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Protein

Probable dual specificity protein phosphatase DDB_G0283417

Gene

DDB_G0283417

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Has a dual specificity toward Ser/Thr and Tyr-containing proteins.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei174Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dual specificity protein phosphatase DDB_G0283417 (EC:3.1.3.16, EC:3.1.3.48)
Gene namesi
ORF Names:DDB_G0283417
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 4, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0283417.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003329511 – 230Probable dual specificity protein phosphatase DDB_G0283417Add BLAST230

Proteomic databases

PaxDbiQ54R42.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0238562.

Structurei

3D structure databases

ProteinModelPortaliQ54R42.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini78 – 229Tyrosine-protein phosphataseAdd BLAST152

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi75 – 80Poly-Asn6

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1716. Eukaryota.
COG2453. LUCA.
InParanoidiQ54R42.
OMAiRYQVANI.
PhylomeDBiQ54R42.

Family and domain databases

CDDicd00127. DSPc. 1 hit.
Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54R42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNLEELSLK RNNMKRTETT FTDISGKRYQ VANINEENSE SNRIELNRTS
60 70 80 90 100
GFVIDTKPDD LSHKIEIIIP QSILNNNNNN YESINLYIGS QDAAFNKLDL
110 120 130 140 150
QLKNIKSILN VGIGINNLFT KENSDINDGF IINYCNVEIF DDVNFNIIEK
160 170 180 190 200
FDKCFEFIDS NIGGVENNGI LVHCNAGVSR SATILISYLM KKLKIPLSLS
210 220 230
LEILKSSRPQ CKPNQGFLKQ LEIFEKELLF
Length:230
Mass (Da):26,189
Last modified:May 24, 2005 - v1
Checksum:i1BD80BC8D911F2AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000055 Genomic DNA. Translation: EAL65693.1.
RefSeqiXP_639049.1. XM_633957.1.

Genome annotation databases

EnsemblProtistsiEAL65693; EAL65693; DDB_G0283417.
GeneIDi8624074.
KEGGiddi:DDB_G0283417.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000055 Genomic DNA. Translation: EAL65693.1.
RefSeqiXP_639049.1. XM_633957.1.

3D structure databases

ProteinModelPortaliQ54R42.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0238562.

Proteomic databases

PaxDbiQ54R42.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL65693; EAL65693; DDB_G0283417.
GeneIDi8624074.
KEGGiddi:DDB_G0283417.

Organism-specific databases

dictyBaseiDDB_G0283417.

Phylogenomic databases

eggNOGiKOG1716. Eukaryota.
COG2453. LUCA.
InParanoidiQ54R42.
OMAiRYQVANI.
PhylomeDBiQ54R42.

Miscellaneous databases

PROiQ54R42.

Family and domain databases

CDDicd00127. DSPc. 1 hit.
Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDUSP2_DICDI
AccessioniPrimary (citable) accession number: Q54R42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: November 30, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.