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Reviewed, UniProtKB/Swiss-Prot Q54RA2 (AL4A1_DICDI)

Last modified February 9, 2010. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
      Short name=P5C dehydrogenase
    EC=1.5.1.12
Alternative name(s):
    Aldehyde dehydrogenase family 4 member A1 homolog
Gene names
ORF Names: DDB_G0283293
OrganismDictyostelium discoideum (Slime mold) [Complete proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length558 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles By similarity.

Catalytic activity

(S)-1-pyrroline-5-carboxylate + NAD(P)+ + 2 H2O = L-glutamate + NAD(P)H.

Pathway

Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.

Subcellular location

Mitochondrion matrix By similarity.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   Biological processProline metabolism
   Cellular componentMitochondrion
   DomainTransit peptide
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

proline biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentmitochondrial matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function1-pyrroline-5-carboxylate dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 558Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrialPRO_0000342183

Regions

Nucleotide binding286 – 2916NAD By similarity

Sites

Active site3061 By similarity
Active site3401 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q54RA2-1 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 6F6ACCB3479EB1AA

FASTA55861,633
        10         20         30         40         50         60 
MLRNTSRVLM SHFARANIPT PVNQPMLNYE VGSTHRKLLK EACAKFRNTT IDIPCVVGGK 

        70         80         90        100        110        120 
EIRTGDVQKQ LICSDHNKVL ATFHQANAEL LKLAVENSME SKAQWESLPF EARSAVFLKA 

       130        140        150        160        170        180 
ADLLNTKYRY DVLASTMLGQ GKTVWQAEID AAAEGIDFLR FNVKYAQEIY QQQPPANSAG 

       190        200        210        220        230        240 
CWNILTYQPL EGYVVAISPF NFTAIGLNLS SAPALMGNVV LWKPASTAVL SNWIVYKALL 

       250        260        270        280        290        300 
EAGLPAGVIQ FLPGSGRLVG EHLFNNRNFS GLHFTGSTGV FNDIYKKTAD NLVAGVYKGY 

       310        320        330        340        350        360 
PRIVGETGGK DFHFLHNSGD VENFVNNTLR GAFEYQGQKC SACSRAYIPQ SLWPQIKDRL 

       370        380        390        400        410        420 
VTGVKSMKMG QSDDFSSFVS AVIDKNSFNN IQSYIEHAKA SPDAEIIVGG KCDSSVGWFV 

       430        440        450        460        470        480 
EPTIILAKDP HYKSMEEEIF GPVLTIYVYE DSKFEETLKI CDETSPYALT GSIFSTCRYA 

       490        500        510        520        530        540 
IETAHKYLKN AAGNFYINDK CTGAVVGQQP FGGSRASGTN DKAGSSLNLL RWISARTIKE 

       550 
NFVPLTSFTY PYMIDPEN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000052 Genomic DNA. Translation: EAL65787.1.
RefSeqXP_639145.1.

3D structure databases

HSSPHSSP built from PDB template 2BJK based on UniProtKB Q5SI02.
SMRQ54RA2. Positions 18-542.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ54RA2.

Genome annotation databases

GeneID8624016.
KEGGddi:DDB_0229934.

Organism-specific databases

dictyBaseDDB_G0283293.

Phylogenomic databases

eggNOGKOG2455.
HOGENOMHBG752218.
OMARAAIFLR.
PhylomeDBQ54RA2.

Family and domain databases

InterProIPR016161. Ald_DH/histidinol_DH.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH.
IPR005931. d-1-pyrroline-5-COlate_DH-1.
[Graphical view]
Gene3DG3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHERPTHR11699. Aldehyde_dehyd. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
TIGRFAMsTIGR01236. D1pyr5carbox1. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAL4A1_DICDI
AccessionPrimary (citable) accession number: Q54RA2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: May 24, 2005
Last modified: February 9, 2010
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents