Reviewed, UniProtKB/Swiss-Prot Q54U44 (ABCCC_DICDI)

Names and origin

Protein names

Recommended name:
    ABC transporter C family member 12
Alternative name(s):
    ABC transporter ABCC.12

Gene names

Name:	abcC12
ORF Names:	DDB_G0280973

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	1323 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification] Contains 2 ABC transmembrane type-1 domains. Contains 2 ABC transporter domains.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Domain	Repeat Transmembrane
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	transmembrane transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of substances Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1323	1323	ABC transporter C family member 12		PRO_0000363856
Regions
	Transmembrane	111 – 131	21	Potential
	Transmembrane	152 – 172	21	Potential
	Transmembrane	227 – 247	21	Potential
	Transmembrane	252 – 272	21	Potential
	Transmembrane	338 – 358	21	Potential
	Transmembrane	375 – 395	21	Potential
	Transmembrane	712 – 732	21	Potential
	Transmembrane	772 – 792	21	Potential
	Transmembrane	840 – 860	21	Potential
	Transmembrane	862 – 882	21	Potential
	Transmembrane	952 – 972	21	Potential
	Domain	110 – 396	287	ABC transmembrane type-1 1
	Domain	428 – 652	225	ABC transporter 1
	Domain	720 – 1010	291	ABC transmembrane type-1 2
	Domain	1047 – 1281	235	ABC transporter 2
	Nucleotide binding	464 – 471	8	ATP Potential
	Nucleotide binding	1081 – 1088	8	ATP Potential
	Compositional bias	662 – 669	8	Poly-Asp
Experimental info
	Sequence conflict	10 – 19	10	DNLETKGGKE → EIWKLREER in AAL85715. Ref.2
	Sequence conflict	829	1	R → C in AAL85715. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q54U44-1 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 338966DE25C8F404	FASTA	1,323	148,126
	10 20 30 40 50 60 MEDIELNSVD NLETKGGKEI KKKEKKIGYG GKKSPEENSN FLSNLTFSWA DGFVIHCFRN 70 80 90 100 110 120 VLQLSHLWDL ASYDKSEYLA KKIAKSWEIE IQKPKPSYLR AGFRAFGKLH CISLFFYSIY 130 140 150 160 170 180 VGSQFVGPEI LSRMVTFVVE SKLGTSTEDP NMGYYYALIM FGTAMIGSFC NYQANRVTVR 190 200 210 220 230 240 TGDRLRSIIV LDVYKKAIKL SNSARSNTSP GQIVNLISND AQRMIEVFGI LNNGLFALPQ 250 260 270 280 290 300 IIICLALLYE KIGWPTFVGL GLMLAAIPFN GLAAKKLTET RRILIGHTDG RVKVTSEILQ 310 320 330 340 350 360 AMKIIKLYAW EDSFAKKVLD RRNNEIKLLF SFTRYRTILI AMIGAIPTAA SILVFSTYYG 370 380 390 400 410 420 YNGSLDAGKI FSALSYLNLL KIPLGFLPIL IALGIQMQIA SKRVTDFLLL PEMKEVQQID 430 440 450 460 470 480 NPSLPNGVYM KNSTTTWNKE KEDSFGLKNI NFEAKGQSLT MVVGSVGSGK STLVQAMLGE 490 500 510 520 530 540 LETIDGEIGI KGSIAYVPQQ AWIINATLKE NIIFGKELDE ERYQKVLEVC ALKRDIELFP 550 560 570 580 590 600 QGDSVEIGER GINLSGGQKQ RVSIARAVYS DADVYILDDP LSAVDSHVGK HLFHKCFKGI 610 620 630 640 650 660 LSSKTVILVA NQINYLPFAD NTVVLKSGEI VERGTYYELI NAKLEFASLL QEYGVDENTK 670 680 690 700 710 720 GDDSDDDDDK KDDDKKEEKV EKPKQSDKDG TLISEEEAEQ GAVAGKVYWK YVTAGGGLLF 730 740 750 760 770 780 LFAMILFLLE TGSKTFTDWW LSHWQTESSE RMESILLGEE PTGLTDDQNL GIYIGVGMAS 790 800 810 820 830 840 IIVTVVRTFS FFEYAVRAAH SIHHELFNAL LKKPMSFFDQ TPLGRIINRF TRDLDIIDNL 850 860 870 880 890 900 IATSIAQFFT LMLSVLATLI LISIIVPWLL IPLAPICILF FILQYFYRYT SRGLQRIEAI 910 920 930 940 950 960 TRSPIFNHFS ETLNGVVSIR AYKKQQENIL KNQKRLDDNN NCYLTLQAMN RWLGLRLDFL 970 980 990 1000 1010 1020 GNLIVFFSCI FITLKKDTIS PSDVGLVLSY ALSITSNLNQ GVLQAADTET KMNSVERISQ 1030 1040 1050 1060 1070 1080 YIRGAVEAPQ IIDDCRPSPD WPINGSIKFD NLVMRYREGL DPVLKGITCE IKAKEKIGIV 1090 1100 1110 1120 1130 1140 GRTGAGKSSI VLALFRLIEA SEGSISIDGE NIAKFGLKDL RRNLAIIPQD PVLFSGTLRE 1150 1160 1170 1180 1190 1200 NLDPFNECPD HELWSILDDI QLSKVFKSTE EGLNSKVTEN GENFSVGQRQ LIVLARALLR 1210 1220 1230 1240 1250 1260 KPKILVLDEA TASVDGQSDS LIQATIRNKF SNCTILTIAH RLNTIMDSDK IMVLDAGKIS 1270 1280 1290 1300 1310 1320 EFDEPWTLLQ NQNGLLTWLV NETGPQNAIY LRKLAEAKKS GLNINEITQI DQQNDNLNTP PRL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
[2]	"Evolutionary analyses of ABC transporters of Dictyostelium discoideum." Anjard C., Loomis W.F. Eukaryot. Cell 1:643-652(2002) [PubMed: 12456012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-1265, NOMENCLATURE. Strain: AX4.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AAFI02000040 Genomic DNA. Translation: EAL66783.1. AF474344 Genomic DNA. Translation: AAL85715.1.
RefSeq	XP_640932.1.
3D structure databases
HSSP	HSSP built from PDB template 2CBZ based on UniProtKB P33527.
ModBase	Search...
Genome annotation databases
GeneID	3391868.
GenomeReviews	Gene locus abcC12 in contig CM000152_GR.
KEGG	ddi:DDB_0214809.
Organism-specific databases
dictyBase	DDB_G0280973. abcC12.
Phylogenomic databases
HOGENOM	HBG758042.
InParanoid	Q54U44.
OMA	CADERIN.
Family and domain databases
InterPro	IPR011527. ABC_TM_1. IPR001140. ABC_TM_transpt. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR017940. ABC_transporter_type1. IPR003593. ATPase_AAA+_core. [Graphical view]
Pfam	PF00664. ABC_membrane. 2 hits. PF00005. ABC_tran. 2 hits. [Graphical view]
SMART	SM00382. AAA. 2 hits. [Graphical view]
PROSITE	PS50929. ABC_TM1F. 2 hits. PS00211. ABC_TRANSPORTER_1. 2 hits. PS50893. ABC_TRANSPORTER_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ABCCC_DICDI

Accession

Primary (citable) accession number: Q54U44
Secondary accession number(s): Q8T6G8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	May 24, 2005
Last modified:	December 15, 2009
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)