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Protein

Probable allantoinase 1

Gene

allB1

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-allantoin + H2O = allantoate.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Pathway: (S)-allantoin degradation

This protein is involved in step 1 of the subpathway that synthesizes allantoate from (S)-allantoin.
Proteins known to be involved in this subpathway in this organism are:
  1. Probable allantoinase 2 (allB2), Probable allantoinase 1 (allB1)
This subpathway is part of the pathway (S)-allantoin degradation, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes allantoate from (S)-allantoin, the pathway (S)-allantoin degradation and in Nitrogen metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi66 – 661Zinc 1By similarity
Metal bindingi68 – 681Zinc 1By similarity
Metal bindingi154 – 1541Zinc 1; via carbamate groupBy similarity
Metal bindingi154 – 1541Zinc 2; via carbamate groupBy similarity
Metal bindingi197 – 1971Zinc 2By similarity
Metal bindingi255 – 2551Zinc 2By similarity
Metal bindingi329 – 3291Zinc 1By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Purine metabolism

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00395; UER00653.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable allantoinase 1 (EC:3.5.2.5)
Gene namesi
Name:allB1
ORF Names:DDB_G0282199
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195 Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0282199. allB1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 649649Probable allantoinase 1PRO_0000330750Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei154 – 1541N6-carboxylysineBy similarity

Post-translational modificationi

Carbamylation allows a single lysine to coordinate two zinc ions.By similarity

Proteomic databases

PRIDEiQ54SV3.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi44689.DDB0231352.

Structurei

3D structure databases

ProteinModelPortaliQ54SV3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DHOase family. Allantoinase subfamily.Curated

Phylogenomic databases

eggNOGiCOG0044.
InParanoidiQ54SV3.
KOiK01466.
OMAiPIIWTEA.
PhylomeDBiQ54SV3.

Family and domain databases

Gene3Di1.10.3330.10. 1 hit.
2.30.40.10. 1 hit.
InterProiIPR017593. Allantoinase.
IPR006680. Amidohydro_1.
IPR002195. Dihydroorotase_CS.
IPR018228. DNase_TatD-rel_CS.
IPR011059. Metal-dep_hydrolase_composite.
IPR018020. OHCU_decarboxylase.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
PF09349. OHCU_decarbox. 1 hit.
[Graphical view]
SUPFAMiSSF51338. SSF51338. 2 hits.
TIGRFAMsiTIGR03178. allantoinase. 1 hit.
PROSITEiPS00482. DIHYDROOROTASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54SV3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSENIIKVI KGKKVVINGE IKPASILIKN GIIIDIKDYS SEIKEEHEVL
60 70 80 90 100
IEEEKLVIMG GLVDSHVHIN EPGRTEWEGF LSATSAAASG GVTTIIDMPL
110 120 130 140 150
NSSPVTTTFE NLQTKIESMP GKLRVDVGLL GGIIPGNSSE ISRMVLEGGV
160 170 180 190 200
VGFKSFLVHS GIDEFPHVKE DDIQEAMNVM KKLKDEQGGR DVVMMFHAEI
210 220 230 240 250
EEPIKEATER LQRENADPKL YDTFLKSRPR VSENIAIDKV IELTKKNMIK
260 270 280 290 300
THIVHLSSSD AIEAIHEAVH NDGVPITAET TYHYLYFESE QVPYGNTLYK
310 320 330 340 350
CCPPVRESEN KDLLWKAVTN GTINIIVSDH SPCTLDLKLI EQGDFMKAWG
360 370 380 390 400
GISSLQLGLP IIWTEASKRG VPLAKLSEYM SDAPSRLVGL NDRKGSIKIG
410 420 430 440 450
RDADFVIWDP EESFTVDQGL LMVKNKNSPY HGEKLLGVVH HTILRGNKIF
460 470 480 490 500
SKGDQTISKI IGKRLIQTKI HTNPIYPSPT LPTIELLNSL TEQKTFFDCI
510 520 530 540 550
HLLFEAAPPL ANALFSKRPF SSYQQLIDQA YSIIQSLNES DKIQVINAHP
560 570 580 590 600
RIGVSASQVK NSSSISYREQ SCDKDSSIDQ SILENLTQLN QQYESKFGFK
610 620 630 640
FVVFVNGRPK NEIIPILQNR LNNNDKQKEL NLGLSEMIEI SKSRLLKLL
Length:649
Mass (Da):72,476
Last modified:May 24, 2005 - v1
Checksum:i1E4C7067D47B28F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000046 Genomic DNA. Translation: EAL66305.1.
RefSeqiXP_640282.1. XM_635190.1.

Genome annotation databases

EnsemblProtistsiDDB0231352; DDB0231352; DDB_G0282199.
GeneIDi8623457.
KEGGiddi:DDB_G0282199.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000046 Genomic DNA. Translation: EAL66305.1.
RefSeqiXP_640282.1. XM_635190.1.

3D structure databases

ProteinModelPortaliQ54SV3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0231352.

Proteomic databases

PRIDEiQ54SV3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0231352; DDB0231352; DDB_G0282199.
GeneIDi8623457.
KEGGiddi:DDB_G0282199.

Organism-specific databases

dictyBaseiDDB_G0282199. allB1.

Phylogenomic databases

eggNOGiCOG0044.
InParanoidiQ54SV3.
KOiK01466.
OMAiPIIWTEA.
PhylomeDBiQ54SV3.

Enzyme and pathway databases

UniPathwayiUPA00395; UER00653.

Miscellaneous databases

PROiQ54SV3.

Family and domain databases

Gene3Di1.10.3330.10. 1 hit.
2.30.40.10. 1 hit.
InterProiIPR017593. Allantoinase.
IPR006680. Amidohydro_1.
IPR002195. Dihydroorotase_CS.
IPR018228. DNase_TatD-rel_CS.
IPR011059. Metal-dep_hydrolase_composite.
IPR018020. OHCU_decarboxylase.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
PF09349. OHCU_decarbox. 1 hit.
[Graphical view]
SUPFAMiSSF51338. SSF51338. 2 hits.
TIGRFAMsiTIGR03178. allantoinase. 1 hit.
PROSITEiPS00482. DIHYDROOROTASE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiALN1_DICDI
AccessioniPrimary (citable) accession number: Q54SV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: June 24, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.