210 1220 1230 1240 1250
RIYDTVFPAI PKNSIKTCEQ FAQLQKIPVS LADSKLLSEV RGNLVFHPLD
1260
FLEGEDLQPS FLFTDDLFQ
Length:1,269
Mass (Da):142,142
Last modified:May 24, 2005 - v1
Checksum:iF719CC299648C287
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000040 Genomic DNA Translation: EAL66812.1
RefSeqiXP_640776.1, XM_635684.1

Genome annotation databases

EnsemblProtistsiEAL66812; EAL66812; DDB_G0281031
GeneIDi8622829
KEGGiddi:DDB_G0281031

Similar proteinsi

Entry informationi

Entry nameiPLDA_DICDI
AccessioniPrimary (citable) accession number: Q54UK0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 24, 2005
Last modified: March 28, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health