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Protein

Probable tyrosine-protein kinase DDB_G0283397

Gene

DDB_G0283397

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei204 – 2041ATPPROSITE-ProRule annotation
Active sitei307 – 3071Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi183 – 1919ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable tyrosine-protein kinase DDB_G0283397 (EC:2.7.10.2)
Gene namesi
ORF Names:DDB_G0283397
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 4, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0283397.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 918918Probable tyrosine-protein kinase DDB_G0283397PRO_0000355146Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ54R58.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini177 – 445269Protein kinasePROSITE-ProRule annotationAdd
BLAST
Repeati626 – 66742WD 1Add
BLAST
Repeati684 – 72239WD 2Add
BLAST
Repeati724 – 76542WD 3Add
BLAST
Repeati776 – 82045WD 4Add
BLAST
Repeati823 – 86240WD 5Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi59 – 679Poly-Asp
Compositional biasi101 – 1044Poly-Asn
Compositional biasi105 – 1117Poly-Gly
Compositional biasi458 – 47215Poly-SerAdd
BLAST
Compositional biasi533 – 54816Poly-AsnAdd
BLAST
Compositional biasi563 – 58624Poly-AsnAdd
BLAST
Compositional biasi772 – 7754Poly-Ser
Compositional biasi856 – 86813Poly-AsnAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 5 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG0515.
InParanoidiQ54R58.
OMAiAWMAPEC.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00400. WD40. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54R58-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFNNDKDDNN QGNENNENNK INIKTSIDMG NYINSSSLVE SFGSGSNRNN
60 70 80 90 100
DKSEDVEYDD DDDDDDDEIA STEEEKESDL DSDSDLAPTQ IIVDDSDDFY
110 120 130 140 150
NNNNGGGGGG GNEDISSTSP TLITSNSFND KINQIFSRGG SSLNSSFLNN
160 170 180 190 200
GENKINFKQL VKLKSTLKKH EIPSRELTVE KEIGQGFFGK VYKARWRGKS
210 220 230 240 250
VALKKITLIK FRDLTETEIF DKEVSIMSKL CHPTCVMFIG ACSLDGPSND
260 270 280 290 300
RSIIMEYMEG GSLRRLLDEK SSYHLPPSLQ LSIARDIAEG MNYLHTNFKE
310 320 330 340 350
GPIVHRDLTS SNILLNSSYT VAKINDFGLS KEMKPGPTEM TAAMGSLAWM
360 370 380 390 400
APECFKAENY TEKVDVYSFA IILWEIVTCR DPYNGMEPLR LAFLASVEDY
410 420 430 440 450
RLPLNGFPPY WVELISKCWN ITPSLRPSFK EILQILNQIE SDPLFLNLNL
460 470 480 490 500
NCSSNNTSSG STSTSSGSSS SSDNNLTKSS ESNNNLRESN INNQIKSNKN
510 520 530 540 550
SSKNGYYAQD INDYSLSMQV ETKNCIYNNV SDNVNNNNNN NNNNNNDNDF
560 570 580 590 600
FKSSFTKKSF LSNNNYNNNN NNINNKNNNT NNLNDNLIIK SLNHISEQNS
610 620 630 640 650
FLVSYQDSNI VKYFSLDNES LTSTLQMEQS VVCMKYQIIN EKVFLVVAMS
660 670 680 690 700
NNNISLFELK KTDFSGSANS PTTLLPIKVI KCDEQRHTIK DITWNGTHVI
710 720 730 740 750
TSSFKDSSIQ IWDLEKSLYP ISKMDNGGVG ILSIDSQSHQ PLMISGDSDG
760 770 780 790 800
KVKLWDIRNS HCFRTLTHSP PSSSSGGSIG VDSVLFRSPH AVRDPIILTG
810 820 830 840 850
SSKDCKFKVW NMYSSTCLNS FQSHNKDLLG IHRNQSSQQM ITWSSEGTIS
860 870 880 890 900
LFNSGNNINN QNNQNNNNDC GNDNDSVEFS KVLNVNSMMS NEPLQSAQII
910
SKNRIIFSSK NKFYSIIA
Length:918
Mass (Da):102,616
Last modified:May 24, 2005 - v1
Checksum:i2E67BA9688A5F45D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000055 Genomic DNA. Translation: EAL65683.1.
RefSeqiXP_639033.1. XM_633941.1.

Genome annotation databases

EnsemblProtistsiDDB0229872; DDB0229872; DDB_G0283397.
GeneIDi8624058.
KEGGiddi:DDB_G0283397.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000055 Genomic DNA. Translation: EAL65683.1.
RefSeqiXP_639033.1. XM_633941.1.

3D structure databases

ProteinModelPortaliQ54R58.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0229872; DDB0229872; DDB_G0283397.
GeneIDi8624058.
KEGGiddi:DDB_G0283397.

Organism-specific databases

dictyBaseiDDB_G0283397.

Phylogenomic databases

eggNOGiCOG0515.
InParanoidiQ54R58.
OMAiAWMAPEC.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00400. WD40. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiYTYK2_DICDI
AccessioniPrimary (citable) accession number: Q54R58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: May 24, 2005
Last modified: January 7, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.