Q54QV7 (GSTA5_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative glutathione S-transferase alpha-5
EC=2.5.1.18

Alternative name(s):
GST class-alpha 5

Gene names

Name:	gsta5
ORF Names:	DDB_G0283575

Organism

Dictyostelium discoideum (Slime mold) [Reference proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	198 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles By similarity.
Catalytic activity	RX + glutathione = HX + R-S-glutathione.
Sequence similarities	Belongs to the GST superfamily. Alpha family. Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.

Ontologies

Keywords
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	glutathione transferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 198	198	Putative glutathione S-transferase alpha-5		PRO_0000350742
Regions
	Domain	2 – 78	77	GST N-terminal
	Domain	80 – 198	119	GST C-terminal
	Region	49 – 50	2	Glutathione binding By similarity
	Region	62 – 63	2	Glutathione binding By similarity
Sites
	Binding site	8	1	Glutathione By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q54QV7 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: A5B154C82270C654	FASTA	198	23,298
	10 20 30 40 50 60 MTKPTLTYFP VRGRVQFPRC LLEYLGEEYN FNEVKTISDD LRKQLLFKQL PLYQEGDFKI 70 80 90 100 110 120 VQTPAIIDYI SEKHDFRGKT KEERARAHQC LAGIMEVLDH CLGYSFKMDK QQQEKFRNES 130 140 150 160 170 180 PIKKFFEGFE MVLSQNKYLA SGEKETYVDL MAFVMVDYVT NLGLMPSGDY PKLISLKKHY 190 ESSPQLKKYL ESRPQSNF

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

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Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000055 Genomic DNA. Translation: EAL65665.1.
RefSeq	XP_639027.1. XM_633935.1.
3D structure databases
HSSP	HSSP built from PDB template 1K3O based on UniProtKB P08263.
ProteinModelPortal	Q54QV7.
ModBase	Search...
Protein-protein interaction databases
STRING	44689.DDB_0231408.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0231408; DDB0231408; DDB_G0283575.
GeneID	8624155.
KEGG	ddi:DDB_G0283575.
Organism-specific databases
dictyBase	DDB_G0283575.
Phylogenomic databases
eggNOG	KOG1695.
KO	K00799.
OMA	LRYLLEY.
ProtClustDB	CLSZ2430358.
Family and domain databases
Gene3D	1.20.1050.10. 1 hit. 3.40.30.10. 1 hit.
InterPro	IPR010987. Glutathione-S-Trfase_C-like. IPR004045. Glutathione_S-Trfase_N. IPR017933. Glutathione_S_Trfase/Cl_chnl_C. IPR004046. GST_C. IPR012336. Thioredoxin-like_fold. [Graphical view]
Pfam	PF00043. GST_C. 1 hit. PF02798. GST_N. 1 hit. [Graphical view]
SUPFAM	SSF47616. GST_C_like. 1 hit. SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS50405. GST_CTER. 1 hit. PS50404. GST_NTER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GSTA5_DICDI

Accession

Primary (citable) accession number: Q54QV7

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 23, 2008
Last sequence update:	May 24, 2005
Last modified:	May 1, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)