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Q54T01

- Y2105_DICDI

UniProt

Q54T01 - Y2105_DICDI

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Protein

Probable protein phosphatase DDB_G0282105

Gene

DDB_G0282105

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi722 – 7221Manganese 1By similarity
Metal bindingi722 – 7221Manganese 2By similarity
Metal bindingi723 – 7231Manganese 1; via carbonyl oxygenBy similarity
Metal bindingi905 – 9051Manganese 2By similarity
Metal bindingi949 – 9491Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein serine/threonine phosphatase activity Source: InterPro

GO - Biological processi

  1. protein dephosphorylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase DDB_G0282105 (EC:3.1.3.16)
Gene namesi
ORF Names:DDB_G0282105
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 3, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0282105.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 958958Probable protein phosphatase DDB_G0282105PRO_0000369246Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi44689.DDBDRAFT_0205134.

Structurei

3D structure databases

ProteinModelPortaliQ54T01.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei2 – 2221HelicalSequence AnalysisAdd
BLAST
Transmembranei26 – 4621HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini619 – 958340PP2C-likeAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili142 – 330189Sequence AnalysisAdd
BLAST
Coiled coili613 – 66654Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi57 – 604Poly-Ser
Compositional biasi65 – 7410Poly-Thr
Compositional biasi82 – 854Poly-Gln
Compositional biasi89 – 924Poly-Gln
Compositional biasi95 – 1006Poly-Gln
Compositional biasi336 – 3394Poly-Ser
Compositional biasi411 – 4166Poly-Ser
Compositional biasi456 – 47318Poly-ThrAdd
BLAST
Compositional biasi486 – 4894Poly-Ser
Compositional biasi504 – 51512Poly-SerAdd
BLAST

Sequence similaritiesi

In the C-terminal section; belongs to the PP2C family.Curated
Contains 1 PP2C-like domain.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0631.
InParanoidiQ54T01.
OMAiQNIGMIS.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PP2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54T01-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVLMMDIKIM SAFSILFLSL MVSNEFLEFL ANTVYAAILF IIILFFYQNR
60 70 80 90 100
QHFFTTSSSS KDSLTSTTTT TTTTSITSSL IQQQQEKEQQ QQLEQQQQQQ
110 120 130 140 150
SIKLITKEIT IENDSEKNTS TTTSIITKEQ SPGSVRLIQN YSASQQSELT
160 170 180 190 200
NTTIKQLQQK NQELQEQINN QIEKSRKDQL KYFNSNNKSQ SEIKEQIEKI
210 220 230 240 250
IKLTEKNDDL LNSIVILNST IDGNRIKMQE ITKDRDSIYS SEQKLLSRLT
260 270 280 290 300
AFEKKEKEYQ DNEKQLQKKL SDQKDQYSTL KKEFDEKVKK SNKLENSIQS
310 320 330 340 350
LESQIQKLLQ KQEKEKQKLE KDKERERSSS FSSDISSSST TSTTASTFLS
360 370 380 390 400
SSPSKSIPIP IPIKTSNAIS DLKRNNSNDS VNGLIGNGNS SVSPPSSSYL
410 420 430 440 450
RESSDDSDNQ SSSSPSEPKF KSLFNKVKSE SSKIVNKAQK GINKHLGSDF
460 470 480 490 500
FTPANTTTST TTTTSTTSTS TTTPITSASA TAAAISSSSI ITSPTTNTTN
510 520 530 540 550
DILSSSSSSS SSSSSLLTTN AILSPPVGNE QQMEVINDKT EVNQSPVKPL
560 570 580 590 600
IFFDDLGNDK LLDSTTEEQI QSKMTISPRD KDRILIDKEQ SLSDLFINSK
610 620 630 640 650
ENISNISVSN LDNFLKTNNN NNKNNIEESN NNNNNNNNNN NNNNNNNNNN
660 670 680 690 700
NNNNKNDNKE VNSKLEFSIK DEENKIGLRR AKKKLSPGCS TMMEDVSIAI
710 720 730 740 750
YPFLKEKKLS NCSNIGLFGV FDGHAGRGAA DSASKLFPKE IEKLLESGNY
760 770 780 790 800
SLTEQDDGGD NNHNQSKLLN DLFSNVDNKM KDHEYEGCTA TLALIWSDGE
810 820 830 840 850
EQQQQQQRYL QVGNVGDSSA FLCRGNESIE LTFDHKANDP SEKQRIKDQG
860 870 880 890 900
IPVSDNQTRI NGVAVSRSLG NHFIKEQNIG MISTPHISNR YLLTPQDKFV
910 920 930 940 950
IIASDGLWDV INGKDAIEKV SSLYDQGATA DSMASCLLET AIQSSLCKDN

VTVIIVKL
Length:958
Mass (Da):106,617
Last modified:May 24, 2005 - v1
Checksum:iD5B23D9AB572162B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000045 Genomic DNA. Translation: EAL66378.1.
RefSeqiXP_640354.1. XM_635262.1.

Genome annotation databases

EnsemblProtistsiDDB0235260; DDB0235260; DDB_G0282105.
GeneIDi8623409.
KEGGiddi:DDB_G0282105.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000045 Genomic DNA. Translation: EAL66378.1 .
RefSeqi XP_640354.1. XM_635262.1.

3D structure databases

ProteinModelPortali Q54T01.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDBDRAFT_0205134.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0235260 ; DDB0235260 ; DDB_G0282105 .
GeneIDi 8623409.
KEGGi ddi:DDB_G0282105.

Organism-specific databases

dictyBasei DDB_G0282105.

Phylogenomic databases

eggNOGi COG0631.
InParanoidi Q54T01.
OMAi QNIGMIS.

Family and domain databases

Gene3Di 3.60.40.10. 1 hit.
InterProi IPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 1 hit.
[Graphical view ]
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 1 hit.
PROSITEi PS01032. PP2C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiY2105_DICDI
AccessioniPrimary (citable) accession number: Q54T01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 24, 2005
Last modified: October 1, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3