Reviewed, UniProtKB/Swiss-Prot Q54TR5 (ABKB_DICDI)

Names and origin

Protein names

Recommended name:
    Probable serine/threonine-protein kinase abkB
    EC=2.7.11.-

Gene names

Name:	abkB
Synonyms:	adckB1
ORF Names:	DDB_G0281799

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	668 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Sequence similarities

Belongs to the protein kinase superfamily. ADCK protein kinase family. Contains 1 protein kinase domain.

Ontologies

Keywords
Domain	Coiled coil
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 668	668	Probable serine/threonine-protein kinase abkB		PRO_0000367577
Regions
	Domain	314 – 668	355	Protein kinase
	Nucleotide binding	320 – 328	9	ATP By similarity
	Coiled coil	131 – 163	33	Potential
	Compositional bias	31 – 39	9	Poly-Asn
	Compositional bias	665 – 668	4	Poly-His
Sites
	Active site	478	1	Proton acceptor By similarity
	Binding site	346	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q54TR5-1 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 32EB77AFCBCD3157	FASTA	668	77,042
	10 20 30 40 50 60 MNQIHSTILK KGILNIKPQI RNITKCTNTI NYNNNNINNR YFTSINKNKN IENLLQQQPQ 70 80 90 100 110 120 QQPQQQLQQQ PILFVQNQNN INYFKREYTN IGGTSPNRQS VPENSTTKTT ATATVETDNV 130 140 150 160 170 180 VNSSTTFTLP KEVEEEIIDK NERGKEQEQE NKQQKEQKDD NKSGSIFSIK GWLTISILSV 190 200 210 220 230 240 LALGTKLVID PPQNIDKLDL AFIRNLRVLY AGFKITFYYK YYLMGLNRGD EGFAENIQIA 250 260 270 280 290 300 HKLAAKAMVD LCYQNKGIFI KVAQIIASLD HILPQEYIKS LSIFQDHAPF VTFEEVEKLF 310 320 330 340 350 360 KIETGKHPDD MFIDFERLPI NSASLAQVHK AKLKLENDEI IEVAVKVQYP GLMNKFQKDM 370 380 390 400 410 420 DSLDNVLTYI TLFFPSFQFS WILGEASSCL SQELDFVNEA KNSEKMKQLF IGNQQLSIPK 430 440 450 460 470 480 VYWNHTTKRI LTMEFIHGVR IDNREGLDKL GIDLKELYYL FSDIFAQQIF VHGFLHSDPH 490 500 510 520 530 540 PGNLLVRKTP NGKPDLVLLD HGLYKKIDEN VRLDFCHLWK SLCLGDAKTS EFYAERLGAG 550 560 570 580 590 600 IYAKHLGILL NLNPSKSREN LRNMKRELKD QTLVVINEIL KNLPKEILLV LKTNNLIRQI 610 620 630 640 650 660 TTHFGIENGF LNMAKTCIKG IYTGNDIITK LKYYLTLCIF NIEIKVIDFI KKRKPPQVEI PSTYHHHH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
[2]	"The dictyostelium kinome -- analysis of the protein kinases from a simple model organism." Goldberg J.M., Manning G., Liu A., Fey P., Pilcher K.E., Xu Y., Smith J.L. PLoS Genet. 2:E38-E38(2006) [PubMed: 16596165] [Abstract] Cited for: GENE FAMILY, NOMENCLATURE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AAFI02000042 Genomic DNA. Translation: EAL66661.1.
RefSeq	XP_640526.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3391630.
GenomeReviews	Gene locus abkB in contig CM000152_GR.
KEGG	ddi:DDB_0229418.
Organism-specific databases
dictyBase	DDB_G0281799. abkB.
Phylogenomic databases
InParanoid	Q54TR5.
Family and domain databases
InterPro	IPR004147. ABC_1. IPR011009. Kinase-like_dom. [Graphical view]
Pfam	PF03109. ABC1. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ABKB_DICDI

Accession

Primary (citable) accession number: Q54TR5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	May 24, 2005
Last modified:	December 15, 2009
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)