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Protein

Cyclin-dependent kinase 11

Gene

cdk11

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei81ATPPROSITE-ProRule annotation1
Active sitei176Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi58 – 66ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 11 (EC:2.7.11.22)
Alternative name(s):
Cell division cycle protein kinase 11
Cell division protein kinase 11
PITSVRE serine/threonine protein-kinase cdk11
Gene namesi
Name:cdk11
ORF Names:DDB_G0283279
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 4, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0283279. cdk11.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003531011 – 358Cyclin-dependent kinase 11Add BLAST358

Proteomic databases

PaxDbiQ54RB2.
PRIDEiQ54RB2.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0216376.

Structurei

3D structure databases

ProteinModelPortaliQ54RB2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 336Protein kinasePROSITE-ProRule annotationAdd BLAST285

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0663. Eukaryota.
ENOG410XQ50. LUCA.
InParanoidiQ54RB2.
KOiK08818.
OMAiCIFAEII.
PhylomeDBiQ54RB2.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

Q54RB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNIQENENK ETCNIKENEN KEILKENFKN KEKQYFSSLR SPYSACRSVD
60 70 80 90 100
CFKKLYTINE GAFGVVYCAQ DKETEEIVAL KKIKMERERE GIPITSVREI
110 120 130 140 150
KVLMELKHDN IVQIKEIVLG KNINSIFMAM EFIDHDLRGL MEVIKKPFLP
160 170 180 190 200
SEIKTLIQQL LNGVSYMHDN WVIHRDLKTA NLLYTNKGVL KIADFGLARE
210 220 230 240 250
YGSPLKPLSK GVVTLWYRAP ELLLDTEIYT PAIDIWSVGC IFAEIISKEV
260 270 280 290 300
LLQGSSEIDQ MDKIFKLFGT PTEKSWPAFF KLPLAKYFNL TDQPYNNLKS
310 320 330 340 350
KFPHITDNAF DLLNKLLELN PEARISASDA LKHPYFFENP QPRDPLLMPT

WPSSHKKT
Length:358
Mass (Da):41,358
Last modified:May 24, 2005 - v1
Checksum:i8458157B95470084
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000052 Genomic DNA. Translation: EAL65780.1.
RefSeqiXP_639135.1. XM_634043.1.

Genome annotation databases

EnsemblProtistsiEAL65780; EAL65780; DDB_G0283279.
GeneIDi8624005.
KEGGiddi:DDB_G0283279.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000052 Genomic DNA. Translation: EAL65780.1.
RefSeqiXP_639135.1. XM_634043.1.

3D structure databases

ProteinModelPortaliQ54RB2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0216376.

Proteomic databases

PaxDbiQ54RB2.
PRIDEiQ54RB2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL65780; EAL65780; DDB_G0283279.
GeneIDi8624005.
KEGGiddi:DDB_G0283279.

Organism-specific databases

dictyBaseiDDB_G0283279. cdk11.

Phylogenomic databases

eggNOGiKOG0663. Eukaryota.
ENOG410XQ50. LUCA.
InParanoidiQ54RB2.
KOiK08818.
OMAiCIFAEII.
PhylomeDBiQ54RB2.

Miscellaneous databases

PROiPR:Q54RB2.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCDK11_DICDI
AccessioniPrimary (citable) accession number: Q54RB2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: May 24, 2005
Last modified: February 15, 2017
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.