SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q54RD6

- PP2AB_DICDI

UniProt

Q54RD6 - PP2AB_DICDI

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Probable serine/threonine-protein phosphatase 2A catalytic subunit B

Gene
DDB_G0283187
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 manganese ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi55 – 551Manganese 1 By similarity
Metal bindingi57 – 571Manganese 1 By similarity
Metal bindingi83 – 831Manganese 1 By similarity
Metal bindingi83 – 831Manganese 2 By similarity
Metal bindingi115 – 1151Manganese 2 By similarity
Active sitei116 – 1161Proton donor By similarity
Metal bindingi165 – 1651Manganese 2 By similarity
Metal bindingi240 – 2401Manganese 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable serine/threonine-protein phosphatase 2A catalytic subunit B (EC:3.1.3.16)
Gene namesi
ORF Names:DDB_G0283187
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 4, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0283187.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Probable serine/threonine-protein phosphatase 2A catalytic subunit BPRO_0000368207Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei312 – 3121Leucine methyl ester By similarity

Post-translational modificationi

Reversibly methyl esterified on Leu-312 by leucine carboxyl methyltransferase (LCMT) and protein phosphatase methylesterase 1 (ppme1). Carboxyl methylation influences the affinity of the catalytic subunit for the different regulatory subunits, thereby modulating the PP2A holoenzyme's substrate specificity, enzyme activity and cellular localization By similarity.

Keywords - PTMi

Methylation

Interactioni

Subunit structurei

PP2A consists of a trimeric holoenzyme, composed of a 37 kDa catalytic subunit (C subunit) and a 65 kDa constant regulatory subunit (A subunit), that associates with a variety of regulatory subunits (B subunit) such as phr2AB (B55) and psrA (B56 homolog). The trimer may partially dissociates into a core "AC" dimer equally active compared to the trimer By similarity.

Protein-protein interaction databases

STRINGi44689.DDBDRAFT_0185403.

Structurei

3D structure databases

ProteinModelPortaliQ54RD6.
SMRiQ54RD6. Positions 6-311.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0639.
InParanoidiQ54RD6.
KOiK17615.
OMAiFYTECVR.
PhylomeDBiQ54RD6.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54RD6-1 [UniParc]FASTAAdd to Basket

« Hide

MNTSTFNLDH CIEKLQKCEI LPESTIKEIT DKMKELLISE SNVQEIRSPV    50
TVVGDVHGQF YDVLEIFKIG GQCPDTNYLF LGDYVDRGYH SVETISLLTC 100
LKLRYPSRIT LLRGNHESRQ ITQVYGFYGE CMRKYGNPTV WKYFTEMFDY 150
LSVAAIIDEA IYCVHGGLSP SALSIDQIKV LDRFQEVPNE GALSDILWSD 200
PDPDREGFVE SQRGAGYSYG KDVTLRFLQN NKMQHIIRAH QLCMDGYQTL 250
FDNKLSTVWS APNYCNRCGN MASIVEVNEK LERYFNTYAA APQSLSNKPT 300
LDTNKELPDY FL 312
Length:312
Mass (Da):35,694
Last modified:May 24, 2005 - v1
Checksum:i11DA221AB338021F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000051 Genomic DNA. Translation: EAL65832.1.
RefSeqiXP_639209.1. XM_634117.1.

Genome annotation databases

EnsemblProtistsiDDB0234188; DDB0234188; DDB_G0283187.
GeneIDi8623982.
KEGGiddi:DDB_G0283187.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000051 Genomic DNA. Translation: EAL65832.1 .
RefSeqi XP_639209.1. XM_634117.1.

3D structure databases

ProteinModelPortali Q54RD6.
SMRi Q54RD6. Positions 6-311.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDBDRAFT_0185403.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0234188 ; DDB0234188 ; DDB_G0283187 .
GeneIDi 8623982.
KEGGi ddi:DDB_G0283187.

Organism-specific databases

dictyBasei DDB_G0283187.

Phylogenomic databases

eggNOGi COG0639.
InParanoidi Q54RD6.
KOi K17615.
OMAi FYTECVR.
PhylomeDBi Q54RD6.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PRINTSi PR00114. STPHPHTASE.
SMARTi SM00156. PP2Ac. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiPP2AB_DICDI
AccessioniPrimary (citable) accession number: Q54RD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 24, 2005
Last modified: September 3, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi