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Q54SC9

- HEXA2_DICDI

UniProt

Q54SC9 - HEXA2_DICDI

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Protein
Beta-hexosaminidase subunit A2
Gene
hexa2, DDB_G0282539
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines By similarity.

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei314 – 3141Proton donor By similarity

GO - Molecular functioni

  1. beta-N-acetylhexosaminidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

ReactomeiREACT_210507. Glycosphingolipid metabolism.
REACT_220518. Keratan sulfate degradation.
REACT_221941. CS/DS degradation.
REACT_226217. Hyaluronan uptake and degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-hexosaminidase subunit A2 (EC:3.2.1.52)
Alternative name(s):
Beta-N-acetylhexosaminidase subunit A2
N-acetyl-beta-glucosaminidase subunit A2
Gene namesi
Name:hexa2
ORF Names:DDB_G0282539
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 3, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0282539. nagB.

Subcellular locationi

Lysosome By similarity

GO - Cellular componenti

  1. lysosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Chaini22 – 541520Beta-hexosaminidase subunit A2
PRO_0000331236Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi322 – 3221N-linked (GlcNAc...) Reviewed prediction
Glycosylationi336 – 3361N-linked (GlcNAc...) Reviewed prediction
Glycosylationi356 – 3561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi435 – 4351N-linked (GlcNAc...) Reviewed prediction
Glycosylationi483 – 4831N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ54SC9.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDBDRAFT_0204822.

Structurei

3D structure databases

ProteinModelPortaliQ54SC9.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3525.
KOiK12373.
OMAiSATCKEP.
PhylomeDBiQ54SC9.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
3.30.379.10. 1 hit.
InterProiIPR025705. Beta_hexosaminidase_sua/sub.
IPR029018. Chitobiase/Hex_dom_2-like.
IPR015883. Glyco_hydro_20_cat-core.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR029019. HEX_eukaryotic_N.
[Graphical view]
PfamiPF00728. Glyco_hydro_20. 1 hit.
PF14845. Glycohydro_20b2. 1 hit.
[Graphical view]
PIRSFiPIRSF001093. B-hxosamndse_ab_euk_. 1 hit.
PRINTSiPR00738. GLHYDRLASE20.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF55545. SSF55545. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q54SC9-1 [UniParc]FASTAAdd to Basket

« Hide

MINKFLTIFL IFSIVIIKVL SQSSNEQPLN VVPYPQEVTM IGCNIPLSVG    50
SISIKSNIES TILSISISRY QSLFFPFVSN NVLKDSSSNI ELSLIIASDD 100
ETLELGIDES YFLLVNQDTY QIKANTIYGA MRGLETFKQM VVYDVVENSY 150
SLTCAEVVDY PTYQWRGLLV DNARHFLPKN MVLHIIDSMG YNKFNTMHWH 200
LIDTVAFPVE SKTYPKLTEA LLGPGAIITH DDILEVVAYA KTYGIRVIPE 250
FDVPGHSASW GVGYPELLSN CPGYPQSSIP LDCSNPYTYS FLENFFSEIA 300
PLFQDSYFHT GGDELVIDCW ANDTSIQKWM KTNNYNTSDA FQYFEDQLDV 350
ILKSINRTKI AWNDVLQHGV KFDKETTLVQ TWTNINDLRD VLAAGYKTIT 400
SFFFYLDRQS PTGNHYHYEW QDTWEDFYAS DPRLNITSNA ENILGGEATM 450
FGEQVSTVNW DARVWPRAIG ISERLWSATE INNITLALPR IGQFSCDMSR 500
RGISSGPLFP DFCSLPDDLS FSFKPVYQLS KDEIKLILKK K 541
Length:541
Mass (Da):61,533
Last modified:May 24, 2005 - v1
Checksum:iF670234F1DD3D075
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000047 Genomic DNA. Translation: EAL66129.1.
RefSeqiXP_640110.1. XM_635018.1.

Genome annotation databases

EnsemblProtistsiDDB0304517; DDB0304517; DDB_G0282539.
GeneIDi8623642.
KEGGiddi:DDB_G0282539.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000047 Genomic DNA. Translation: EAL66129.1 .
RefSeqi XP_640110.1. XM_635018.1.

3D structure databases

ProteinModelPortali Q54SC9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDBDRAFT_0204822.

Proteomic databases

PRIDEi Q54SC9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0304517 ; DDB0304517 ; DDB_G0282539 .
GeneIDi 8623642.
KEGGi ddi:DDB_G0282539.

Organism-specific databases

dictyBasei DDB_G0282539. nagB.

Phylogenomic databases

eggNOGi COG3525.
KOi K12373.
OMAi SATCKEP.
PhylomeDBi Q54SC9.

Enzyme and pathway databases

Reactomei REACT_210507. Glycosphingolipid metabolism.
REACT_220518. Keratan sulfate degradation.
REACT_221941. CS/DS degradation.
REACT_226217. Hyaluronan uptake and degradation.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
3.30.379.10. 1 hit.
InterProi IPR025705. Beta_hexosaminidase_sua/sub.
IPR029018. Chitobiase/Hex_dom_2-like.
IPR015883. Glyco_hydro_20_cat-core.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR029019. HEX_eukaryotic_N.
[Graphical view ]
Pfami PF00728. Glyco_hydro_20. 1 hit.
PF14845. Glycohydro_20b2. 1 hit.
[Graphical view ]
PIRSFi PIRSF001093. B-hxosamndse_ab_euk_. 1 hit.
PRINTSi PR00738. GLHYDRLASE20.
SUPFAMi SSF51445. SSF51445. 1 hit.
SSF55545. SSF55545. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiHEXA2_DICDI
AccessioniPrimary (citable) accession number: Q54SC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: September 3, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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