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Q54RB2

- CDK11_DICDI

UniProt

Q54RB2 - CDK11_DICDI

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Protein

Cyclin-dependent kinase 11

Gene

cdk11

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei81 – 811ATPPROSITE-ProRule annotation
Active sitei176 – 1761Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi58 – 669ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: dictyBase
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
  3. protein serine/threonine kinase activity Source: dictyBase

GO - Biological processi

  1. protein phosphorylation Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 11 (EC:2.7.11.22)
Alternative name(s):
Cell division cycle protein kinase 11
Cell division protein kinase 11
PITSVRE serine/threonine protein-kinase cdk11
Gene namesi
Name:cdk11
ORF Names:DDB_G0283279
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 4, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0283279. cdk11.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 358358Cyclin-dependent kinase 11PRO_0000353101Add
BLAST

Proteomic databases

PRIDEiQ54RB2.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0216376.

Structurei

3D structure databases

ProteinModelPortaliQ54RB2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini52 – 336285Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
InParanoidiQ54RB2.
KOiK08818.
OMAiKKLYTIN.
PhylomeDBiQ54RB2.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54RB2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSNIQENENK ETCNIKENEN KEILKENFKN KEKQYFSSLR SPYSACRSVD
60 70 80 90 100
CFKKLYTINE GAFGVVYCAQ DKETEEIVAL KKIKMERERE GIPITSVREI
110 120 130 140 150
KVLMELKHDN IVQIKEIVLG KNINSIFMAM EFIDHDLRGL MEVIKKPFLP
160 170 180 190 200
SEIKTLIQQL LNGVSYMHDN WVIHRDLKTA NLLYTNKGVL KIADFGLARE
210 220 230 240 250
YGSPLKPLSK GVVTLWYRAP ELLLDTEIYT PAIDIWSVGC IFAEIISKEV
260 270 280 290 300
LLQGSSEIDQ MDKIFKLFGT PTEKSWPAFF KLPLAKYFNL TDQPYNNLKS
310 320 330 340 350
KFPHITDNAF DLLNKLLELN PEARISASDA LKHPYFFENP QPRDPLLMPT

WPSSHKKT
Length:358
Mass (Da):41,358
Last modified:May 24, 2005 - v1
Checksum:i8458157B95470084
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000052 Genomic DNA. Translation: EAL65780.1.
RefSeqiXP_639135.1. XM_634043.1.

Genome annotation databases

EnsemblProtistsiDDB0216376; DDB0216376; DDB_G0283279.
GeneIDi8624005.
KEGGiddi:DDB_G0283279.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000052 Genomic DNA. Translation: EAL65780.1 .
RefSeqi XP_639135.1. XM_634043.1.

3D structure databases

ProteinModelPortali Q54RB2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0216376.

Proteomic databases

PRIDEi Q54RB2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0216376 ; DDB0216376 ; DDB_G0283279 .
GeneIDi 8624005.
KEGGi ddi:DDB_G0283279.

Organism-specific databases

dictyBasei DDB_G0283279. cdk11.

Phylogenomic databases

eggNOGi COG0515.
InParanoidi Q54RB2.
KOi K08818.
OMAi KKLYTIN.
PhylomeDBi Q54RB2.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiCDK11_DICDI
AccessioniPrimary (citable) accession number: Q54RB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: May 24, 2005
Last modified: October 29, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3