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Q54SV3

- ALN1_DICDI

UniProt

Q54SV3 - ALN1_DICDI

Protein

Probable allantoinase 1

Gene

allB1

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-allantoin + H2O = allantoate.

    Cofactori

    Binds 2 zinc ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi66 – 661Zinc 1By similarity
    Metal bindingi68 – 681Zinc 1By similarity
    Metal bindingi154 – 1541Zinc 1; via carbamate groupBy similarity
    Metal bindingi154 – 1541Zinc 2; via carbamate groupBy similarity
    Metal bindingi197 – 1971Zinc 2By similarity
    Metal bindingi255 – 2551Zinc 2By similarity
    Metal bindingi329 – 3291Zinc 1By similarity

    GO - Molecular functioni

    1. allantoinase activity Source: dictyBase
    2. cobalt ion binding Source: InterPro
    3. endodeoxyribonuclease activity, producing 5'-phosphomonoesters Source: InterPro
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. allantoin catabolic process Source: dictyBase
    2. purine nucleobase metabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Purine metabolism

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00395; UER00653.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable allantoinase 1 (EC:3.5.2.5)
    Gene namesi
    Name:allB1
    ORF Names:DDB_G0282199
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 3, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0282199. allB1.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: dictyBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 649649Probable allantoinase 1PRO_0000330750Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei154 – 1541N6-carboxylysineBy similarity

    Post-translational modificationi

    Carbamylation allows a single lysine to coordinate two zinc ions.By similarity

    Proteomic databases

    PRIDEiQ54SV3.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi44689.DDB_0231352.

    Structurei

    3D structure databases

    ProteinModelPortaliQ54SV3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DHOase family. Allantoinase subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG0044.
    KOiK01466.
    OMAiYERFNAK.
    PhylomeDBiQ54SV3.

    Family and domain databases

    Gene3Di1.10.3330.10. 1 hit.
    2.30.40.10. 1 hit.
    InterProiIPR017593. Allantoinase.
    IPR006680. Amidohydro_1.
    IPR002195. Dihydroorotase_CS.
    IPR018228. DNase_TatD-rel_CS.
    IPR011059. Metal-dep_hydrolase_composite.
    IPR018020. OHCU_decarboxylase.
    [Graphical view]
    PfamiPF01979. Amidohydro_1. 1 hit.
    PF09349. OHCU_decarbox. 1 hit.
    [Graphical view]
    SUPFAMiSSF51338. SSF51338. 2 hits.
    TIGRFAMsiTIGR03178. allantoinase. 1 hit.
    PROSITEiPS00482. DIHYDROOROTASE_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q54SV3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSENIIKVI KGKKVVINGE IKPASILIKN GIIIDIKDYS SEIKEEHEVL    50
    IEEEKLVIMG GLVDSHVHIN EPGRTEWEGF LSATSAAASG GVTTIIDMPL 100
    NSSPVTTTFE NLQTKIESMP GKLRVDVGLL GGIIPGNSSE ISRMVLEGGV 150
    VGFKSFLVHS GIDEFPHVKE DDIQEAMNVM KKLKDEQGGR DVVMMFHAEI 200
    EEPIKEATER LQRENADPKL YDTFLKSRPR VSENIAIDKV IELTKKNMIK 250
    THIVHLSSSD AIEAIHEAVH NDGVPITAET TYHYLYFESE QVPYGNTLYK 300
    CCPPVRESEN KDLLWKAVTN GTINIIVSDH SPCTLDLKLI EQGDFMKAWG 350
    GISSLQLGLP IIWTEASKRG VPLAKLSEYM SDAPSRLVGL NDRKGSIKIG 400
    RDADFVIWDP EESFTVDQGL LMVKNKNSPY HGEKLLGVVH HTILRGNKIF 450
    SKGDQTISKI IGKRLIQTKI HTNPIYPSPT LPTIELLNSL TEQKTFFDCI 500
    HLLFEAAPPL ANALFSKRPF SSYQQLIDQA YSIIQSLNES DKIQVINAHP 550
    RIGVSASQVK NSSSISYREQ SCDKDSSIDQ SILENLTQLN QQYESKFGFK 600
    FVVFVNGRPK NEIIPILQNR LNNNDKQKEL NLGLSEMIEI SKSRLLKLL 649
    Length:649
    Mass (Da):72,476
    Last modified:May 24, 2005 - v1
    Checksum:i1E4C7067D47B28F2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000046 Genomic DNA. Translation: EAL66305.1.
    RefSeqiXP_640282.1. XM_635190.1.

    Genome annotation databases

    EnsemblProtistsiDDB0231352; DDB0231352; DDB_G0282199.
    GeneIDi8623457.
    KEGGiddi:DDB_G0282199.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000046 Genomic DNA. Translation: EAL66305.1 .
    RefSeqi XP_640282.1. XM_635190.1.

    3D structure databases

    ProteinModelPortali Q54SV3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDB_0231352.

    Proteomic databases

    PRIDEi Q54SV3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0231352 ; DDB0231352 ; DDB_G0282199 .
    GeneIDi 8623457.
    KEGGi ddi:DDB_G0282199.

    Organism-specific databases

    dictyBasei DDB_G0282199. allB1.

    Phylogenomic databases

    eggNOGi COG0044.
    KOi K01466.
    OMAi YERFNAK.
    PhylomeDBi Q54SV3.

    Enzyme and pathway databases

    UniPathwayi UPA00395 ; UER00653 .

    Miscellaneous databases

    PROi Q54SV3.

    Family and domain databases

    Gene3Di 1.10.3330.10. 1 hit.
    2.30.40.10. 1 hit.
    InterProi IPR017593. Allantoinase.
    IPR006680. Amidohydro_1.
    IPR002195. Dihydroorotase_CS.
    IPR018228. DNase_TatD-rel_CS.
    IPR011059. Metal-dep_hydrolase_composite.
    IPR018020. OHCU_decarboxylase.
    [Graphical view ]
    Pfami PF01979. Amidohydro_1. 1 hit.
    PF09349. OHCU_decarbox. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51338. SSF51338. 2 hits.
    TIGRFAMsi TIGR03178. allantoinase. 1 hit.
    PROSITEi PS00482. DIHYDROOROTASE_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiALN1_DICDI
    AccessioniPrimary (citable) accession number: Q54SV3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3