Reviewed, UniProtKB/Swiss-Prot Q54R47 (GCDH_DICDI)

Names and origin

Protein names

Recommended name:
    Glutaryl-CoA dehydrogenase, mitochondrial
      Short name=GCD
    EC=1.3.99.7

Gene names

Name:	gcdh
ORF Names:	DDB_G0283411

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	420 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor.
Cofactor	FAD By similarity.
Pathway	Amino-acid metabolism; lysine degradation. Amino-acid metabolism; tryptophan metabolism.
Subcellular location	Mitochondrion matrix Potential.
Sequence similarities	Belongs to the acyl-CoA dehydrogenase family.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro electron carrier activity Inferred from electronic annotation. Source: InterPro glutaryl-CoA dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion Potential
	Chain	? – 420		Glutaryl-CoA dehydrogenase, mitochondrial		PRO_0000330829
Regions
	Nucleotide binding	164 – 167	4	FAD By similarity
	Nucleotide binding	198 – 200	3	FAD By similarity
	Region	125 – 126	2	Substrate binding By similarity
	Region	273 – 277	5	Substrate binding By similarity
Sites
	Active site	400	1	Proton acceptor By similarity
	Binding site	173	1	FAD By similarity
	Binding site	173	1	Substrate; via carbonyl oxygen By similarity
	Binding site	280	1	Substrate By similarity
	Binding site	402	1	FAD By similarity
	Binding site	420	1	FAD; via carboxyl oxygen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q54R47-1 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 659A877F3251AF6E	FASTA	420	45,875
	10 20 30 40 50 60 MLSNLSKSLL SKGKFINKNN LLKNKRSFGT IVPGDKFEWN DPLSLESLLT EEEVMIRDQV 70 80 90 100 110 120 NKFCQDELMP RIQMAYRDEK FDREIMREYG KMGMLGATIP AYGGVSHVAY GLMANAVEKV 130 140 150 160 170 180 DSGYRSAMSV QSSLVMHPIN TFGTDAQKSK YLDGLASGDL VGCFGLTEPN AGSDPAGMQT 190 200 210 220 230 240 RAVKNSAGNY VLNGTKTWIT NSPIADVFVV WAKVENGDIR GFVLEKGMKG LSAPKIEGKL 250 260 270 280 290 300 SLRASITGMI VMEDVEVPPT AMFPEVKGLR GPFSCLNKAR YGIGWGSLGA AEFCYSTARQ 310 320 330 340 350 360 YGLDRKQFGK PLAANQLYQK KLADMATEIS LGLQACYQVG RLIDAGKATP ERISLIKRNS 370 380 390 400 410 420 CGKSLDIARQ SRDMLGGNGI ADEYHVIRHA ANLETVNTYE GTHDIHALIL GRAITGIPSF

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AAFI02000055 Genomic DNA. Translation: EAL65690.1.
RefSeq	XP_639044.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3390655.
KEGG	ddi:DDB_0234151.
Organism-specific databases
dictyBase	DDB_G0283411. gcdh.
Phylogenomic databases
OMA	Q54R47. CFETARE.
Family and domain databases
InterPro	IPR006089. Acyl-CoA_DH_CS. IPR006092. Acyl-CoA_DH_N. IPR006090. Acyl-CoA_Oxase/DH_1. IPR006091. Acyl-CoA_Oxase/DH_M. IPR013786. AcylCoA_DH/ox_N. IPR013764. AcylCoA_oxidase/DH_1/2_C. [Graphical view]
Gene3D	G3DSA:2.40.110.10. Acyl_CoA_DH/ox_M. 1 hit. G3DSA:1.10.540.10. AcylCoA_DH/ox_N. 1 hit. G3DSA:1.20.140.10. AcylCoA_DH_1/2_C. 1 hit.
Pfam	PF00441. Acyl-CoA_dh_1. 1 hit. PF02770. Acyl-CoA_dh_M. 1 hit. PF02771. Acyl-CoA_dh_N. 1 hit. [Graphical view]
PROSITE	PS00072. ACYL_COA_DH_1. 1 hit. PS00073. ACYL_COA_DH_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCDH_DICDI

Accession

Primary (citable) accession number: Q54R47

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	May 24, 2005
Last modified:	June 16, 2009
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)