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Q54S02 (3HAO_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-hydroxyanthranilate 3,4-dioxygenase

EC=1.13.11.6
Alternative name(s):
3-hydroxyanthranilate oxygenase
Short name=3-HAO
3-hydroxyanthranilic acid dioxygenase
Short name=HAD
Gene names
Name:haao
ORF Names:DDB_G0282743
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length182 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate By similarity. HAMAP-Rule MF_03019

Catalytic activity

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde. HAMAP-Rule MF_03019

Cofactor

Fe2+ ion By similarity. HAMAP-Rule MF_03019

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3. HAMAP-Rule MF_03019

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_03019.

Sequence similarities

Belongs to the 3-HAO family.

Ontologies

Keywords
   Biological processPyridine nucleotide biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionDioxygenase
Oxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processNAD biosynthetic process

Inferred from sequence or structural similarity. Source: dictyBase

   Cellular_componentcytoplasm

Inferred from sequence or structural similarity. Source: dictyBase

   Molecular_function3-hydroxyanthranilate 3,4-dioxygenase activity

Inferred from sequence or structural similarity. Source: dictyBase

iron ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 1821823-hydroxyanthranilate 3,4-dioxygenase HAMAP-Rule MF_03019
PRO_0000328344

Sites

Metal binding501Iron; catalytic By similarity
Metal binding561Iron; catalytic By similarity
Metal binding951Iron; catalytic By similarity
Metal binding1241Divalent metal cation By similarity
Metal binding1291Divalent metal cation By similarity
Metal binding1651Divalent metal cation By similarity
Metal binding1681Divalent metal cation By similarity
Binding site461Dioxygen By similarity
Binding site561Substrate By similarity
Binding site991Substrate By similarity
Binding site1091Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q54S02 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: AB372715BAA44ED4

FASTA18221,210
        10         20         30         40         50         60 
MLPPININKW IEENKSLLQP PVGAKLLYTD IDSTFVVMIV GGPNQRTDYH VNETDEFFYQ 

        70         80         90        100        110        120 
FKGDMILKIV DKDGSFRDIN IREGETFILP GNTPHSPQRY RDTIGLVIEK KRSSENIDKL 

       130        140        150        160        170        180 
LWFCDNKDCR KLLFSRSFHV DDLDLGKQLT PIINEFYGNE ENRTCKHCNH ISQKPTVNDY 


IQ 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000047 Genomic DNA. Translation: EAL66231.1.

3D structure databases

ProteinModelPortalQ54S02.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDB_0231359.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0231359; DDB0231359; DDB_G0282743.
KEGGddi:DDB_G0282743.

Organism-specific databases

dictyBaseDDB_G0282743. haao.

Phylogenomic databases

eggNOGNOG77058.
KOK00452.
OMAHINQTPE.
PhylomeDBQ54S02.
ProtClustDBCLSZ2729014.

Enzyme and pathway databases

UniPathwayUPA00253; UER00330.

Family and domain databases

Gene3D2.60.120.10. 1 hit.
HAMAPMF_00825. 3_HAO.
InterProIPR010329. 3hydroanth_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERPTHR15497. PTHR15497. 1 hit.
PfamPF06052. 3-HAO. 1 hit.
[Graphical view]
SUPFAMSSF51182. SSF51182. 1 hit.
TIGRFAMsTIGR03037. anthran_nbaC. 1 hit.
ProtoNetSearch...

Other

PROQ54S02.

Entry information

Entry name3HAO_DICDI
AccessionPrimary (citable) accession number: Q54S02
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: April 16, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase