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Q54R58 (YTYK2_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable tyrosine-protein kinase DDB_G0283397

EC=2.7.10.2
Gene names
ORF Names:DDB_G0283397
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length918 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Sequence similarities

Belongs to the protein kinase superfamily. TKL Tyr protein kinase family.

Contains 1 protein kinase domain.

Contains 5 WD repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 918918Probable tyrosine-protein kinase DDB_G0283397
PRO_0000355146

Regions

Domain177 – 445269Protein kinase
Repeat626 – 66742WD 1
Repeat684 – 72239WD 2
Repeat724 – 76542WD 3
Repeat776 – 82045WD 4
Repeat823 – 86240WD 5
Nucleotide binding183 – 1919ATP By similarity
Compositional bias59 – 679Poly-Asp
Compositional bias101 – 1044Poly-Asn
Compositional bias105 – 1117Poly-Gly
Compositional bias458 – 47215Poly-Ser
Compositional bias533 – 54816Poly-Asn
Compositional bias563 – 58624Poly-Asn
Compositional bias772 – 7754Poly-Ser
Compositional bias856 – 86813Poly-Asn

Sites

Active site3071Proton acceptor By similarity
Binding site2041ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q54R58 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 2E67BA9688A5F45D

FASTA918102,616
        10         20         30         40         50         60 
MFNNDKDDNN QGNENNENNK INIKTSIDMG NYINSSSLVE SFGSGSNRNN DKSEDVEYDD 

        70         80         90        100        110        120 
DDDDDDDEIA STEEEKESDL DSDSDLAPTQ IIVDDSDDFY NNNNGGGGGG GNEDISSTSP 

       130        140        150        160        170        180 
TLITSNSFND KINQIFSRGG SSLNSSFLNN GENKINFKQL VKLKSTLKKH EIPSRELTVE 

       190        200        210        220        230        240 
KEIGQGFFGK VYKARWRGKS VALKKITLIK FRDLTETEIF DKEVSIMSKL CHPTCVMFIG 

       250        260        270        280        290        300 
ACSLDGPSND RSIIMEYMEG GSLRRLLDEK SSYHLPPSLQ LSIARDIAEG MNYLHTNFKE 

       310        320        330        340        350        360 
GPIVHRDLTS SNILLNSSYT VAKINDFGLS KEMKPGPTEM TAAMGSLAWM APECFKAENY 

       370        380        390        400        410        420 
TEKVDVYSFA IILWEIVTCR DPYNGMEPLR LAFLASVEDY RLPLNGFPPY WVELISKCWN 

       430        440        450        460        470        480 
ITPSLRPSFK EILQILNQIE SDPLFLNLNL NCSSNNTSSG STSTSSGSSS SSDNNLTKSS 

       490        500        510        520        530        540 
ESNNNLRESN INNQIKSNKN SSKNGYYAQD INDYSLSMQV ETKNCIYNNV SDNVNNNNNN 

       550        560        570        580        590        600 
NNNNNNDNDF FKSSFTKKSF LSNNNYNNNN NNINNKNNNT NNLNDNLIIK SLNHISEQNS 

       610        620        630        640        650        660 
FLVSYQDSNI VKYFSLDNES LTSTLQMEQS VVCMKYQIIN EKVFLVVAMS NNNISLFELK 

       670        680        690        700        710        720 
KTDFSGSANS PTTLLPIKVI KCDEQRHTIK DITWNGTHVI TSSFKDSSIQ IWDLEKSLYP 

       730        740        750        760        770        780 
ISKMDNGGVG ILSIDSQSHQ PLMISGDSDG KVKLWDIRNS HCFRTLTHSP PSSSSGGSIG 

       790        800        810        820        830        840 
VDSVLFRSPH AVRDPIILTG SSKDCKFKVW NMYSSTCLNS FQSHNKDLLG IHRNQSSQQM 

       850        860        870        880        890        900 
ITWSSEGTIS LFNSGNNINN QNNQNNNNDC GNDNDSVEFS KVLNVNSMMS NEPLQSAQII 

       910 
SKNRIIFSSK NKFYSIIA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000055 Genomic DNA. Translation: EAL65683.1.

3D structure databases

ProteinModelPortalQ54R58.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0229872; DDB0229872; DDB_G0283397.
KEGGddi:DDB_G0283397.

Organism-specific databases

dictyBaseDDB_G0283397.

Phylogenomic databases

eggNOGCOG0515.
OMAAWMAPEC.

Family and domain databases

Gene3D2.130.10.10. 1 hit.
InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamPF07714. Pkinase_Tyr. 1 hit.
PF00400. WD40. 1 hit.
[Graphical view]
PRINTSPR00109. TYRKINASE.
SMARTSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMSSF50978. SSF50978. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameYTYK2_DICDI
AccessionPrimary (citable) accession number: Q54R58
Entry history
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: May 24, 2005
Last modified: April 16, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase