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Q54T01

- Y2105_DICDI

UniProt

Q54T01 - Y2105_DICDI

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Protein
Probable protein phosphatase DDB_G0282105
Gene
DDB_G0282105
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 magnesium or manganese ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi722 – 7221Manganese 1 By similarity
Metal bindingi722 – 7221Manganese 2 By similarity
Metal bindingi723 – 7231Manganese 1; via carbonyl oxygen By similarity
Metal bindingi905 – 9051Manganese 2 By similarity
Metal bindingi949 – 9491Manganese 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein serine/threonine phosphatase activity Source: InterPro

GO - Biological processi

  1. protein dephosphorylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase DDB_G0282105 (EC:3.1.3.16)
Gene namesi
ORF Names:DDB_G0282105
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 3, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0282105.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei2 – 2221Helical; Reviewed prediction
Add
BLAST
Transmembranei26 – 4621Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 958958Probable protein phosphatase DDB_G0282105
PRO_0000369246Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi44689.DDBDRAFT_0205134.

Structurei

3D structure databases

ProteinModelPortaliQ54T01.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini619 – 958340PP2C-like
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili142 – 330189 Reviewed prediction
Add
BLAST
Coiled coili613 – 66654 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi57 – 604Poly-Ser
Compositional biasi65 – 7410Poly-Thr
Compositional biasi82 – 854Poly-Gln
Compositional biasi89 – 924Poly-Gln
Compositional biasi95 – 1006Poly-Gln
Compositional biasi336 – 3394Poly-Ser
Compositional biasi411 – 4166Poly-Ser
Compositional biasi456 – 47318Poly-Thr
Add
BLAST
Compositional biasi486 – 4894Poly-Ser
Compositional biasi504 – 51512Poly-Ser
Add
BLAST

Sequence similaritiesi

In the C-terminal section; belongs to the PP2C family.
Contains 1 PP2C-like domain.

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0631.
InParanoidiQ54T01.
OMAiQNIGMIS.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PP2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54T01-1 [UniParc]FASTAAdd to Basket

« Hide

MVLMMDIKIM SAFSILFLSL MVSNEFLEFL ANTVYAAILF IIILFFYQNR    50
QHFFTTSSSS KDSLTSTTTT TTTTSITSSL IQQQQEKEQQ QQLEQQQQQQ 100
SIKLITKEIT IENDSEKNTS TTTSIITKEQ SPGSVRLIQN YSASQQSELT 150
NTTIKQLQQK NQELQEQINN QIEKSRKDQL KYFNSNNKSQ SEIKEQIEKI 200
IKLTEKNDDL LNSIVILNST IDGNRIKMQE ITKDRDSIYS SEQKLLSRLT 250
AFEKKEKEYQ DNEKQLQKKL SDQKDQYSTL KKEFDEKVKK SNKLENSIQS 300
LESQIQKLLQ KQEKEKQKLE KDKERERSSS FSSDISSSST TSTTASTFLS 350
SSPSKSIPIP IPIKTSNAIS DLKRNNSNDS VNGLIGNGNS SVSPPSSSYL 400
RESSDDSDNQ SSSSPSEPKF KSLFNKVKSE SSKIVNKAQK GINKHLGSDF 450
FTPANTTTST TTTTSTTSTS TTTPITSASA TAAAISSSSI ITSPTTNTTN 500
DILSSSSSSS SSSSSLLTTN AILSPPVGNE QQMEVINDKT EVNQSPVKPL 550
IFFDDLGNDK LLDSTTEEQI QSKMTISPRD KDRILIDKEQ SLSDLFINSK 600
ENISNISVSN LDNFLKTNNN NNKNNIEESN NNNNNNNNNN NNNNNNNNNN 650
NNNNKNDNKE VNSKLEFSIK DEENKIGLRR AKKKLSPGCS TMMEDVSIAI 700
YPFLKEKKLS NCSNIGLFGV FDGHAGRGAA DSASKLFPKE IEKLLESGNY 750
SLTEQDDGGD NNHNQSKLLN DLFSNVDNKM KDHEYEGCTA TLALIWSDGE 800
EQQQQQQRYL QVGNVGDSSA FLCRGNESIE LTFDHKANDP SEKQRIKDQG 850
IPVSDNQTRI NGVAVSRSLG NHFIKEQNIG MISTPHISNR YLLTPQDKFV 900
IIASDGLWDV INGKDAIEKV SSLYDQGATA DSMASCLLET AIQSSLCKDN 950
VTVIIVKL 958
Length:958
Mass (Da):106,617
Last modified:May 24, 2005 - v1
Checksum:iD5B23D9AB572162B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000045 Genomic DNA. Translation: EAL66378.1.
RefSeqiXP_640354.1. XM_635262.1.

Genome annotation databases

EnsemblProtistsiDDB0235260; DDB0235260; DDB_G0282105.
GeneIDi8623409.
KEGGiddi:DDB_G0282105.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000045 Genomic DNA. Translation: EAL66378.1 .
RefSeqi XP_640354.1. XM_635262.1.

3D structure databases

ProteinModelPortali Q54T01.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDBDRAFT_0205134.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0235260 ; DDB0235260 ; DDB_G0282105 .
GeneIDi 8623409.
KEGGi ddi:DDB_G0282105.

Organism-specific databases

dictyBasei DDB_G0282105.

Phylogenomic databases

eggNOGi COG0631.
InParanoidi Q54T01.
OMAi QNIGMIS.

Family and domain databases

Gene3Di 3.60.40.10. 1 hit.
InterProi IPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 1 hit.
[Graphical view ]
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 1 hit.
PROSITEi PS01032. PP2C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiY2105_DICDI
AccessioniPrimary (citable) accession number: Q54T01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 24, 2005
Last modified: May 14, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3