Q54RR5 (ACDSB_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable short/branched chain specific acyl-CoA dehydrogenase
Short name=SBCAD
EC=1.3.99.-

Gene names

Name:	acadsb
ORF Names:	DDB_G0282967

Organism

Dictyostelium discoideum (Slime mold)

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	413 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor.
Cofactor	FAD By similarity.
Pathway	Lipid metabolism; mitochondrial fatty acid beta-oxidation.
Subunit structure	Homotetramer Potential.
Sequence similarities	Belongs to the acyl-CoA dehydrogenase family.

Ontologies

Keywords
Biological process	Fatty acid metabolism Lipid metabolism
Domain	Transit peptide
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	fatty acid metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	acyl-CoA dehydrogenase activity Inferred from electronic annotation. Source: InterPro flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 413	413	Probable short/branched chain specific acyl-CoA dehydrogenase		PRO_0000330466
Sites
	Active site	393	1	Proton acceptor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q54RR5 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 918A06E0D0A89692	FASTA	413	45,030
	10 20 30 40 50 60 MIKKLILDPK NVSIIKNGIR NYSKSKSFIQ PITTLSEEET LLKETVANFA NEKVRPLVKV 70 80 90 100 110 120 MDETSELNKG LLKDLFDMNL MGIDISDSYG GANMNFMGSI IAIEELAKVD PAISVIVDVQ 130 140 150 160 170 180 NTLVNNCINR YGSIQQREKY LSMLATNTVG SFCLSESGSG SDAFALATRA VRQSDGTFVL 190 200 210 220 230 240 NGTKQWITNA KEAGVFIVMA NVDPSQGYKG ITAFIVESNN PGLRIGKKED KLGIRASSTC 250 260 270 280 290 300 EVILDNCVVK PTDILGELGR GYKIAIEGLN EGRIGIAAQM LGLAQGVFDS TIPYLMERKQ 310 320 330 340 350 360 FGKPIATFQG MQFTYADLAV DIEAGRLLTY NAARIKEAGL PFVFQASMAK LHCSRVAEKA 370 380 390 400 410 ASACISMLGG VGFTKEFPAE KFFRDSKVGQ IYEGTSNIQL QTIAKEIVKN FNK

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000049 Genomic DNA. Translation: EAL65927.1.
RefSeq	XP_639286.1. XM_634194.1.
3D structure databases
HSSP	HSSP built from PDB template 1JQI based on UniProtKB P15651.
ProteinModelPortal	Q54RR5.
SMR	Q54RR5. Positions 31-411.
ModBase	Search...
Protein-protein interaction databases
STRING	Q54RR5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0237707; DDB0237707; DDB_G0282967.
GeneID	8623855.
GenomeReviews	Gene locus acadsb in contig CM000153_GR.
KEGG	ddi:DDB_G0282967.
Organism-specific databases
dictyBase	DDB_G0282967. acadsb.
Phylogenomic databases
eggNOG	KOG0139.
GeneTree	EPrGT00050000005237.
HOGENOM	HBG699365.
OMA	DIHNTLV.
PhylomeDB	Q54RR5.
ProtClustDB	CLSZ2430405.
Family and domain databases
InterPro	IPR006089. Acyl-CoA_DH_CS. IPR006092. Acyl-CoA_DH_N. IPR006090. Acyl-CoA_Oxase/DH_1. IPR006091. Acyl-CoA_Oxase/DH_cen-dom. IPR009075. AcylCo_DH/oxidase_C. IPR013786. AcylCoA_DH/ox_N. IPR009100. AcylCoA_DH/oxidase. [Graphical view]
Gene3D	G3DSA:2.40.110.10. Acyl_CoA_DH/ox_M. 1 hit. G3DSA:1.10.540.10. AcylCoA_DH/ox_N. 1 hit. G3DSA:1.20.140.10. AcylCoA_DH_1/2_C. 1 hit.
KO	K00257.
Pfam	PF00441. Acyl-CoA_dh_1. 1 hit. PF02770. Acyl-CoA_dh_M. 1 hit. PF02771. Acyl-CoA_dh_N. 1 hit. [Graphical view]
SUPFAM	SSF56645. AcylCoA_dehyd_NM. 1 hit. SSF47203. AcylCoADH_C_like. 1 hit.
PROSITE	PS00072. ACYL_COA_DH_1. 1 hit. PS00073. ACYL_COA_DH_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACDSB_DICDI

Accession

Primary (citable) accession number: Q54RR5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	May 24, 2005
Last modified:	November 16, 2011
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)