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Protein

Mitochondrial substrate carrier family protein R

Gene

mcfR

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May be involved in the accumulation of coenzyme A in the mitochondrial matrix (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-DDI-196783. Coenzyme A biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial substrate carrier family protein R
Alternative name(s):
Solute carrier family 25 member 16 homolog B
Gene namesi
Name:mcfR
Synonyms:slc25a16B
ORF Names:DDB_G0283811
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 4, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0283811. mcfR.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 32Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei64 – 84Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei104 – 124Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei185 – 205Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei226 – 246Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei290 – 310Helical; Name=6Sequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003294301 – 326Mitochondrial substrate carrier family protein RAdd BLAST326

Proteomic databases

PaxDbiQ54QI8.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0234096.

Structurei

3D structure databases

ProteinModelPortaliQ54QI8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati9 – 95Solcar 1Add BLAST87
Repeati101 – 214Solcar 2Add BLAST114
Repeati226 – 318Solcar 3Add BLAST93

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0752. Eukaryota.
ENOG410ZRF1. LUCA.
InParanoidiQ54QI8.
KOiK15084.
OMAiRRAEFHG.
PhylomeDBiQ54QI8.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiView protein in InterPro
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
PfamiView protein in Pfam
PF00153. Mito_carr. 3 hits.
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 2 hits.
PROSITEiView protein in PROSITE
PS50920. SOLCAR. 3 hits.

Sequencei

Sequence statusi: Complete.

Q54QI8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVHGNTKTS PMVTLLAGGV SGVIAKSTIA PLERVKILYQ VKSKMYSFNS
60 70 80 90 100
VYGLMKNIIK NEGLAGLWKG NTATILRIFP YSAIQWTSYD YLKNNFVTDK
110 120 130 140 150
KSSVQIFIAG SLGFSCAILL TYPLDVIRAR LALSYSNNNN NNSINSKNLN
160 170 180 190 200
SSTQPPKVLK NGIGAVNIEK SIDFNGYKTK GLFKGIWRGI LPTLYGSIPY
210 220 230 240 250
AGVGYSSFEY FKRIAPDSFR NEKGDVIGIY KLISGGVAGG LGQTAAYPLD
260 270 280 290 300
VVRRRIQTTG YGDGKGVENL KHSTLKTMFT IFQKEGIYAL FKGISINYIK
310 320
VIPTNGVAFL TYETLCDYFN SKLNKN
Length:326
Mass (Da):35,861
Last modified:May 24, 2005 - v1
Checksum:i8B2A96B7A147C77A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000057 Genomic DNA. Translation: EAL65520.1.
RefSeqiXP_638883.1. XM_633791.1.

Genome annotation databases

EnsemblProtistsiEAL65520; EAL65520; DDB_G0283811.
GeneIDi8624281.
KEGGiddi:DDB_G0283811.

Entry informationi

Entry nameiMCFR_DICDI
AccessioniPrimary (citable) accession number: Q54QI8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: September 27, 2017
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families