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Q54R58

- YTYK2_DICDI

UniProt

Q54R58 - YTYK2_DICDI

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Protein
Probable tyrosine-protein kinase DDB_G0283397
Gene
DDB_G0283397
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei204 – 2041ATP By similarity
Active sitei307 – 3071Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi183 – 1919ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable tyrosine-protein kinase DDB_G0283397 (EC:2.7.10.2)
Gene namesi
ORF Names:DDB_G0283397
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 4, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0283397.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 918918Probable tyrosine-protein kinase DDB_G0283397
PRO_0000355146Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ54R58.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini177 – 445269Protein kinase
Add
BLAST
Repeati626 – 66742WD 1
Add
BLAST
Repeati684 – 72239WD 2
Add
BLAST
Repeati724 – 76542WD 3
Add
BLAST
Repeati776 – 82045WD 4
Add
BLAST
Repeati823 – 86240WD 5
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi59 – 679Poly-Asp
Compositional biasi101 – 1044Poly-Asn
Compositional biasi105 – 1117Poly-Gly
Compositional biasi458 – 47215Poly-Ser
Add
BLAST
Compositional biasi533 – 54816Poly-Asn
Add
BLAST
Compositional biasi563 – 58624Poly-Asn
Add
BLAST
Compositional biasi772 – 7754Poly-Ser
Compositional biasi856 – 86813Poly-Asn
Add
BLAST

Sequence similaritiesi

Contains 5 WD repeats.

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG0515.
OMAiAWMAPEC.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00400. WD40. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54R58-1 [UniParc]FASTAAdd to Basket

« Hide

MFNNDKDDNN QGNENNENNK INIKTSIDMG NYINSSSLVE SFGSGSNRNN    50
DKSEDVEYDD DDDDDDDEIA STEEEKESDL DSDSDLAPTQ IIVDDSDDFY 100
NNNNGGGGGG GNEDISSTSP TLITSNSFND KINQIFSRGG SSLNSSFLNN 150
GENKINFKQL VKLKSTLKKH EIPSRELTVE KEIGQGFFGK VYKARWRGKS 200
VALKKITLIK FRDLTETEIF DKEVSIMSKL CHPTCVMFIG ACSLDGPSND 250
RSIIMEYMEG GSLRRLLDEK SSYHLPPSLQ LSIARDIAEG MNYLHTNFKE 300
GPIVHRDLTS SNILLNSSYT VAKINDFGLS KEMKPGPTEM TAAMGSLAWM 350
APECFKAENY TEKVDVYSFA IILWEIVTCR DPYNGMEPLR LAFLASVEDY 400
RLPLNGFPPY WVELISKCWN ITPSLRPSFK EILQILNQIE SDPLFLNLNL 450
NCSSNNTSSG STSTSSGSSS SSDNNLTKSS ESNNNLRESN INNQIKSNKN 500
SSKNGYYAQD INDYSLSMQV ETKNCIYNNV SDNVNNNNNN NNNNNNDNDF 550
FKSSFTKKSF LSNNNYNNNN NNINNKNNNT NNLNDNLIIK SLNHISEQNS 600
FLVSYQDSNI VKYFSLDNES LTSTLQMEQS VVCMKYQIIN EKVFLVVAMS 650
NNNISLFELK KTDFSGSANS PTTLLPIKVI KCDEQRHTIK DITWNGTHVI 700
TSSFKDSSIQ IWDLEKSLYP ISKMDNGGVG ILSIDSQSHQ PLMISGDSDG 750
KVKLWDIRNS HCFRTLTHSP PSSSSGGSIG VDSVLFRSPH AVRDPIILTG 800
SSKDCKFKVW NMYSSTCLNS FQSHNKDLLG IHRNQSSQQM ITWSSEGTIS 850
LFNSGNNINN QNNQNNNNDC GNDNDSVEFS KVLNVNSMMS NEPLQSAQII 900
SKNRIIFSSK NKFYSIIA 918
Length:918
Mass (Da):102,616
Last modified:May 24, 2005 - v1
Checksum:i2E67BA9688A5F45D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000055 Genomic DNA. Translation: EAL65683.1.
RefSeqiXP_639033.1. XM_633941.1.

Genome annotation databases

EnsemblProtistsiDDB0229872; DDB0229872; DDB_G0283397.
GeneIDi8624058.
KEGGiddi:DDB_G0283397.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000055 Genomic DNA. Translation: EAL65683.1 .
RefSeqi XP_639033.1. XM_633941.1.

3D structure databases

ProteinModelPortali Q54R58.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0229872 ; DDB0229872 ; DDB_G0283397 .
GeneIDi 8624058.
KEGGi ddi:DDB_G0283397.

Organism-specific databases

dictyBasei DDB_G0283397.

Phylogenomic databases

eggNOGi COG0515.
OMAi AWMAPEC.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF07714. Pkinase_Tyr. 1 hit.
PF00400. WD40. 1 hit.
[Graphical view ]
PRINTSi PR00109. TYRKINASE.
SMARTi SM00320. WD40. 4 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiYTYK2_DICDI
AccessioniPrimary (citable) accession number: Q54R58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: May 24, 2005
Last modified: May 14, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3