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Protein

Probable tyrosine-protein kinase DDB_G0283397

Gene

DDB_G0283397

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei204ATPPROSITE-ProRule annotation1
Active sitei307Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi183 – 191ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable tyrosine-protein kinase DDB_G0283397 (EC:2.7.10.2)
Gene namesi
ORF Names:DDB_G0283397
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 4, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0283397.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003551461 – 918Probable tyrosine-protein kinase DDB_G0283397Add BLAST918

Proteomic databases

PaxDbiQ54R58.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0229872.

Structurei

3D structure databases

ProteinModelPortaliQ54R58.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini177 – 445Protein kinasePROSITE-ProRule annotationAdd BLAST269
Repeati626 – 667WD 1Add BLAST42
Repeati684 – 722WD 2Add BLAST39
Repeati724 – 765WD 3Add BLAST42
Repeati776 – 820WD 4Add BLAST45
Repeati823 – 862WD 5Add BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi59 – 67Poly-Asp9
Compositional biasi101 – 104Poly-Asn4
Compositional biasi105 – 111Poly-Gly7
Compositional biasi458 – 472Poly-SerAdd BLAST15
Compositional biasi533 – 548Poly-AsnAdd BLAST16
Compositional biasi563 – 586Poly-AsnAdd BLAST24
Compositional biasi772 – 775Poly-Ser4
Compositional biasi856 – 868Poly-AsnAdd BLAST13

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 5 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0192. Eukaryota.
COG0515. LUCA.
InParanoidiQ54R58.
OMAiAWMAPEC.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54R58-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFNNDKDDNN QGNENNENNK INIKTSIDMG NYINSSSLVE SFGSGSNRNN
60 70 80 90 100
DKSEDVEYDD DDDDDDDEIA STEEEKESDL DSDSDLAPTQ IIVDDSDDFY
110 120 130 140 150
NNNNGGGGGG GNEDISSTSP TLITSNSFND KINQIFSRGG SSLNSSFLNN
160 170 180 190 200
GENKINFKQL VKLKSTLKKH EIPSRELTVE KEIGQGFFGK VYKARWRGKS
210 220 230 240 250
VALKKITLIK FRDLTETEIF DKEVSIMSKL CHPTCVMFIG ACSLDGPSND
260 270 280 290 300
RSIIMEYMEG GSLRRLLDEK SSYHLPPSLQ LSIARDIAEG MNYLHTNFKE
310 320 330 340 350
GPIVHRDLTS SNILLNSSYT VAKINDFGLS KEMKPGPTEM TAAMGSLAWM
360 370 380 390 400
APECFKAENY TEKVDVYSFA IILWEIVTCR DPYNGMEPLR LAFLASVEDY
410 420 430 440 450
RLPLNGFPPY WVELISKCWN ITPSLRPSFK EILQILNQIE SDPLFLNLNL
460 470 480 490 500
NCSSNNTSSG STSTSSGSSS SSDNNLTKSS ESNNNLRESN INNQIKSNKN
510 520 530 540 550
SSKNGYYAQD INDYSLSMQV ETKNCIYNNV SDNVNNNNNN NNNNNNDNDF
560 570 580 590 600
FKSSFTKKSF LSNNNYNNNN NNINNKNNNT NNLNDNLIIK SLNHISEQNS
610 620 630 640 650
FLVSYQDSNI VKYFSLDNES LTSTLQMEQS VVCMKYQIIN EKVFLVVAMS
660 670 680 690 700
NNNISLFELK KTDFSGSANS PTTLLPIKVI KCDEQRHTIK DITWNGTHVI
710 720 730 740 750
TSSFKDSSIQ IWDLEKSLYP ISKMDNGGVG ILSIDSQSHQ PLMISGDSDG
760 770 780 790 800
KVKLWDIRNS HCFRTLTHSP PSSSSGGSIG VDSVLFRSPH AVRDPIILTG
810 820 830 840 850
SSKDCKFKVW NMYSSTCLNS FQSHNKDLLG IHRNQSSQQM ITWSSEGTIS
860 870 880 890 900
LFNSGNNINN QNNQNNNNDC GNDNDSVEFS KVLNVNSMMS NEPLQSAQII
910
SKNRIIFSSK NKFYSIIA
Length:918
Mass (Da):102,616
Last modified:May 24, 2005 - v1
Checksum:i2E67BA9688A5F45D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000055 Genomic DNA. Translation: EAL65683.1.
RefSeqiXP_639033.1. XM_633941.1.

Genome annotation databases

EnsemblProtistsiEAL65683; EAL65683; DDB_G0283397.
GeneIDi8624058.
KEGGiddi:DDB_G0283397.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000055 Genomic DNA. Translation: EAL65683.1.
RefSeqiXP_639033.1. XM_633941.1.

3D structure databases

ProteinModelPortaliQ54R58.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0229872.

Proteomic databases

PaxDbiQ54R58.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL65683; EAL65683; DDB_G0283397.
GeneIDi8624058.
KEGGiddi:DDB_G0283397.

Organism-specific databases

dictyBaseiDDB_G0283397.

Phylogenomic databases

eggNOGiKOG0192. Eukaryota.
COG0515. LUCA.
InParanoidiQ54R58.
OMAiAWMAPEC.

Miscellaneous databases

PROiQ54R58.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYTYK2_DICDI
AccessioniPrimary (citable) accession number: Q54R58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: May 24, 2005
Last modified: November 2, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.