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Q54T76

- DUSP4_DICDI

UniProt

Q54T76 - DUSP4_DICDI

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Protein

Probable dual specificity protein phosphatase DDB_G0281963

Gene

DDB_G0281963

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Has a dual specificity toward Ser/Thr and Tyr-containing proteins.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei86 – 861Phosphocysteine intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. protein tyrosine/serine/threonine phosphatase activity Source: RefGenome
  2. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. protein dephosphorylation Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dual specificity protein phosphatase DDB_G0281963 (EC:3.1.3.16, EC:3.1.3.48)
Gene namesi
ORF Names:DDB_G0281963
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 3, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0281963.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 394394Probable dual specificity protein phosphatase DDB_G0281963PRO_0000332953Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ54T76.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 141139Tyrosine-protein phosphataseAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi158 – 18225Asp-richAdd
BLAST
Compositional biasi195 – 1984Poly-Asn
Compositional biasi220 – 25233Thr-richAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2453.
InParanoidiQ54T76.
KOiK14819.
OMAiIRCRMCR.
PhylomeDBiQ54T76.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54T76 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNDVSRIFPG FYIGSLPAVN RNTLDKYQIT HVCSVLNEFQ PKWTKIYKYL
60 70 80 90 100
HIDIYDSPSV DIMKYFDKTF QFIEEGRKDG GVLVHCFAGI SRSATICIAY
110 120 130 140 150
IMRKLNISFE DAHGLVSDAR PIIYPNESFI KQLKKYELIL KKNRENPQIV
160 170 180 190 200
EKESEEEDDD EDDDDDDYDS DEDDDDDSED DDFEEEFDNV VKKKNNNNKK
210 220 230 240 250
VNVKNTTKVF SNISISSEQT TTSTTTVPTP TLNPETKIEE TTTTTTATAT
260 270 280 290 300
ATLVEEVVES TSPKATLGEH RYSCRKCSKD LFLDFDILDH EQGQGQTSFK
310 320 330 340 350
WNKRDNTTCN KSVGANGEQI EDQNKVICTS YFISEIEFSL SQTYSGMEGK
360 370 380 390
LFCPSCNEKL GSWSWSGEQC SCGAWIAPSF QIPKTRVDEK KVLK
Length:394
Mass (Da):44,884
Last modified:May 24, 2005 - v1
Checksum:i9774CCEE21F961F5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000044 Genomic DNA. Translation: EAL66403.1.
RefSeqiXP_640375.1. XM_635283.1.

Genome annotation databases

EnsemblProtistsiDDB0238872; DDB0238872; DDB_G0281963.
GeneIDi8623328.
KEGGiddi:DDB_G0281963.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000044 Genomic DNA. Translation: EAL66403.1 .
RefSeqi XP_640375.1. XM_635283.1.

3D structure databases

ProteinModelPortali Q54T76.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0238872 ; DDB0238872 ; DDB_G0281963 .
GeneIDi 8623328.
KEGGi ddi:DDB_G0281963.

Organism-specific databases

dictyBasei DDB_G0281963.

Phylogenomic databases

eggNOGi COG2453.
InParanoidi Q54T76.
KOi K14819.
OMAi IRCRMCR.
PhylomeDBi Q54T76.

Miscellaneous databases

PROi Q54T76.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view ]
PANTHERi PTHR10159. PTHR10159. 1 hit.
Pfami PF00782. DSPc. 1 hit.
[Graphical view ]
SMARTi SM00195. DSPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiDUSP4_DICDI
AccessioniPrimary (citable) accession number: Q54T76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: October 29, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3