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Q54SV3

- ALN1_DICDI

UniProt

Q54SV3 - ALN1_DICDI

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Protein

Probable allantoinase 1

Gene

allB1

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-allantoin + H2O = allantoate.

Cofactori

Binds 2 zinc ions per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi66 – 661Zinc 1By similarity
Metal bindingi68 – 681Zinc 1By similarity
Metal bindingi154 – 1541Zinc 1; via carbamate groupBy similarity
Metal bindingi154 – 1541Zinc 2; via carbamate groupBy similarity
Metal bindingi197 – 1971Zinc 2By similarity
Metal bindingi255 – 2551Zinc 2By similarity
Metal bindingi329 – 3291Zinc 1By similarity

GO - Molecular functioni

  1. allantoinase activity Source: dictyBase
  2. cobalt ion binding Source: InterPro
  3. endodeoxyribonuclease activity, producing 5'-phosphomonoesters Source: InterPro
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. allantoin catabolic process Source: dictyBase
  2. purine nucleobase metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Purine metabolism

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00395; UER00653.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable allantoinase 1 (EC:3.5.2.5)
Gene namesi
Name:allB1
ORF Names:DDB_G0282199
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 3, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0282199. allB1.

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: dictyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 649649Probable allantoinase 1PRO_0000330750Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei154 – 1541N6-carboxylysineBy similarity

Post-translational modificationi

Carbamylation allows a single lysine to coordinate two zinc ions.By similarity

Proteomic databases

PRIDEiQ54SV3.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi44689.DDB_0231352.

Structurei

3D structure databases

ProteinModelPortaliQ54SV3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DHOase family. Allantoinase subfamily.Curated

Phylogenomic databases

eggNOGiCOG0044.
InParanoidiQ54SV3.
KOiK01466.
OMAiYERFNAK.
PhylomeDBiQ54SV3.

Family and domain databases

Gene3Di1.10.3330.10. 1 hit.
2.30.40.10. 1 hit.
InterProiIPR017593. Allantoinase.
IPR006680. Amidohydro_1.
IPR002195. Dihydroorotase_CS.
IPR018228. DNase_TatD-rel_CS.
IPR011059. Metal-dep_hydrolase_composite.
IPR018020. OHCU_decarboxylase.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
PF09349. OHCU_decarbox. 1 hit.
[Graphical view]
SUPFAMiSSF51338. SSF51338. 2 hits.
TIGRFAMsiTIGR03178. allantoinase. 1 hit.
PROSITEiPS00482. DIHYDROOROTASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54SV3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNSENIIKVI KGKKVVINGE IKPASILIKN GIIIDIKDYS SEIKEEHEVL
60 70 80 90 100
IEEEKLVIMG GLVDSHVHIN EPGRTEWEGF LSATSAAASG GVTTIIDMPL
110 120 130 140 150
NSSPVTTTFE NLQTKIESMP GKLRVDVGLL GGIIPGNSSE ISRMVLEGGV
160 170 180 190 200
VGFKSFLVHS GIDEFPHVKE DDIQEAMNVM KKLKDEQGGR DVVMMFHAEI
210 220 230 240 250
EEPIKEATER LQRENADPKL YDTFLKSRPR VSENIAIDKV IELTKKNMIK
260 270 280 290 300
THIVHLSSSD AIEAIHEAVH NDGVPITAET TYHYLYFESE QVPYGNTLYK
310 320 330 340 350
CCPPVRESEN KDLLWKAVTN GTINIIVSDH SPCTLDLKLI EQGDFMKAWG
360 370 380 390 400
GISSLQLGLP IIWTEASKRG VPLAKLSEYM SDAPSRLVGL NDRKGSIKIG
410 420 430 440 450
RDADFVIWDP EESFTVDQGL LMVKNKNSPY HGEKLLGVVH HTILRGNKIF
460 470 480 490 500
SKGDQTISKI IGKRLIQTKI HTNPIYPSPT LPTIELLNSL TEQKTFFDCI
510 520 530 540 550
HLLFEAAPPL ANALFSKRPF SSYQQLIDQA YSIIQSLNES DKIQVINAHP
560 570 580 590 600
RIGVSASQVK NSSSISYREQ SCDKDSSIDQ SILENLTQLN QQYESKFGFK
610 620 630 640
FVVFVNGRPK NEIIPILQNR LNNNDKQKEL NLGLSEMIEI SKSRLLKLL
Length:649
Mass (Da):72,476
Last modified:May 24, 2005 - v1
Checksum:i1E4C7067D47B28F2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000046 Genomic DNA. Translation: EAL66305.1.
RefSeqiXP_640282.1. XM_635190.1.

Genome annotation databases

EnsemblProtistsiDDB0231352; DDB0231352; DDB_G0282199.
GeneIDi8623457.
KEGGiddi:DDB_G0282199.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000046 Genomic DNA. Translation: EAL66305.1 .
RefSeqi XP_640282.1. XM_635190.1.

3D structure databases

ProteinModelPortali Q54SV3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0231352.

Proteomic databases

PRIDEi Q54SV3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0231352 ; DDB0231352 ; DDB_G0282199 .
GeneIDi 8623457.
KEGGi ddi:DDB_G0282199.

Organism-specific databases

dictyBasei DDB_G0282199. allB1.

Phylogenomic databases

eggNOGi COG0044.
InParanoidi Q54SV3.
KOi K01466.
OMAi YERFNAK.
PhylomeDBi Q54SV3.

Enzyme and pathway databases

UniPathwayi UPA00395 ; UER00653 .

Miscellaneous databases

PROi Q54SV3.

Family and domain databases

Gene3Di 1.10.3330.10. 1 hit.
2.30.40.10. 1 hit.
InterProi IPR017593. Allantoinase.
IPR006680. Amidohydro_1.
IPR002195. Dihydroorotase_CS.
IPR018228. DNase_TatD-rel_CS.
IPR011059. Metal-dep_hydrolase_composite.
IPR018020. OHCU_decarboxylase.
[Graphical view ]
Pfami PF01979. Amidohydro_1. 1 hit.
PF09349. OHCU_decarbox. 1 hit.
[Graphical view ]
SUPFAMi SSF51338. SSF51338. 2 hits.
TIGRFAMsi TIGR03178. allantoinase. 1 hit.
PROSITEi PS00482. DIHYDROOROTASE_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiALN1_DICDI
AccessioniPrimary (citable) accession number: Q54SV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: October 29, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3