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Q54QR2

- PSB7_DICDI

UniProt

Q54QR2 - PSB7_DICDI

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Protein
Proteasome subunit beta type-7
Gene
psmB7, DDB_G0283679
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity By similarity.

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei35 – 351Nucleophile Inferred

GO - Molecular functioni

  1. threonine-type endopeptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. proteolysis Source: dictyBase
  2. proteolysis involved in cellular protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiREACT_204617. Antigen processing: Ubiquitination & Proteasome degradation.
REACT_210566. AUF1 (hnRNP D0) destabilizes mRNA.
REACT_212010. Regulation of activated PAK-2p34 by proteasome mediated degradation.
REACT_214682. Cross-presentation of soluble exogenous antigens (endosomes).
REACT_217211. ER-Phagosome pathway.
REACT_217636. Autodegradation of the E3 ubiquitin ligase COP1.
REACT_221036. Separation of Sister Chromatids.
REACT_225025. APC/C:Cdc20 mediated degradation of Securin.
REACT_226311. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
REACT_226712. Autodegradation of Cdh1 by Cdh1:APC/C.
REACT_95813. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.

Protein family/group databases

MEROPSiT01.011.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit beta type-7 (EC:3.4.25.1)
Gene namesi
Name:psmB7
ORF Names:DDB_G0283679
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 4, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0283679. psmB7.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: dictyBase
  2. nucleus Source: dictyBase
  3. proteasome core complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 3434Removed in mature form By similarity
PRO_0000328484Add
BLAST
Chaini35 – 266232Proteasome subunit beta type-7
PRO_0000328483Add
BLAST

Proteomic databases

PRIDEiQ54QR2.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.

Protein-protein interaction databases

STRINGi44689.DDB_0232933.

Structurei

3D structure databases

ProteinModelPortaliQ54QR2.
SMRiQ54QR2. Positions 35-253.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.

Phylogenomic databases

eggNOGiCOG0638.
KOiK02739.
OMAiQIWCAGA.
PhylomeDBiQ54QR2.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR000243. Pept_T1A_subB.
IPR024689. Proteasome_bsu_C.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamiPF12465. Pr_beta_C. 1 hit.
PF00227. Proteasome. 1 hit.
[Graphical view]
PRINTSiPR00141. PROTEASOME.
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q54QR2-1 [UniParc]FASTAAdd to Basket

« Hide

MENLNRGGFD FDLCNRNNVL EKTGLRMKGF MKTGTTIVGV VYKGGVVLGA    50
DTRATEGPIV ADKNCEKIHY IADNIYCCGA GTAADTESAT ALISSKLKLH 100
KLSTGKQTRV ITALTMLKQM LFKYQGHISA ALILGGIDIN GPSLHTIYPH 150
GSTDQLPYVT MGSGSLAAMA VFEAKYKNDM TKEEAIALVA EAISSGIFND 200
LGSGSNVDVT VIEPSGVTVL RNYQTPNERK FRNNPYIFKQ GTTPVLKQDI 250
APLSTKVVIE DIMMGQ 266
Length:266
Mass (Da):28,659
Last modified:May 24, 2005 - v1
Checksum:iC89700F94FF61842
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000056 Genomic DNA. Translation: EAL65606.1.
RefSeqiXP_638961.1. XM_633869.1.

Genome annotation databases

EnsemblProtistsiDDB0232933; DDB0232933; DDB_G0283679.
GeneIDi8624207.
KEGGiddi:DDB_G0283679.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000056 Genomic DNA. Translation: EAL65606.1 .
RefSeqi XP_638961.1. XM_633869.1.

3D structure databases

ProteinModelPortali Q54QR2.
SMRi Q54QR2. Positions 35-253.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0232933.

Protein family/group databases

MEROPSi T01.011.

Proteomic databases

PRIDEi Q54QR2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0232933 ; DDB0232933 ; DDB_G0283679 .
GeneIDi 8624207.
KEGGi ddi:DDB_G0283679.

Organism-specific databases

dictyBasei DDB_G0283679. psmB7.

Phylogenomic databases

eggNOGi COG0638.
KOi K02739.
OMAi QIWCAGA.
PhylomeDBi Q54QR2.

Enzyme and pathway databases

Reactomei REACT_204617. Antigen processing: Ubiquitination & Proteasome degradation.
REACT_210566. AUF1 (hnRNP D0) destabilizes mRNA.
REACT_212010. Regulation of activated PAK-2p34 by proteasome mediated degradation.
REACT_214682. Cross-presentation of soluble exogenous antigens (endosomes).
REACT_217211. ER-Phagosome pathway.
REACT_217636. Autodegradation of the E3 ubiquitin ligase COP1.
REACT_221036. Separation of Sister Chromatids.
REACT_225025. APC/C:Cdc20 mediated degradation of Securin.
REACT_226311. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
REACT_226712. Autodegradation of Cdh1 by Cdh1:APC/C.
REACT_95813. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.

Miscellaneous databases

PROi Q54QR2.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
InterProi IPR029055. Ntn_hydrolases_N.
IPR000243. Pept_T1A_subB.
IPR024689. Proteasome_bsu_C.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view ]
Pfami PF12465. Pr_beta_C. 1 hit.
PF00227. Proteasome. 1 hit.
[Graphical view ]
PRINTSi PR00141. PROTEASOME.
SUPFAMi SSF56235. SSF56235. 1 hit.
PROSITEi PS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiPSB7_DICDI
AccessioniPrimary (citable) accession number: Q54QR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: September 3, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi