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Protein

Homogentisate 1,2-dioxygenase

Gene

hgd

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Homogentisate + O2 = 4-maleylacetoacetate.

Cofactori

Fe cationBy similarity

Pathway:iL-phenylalanine degradation

This protein is involved in step 4 of the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine.
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. Phenylalanine-4-hydroxylase (pah)
  2. Tyrosine aminotransferase (tat)
  3. 4-hydroxyphenylpyruvate dioxygenase (hpd)
  4. Homogentisate 1,2-dioxygenase (hgd)
  5. Maleylacetoacetate isomerase (mai)
  6. Fumarylacetoacetase (fah)
This subpathway is part of the pathway L-phenylalanine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine, the pathway L-phenylalanine degradation and in Amino-acid degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi333 – 3331IronBy similarity
Metal bindingi339 – 3391IronBy similarity
Metal bindingi369 – 3691IronBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Phenylalanine catabolism, Tyrosine catabolism

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_325154. Phenylalanine and tyrosine catabolism.
UniPathwayiUPA00139; UER00339.

Names & Taxonomyi

Protein namesi
Recommended name:
Homogentisate 1,2-dioxygenase (EC:1.13.11.5)
Alternative name(s):
Homogentisate oxygenase
Homogentisic acid oxidase
Homogentisicase
Gene namesi
Name:hgd
Synonyms:hgo
ORF Names:DDB_G0283765
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195 Componentsi: Chromosome 4, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0283765. hgd.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 432432Homogentisate 1,2-dioxygenasePRO_0000312407Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0191461.

Structurei

3D structure databases

ProteinModelPortaliQ54QI4.
SMRiQ54QI4. Positions 7-412.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the homogentisate dioxygenase family.Curated

Phylogenomic databases

eggNOGiCOG3508.
InParanoidiQ54QI4.
KOiK00451.
OMAiRGYLCEN.
PhylomeDBiQ54QI4.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
InterProiIPR005708. Homogentis_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR11056. PTHR11056. 1 hit.
PfamiPF04209. HgmA. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR01015. hmgA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q54QI4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALEQIDYEY QSGFGNSFES EAIKGTLPKG RNAPQNCPLD LYAEQLSGNA
60 70 80 90 100
FTAPRHTQQR SWLYRIRPSV CHTPLKPIDS GLVCDLNNLH VDPNQLRWKP
110 120 130 140 150
FPITEDKPHD FVEGLITIAG AGHASVRHGL AIHIYTATKS MENKSFYNSD
160 170 180 190 200
GDFLIVPQQG TLDIQTEFGF MKVKSGEICV IQRGITFSVN VEGPTRGYIC
210 220 230 240 250
EVFGSHFKLP DLGPIGANGL ANPRDFLSPV AAYEKKEGIE HTKINKFLGK
260 270 280 290 300
LFSATQTYSP FNVVAWHGNY CPYKYDLSLF CVVNSVSFDH LDPSIFTVLT
310 320 330 340 350
APTNEVGVAA ADFVIFPPRW LVQENTFRPP YFHRNCMSEF MGLIRGVYEA
360 370 380 390 400
KKEGFLPGGG SLHSCMTPHG PDSDTFYAAI KAELKPTKIP DVALAFMFES
410 420 430
SLILGISDYA KKNFIDDDYW KCWQGLKDNS KI
Length:432
Mass (Da):48,234
Last modified:May 24, 2005 - v1
Checksum:iF704C3DCA58CAC53
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 43ALE → TRP in AAG17115 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000057 Genomic DNA. Translation: EAL65497.1.
AF189237 mRNA. Translation: AAG17115.1.
RefSeqiXP_638887.1. XM_633795.1.

Genome annotation databases

EnsemblProtistsiDDB0191461; DDB0191461; DDB_G0283765.
GeneIDi8624285.
KEGGiddi:DDB_G0283765.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000057 Genomic DNA. Translation: EAL65497.1.
AF189237 mRNA. Translation: AAG17115.1.
RefSeqiXP_638887.1. XM_633795.1.

3D structure databases

ProteinModelPortaliQ54QI4.
SMRiQ54QI4. Positions 7-412.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0191461.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0191461; DDB0191461; DDB_G0283765.
GeneIDi8624285.
KEGGiddi:DDB_G0283765.

Organism-specific databases

dictyBaseiDDB_G0283765. hgd.

Phylogenomic databases

eggNOGiCOG3508.
InParanoidiQ54QI4.
KOiK00451.
OMAiRGYLCEN.
PhylomeDBiQ54QI4.

Enzyme and pathway databases

UniPathwayiUPA00139; UER00339.
ReactomeiREACT_325154. Phenylalanine and tyrosine catabolism.

Miscellaneous databases

PROiQ54QI4.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
InterProiIPR005708. Homogentis_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR11056. PTHR11056. 1 hit.
PfamiPF04209. HgmA. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR01015. hmgA. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "Identification of HGO homologs in different organisms."
    Schmidt S.R.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-432.

Entry informationi

Entry nameiHGD_DICDI
AccessioniPrimary (citable) accession number: Q54QI4
Secondary accession number(s): Q9GU65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: May 24, 2005
Last modified: June 24, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.