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Protein

Probable short/branched chain specific acyl-CoA dehydrogenase

Gene

acadsb

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor.
2-methylbutanoyl-CoA + electron-transfer flavoprotein = (E)-2-methylbut-2-enoyl-CoA + reduced electron-transfer flavoprotein + H+.

Cofactori

FADBy similarity

Pathwayi: mitochondrial fatty acid beta-oxidation

This protein is involved in the pathway mitochondrial fatty acid beta-oxidation, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway mitochondrial fatty acid beta-oxidation and in Lipid metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei393 – 3931Proton acceptorBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

ReactomeiR-DDI-70895. Branched-chain amino acid catabolism.
UniPathwayiUPA00660.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable short/branched chain specific acyl-CoA dehydrogenase (EC:1.3.8.5)
Short name:
SBCAD
Gene namesi
Name:acadsb
ORF Names:DDB_G0282967
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 4, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0282967. acadsb.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 413413Probable short/branched chain specific acyl-CoA dehydrogenasePRO_0000330466Add
BLAST

Proteomic databases

PaxDbiQ54RR5.
PRIDEiQ54RR5.

Interactioni

Subunit structurei

Homotetramer.Curated

Protein-protein interaction databases

STRINGi44689.DDB0237707.

Structurei

3D structure databases

ProteinModelPortaliQ54RR5.
SMRiQ54RR5. Positions 31-411.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acyl-CoA dehydrogenase family.Curated

Phylogenomic databases

eggNOGiKOG0139. Eukaryota.
COG1960. LUCA.
InParanoidiQ54RR5.
KOiK09478.
OMAiAMMSIHN.
PhylomeDBiQ54RR5.

Family and domain databases

Gene3Di1.10.540.10. 1 hit.
InterProiIPR006089. Acyl-CoA_DH_CS.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
PfamiPF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
[Graphical view]
SUPFAMiSSF47203. SSF47203. 1 hit.
SSF56645. SSF56645. 1 hit.
PROSITEiPS00072. ACYL_COA_DH_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54RR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKKLILDPK NVSIIKNGIR NYSKSKSFIQ PITTLSEEET LLKETVANFA
60 70 80 90 100
NEKVRPLVKV MDETSELNKG LLKDLFDMNL MGIDISDSYG GANMNFMGSI
110 120 130 140 150
IAIEELAKVD PAISVIVDVQ NTLVNNCINR YGSIQQREKY LSMLATNTVG
160 170 180 190 200
SFCLSESGSG SDAFALATRA VRQSDGTFVL NGTKQWITNA KEAGVFIVMA
210 220 230 240 250
NVDPSQGYKG ITAFIVESNN PGLRIGKKED KLGIRASSTC EVILDNCVVK
260 270 280 290 300
PTDILGELGR GYKIAIEGLN EGRIGIAAQM LGLAQGVFDS TIPYLMERKQ
310 320 330 340 350
FGKPIATFQG MQFTYADLAV DIEAGRLLTY NAARIKEAGL PFVFQASMAK
360 370 380 390 400
LHCSRVAEKA ASACISMLGG VGFTKEFPAE KFFRDSKVGQ IYEGTSNIQL
410
QTIAKEIVKN FNK
Length:413
Mass (Da):45,030
Last modified:May 24, 2005 - v1
Checksum:i918A06E0D0A89692
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000049 Genomic DNA. Translation: EAL65927.1.
RefSeqiXP_639286.1. XM_634194.1.

Genome annotation databases

EnsemblProtistsiDDB0237707; DDB0237707; DDB_G0282967.
GeneIDi8623855.
KEGGiddi:DDB_G0282967.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000049 Genomic DNA. Translation: EAL65927.1.
RefSeqiXP_639286.1. XM_634194.1.

3D structure databases

ProteinModelPortaliQ54RR5.
SMRiQ54RR5. Positions 31-411.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0237707.

Proteomic databases

PaxDbiQ54RR5.
PRIDEiQ54RR5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0237707; DDB0237707; DDB_G0282967.
GeneIDi8623855.
KEGGiddi:DDB_G0282967.

Organism-specific databases

dictyBaseiDDB_G0282967. acadsb.

Phylogenomic databases

eggNOGiKOG0139. Eukaryota.
COG1960. LUCA.
InParanoidiQ54RR5.
KOiK09478.
OMAiAMMSIHN.
PhylomeDBiQ54RR5.

Enzyme and pathway databases

UniPathwayiUPA00660.
ReactomeiR-DDI-70895. Branched-chain amino acid catabolism.

Miscellaneous databases

PROiQ54RR5.

Family and domain databases

Gene3Di1.10.540.10. 1 hit.
InterProiIPR006089. Acyl-CoA_DH_CS.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
PfamiPF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
[Graphical view]
SUPFAMiSSF47203. SSF47203. 1 hit.
SSF56645. SSF56645. 1 hit.
PROSITEiPS00072. ACYL_COA_DH_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiACDSB_DICDI
AccessioniPrimary (citable) accession number: Q54RR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: May 11, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.