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Protein

Probable protein phosphatase DDB_G0282105

Gene

DDB_G0282105

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi722Manganese 1By similarity1
Metal bindingi722Manganese 2By similarity1
Metal bindingi723Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi905Manganese 2By similarity1
Metal bindingi949Manganese 2By similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase DDB_G0282105 (EC:3.1.3.16)
Gene namesi
ORF Names:DDB_G0282105
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0282105.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei2 – 22HelicalSequence analysisAdd BLAST21
Transmembranei26 – 46HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003692461 – 958Probable protein phosphatase DDB_G0282105Add BLAST958

Proteomic databases

PaxDbiQ54T01.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0235260.

Structurei

3D structure databases

ProteinModelPortaliQ54T01.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini675 – 958PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST284

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili142 – 330Sequence analysisAdd BLAST189
Coiled coili613 – 666Sequence analysisAdd BLAST54

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi57 – 60Poly-Ser4
Compositional biasi65 – 74Poly-Thr10
Compositional biasi82 – 85Poly-Gln4
Compositional biasi89 – 92Poly-Gln4
Compositional biasi95 – 100Poly-Gln6
Compositional biasi336 – 339Poly-Ser4
Compositional biasi411 – 416Poly-Ser6
Compositional biasi456 – 473Poly-ThrAdd BLAST18
Compositional biasi486 – 489Poly-Ser4
Compositional biasi504 – 515Poly-SerAdd BLAST12

Sequence similaritiesi

In the C-terminal section; belongs to the PP2C family.Curated
Contains 1 PPM-type phosphatase domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0698. Eukaryota.
COG0631. LUCA.
InParanoidiQ54T01.
OMAiQNIGMIS.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR015655. PP2C.
IPR000222. PP2C_BS.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 2 hits.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PPM_1. 1 hit.
PS51746. PPM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54T01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLMMDIKIM SAFSILFLSL MVSNEFLEFL ANTVYAAILF IIILFFYQNR
60 70 80 90 100
QHFFTTSSSS KDSLTSTTTT TTTTSITSSL IQQQQEKEQQ QQLEQQQQQQ
110 120 130 140 150
SIKLITKEIT IENDSEKNTS TTTSIITKEQ SPGSVRLIQN YSASQQSELT
160 170 180 190 200
NTTIKQLQQK NQELQEQINN QIEKSRKDQL KYFNSNNKSQ SEIKEQIEKI
210 220 230 240 250
IKLTEKNDDL LNSIVILNST IDGNRIKMQE ITKDRDSIYS SEQKLLSRLT
260 270 280 290 300
AFEKKEKEYQ DNEKQLQKKL SDQKDQYSTL KKEFDEKVKK SNKLENSIQS
310 320 330 340 350
LESQIQKLLQ KQEKEKQKLE KDKERERSSS FSSDISSSST TSTTASTFLS
360 370 380 390 400
SSPSKSIPIP IPIKTSNAIS DLKRNNSNDS VNGLIGNGNS SVSPPSSSYL
410 420 430 440 450
RESSDDSDNQ SSSSPSEPKF KSLFNKVKSE SSKIVNKAQK GINKHLGSDF
460 470 480 490 500
FTPANTTTST TTTTSTTSTS TTTPITSASA TAAAISSSSI ITSPTTNTTN
510 520 530 540 550
DILSSSSSSS SSSSSLLTTN AILSPPVGNE QQMEVINDKT EVNQSPVKPL
560 570 580 590 600
IFFDDLGNDK LLDSTTEEQI QSKMTISPRD KDRILIDKEQ SLSDLFINSK
610 620 630 640 650
ENISNISVSN LDNFLKTNNN NNKNNIEESN NNNNNNNNNN NNNNNNNNNN
660 670 680 690 700
NNNNKNDNKE VNSKLEFSIK DEENKIGLRR AKKKLSPGCS TMMEDVSIAI
710 720 730 740 750
YPFLKEKKLS NCSNIGLFGV FDGHAGRGAA DSASKLFPKE IEKLLESGNY
760 770 780 790 800
SLTEQDDGGD NNHNQSKLLN DLFSNVDNKM KDHEYEGCTA TLALIWSDGE
810 820 830 840 850
EQQQQQQRYL QVGNVGDSSA FLCRGNESIE LTFDHKANDP SEKQRIKDQG
860 870 880 890 900
IPVSDNQTRI NGVAVSRSLG NHFIKEQNIG MISTPHISNR YLLTPQDKFV
910 920 930 940 950
IIASDGLWDV INGKDAIEKV SSLYDQGATA DSMASCLLET AIQSSLCKDN

VTVIIVKL
Length:958
Mass (Da):106,617
Last modified:May 24, 2005 - v1
Checksum:iD5B23D9AB572162B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000045 Genomic DNA. Translation: EAL66378.1.
RefSeqiXP_640354.1. XM_635262.1.

Genome annotation databases

EnsemblProtistsiEAL66378; EAL66378; DDB_G0282105.
GeneIDi8623409.
KEGGiddi:DDB_G0282105.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000045 Genomic DNA. Translation: EAL66378.1.
RefSeqiXP_640354.1. XM_635262.1.

3D structure databases

ProteinModelPortaliQ54T01.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0235260.

Proteomic databases

PaxDbiQ54T01.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL66378; EAL66378; DDB_G0282105.
GeneIDi8623409.
KEGGiddi:DDB_G0282105.

Organism-specific databases

dictyBaseiDDB_G0282105.

Phylogenomic databases

eggNOGiKOG0698. Eukaryota.
COG0631. LUCA.
InParanoidiQ54T01.
OMAiQNIGMIS.

Miscellaneous databases

PROiQ54T01.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR015655. PP2C.
IPR000222. PP2C_BS.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 2 hits.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PPM_1. 1 hit.
PS51746. PPM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiY2105_DICDI
AccessioniPrimary (citable) accession number: Q54T01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 24, 2005
Last modified: November 2, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.