Q54UF3 (DCOR_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable ornithine decarboxylase
Short name=ODC
EC=4.1.1.17

Gene names

Name:	odc
ORF Names:	DDB_G0281109

Organism

Dictyostelium discoideum (Slime mold)

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	461 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-ornithine = putrescine + CO2.
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the Orn/Lys/Arg decarboxylase class-II family.

Ontologies

Keywords
Biological process	Polyamine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	polyamine biosynthetic process Inferred from sequence or structural similarity. Source: dictyBase
Molecular function	ornithine decarboxylase activity Inferred from sequence or structural similarity. Source: dictyBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 461	461	Probable ornithine decarboxylase		PRO_0000328317
Regions
	Compositional bias	13 – 19	7	Poly-Asn
Sites
	Active site	402	1	Proton donor; shared with dimeric partner By similarity
Amino acid modifications
	Modified residue	116	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q54UF3 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 500BF0DC382CE846	FASTA	461	51,695
	10 20 30 40 50 60 MTGTKRNGEE VVNENNNNNV AEETNKKAKV DESSTETTES TSCSLLSRCE KLDIVRKELD 70 80 90 100 110 120 VKPWDQGKVT IQELITSLLD KTDRDAFFVA DVGVIIKQWQ KWVKNLPNVK PYYAVKCNPT 130 140 150 160 170 180 VGVLRVLDAL GTNYDCASRT EIESVLNLGV DPSRIIYANP CKQISALKFA RAHNVKLMTF 190 200 210 220 230 240 DNLSELEKIE KFFPEAELVL RIAPDDSKSV MRFGSKFGVH IDDCNDLLEM AKEMNLKVVG 250 260 270 280 290 300 VSFHVGSGCQ SGDSYADALI MVKSVFDMAK KLNMELTLVD VGGGFTGSDD EKFNAFTKVI 310 320 330 340 350 360 REKTAELFSP NVKIIAEPGR YFAAQSHTLA VTVISKRSIK QEDNRQHPRR TSNNMRQYNY 370 380 390 400 410 420 YLADGVYGSF NNTKFDYAKV EPLLLKPSTK QPTPCTLFGP TCDSIDVVLK DTQIPELKIG 430 440 450 460 DWLYFQDMGA YTIASSSSFN GFCPPPVYYY NSIPEEELKN L

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000040 Genomic DNA. Translation: EAL66851.1.
RefSeq	XP_640823.1. XM_635731.1.
3D structure databases
HSSP	HSSP built from PDB template 1F3T based on UniProtKB P07805.
ProteinModelPortal	Q54UF3.
ModBase	Search...
Protein-protein interaction databases
STRING	Q54UF3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0237755; DDB0237755; DDB_G0281109.
GeneID	8622878.
GenomeReviews	Gene locus odc in contig CM000152_GR.
KEGG	ddi:DDB_G0281109.
Organism-specific databases
dictyBase	DDB_G0281109. odc.
Phylogenomic databases
eggNOG	KOG0622.
GeneTree	EPrGT00050000004483.
HOGENOM	HBG672375.
OMA	PRTLYFR.
PhylomeDB	Q54UF3.
ProtClustDB	CLSZ2430568.
Family and domain databases
InterPro	IPR009006. Ala_racemase/Decarboxylase_C. IPR022643. De-COase2_C. IPR022644. De-COase2_N. IPR022653. De-COase2_pyr-phos_BS. IPR000183. Orn/DAP/Arg_de-COase. IPR002433. Orn_de-COase. [Graphical view]
Gene3D	G3DSA:2.40.37.10. Ala_racemase/Decarboxylase_C. 1 hit.
KO	K01581.
Pfam	PF02784. Orn_Arg_deC_N. 1 hit. PF00278. Orn_DAP_Arg_deC. 1 hit. [Graphical view]
PRINTS	PR01179. ODADCRBXLASE. PR01182. ORNDCRBXLASE.
SUPFAM	SSF50621. Racem_decarbox_C. 1 hit.
PROSITE	PS00878. ODR_DC_2_1. 1 hit. PS00879. ODR_DC_2_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DCOR_DICDI

Accession

Primary (citable) accession number: Q54UF3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	May 24, 2005
Last modified:	November 16, 2011
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)