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Q54QI4

- HGD_DICDI

UniProt

Q54QI4 - HGD_DICDI

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Protein

Homogentisate 1,2-dioxygenase

Gene

hgd

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Homogentisate + O2 = 4-maleylacetoacetate.

Cofactori

Fe cationBy similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi333 – 3331IronBy similarity
Metal bindingi339 – 3391IronBy similarity
Metal bindingi369 – 3691IronBy similarity

GO - Molecular functioni

  1. homogentisate 1,2-dioxygenase activity Source: dictyBase
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. L-phenylalanine catabolic process Source: dictyBase
  2. tyrosine catabolic process Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Phenylalanine catabolism, Tyrosine catabolism

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00139; UER00339.

Names & Taxonomyi

Protein namesi
Recommended name:
Homogentisate 1,2-dioxygenase (EC:1.13.11.5)
Alternative name(s):
Homogentisate oxygenase
Homogentisic acid oxidase
Homogentisicase
Gene namesi
Name:hgd
Synonyms:hgo
ORF Names:DDB_G0283765
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 4, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0283765. hgd.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 432432Homogentisate 1,2-dioxygenasePRO_0000312407Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0191461.

Structurei

3D structure databases

ProteinModelPortaliQ54QI4.
SMRiQ54QI4. Positions 7-412.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the homogentisate dioxygenase family.Curated

Phylogenomic databases

eggNOGiCOG3508.
InParanoidiQ54QI4.
KOiK00451.
OMAiRCFYNSD.
PhylomeDBiQ54QI4.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
InterProiIPR005708. Homogentis_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR11056. PTHR11056. 1 hit.
PfamiPF04209. HgmA. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR01015. hmgA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q54QI4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALEQIDYEY QSGFGNSFES EAIKGTLPKG RNAPQNCPLD LYAEQLSGNA
60 70 80 90 100
FTAPRHTQQR SWLYRIRPSV CHTPLKPIDS GLVCDLNNLH VDPNQLRWKP
110 120 130 140 150
FPITEDKPHD FVEGLITIAG AGHASVRHGL AIHIYTATKS MENKSFYNSD
160 170 180 190 200
GDFLIVPQQG TLDIQTEFGF MKVKSGEICV IQRGITFSVN VEGPTRGYIC
210 220 230 240 250
EVFGSHFKLP DLGPIGANGL ANPRDFLSPV AAYEKKEGIE HTKINKFLGK
260 270 280 290 300
LFSATQTYSP FNVVAWHGNY CPYKYDLSLF CVVNSVSFDH LDPSIFTVLT
310 320 330 340 350
APTNEVGVAA ADFVIFPPRW LVQENTFRPP YFHRNCMSEF MGLIRGVYEA
360 370 380 390 400
KKEGFLPGGG SLHSCMTPHG PDSDTFYAAI KAELKPTKIP DVALAFMFES
410 420 430
SLILGISDYA KKNFIDDDYW KCWQGLKDNS KI
Length:432
Mass (Da):48,234
Last modified:May 24, 2005 - v1
Checksum:iF704C3DCA58CAC53
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 43ALE → TRP in AAG17115. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000057 Genomic DNA. Translation: EAL65497.1.
AF189237 mRNA. Translation: AAG17115.1.
RefSeqiXP_638887.1. XM_633795.1.

Genome annotation databases

EnsemblProtistsiDDB0191461; DDB0191461; DDB_G0283765.
GeneIDi8624285.
KEGGiddi:DDB_G0283765.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000057 Genomic DNA. Translation: EAL65497.1 .
AF189237 mRNA. Translation: AAG17115.1 .
RefSeqi XP_638887.1. XM_633795.1.

3D structure databases

ProteinModelPortali Q54QI4.
SMRi Q54QI4. Positions 7-412.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0191461.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0191461 ; DDB0191461 ; DDB_G0283765 .
GeneIDi 8624285.
KEGGi ddi:DDB_G0283765.

Organism-specific databases

dictyBasei DDB_G0283765. hgd.

Phylogenomic databases

eggNOGi COG3508.
InParanoidi Q54QI4.
KOi K00451.
OMAi RCFYNSD.
PhylomeDBi Q54QI4.

Enzyme and pathway databases

UniPathwayi UPA00139 ; UER00339 .

Miscellaneous databases

PROi Q54QI4.

Family and domain databases

Gene3Di 2.60.120.10. 2 hits.
InterProi IPR005708. Homogentis_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR11056. PTHR11056. 1 hit.
Pfami PF04209. HgmA. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
TIGRFAMsi TIGR01015. hmgA. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "Identification of HGO homologs in different organisms."
    Schmidt S.R.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-432.

Entry informationi

Entry nameiHGD_DICDI
AccessioniPrimary (citable) accession number: Q54QI4
Secondary accession number(s): Q9GU65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: May 24, 2005
Last modified: November 26, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3