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Q54QR2 (PSB7_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proteasome subunit beta type-7

EC=3.4.25.1
Gene names
Name:psmB7
ORF Names:DDB_G0283679
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length266 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity By similarity.

Catalytic activity

Cleavage of peptide bonds with very broad specificity.

Subunit structure

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the peptidase T1B family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Propeptide1 – 3434Removed in mature form By similarity
PRO_0000328484
Chain35 – 266232Proteasome subunit beta type-7
PRO_0000328483

Sites

Active site351Nucleophile Probable

Sequences

Sequence LengthMass (Da)Tools
Q54QR2 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: C89700F94FF61842

FASTA26628,659
        10         20         30         40         50         60 
MENLNRGGFD FDLCNRNNVL EKTGLRMKGF MKTGTTIVGV VYKGGVVLGA DTRATEGPIV 

        70         80         90        100        110        120 
ADKNCEKIHY IADNIYCCGA GTAADTESAT ALISSKLKLH KLSTGKQTRV ITALTMLKQM 

       130        140        150        160        170        180 
LFKYQGHISA ALILGGIDIN GPSLHTIYPH GSTDQLPYVT MGSGSLAAMA VFEAKYKNDM 

       190        200        210        220        230        240 
TKEEAIALVA EAISSGIFND LGSGSNVDVT VIEPSGVTVL RNYQTPNERK FRNNPYIFKQ 

       250        260 
GTTPVLKQDI APLSTKVVIE DIMMGQ 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000056 Genomic DNA. Translation: EAL65606.1.
RefSeqXP_638961.1. XM_633869.1.

3D structure databases

ProteinModelPortalQ54QR2.
SMRQ54QR2. Positions 35-253.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDB_0232933.

Protein family/group databases

MEROPST01.011.

Proteomic databases

PRIDEQ54QR2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0232933; DDB0232933; DDB_G0283679.
GeneID8624207.
KEGGddi:DDB_G0283679.

Organism-specific databases

dictyBaseDDB_G0283679. psmB7.

Phylogenomic databases

eggNOGCOG0638.
OMAQIWCAGA.
PhylomeDBQ54QR2.

Family and domain databases

Gene3D3.60.20.10. 1 hit.
InterProIPR029055. Ntn_hydrolases_N.
IPR000243. Pept_T1A_subB.
IPR024689. Proteasome_bsu_C.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamPF12465. Pr_beta_C. 1 hit.
PF00227. Proteasome. 1 hit.
[Graphical view]
PRINTSPR00141. PROTEASOME.
SUPFAMSSF56235. SSF56235. 1 hit.
PROSITEPS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ54QR2.

Entry information

Entry namePSB7_DICDI
AccessionPrimary (citable) accession number: Q54QR2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: July 9, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase