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Protein

Probable H/ACA ribonucleoprotein complex subunit 4

Gene

nola4

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a central role in ribosomal RNA processing. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity).By similarity

Catalytic activityi

RNA uridine = RNA pseudouridine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei109NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Ribonucleoprotein

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-DDI-171319. Telomere Extension By Telomerase.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable H/ACA ribonucleoprotein complex subunit 4 (EC:5.4.99.-)
Gene namesi
Name:nola4
Synonyms:dkc1
ORF Names:DDB_G0281933
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0281933. nola4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003312021 – 540Probable H/ACA ribonucleoprotein complex subunit 4Add BLAST540

Proteomic databases

PaxDbiQ54T81.

Interactioni

Subunit structurei

Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).By similarity

Protein-protein interaction databases

IntActiQ54T81. 1 interactor.
STRINGi44689.DDB0233679.

Structurei

3D structure databases

ProteinModelPortaliQ54T81.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini280 – 355PUAPROSITE-ProRule annotationAdd BLAST76

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili448 – 494Sequence analysisAdd BLAST47

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi409 – 413Poly-Thr5

Sequence similaritiesi

Belongs to the pseudouridine synthase TruB family.Curated
Contains 1 PUA domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2529. Eukaryota.
COG0130. LUCA.
InParanoidiQ54T81.
KOiK11131.
PhylomeDBiQ54T81.

Family and domain databases

Gene3Di2.30.130.10. 1 hit.
InterProiIPR012960. Dyskerin-like.
IPR020103. PsdUridine_synth_cat_dom.
IPR002501. PsdUridine_synth_N.
IPR002478. PUA.
IPR015947. PUA-like_domain.
IPR004802. tRNA_PsdUridine_synth_B_fam.
IPR032819. TruB_C.
IPR004521. Uncharacterised_CHP00451.
[Graphical view]
PANTHERiPTHR23127. PTHR23127. 1 hit.
PfamiPF08068. DKCLD. 1 hit.
PF01472. PUA. 1 hit.
PF16198. TruB_C_2. 1 hit.
PF01509. TruB_N. 1 hit.
[Graphical view]
SMARTiSM01136. DKCLD. 1 hit.
SM00359. PUA. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsiTIGR00425. CBF5. 1 hit.
TIGR00451. unchar_dom_2. 1 hit.
PROSITEiPS50890. PUA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54T81-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTDKKSKSK SSEKSTQEVE QVIKPEKTPI LDTSKWPLLL KNYDQLSVRT
60 70 80 90 100
GHYTPIPNGH SPLKRPIKEY VKYGIINLDK PSNPSSHEVV AWIRTILRVT
110 120 130 140 150
KTGHSGTLDP KVTGCLIVCI ERATRLVKSQ QGAGKEYIGI VRLHGAIEGT
160 170 180 190 200
TELSKAVDTL TGALFQRPPQ KSAVKKRLRV RTIHNSKLLE FDPERNLGLI
210 220 230 240 250
WVDCEAGTYI RTLCVHIGLL MGVGGHMQEL RRVRSGIMSE KKGQVTMHDV
260 270 280 290 300
KDAQYEYDNS KDESYLRRVI QPLEAILTNY KRIVVKDSAI NAICYGAKLM
310 320 330 340 350
IPGLLRYEQD IESNEEVVLI TTKGEAIAIG IAQMTTASMA TCDHGVVATI
360 370 380 390 400
KRVIMDRDVY PVRWGLGPKA KVKKEMIKDG KLDKFGKPNE KTPSDWTNTY
410 420 430 440 450
TYYTGQVATT TTTSPVESMN VDTPKKATAS VAVKAEVESS EDEKPVPKKE
460 470 480 490 500
KKDKKEKKKD SSDDESEEEK SSKKDKKEKK EKKEKKEKKS SKDDSDDESS
510 520 530 540
KKEKKDKKRK KSSDKDSDSE KESSDKKDKK DKKEKKKSKN
Length:540
Mass (Da):60,804
Last modified:May 24, 2005 - v1
Checksum:i9418744A362617C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000043 Genomic DNA. Translation: EAL66526.1.
RefSeqiXP_640508.1. XM_635416.1.

Genome annotation databases

EnsemblProtistsiEAL66526; EAL66526; DDB_G0281933.
GeneIDi8623323.
KEGGiddi:DDB_G0281933.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000043 Genomic DNA. Translation: EAL66526.1.
RefSeqiXP_640508.1. XM_635416.1.

3D structure databases

ProteinModelPortaliQ54T81.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ54T81. 1 interactor.
STRINGi44689.DDB0233679.

Proteomic databases

PaxDbiQ54T81.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL66526; EAL66526; DDB_G0281933.
GeneIDi8623323.
KEGGiddi:DDB_G0281933.

Organism-specific databases

dictyBaseiDDB_G0281933. nola4.

Phylogenomic databases

eggNOGiKOG2529. Eukaryota.
COG0130. LUCA.
InParanoidiQ54T81.
KOiK11131.
PhylomeDBiQ54T81.

Enzyme and pathway databases

ReactomeiR-DDI-171319. Telomere Extension By Telomerase.

Miscellaneous databases

PROiQ54T81.

Family and domain databases

Gene3Di2.30.130.10. 1 hit.
InterProiIPR012960. Dyskerin-like.
IPR020103. PsdUridine_synth_cat_dom.
IPR002501. PsdUridine_synth_N.
IPR002478. PUA.
IPR015947. PUA-like_domain.
IPR004802. tRNA_PsdUridine_synth_B_fam.
IPR032819. TruB_C.
IPR004521. Uncharacterised_CHP00451.
[Graphical view]
PANTHERiPTHR23127. PTHR23127. 1 hit.
PfamiPF08068. DKCLD. 1 hit.
PF01472. PUA. 1 hit.
PF16198. TruB_C_2. 1 hit.
PF01509. TruB_N. 1 hit.
[Graphical view]
SMARTiSM01136. DKCLD. 1 hit.
SM00359. PUA. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsiTIGR00425. CBF5. 1 hit.
TIGR00451. unchar_dom_2. 1 hit.
PROSITEiPS50890. PUA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDKC1_DICDI
AccessioniPrimary (citable) accession number: Q54T81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: November 2, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.