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Protein

Mitochondrial substrate carrier family protein M

Gene

mcfM

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. Transports folate across the inner membranes of mitochondria (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-DDI-196757. Metabolism of folate and pterines.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial substrate carrier family protein M
Alternative name(s):
Solute carrier family 25 member 32 homolog
Gene namesi
Name:mcfM
Synonyms:slc25a32
ORF Names:DDB_G0283751
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 4, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0283751. mcfM.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010Mitochondrial intermembraneBy similarity
Transmembranei11 – 3121Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini32 – 7241Mitochondrial matrixBy similarityAdd
BLAST
Transmembranei73 – 8917Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini90 – 11324Mitochondrial intermembraneBy similarityAdd
BLAST
Transmembranei114 – 13421Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini135 – 16329Mitochondrial matrixBy similarityAdd
BLAST
Transmembranei164 – 18421Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini185 – 21127Mitochondrial intermembraneBy similarityAdd
BLAST
Transmembranei212 – 23221Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini233 – 27846Mitochondrial matrixBy similarityAdd
BLAST
Transmembranei279 – 29618Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini297 – 30610Mitochondrial intermembraneBy similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306Mitochondrial substrate carrier family protein MPRO_0000385533Add
BLAST

Proteomic databases

PaxDbiQ54QN2.
PRIDEiQ54QN2.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0237607.

Structurei

3D structure databases

ProteinModelPortaliQ54QN2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati5 – 9894Solcar 1Add
BLAST
Repeati108 – 19588Solcar 2Add
BLAST
Repeati207 – 29993Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0764. Eukaryota.
ENOG410XPAJ. LUCA.
InParanoidiQ54QN2.
KOiK15115.
OMAiVIKTRMC.
PhylomeDBiQ54QN2.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54QN2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYILNNNVE GTSALLGSTV ATAFLQPFDF LKIRLQGSGF ASGGDLNKFK
60 70 80 90 100
RVGVIDTCKN VLKNEGIKQF WRGSSPTIVA SGIAWGTYMH FYEAYKNILK
110 120 130 140 150
SKYNVTQLNT FDHFICAVGA SATQVFITNP IFLIKTRMQL QTPGSANYYT
160 170 180 190 200
GIFDGIKKTV KVEGFKGLYK GVIPSLWLTF HGGIQMSSYE HIKFYFSSNS
210 220 230 240 250
GKSLDSLNAS EIFIASSISK FLASTILYPF QVVKTRLQDE RNIPNQNNVR
260 270 280 290 300
VYNGTKDVIF KILKNEGIIG FYRGLVPNTL KVIPNTSITL LLYEEIKKSF

NYIINE
Length:306
Mass (Da):34,343
Last modified:May 24, 2005 - v1
Checksum:iB728874AA7D85146
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000056 Genomic DNA. Translation: EAL65642.1.
RefSeqiXP_638991.1. XM_633899.1.

Genome annotation databases

EnsemblProtistsiDDB0237607; DDB0237607; DDB_G0283751.
GeneIDi8624237.
KEGGiddi:DDB_G0283751.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000056 Genomic DNA. Translation: EAL65642.1.
RefSeqiXP_638991.1. XM_633899.1.

3D structure databases

ProteinModelPortaliQ54QN2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0237607.

Proteomic databases

PaxDbiQ54QN2.
PRIDEiQ54QN2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0237607; DDB0237607; DDB_G0283751.
GeneIDi8624237.
KEGGiddi:DDB_G0283751.

Organism-specific databases

dictyBaseiDDB_G0283751. mcfM.

Phylogenomic databases

eggNOGiKOG0764. Eukaryota.
ENOG410XPAJ. LUCA.
InParanoidiQ54QN2.
KOiK15115.
OMAiVIKTRMC.
PhylomeDBiQ54QN2.

Enzyme and pathway databases

ReactomeiR-DDI-196757. Metabolism of folate and pterines.

Miscellaneous databases

PROiQ54QN2.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "Mitochondrial carrier family: repertoire and peculiarities of the cellular slime mould Dictyostelium discoideum."
    Satre M., Mattei S., Aubry L., Gaudet P., Pelosi L., Brandolin G., Klein G.
    Biochimie 89:1058-1069(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiMCFM_DICDI
AccessioniPrimary (citable) accession number: Q54QN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 13, 2009
Last sequence update: May 24, 2005
Last modified: July 6, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.