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Q54SV3

- ALN1_DICDI

UniProt

Q54SV3 - ALN1_DICDI

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Protein
Probable allantoinase 1
Gene
allB1, DDB_G0282199
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-allantoin + H2O = allantoate.

Cofactori

Binds 2 zinc ions per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi66 – 661Zinc 1 By similarity
Metal bindingi68 – 681Zinc 1 By similarity
Metal bindingi154 – 1541Zinc 1; via carbamate group By similarity
Metal bindingi154 – 1541Zinc 2; via carbamate group By similarity
Metal bindingi197 – 1971Zinc 2 By similarity
Metal bindingi255 – 2551Zinc 2 By similarity
Metal bindingi329 – 3291Zinc 1 By similarity

GO - Molecular functioni

  1. allantoinase activity Source: dictyBase
  2. cobalt ion binding Source: InterPro
  3. endodeoxyribonuclease activity, producing 5'-phosphomonoesters Source: InterPro
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. allantoin catabolic process Source: dictyBase
  2. purine nucleobase metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Purine metabolism

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00395; UER00653.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable allantoinase 1 (EC:3.5.2.5)
Gene namesi
Name:allB1
ORF Names:DDB_G0282199
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 3, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0282199. allB1.

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: dictyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 649649Probable allantoinase 1
PRO_0000330750Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei154 – 1541N6-carboxylysine By similarity

Post-translational modificationi

Carbamylation allows a single lysine to coordinate two zinc ions By similarity.

Proteomic databases

PRIDEiQ54SV3.

Interactioni

Subunit structurei

Homotetramer By similarity.

Protein-protein interaction databases

STRINGi44689.DDB_0231352.

Structurei

3D structure databases

ProteinModelPortaliQ54SV3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0044.
KOiK01466.
OMAiYERFNAK.
PhylomeDBiQ54SV3.

Family and domain databases

Gene3Di1.10.3330.10. 1 hit.
2.30.40.10. 1 hit.
InterProiIPR017593. Allantoinase.
IPR006680. Amidohydro_1.
IPR002195. Dihydroorotase_CS.
IPR018228. DNase_TatD-rel_CS.
IPR011059. Metal-dep_hydrolase_composite.
IPR018020. OHCU_decarboxylase.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
PF09349. OHCU_decarbox. 1 hit.
[Graphical view]
SUPFAMiSSF51338. SSF51338. 2 hits.
TIGRFAMsiTIGR03178. allantoinase. 1 hit.
PROSITEiPS00482. DIHYDROOROTASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54SV3-1 [UniParc]FASTAAdd to Basket

« Hide

MNSENIIKVI KGKKVVINGE IKPASILIKN GIIIDIKDYS SEIKEEHEVL    50
IEEEKLVIMG GLVDSHVHIN EPGRTEWEGF LSATSAAASG GVTTIIDMPL 100
NSSPVTTTFE NLQTKIESMP GKLRVDVGLL GGIIPGNSSE ISRMVLEGGV 150
VGFKSFLVHS GIDEFPHVKE DDIQEAMNVM KKLKDEQGGR DVVMMFHAEI 200
EEPIKEATER LQRENADPKL YDTFLKSRPR VSENIAIDKV IELTKKNMIK 250
THIVHLSSSD AIEAIHEAVH NDGVPITAET TYHYLYFESE QVPYGNTLYK 300
CCPPVRESEN KDLLWKAVTN GTINIIVSDH SPCTLDLKLI EQGDFMKAWG 350
GISSLQLGLP IIWTEASKRG VPLAKLSEYM SDAPSRLVGL NDRKGSIKIG 400
RDADFVIWDP EESFTVDQGL LMVKNKNSPY HGEKLLGVVH HTILRGNKIF 450
SKGDQTISKI IGKRLIQTKI HTNPIYPSPT LPTIELLNSL TEQKTFFDCI 500
HLLFEAAPPL ANALFSKRPF SSYQQLIDQA YSIIQSLNES DKIQVINAHP 550
RIGVSASQVK NSSSISYREQ SCDKDSSIDQ SILENLTQLN QQYESKFGFK 600
FVVFVNGRPK NEIIPILQNR LNNNDKQKEL NLGLSEMIEI SKSRLLKLL 649
Length:649
Mass (Da):72,476
Last modified:May 24, 2005 - v1
Checksum:i1E4C7067D47B28F2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000046 Genomic DNA. Translation: EAL66305.1.
RefSeqiXP_640282.1. XM_635190.1.

Genome annotation databases

EnsemblProtistsiDDB0231352; DDB0231352; DDB_G0282199.
GeneIDi8623457.
KEGGiddi:DDB_G0282199.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000046 Genomic DNA. Translation: EAL66305.1 .
RefSeqi XP_640282.1. XM_635190.1.

3D structure databases

ProteinModelPortali Q54SV3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0231352.

Proteomic databases

PRIDEi Q54SV3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0231352 ; DDB0231352 ; DDB_G0282199 .
GeneIDi 8623457.
KEGGi ddi:DDB_G0282199.

Organism-specific databases

dictyBasei DDB_G0282199. allB1.

Phylogenomic databases

eggNOGi COG0044.
KOi K01466.
OMAi YERFNAK.
PhylomeDBi Q54SV3.

Enzyme and pathway databases

UniPathwayi UPA00395 ; UER00653 .

Miscellaneous databases

PROi Q54SV3.

Family and domain databases

Gene3Di 1.10.3330.10. 1 hit.
2.30.40.10. 1 hit.
InterProi IPR017593. Allantoinase.
IPR006680. Amidohydro_1.
IPR002195. Dihydroorotase_CS.
IPR018228. DNase_TatD-rel_CS.
IPR011059. Metal-dep_hydrolase_composite.
IPR018020. OHCU_decarboxylase.
[Graphical view ]
Pfami PF01979. Amidohydro_1. 1 hit.
PF09349. OHCU_decarbox. 1 hit.
[Graphical view ]
SUPFAMi SSF51338. SSF51338. 2 hits.
TIGRFAMsi TIGR03178. allantoinase. 1 hit.
PROSITEi PS00482. DIHYDROOROTASE_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiALN1_DICDI
AccessioniPrimary (citable) accession number: Q54SV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: September 3, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi