Q54R52 (ABCAA_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ABC transporter A family member 10

Alternative name(s):
ABC transporter ABCA.10

Gene names

Name:	abcA10
ORF Names:	DDB_G0283387

Organism

Dictyostelium discoideum (Slime mold)

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	887 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the ABC transporter superfamily. ABCA family. Contains 1 ABC transporter domain.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of substances Inferred from sequence or structural similarity Ref.1. Source: dictyBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 887	887	ABC transporter A family member 10		PRO_0000363842
Regions
	Transmembrane	38 – 58	21	Helical; Potential
	Transmembrane	198 – 218	21	Helical; Potential
	Transmembrane	245 – 265	21	Helical; Potential
	Transmembrane	277 – 297	21	Helical; Potential
	Transmembrane	309 – 329	21	Helical; Potential
	Transmembrane	335 – 355	21	Helical; Potential
	Transmembrane	376 – 396	21	Helical; Potential
	Domain	481 – 728	248	ABC transporter
	Nucleotide binding	519 – 526	8	ATP Potential
	Compositional bias	24 – 29	6	Poly-Lys
	Compositional bias	173 – 179	7	Poly-Thr
	Compositional bias	429 – 435	7	Poly-Ser
	Compositional bias	440 – 449	10	Poly-Asn
	Compositional bias	451 – 461	11	Poly-Ser
	Compositional bias	774 – 784	11	Poly-Asn
	Compositional bias	788 – 797	10	Poly-Ser
	Compositional bias	806 – 814	9	Poly-Asn
Experimental info
	Sequence conflict	636 – 637	2	RR → KK in AAL85303. Ref.1
	Sequence conflict	641	1	A → P in AAL85303. Ref.1
	Sequence conflict	689	1	D → N in AAL85303. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q54R52 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 279A4D56D06A86EF	FASTA	887	99,603
	10 20 30 40 50 60 MTNNCKITFK NQLKALLGKA ILLKKKKRKE TITEFTQGIQ YIIVLVILHY TIPNVITLNT 70 80 90 100 110 120 YSPVGLGYPT SGFPLCYVSN VPFNQTSNLH LLLNSTQLPI SQIVQFPNEQ SLIDSYKSNP 130 140 150 160 170 180 QSITYGISFN NIDYQNNILD YNILLNSTFQ NTQLISIVQN LFLSTFAEIK GITTTTTTTL 190 200 210 220 230 240 SSIEEFPNLT SSVSVSSYLY VIYLPLLFLF SLQQLLVTSV TERKNHIKEV MKVMGLKELV 250 260 270 280 290 300 YWVTIIIVQT ITNVINILLV MVVLYFTKTL TTSLNPVMLF LQFLLYSFSM VAIGIILSNL 310 320 330 340 350 360 VDTPKTASAI SSFLLLILVG VSCFYQFYLK SKTSSSWLRS ILFLFSPCAF GEFLYKMGND 370 380 390 400 410 420 QQMMLTTNWS DPQVKISFLF LIIDIFLYFT IAWYITELYK DNTDENSITK SFTFFLSLSY 430 440 450 460 470 480 WKSIFNLRSS SSSSSLPLLN NNNNCNNNNT SPSSSSSSQS SPLNKPLLSG DSDDDENDIG 490 500 510 520 530 540 IRLVNLKKTY KNPITKETVN AVNDVSYTIK KGTILALLGQ NGSGKTSTIG MLNGMRSPSS 550 560 570 580 590 600 GDAFINGLSI KYDMDKIREN GIGLCHQSNI LYDEFTCAEH IALYSRLKGL FVDGGGANGD 610 620 630 640 650 660 NKRIMMDNFI MESLGEVNLV DKKDTQSIKL SGGMKRRLCL AISLIGNPSI LLLDEPSSGL 670 680 690 700 710 720 DSLSQHMICE LLQRKKPNKT IILTTHNLDS AELLGDKICI MTSGKVKAMG SSLELKNQFN 730 740 750 760 770 780 LGYILTIVYD KSLSLLQPPN INQQFESFFF NKFNDSTQSK QNLKNIQSFY NIFNNNNNEN 790 800 810 820 830 840 NSNNSDGSSS SSDSSSSKDV LLNIKNNNNN NNNNEERGFS SGQRDLELEY SLTHQSTDVI 850 860 870 880 TEFLEELESR QDEFKIKRIS MSMTTLDEVF LKVSEEETIN KNKQPTS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Evolutionary analyses of ABC transporters of Dictyostelium discoideum." Anjard C., Loomis W.F. Eukaryot. Cell 1:643-652(2002) [PubMed: 12456012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], NOMENCLATURE. Strain: AX4.
[2]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF465312 Genomic DNA. Translation: AAL85303.1. AAFI02000055 Genomic DNA. Translation: EAL65678.1.
RefSeq	XP_639039.1. XM_633947.1.
3D structure databases
ProteinModelPortal	Q54R52.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0191529; DDB0191529; DDB_G0283387.
GeneID	8624064.
GenomeReviews	Gene locus abcA10 in contig CM000153_GR.
KEGG	ddi:DDB_G0283387.
Organism-specific databases
dictyBase	DDB_G0283387. abcA10.
Phylogenomic databases
eggNOG	KOG0059.
GeneTree	EPrGT00050000002981.
InParanoid	Q54R52.
Family and domain databases
InterPro	IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR003593. ATPase_AAA+_core. [Graphical view]
KO	K01990.
Pfam	PF00005. ABC_tran. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
PROSITE	PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ABCAA_DICDI

Accession

Primary (citable) accession number: Q54R52
Secondary accession number(s): Q8T6I7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	May 24, 2005
Last modified:	November 16, 2011
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)