Q54R58 (YTYK2_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable tyrosine-protein kinase DDB_G0283397
EC=2.7.10.2

Gene names

ORF Names:

DDB_G0283397

Organism

Dictyostelium discoideum (Slime mold) [Reference proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	918 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Sequence similarities	Belongs to the protein kinase superfamily. TKL Tyr protein kinase family. Contains 1 protein kinase domain. Contains 5 WD repeats.

Ontologies

Keywords
Domain	Repeat WD repeat
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase Tyrosine-protein kinase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW non-membrane spanning protein tyrosine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 918	918	Probable tyrosine-protein kinase DDB_G0283397		PRO_0000355146
Regions
	Domain	177 – 445	269	Protein kinase
	Repeat	626 – 667	42	WD 1
	Repeat	684 – 722	39	WD 2
	Repeat	724 – 765	42	WD 3
	Repeat	776 – 820	45	WD 4
	Repeat	823 – 862	40	WD 5
	Nucleotide binding	183 – 191	9	ATP By similarity
	Compositional bias	59 – 67	9	Poly-Asp
	Compositional bias	101 – 104	4	Poly-Asn
	Compositional bias	105 – 111	7	Poly-Gly
	Compositional bias	458 – 472	15	Poly-Ser
	Compositional bias	533 – 548	16	Poly-Asn
	Compositional bias	563 – 586	24	Poly-Asn
	Compositional bias	772 – 775	4	Poly-Ser
	Compositional bias	856 – 868	13	Poly-Asn
Sites
	Active site	307	1	Proton acceptor By similarity
	Binding site	204	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q54R58 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 2E67BA9688A5F45D	FASTA	918	102,616
	10 20 30 40 50 60 MFNNDKDDNN QGNENNENNK INIKTSIDMG NYINSSSLVE SFGSGSNRNN DKSEDVEYDD 70 80 90 100 110 120 DDDDDDDEIA STEEEKESDL DSDSDLAPTQ IIVDDSDDFY NNNNGGGGGG GNEDISSTSP 130 140 150 160 170 180 TLITSNSFND KINQIFSRGG SSLNSSFLNN GENKINFKQL VKLKSTLKKH EIPSRELTVE 190 200 210 220 230 240 KEIGQGFFGK VYKARWRGKS VALKKITLIK FRDLTETEIF DKEVSIMSKL CHPTCVMFIG 250 260 270 280 290 300 ACSLDGPSND RSIIMEYMEG GSLRRLLDEK SSYHLPPSLQ LSIARDIAEG MNYLHTNFKE 310 320 330 340 350 360 GPIVHRDLTS SNILLNSSYT VAKINDFGLS KEMKPGPTEM TAAMGSLAWM APECFKAENY 370 380 390 400 410 420 TEKVDVYSFA IILWEIVTCR DPYNGMEPLR LAFLASVEDY RLPLNGFPPY WVELISKCWN 430 440 450 460 470 480 ITPSLRPSFK EILQILNQIE SDPLFLNLNL NCSSNNTSSG STSTSSGSSS SSDNNLTKSS 490 500 510 520 530 540 ESNNNLRESN INNQIKSNKN SSKNGYYAQD INDYSLSMQV ETKNCIYNNV SDNVNNNNNN 550 560 570 580 590 600 NNNNNNDNDF FKSSFTKKSF LSNNNYNNNN NNINNKNNNT NNLNDNLIIK SLNHISEQNS 610 620 630 640 650 660 FLVSYQDSNI VKYFSLDNES LTSTLQMEQS VVCMKYQIIN EKVFLVVAMS NNNISLFELK 670 680 690 700 710 720 KTDFSGSANS PTTLLPIKVI KCDEQRHTIK DITWNGTHVI TSSFKDSSIQ IWDLEKSLYP 730 740 750 760 770 780 ISKMDNGGVG ILSIDSQSHQ PLMISGDSDG KVKLWDIRNS HCFRTLTHSP PSSSSGGSIG 790 800 810 820 830 840 VDSVLFRSPH AVRDPIILTG SSKDCKFKVW NMYSSTCLNS FQSHNKDLLG IHRNQSSQQM 850 860 870 880 890 900 ITWSSEGTIS LFNSGNNINN QNNQNNNNDC GNDNDSVEFS KVLNVNSMMS NEPLQSAQII 910 SKNRIIFSSK NKFYSIIA

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000055 Genomic DNA. Translation: EAL65683.1.
RefSeq	XP_639033.1. XM_633941.1.
3D structure databases
HSSP	HSSP built from PDB template 2A19 based on UniProtKB P19525.
ProteinModelPortal	Q54R58.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0229872; DDB0229872; DDB_G0283397.
GeneID	8624058.
KEGG	ddi:DDB_G0283397.
Organism-specific databases
dictyBase	DDB_G0283397.
Phylogenomic databases
eggNOG	COG0515.
OMA	AWMAPEC.
Family and domain databases
Gene3D	2.130.10.10. 1 hit.
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR008266. Tyr_kinase_AS. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. [Graphical view]
Pfam	PF07714. Pkinase_Tyr. 1 hit. PF00400. WD40. 1 hit. [Graphical view]
PRINTS	PR00109. TYRKINASE.
SMART	SM00320. WD40. 4 hits. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit. SSF50978. WD40_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS00678. WD_REPEATS_1. 2 hits. PS50082. WD_REPEATS_2. 1 hit. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

YTYK2_DICDI

Accession

Primary (citable) accession number: Q54R58

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 25, 2008
Last sequence update:	May 24, 2005
Last modified:	March 6, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)