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Protein

Probable dual specificity protein phosphatase DDB_G0281963

Gene

DDB_G0281963

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Has a dual specificity toward Ser/Thr and Tyr-containing proteins.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei86Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dual specificity protein phosphatase DDB_G0281963 (EC:3.1.3.16, EC:3.1.3.48)
Gene namesi
ORF Names:DDB_G0281963
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0281963

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003329531 – 394Probable dual specificity protein phosphatase DDB_G0281963Add BLAST394

Proteomic databases

PaxDbiQ54T76

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0238872

Structurei

3D structure databases

ProteinModelPortaliQ54T76
SMRiQ54T76
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 141Tyrosine-protein phosphataseAdd BLAST139

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi158 – 182Asp-richAdd BLAST25
Compositional biasi195 – 198Poly-Asn4
Compositional biasi220 – 252Thr-richAdd BLAST33

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1716 Eukaryota
COG2453 LUCA
InParanoidiQ54T76
KOiK14819
OMAiQGRLYCP
PhylomeDBiQ54T76

Family and domain databases

CDDicd00127 DSPc, 1 hit
Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR000340 Dual-sp_phosphatase_cat-dom
IPR024950 DUSP
IPR016278 DUSP12
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom
PANTHERiPTHR10159 PTHR10159, 1 hit
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PIRSFiPIRSF000941 DUSP12, 1 hit
SMARTiView protein in SMART
SM00195 DSPc, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50054 TYR_PHOSPHATASE_DUAL, 1 hit

Sequencei

Sequence statusi: Complete.

Q54T76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDVSRIFPG FYIGSLPAVN RNTLDKYQIT HVCSVLNEFQ PKWTKIYKYL
60 70 80 90 100
HIDIYDSPSV DIMKYFDKTF QFIEEGRKDG GVLVHCFAGI SRSATICIAY
110 120 130 140 150
IMRKLNISFE DAHGLVSDAR PIIYPNESFI KQLKKYELIL KKNRENPQIV
160 170 180 190 200
EKESEEEDDD EDDDDDDYDS DEDDDDDSED DDFEEEFDNV VKKKNNNNKK
210 220 230 240 250
VNVKNTTKVF SNISISSEQT TTSTTTVPTP TLNPETKIEE TTTTTTATAT
260 270 280 290 300
ATLVEEVVES TSPKATLGEH RYSCRKCSKD LFLDFDILDH EQGQGQTSFK
310 320 330 340 350
WNKRDNTTCN KSVGANGEQI EDQNKVICTS YFISEIEFSL SQTYSGMEGK
360 370 380 390
LFCPSCNEKL GSWSWSGEQC SCGAWIAPSF QIPKTRVDEK KVLK
Length:394
Mass (Da):44,884
Last modified:May 24, 2005 - v1
Checksum:i9774CCEE21F961F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000044 Genomic DNA Translation: EAL66403.1
RefSeqiXP_640375.1, XM_635283.1

Genome annotation databases

EnsemblProtistsiEAL66403; EAL66403; DDB_G0281963
GeneIDi8623328
KEGGiddi:DDB_G0281963

Similar proteinsi

Entry informationi

Entry nameiDUSP4_DICDI
AccessioniPrimary (citable) accession number: Q54T76
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: March 28, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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