Q54RB2 (CDK11_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cyclin-dependent kinase 11
EC=2.7.11.22

Alternative name(s):
Cell division cycle protein kinase 11
Cell division protein kinase 11
PITSVRE serine/threonine protein-kinase cdk11

Gene names

Name:	cdk11
ORF Names:	DDB_G0283279

Organism

Dictyostelium discoideum (Slime mold) [Reference proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	358 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Sequence similarities	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell cycle Inferred from electronic annotation. Source: GOC
Molecular_function	ATP binding Inferred from sequence or structural similarity. Source: dictyBase cyclin-dependent protein serine/threonine kinase activity Inferred from electronic annotation. Source: EC protein serine/threonine kinase activity Inferred from sequence or structural similarity. Source: dictyBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 358	358	Cyclin-dependent kinase 11		PRO_0000353101
Regions
	Domain	52 – 336	285	Protein kinase
	Nucleotide binding	58 – 66	9	ATP By similarity
Sites
	Active site	176	1	Proton acceptor By similarity
	Binding site	81	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q54RB2 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 8458157B95470084	FASTA	358	41,358
	10 20 30 40 50 60 MSNIQENENK ETCNIKENEN KEILKENFKN KEKQYFSSLR SPYSACRSVD CFKKLYTINE 70 80 90 100 110 120 GAFGVVYCAQ DKETEEIVAL KKIKMERERE GIPITSVREI KVLMELKHDN IVQIKEIVLG 130 140 150 160 170 180 KNINSIFMAM EFIDHDLRGL MEVIKKPFLP SEIKTLIQQL LNGVSYMHDN WVIHRDLKTA 190 200 210 220 230 240 NLLYTNKGVL KIADFGLARE YGSPLKPLSK GVVTLWYRAP ELLLDTEIYT PAIDIWSVGC 250 260 270 280 290 300 IFAEIISKEV LLQGSSEIDQ MDKIFKLFGT PTEKSWPAFF KLPLAKYFNL TDQPYNNLKS 310 320 330 340 350 KFPHITDNAF DLLNKLLELN PEARISASDA LKHPYFFENP QPRDPLLMPT WPSSHKKT

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000052 Genomic DNA. Translation: EAL65780.1.
RefSeq	XP_639135.1. XM_634043.1.
3D structure databases
HSSP	HSSP built from PDB template 1PYE based on UniProtKB P24941.
ProteinModelPortal	Q54RB2.
ModBase	Search...
Protein-protein interaction databases
STRING	44689.DDB_0216376.
Proteomic databases
PRIDE	Q54RB2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0216376; DDB0216376; DDB_G0283279.
GeneID	8624005.
KEGG	ddi:DDB_G0283279.
Organism-specific databases
dictyBase	DDB_G0283279. cdk11.
Phylogenomic databases
eggNOG	COG0515.
KO	K08818.
OMA	INEGAFG.
ProtClustDB	CLSZ2430383.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDK11_DICDI

Accession

Primary (citable) accession number: Q54RB2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 25, 2008
Last sequence update:	May 24, 2005
Last modified:	May 1, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)