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Q54T76 (DUSP4_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable dual specificity protein phosphatase DDB_G0281963

EC=3.1.3.16
EC=3.1.3.48
Gene names
ORF Names:DDB_G0281963
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length394 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Has a dual specificity toward Ser/Thr and Tyr-containing proteins By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Contains 1 tyrosine-protein phosphatase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 394394Probable dual specificity protein phosphatase DDB_G0281963
PRO_0000332953

Regions

Domain3 – 141139Tyrosine-protein phosphatase
Compositional bias158 – 18225Asp-rich
Compositional bias195 – 1984Poly-Asn
Compositional bias220 – 25233Thr-rich

Sites

Active site861Phosphocysteine intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q54T76 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 9774CCEE21F961F5

FASTA39444,884
        10         20         30         40         50         60 
MNDVSRIFPG FYIGSLPAVN RNTLDKYQIT HVCSVLNEFQ PKWTKIYKYL HIDIYDSPSV 

        70         80         90        100        110        120 
DIMKYFDKTF QFIEEGRKDG GVLVHCFAGI SRSATICIAY IMRKLNISFE DAHGLVSDAR 

       130        140        150        160        170        180 
PIIYPNESFI KQLKKYELIL KKNRENPQIV EKESEEEDDD EDDDDDDYDS DEDDDDDSED 

       190        200        210        220        230        240 
DDFEEEFDNV VKKKNNNNKK VNVKNTTKVF SNISISSEQT TTSTTTVPTP TLNPETKIEE 

       250        260        270        280        290        300 
TTTTTTATAT ATLVEEVVES TSPKATLGEH RYSCRKCSKD LFLDFDILDH EQGQGQTSFK 

       310        320        330        340        350        360 
WNKRDNTTCN KSVGANGEQI EDQNKVICTS YFISEIEFSL SQTYSGMEGK LFCPSCNEKL 

       370        380        390 
GSWSWSGEQC SCGAWIAPSF QIPKTRVDEK KVLK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000044 Genomic DNA. Translation: EAL66403.1.

3D structure databases

ProteinModelPortalQ54T76.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0238872; DDB0238872; DDB_G0281963.
KEGGddi:DDB_G0281963.

Organism-specific databases

dictyBaseDDB_G0281963.

Phylogenomic databases

eggNOGCOG2453.
KOK14819.
OMAIRCRMCR.
PhylomeDBQ54T76.

Family and domain databases

InterProIPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERPTHR10159. PTHR10159. 1 hit.
PfamPF00782. DSPc. 1 hit.
[Graphical view]
SMARTSM00195. DSPc. 1 hit.
[Graphical view]
PROSITEPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ54T76.

Entry information

Entry nameDUSP4_DICDI
AccessionPrimary (citable) accession number: Q54T76
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: April 16, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase