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Protein

Beta-hexosaminidase subunit A2

Gene

hexa2

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines.By similarity

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei314Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase

Enzyme and pathway databases

ReactomeiR-DDI-1660662 Glycosphingolipid metabolism
R-DDI-2022857 Keratan sulfate degradation
R-DDI-2024101 CS/DS degradation
R-DDI-2160916 Hyaluronan uptake and degradation
R-DDI-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-hexosaminidase subunit A2 (EC:3.2.1.52)
Alternative name(s):
Beta-N-acetylhexosaminidase subunit A2
N-acetyl-beta-glucosaminidase subunit A2
Gene namesi
Name:hexa2
ORF Names:DDB_G0282539
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0282539 nagB

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000033123622 – 541Beta-hexosaminidase subunit A2Add BLAST520

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi322N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi336N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi356N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi435N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi483N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ54SC9

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0304517

Structurei

3D structure databases

ProteinModelPortaliQ54SC9
SMRiQ54SC9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 20 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2499 Eukaryota
COG3525 LUCA
InParanoidiQ54SC9
KOiK12373
OMAiMSMVGST
PhylomeDBiQ54SC9

Family and domain databases

Gene3Di3.30.379.10, 1 hit
InterProiView protein in InterPro
IPR025705 Beta_hexosaminidase_sua/sub
IPR015883 Glyco_hydro_20_cat
IPR017853 Glycoside_hydrolase_SF
IPR029018 Hex-like_dom2
IPR029019 HEX_eukaryotic_N
PfamiView protein in Pfam
PF00728 Glyco_hydro_20, 1 hit
PF14845 Glycohydro_20b2, 1 hit
PIRSFiPIRSF001093 B-hxosamndse_ab_euk_, 1 hit
PRINTSiPR00738 GLHYDRLASE20
SUPFAMiSSF51445 SSF51445, 1 hit
SSF55545 SSF55545, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q54SC9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINKFLTIFL IFSIVIIKVL SQSSNEQPLN VVPYPQEVTM IGCNIPLSVG
60 70 80 90 100
SISIKSNIES TILSISISRY QSLFFPFVSN NVLKDSSSNI ELSLIIASDD
110 120 130 140 150
ETLELGIDES YFLLVNQDTY QIKANTIYGA MRGLETFKQM VVYDVVENSY
160 170 180 190 200
SLTCAEVVDY PTYQWRGLLV DNARHFLPKN MVLHIIDSMG YNKFNTMHWH
210 220 230 240 250
LIDTVAFPVE SKTYPKLTEA LLGPGAIITH DDILEVVAYA KTYGIRVIPE
260 270 280 290 300
FDVPGHSASW GVGYPELLSN CPGYPQSSIP LDCSNPYTYS FLENFFSEIA
310 320 330 340 350
PLFQDSYFHT GGDELVIDCW ANDTSIQKWM KTNNYNTSDA FQYFEDQLDV
360 370 380 390 400
ILKSINRTKI AWNDVLQHGV KFDKETTLVQ TWTNINDLRD VLAAGYKTIT
410 420 430 440 450
SFFFYLDRQS PTGNHYHYEW QDTWEDFYAS DPRLNITSNA ENILGGEATM
460 470 480 490 500
FGEQVSTVNW DARVWPRAIG ISERLWSATE INNITLALPR IGQFSCDMSR
510 520 530 540
RGISSGPLFP DFCSLPDDLS FSFKPVYQLS KDEIKLILKK K
Length:541
Mass (Da):61,533
Last modified:May 24, 2005 - v1
Checksum:iF670234F1DD3D075
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000047 Genomic DNA Translation: EAL66129.1
RefSeqiXP_640110.1, XM_635018.1

Genome annotation databases

EnsemblProtistsiEAL66129; EAL66129; DDB_G0282539
GeneIDi8623642
KEGGiddi:DDB_G0282539

Similar proteinsi

Entry informationi

Entry nameiHEXA2_DICDI
AccessioniPrimary (citable) accession number: Q54SC9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: March 28, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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