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Reviewed, UniProtKB/Swiss-Prot Q54RQ1 (SODC3_DICDI)

Last modified February 9, 2010. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Extracellular superoxide dismutase [Cu-Zn] 3
      Short name=EC-SOD 3
    EC=1.15.1.1
Gene names
Name: sodC
ORF Names: DDB_G0282993
OrganismDictyostelium discoideum (Slime mold) [Complete proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

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Protein attributes

Sequence length407 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxyde radicals into hydrogen peroxyde and oxygen By similarity.

Catalytic activity

2 superoxide + 2 H+ = O2 + H2O2.

Cofactor

Binds 1 copper ion per subunit By similarity.

Binds 1 zinc ion per subunit By similarity.

Subcellular location

Cell membrane; Single-pass type I membrane protein; Extracellular side Potential.

Sequence similarities

Belongs to the Cu-Zn superoxide dismutase family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 407388Extracellular superoxide dismutase [Cu-Zn] 3
PRO_0000327853

Regions

Topological domain20 – 386367Extracellular Potential
Transmembrane387 – 40620 Potential
Topological domain4071Cytoplasmic Potential

Sites

Metal binding2451Copper; catalytic By similarity
Metal binding2471Copper; catalytic By similarity
Metal binding2631Copper; catalytic By similarity
Metal binding2631Zinc; structural By similarity
Metal binding2711Zinc; structural By similarity
Metal binding2801Zinc; structural By similarity
Metal binding2831Zinc; structural By similarity
Metal binding3201Copper; catalytic By similarity

Amino acid modifications

Glycosylation511N-linked (GlcNAc...) Potential
Glycosylation2051N-linked (GlcNAc...) Potential
Glycosylation2241N-linked (GlcNAc...) Potential
Glycosylation2561N-linked (GlcNAc...) Potential
Glycosylation3211N-linked (GlcNAc...) Potential
Glycosylation3641N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict681A → V in FAA00020. Ref.1
Sequence conflict352 – 3532LP → HT in FAA00020. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
Q54RQ1-1 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: F969421CE55F4F17

FASTA40743,572
        10         20         30         40         50         60 
MRLLSVLVFL ISVISIAKAD YQYAFCKFNE LSIGGVEGIA HLLSTDGTTL NITFDFTTSY 

        70         80         90        100        110        120 
AQNTQFAAQI LTYGYNPSSM TNLGSVFDPT NVKTAGCPSG TPRAGDIGNI QANGGNVEAQ 

       130        140        150        160        170        180 
TISLNIPNIK DDANSIIGRS IAIYGGSYDC SDPSKSVIGD MISFCTIGVG NIDYSSFDKS 

       190        200        210        220        230        240 
KLTGVNTASS YSNLENAIGL AVVYNTTITK GDYIEGRVLF KALNSSFIQV SAKVSGLSYQ 

       250        260        270        280        290        300 
AHGFHVHQFG DVSSDNGTSI GGHFLKTGQE HSLPPSGTRH YGDFGNFCAF SQDMMDTGYY 

       310        320        330        340        350        360 
YYETDHVTAA LVIGRGMAVH NFTDKGNSDV GGSRCGQGVI ALIQDADYSL NLPMDWKWDV 

       370        380        390        400 
ICANGSYYGD MSTSMNSESY NDNEPGSSST VIPFFALIIF SIIFALL

« Hide

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References

« Hide 'large scale' references
[1]"The genome of the social amoeba Dictyostelium discoideum."
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. expand/collapse author list , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
Nature 435:43-57(2005) [PubMed: 15875012] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.
[2]"Multinucleation of the sodC-deficient Dictyostelium discoideum."
Tsuji A., Akaza Y., Nakamura S., Kodaira K., Yasukawa H.
Biol. Pharm. Bull. 26:1174-1177(2003) [PubMed: 12913271] [Abstract]
Cited for: IDENTIFICATION.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AAFI02000049 Genomic DNA. Translation: EAL65940.1.
BR000218 mRNA. Translation: FAA00020.1.
RefSeqXP_639300.1.

3D structure databases

HSSPHSSP built from PDB template 1OZT based on UniProtKB P00441.
SMRQ54RQ1. Positions 34-171.
ModBaseSearch...

Genome annotation databases

GeneID8623871.
KEGGddi:DDB_0232186.

Organism-specific databases

dictyBaseDDB_G0282993. sodC.

Phylogenomic databases

eggNOGKOG0441.
HOGENOMHBG080616.
PhylomeDBQ54RQ1.

Enzyme and pathway databases

BRENDA1.15.1.1. 424.

Family and domain databases

InterProIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn.
[Graphical view]
Gene3DG3DSA:2.60.40.200. SOD_Cu_Zn. 2 hits.
PANTHERPTHR10003. SOD_Cu_Zn. 1 hit.
PfamPF00080. Sod_Cu. 2 hits.
[Graphical view]
PROSITEPS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. False negative.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameSODC3_DICDI
AccessionPrimary (citable) accession number: Q54RQ1
Secondary accession number(s): Q52KB2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: February 9, 2010
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

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Relevant documents

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents