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Protein

Alcohol dehydrogenase class-3

Gene

adh5

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.By similarity

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.
S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47Zinc 1; catalyticBy similarity1
Metal bindingi69Zinc 1; catalyticBy similarity1
Metal bindingi99Zinc 2By similarity1
Metal bindingi102Zinc 2By similarity1
Metal bindingi105Zinc 2By similarity1
Metal bindingi113Zinc 2By similarity1
Metal bindingi176Zinc 1; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

ReactomeiR-DDI-2161541. Abacavir metabolism.
R-DDI-5365859. RA biosynthesis pathway.
R-DDI-71384. Ethanol oxidation.

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase class-3 (EC:1.1.1.1)
Alternative name(s):
Alcohol dehydrogenase class-III
Glutathione-dependent formaldehyde dehydrogenase (EC:1.1.1.-)
Short name:
FALDH
Short name:
FDH
Short name:
GSH-FDH
S-(hydroxymethyl)glutathione dehydrogenase (EC:1.1.1.284)
Gene namesi
Name:adh5
ORF Names:DDB_G0281865
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0281865. adh5.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003450231 – 379Alcohol dehydrogenase class-3Add BLAST379

Proteomic databases

PaxDbiQ54TC2.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi44689.DDB0238276.

Structurei

3D structure databases

ProteinModelPortaliQ54TC2.
SMRiQ54TC2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0022. Eukaryota.
COG1062. LUCA.
InParanoidiQ54TC2.
KOiK00121.
OMAiMNGEFRL.
PhylomeDBiQ54TC2.

Family and domain databases

CDDicd08300. alcohol_DH_class_III. 1 hit.
Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiView protein in InterPro
IPR014183. ADH_3.
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR02818. adh_III_F_hyde. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q54TC2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTEGKVITC KAAVAWEAKK PLVIEDIEVQ PPQKGEVRIK ILYTGVCHTD
60 70 80 90 100
SYTLSGSDPE GIFPCILGHE GGGIVESIGE GVTSVKVGDH VIPLYIPECG
110 120 130 140 150
TCKFCTSNKT NLCSKIRITQ GKGQMPDGTT RFKCKGKEIF HFMGTSTFSQ
160 170 180 190 200
YTVLPEISCC VVREDAPLDK VCLLGCGITT GFGAAKITAK VEEGSTVAIF
210 220 230 240 250
GLGAVGLSVA QGAVDCGAKR IIGIDNNETK FGPGKDFGCT EFINPSKDLP
260 270 280 290 300
EGKTIQQHLV DITDGGVDYS FECIGNVNVM RAALECCHKG WGVSTIVGVA
310 320 330 340 350
PAGAEISTRP FQLVTGRVWK GSAFGGVKSR SQLPSIIDKY MDKKLKVDEY
360 370
VTFTYPLNEI NTAFDVMHEG KSLRSVVNL
Length:379
Mass (Da):40,553
Last modified:May 24, 2005 - v1
Checksum:i5E5B438509D3E3C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000043 Genomic DNA. Translation: EAL66492.1.
RefSeqiXP_640467.1. XM_635375.1.

Genome annotation databases

EnsemblProtistsiEAL66492; EAL66492; DDB_G0281865.
GeneIDi8623280.
KEGGiddi:DDB_G0281865.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000043 Genomic DNA. Translation: EAL66492.1.
RefSeqiXP_640467.1. XM_635375.1.

3D structure databases

ProteinModelPortaliQ54TC2.
SMRiQ54TC2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0238276.

Proteomic databases

PaxDbiQ54TC2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL66492; EAL66492; DDB_G0281865.
GeneIDi8623280.
KEGGiddi:DDB_G0281865.

Organism-specific databases

dictyBaseiDDB_G0281865. adh5.

Phylogenomic databases

eggNOGiKOG0022. Eukaryota.
COG1062. LUCA.
InParanoidiQ54TC2.
KOiK00121.
OMAiMNGEFRL.
PhylomeDBiQ54TC2.

Enzyme and pathway databases

ReactomeiR-DDI-2161541. Abacavir metabolism.
R-DDI-5365859. RA biosynthesis pathway.
R-DDI-71384. Ethanol oxidation.

Miscellaneous databases

PROiQ54TC2.

Family and domain databases

CDDicd08300. alcohol_DH_class_III. 1 hit.
Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiView protein in InterPro
IPR014183. ADH_3.
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR02818. adh_III_F_hyde. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADHX_DICDI
AccessioniPrimary (citable) accession number: Q54TC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: May 24, 2005
Last modified: March 15, 2017
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.