Reviewed,
UniProtKB/Swiss-Prot Q54RT9 (FNTA_DICDI)
Last modified
February 9, 2010.
Version 40.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha EC=2.5.1.58 EC=2.5.1.59 Alternative name(s): CAAX farnesyltransferase subunit alpha Ras proteins prenyltransferase subunit alpha FTase-alpha Type I protein geranyl-geranyltransferase subunit alpha Short name=GGTase-I-alpha | ||||
| Gene names |
| ||||
| Organism | Dictyostelium discoideum (Slime mold) [Complete proteome] | ||||
| Taxonomic identifier | 44689 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium |
Protein attributes
| Sequence length | 322 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate By similarity. |
| Catalytic activity | Farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate. Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. |
| Subunit structure | Heterodimer of an alpha and a beta subunit By similarity. |
| Sequence similarities | Belongs to the protein prenyltransferase subunit alpha family. Contains 6 PFTA repeats. |
Ontologies
| Keywords | |
|---|---|
| Domain | Repeat |
| Molecular function | Prenyltransferase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | protein amino acid prenylation Inferred from electronic annotation. Source: InterPro |
| Molecular function | CAAX-protein geranylgeranyltransferase activity Inferred from electronic annotation. Source: EC protein farnesyltransferase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 322 | 322 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | PRO_0000328341 | |||||
Regions | |||||||||
| Repeat | 62 – 95 | 34 | PFTA 1 | ||||||
| Repeat | 103 – 136 | 34 | PFTA 2 | ||||||
| Repeat | 138 – 171 | 34 | PFTA 3 | ||||||
| Repeat | 173 – 205 | 33 | PFTA 4 | ||||||
| Repeat | 213 – 246 | 34 | PFTA 5 | ||||||
| Repeat | 287 – 321 | 35 | PFTA 6 | ||||||
Sequences
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References
| [1] | "The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. Kuspa A.Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AAFI02000049 Genomic DNA. Translation: EAL65970.1. |
| RefSeq | XP_639262.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1S63 based on UniProtKB P49354. |
| SMR | Q54RT9. Positions 4-319. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q54RT9. |
Genome annotation databases | |
| GeneID | 8623832. |
| KEGG | ddi:DDB_0237551. |
Organism-specific databases | |
| dictyBase | DDB_G0283053. fntA. |
Phylogenomic databases | |
| eggNOG | KOG0530. |
| HOGENOM | HBG623262. |
| OMA | VEWLRDP. |
| PhylomeDB | Q54RT9. |
Enzyme and pathway databases | |
| BRENDA | 2.5.1.58. 424. 2.5.1.59. 424. |
Family and domain databases | |
| InterPro | IPR002088. Prenyl_trans_a. IPR008940. Prenyltransferase. [Graphical view] |
| Gene3D | G3DSA:1.25.40.120. Prenyl_trans. 1 hit. |
| Pfam | PF01239. PPTA. 4 hits. [Graphical view] |
| PROSITE | PS51147. PFTA. 5 hits. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | FNTA_DICDI | ||||||||
| Accession | Primary (citable) accession number: Q54RT9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
Relevant documents
| Dictyostelium discoideum Dictyostelium discoideum: entries, gene names and cross-references to dictyBase |
| SIMILARITY comments Index of protein domains and families |

Clusters with


