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Q54QI4

- HGD_DICDI

UniProt

Q54QI4 - HGD_DICDI

Protein

Homogentisate 1,2-dioxygenase

Gene

hgd

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Homogentisate + O2 = 4-maleylacetoacetate.

    Cofactori

    Iron.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi333 – 3331IronBy similarity
    Metal bindingi339 – 3391IronBy similarity
    Metal bindingi369 – 3691IronBy similarity

    GO - Molecular functioni

    1. homogentisate 1,2-dioxygenase activity Source: dictyBase
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. L-phenylalanine catabolic process Source: dictyBase
    2. tyrosine catabolic process Source: dictyBase

    Keywords - Molecular functioni

    Dioxygenase, Oxidoreductase

    Keywords - Biological processi

    Phenylalanine catabolism, Tyrosine catabolism

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00139; UER00339.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homogentisate 1,2-dioxygenase (EC:1.13.11.5)
    Alternative name(s):
    Homogentisate oxygenase
    Homogentisic acid oxidase
    Homogentisicase
    Gene namesi
    Name:hgd
    Synonyms:hgo
    ORF Names:DDB_G0283765
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 4, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0283765. hgd.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 432432Homogentisate 1,2-dioxygenasePRO_0000312407Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi44689.DDB_0191461.

    Structurei

    3D structure databases

    ProteinModelPortaliQ54QI4.
    SMRiQ54QI4. Positions 7-412.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the homogentisate dioxygenase family.Curated

    Phylogenomic databases

    eggNOGiCOG3508.
    KOiK00451.
    OMAiRCFYNSD.
    PhylomeDBiQ54QI4.

    Family and domain databases

    Gene3Di2.60.120.10. 2 hits.
    InterProiIPR005708. Homogentis_dOase.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view]
    PANTHERiPTHR11056. PTHR11056. 1 hit.
    PfamiPF04209. HgmA. 1 hit.
    [Graphical view]
    SUPFAMiSSF51182. SSF51182. 1 hit.
    TIGRFAMsiTIGR01015. hmgA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q54QI4-1 [UniParc]FASTAAdd to Basket

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    MALEQIDYEY QSGFGNSFES EAIKGTLPKG RNAPQNCPLD LYAEQLSGNA    50
    FTAPRHTQQR SWLYRIRPSV CHTPLKPIDS GLVCDLNNLH VDPNQLRWKP 100
    FPITEDKPHD FVEGLITIAG AGHASVRHGL AIHIYTATKS MENKSFYNSD 150
    GDFLIVPQQG TLDIQTEFGF MKVKSGEICV IQRGITFSVN VEGPTRGYIC 200
    EVFGSHFKLP DLGPIGANGL ANPRDFLSPV AAYEKKEGIE HTKINKFLGK 250
    LFSATQTYSP FNVVAWHGNY CPYKYDLSLF CVVNSVSFDH LDPSIFTVLT 300
    APTNEVGVAA ADFVIFPPRW LVQENTFRPP YFHRNCMSEF MGLIRGVYEA 350
    KKEGFLPGGG SLHSCMTPHG PDSDTFYAAI KAELKPTKIP DVALAFMFES 400
    SLILGISDYA KKNFIDDDYW KCWQGLKDNS KI 432
    Length:432
    Mass (Da):48,234
    Last modified:May 24, 2005 - v1
    Checksum:iF704C3DCA58CAC53
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti2 – 43ALE → TRP in AAG17115. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000057 Genomic DNA. Translation: EAL65497.1.
    AF189237 mRNA. Translation: AAG17115.1.
    RefSeqiXP_638887.1. XM_633795.1.

    Genome annotation databases

    EnsemblProtistsiDDB0191461; DDB0191461; DDB_G0283765.
    GeneIDi8624285.
    KEGGiddi:DDB_G0283765.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000057 Genomic DNA. Translation: EAL65497.1 .
    AF189237 mRNA. Translation: AAG17115.1 .
    RefSeqi XP_638887.1. XM_633795.1.

    3D structure databases

    ProteinModelPortali Q54QI4.
    SMRi Q54QI4. Positions 7-412.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDB_0191461.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0191461 ; DDB0191461 ; DDB_G0283765 .
    GeneIDi 8624285.
    KEGGi ddi:DDB_G0283765.

    Organism-specific databases

    dictyBasei DDB_G0283765. hgd.

    Phylogenomic databases

    eggNOGi COG3508.
    KOi K00451.
    OMAi RCFYNSD.
    PhylomeDBi Q54QI4.

    Enzyme and pathway databases

    UniPathwayi UPA00139 ; UER00339 .

    Miscellaneous databases

    PROi Q54QI4.

    Family and domain databases

    Gene3Di 2.60.120.10. 2 hits.
    InterProi IPR005708. Homogentis_dOase.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view ]
    PANTHERi PTHR11056. PTHR11056. 1 hit.
    Pfami PF04209. HgmA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51182. SSF51182. 1 hit.
    TIGRFAMsi TIGR01015. hmgA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.
    2. "Identification of HGO homologs in different organisms."
      Schmidt S.R.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-432.

    Entry informationi

    Entry nameiHGD_DICDI
    AccessioniPrimary (citable) accession number: Q54QI4
    Secondary accession number(s): Q9GU65
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3