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Protein

Probable glycerol-3-phosphate dehydrogenase, mitochondrial

Gene

DDB_G0283951

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.

Cofactori

FADBy similarity

Pathway: glycerol degradation via glycerol kinase pathway

This protein is involved in step 1 of the subpathway that synthesizes glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route).
Proteins known to be involved in this subpathway in this organism are:
  1. Probable glycerol-3-phosphate dehydrogenase, mitochondrial (DDB_G0283951)
This subpathway is part of the pathway glycerol degradation via glycerol kinase pathway, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route), the pathway glycerol degradation via glycerol kinase pathway and in Polyol metabolism.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi100 – 12829FADSequence AnalysisAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

ReactomeiREACT_285861. Fatty acid, triacylglycerol, and ketone body metabolism.
UniPathwayiUPA00618; UER00673.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycerol-3-phosphate dehydrogenase, mitochondrial (EC:1.1.5.3)
Short name:
GPD-M
Short name:
GPDH-M
Gene namesi
ORF Names:DDB_G0283951
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195 Componentsi: Chromosome 4, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0283951.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 638Probable glycerol-3-phosphate dehydrogenase, mitochondrialPRO_0000355967
Transit peptidei1 – ?MitochondrionSequence Analysis

Proteomic databases

PRIDEiQ54QC1.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0185769.

Structurei

3D structure databases

ProteinModelPortaliQ54QC1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0578.
InParanoidiQ54QC1.
KOiK00111.
OMAiKMGEDTV.
PhylomeDBiQ54QC1.

Family and domain databases

InterProiIPR006076. FAD-dep_OxRdtase.
IPR000447. G3P_DH_FAD-dep.
[Graphical view]
PfamiPF01266. DAO. 1 hit.
[Graphical view]
PRINTSiPR01001. FADG3PDH.
PROSITEiPS00977. FAD_G3PDH_1. 1 hit.
PS00978. FAD_G3PDH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q54QC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQLLSKSFK PLVVAGVAVI GISAFSGNRA YDEYRKERES ISKKMINDLN
60 70 80 90 100
ENKITMFDYF QECKTLGRDE QLSKLNKLSK VYNKQKLNEQ ENQEELIDLD
110 120 130 140 150
LIVIGGGATG TGVALDAQSR GMKVALFEKY DFSSGTSSKS TKLVHGGIRY
160 170 180 190 200
LESAIMKLKP SELTLVKEAL RERSNLLNNA PHLSRQLPIV IPAYSIFDAS
210 220 230 240 250
KFWIGCKLYD FFYPFNDIPK SYLQTSAQTY KEFPFLREGL VSSVVYYDGQ
260 270 280 290 300
HNDSRMNVSL ALTAAQQGAL TLNYTEVVEL IKDDKINNNN KQQQLKGVVI
310 320 330 340 350
RDRLTGKKYS VPAKCVVNAT GPYCDSIRNL DDPRADPIIT ASSGVHIMLP
360 370 380 390 400
GNLIPSDKGF LNPKTKDGRV LFILPFEGKT LVGTTDDPSP IIENPQPLEK
410 420 430 440 450
DVEFILDSIK EYSNPNVKLD KSQVLACWSG IRPLVSDEPA AQGDNKKSTS
460 470 480 490 500
QVTRSHSLRM SESGLITIVG GKWTTYRSMA EATVNLVCSK HDIFTPKGCI
510 520 530 540 550
TKNLPLIGGE KYYNTLNQYL IKNFNLPEDI AEHLAHSYGD QAPFVAKLAN
560 570 580 590 600
ENGSNKRLVE GYPYIEAEVT YGVKKEYACT AEDIIGRRTR LSFLDHDKAE
610 620 630
IALPKIINIM APLLKWSNER KKEELKNSQN YLKTMTSK
Length:638
Mass (Da):71,425
Last modified:May 24, 2005 - v1
Checksum:i19DA700617840BBC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000058 Genomic DNA. Translation: EAL65463.1.
RefSeqiXP_638823.1. XM_633731.1.

Genome annotation databases

EnsemblProtistsiDDB0185769; DDB0185769; DDB_G0283951.
GeneIDi8624347.
KEGGiddi:DDB_G0283951.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000058 Genomic DNA. Translation: EAL65463.1.
RefSeqiXP_638823.1. XM_633731.1.

3D structure databases

ProteinModelPortaliQ54QC1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0185769.

Proteomic databases

PRIDEiQ54QC1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0185769; DDB0185769; DDB_G0283951.
GeneIDi8624347.
KEGGiddi:DDB_G0283951.

Organism-specific databases

dictyBaseiDDB_G0283951.

Phylogenomic databases

eggNOGiCOG0578.
InParanoidiQ54QC1.
KOiK00111.
OMAiKMGEDTV.
PhylomeDBiQ54QC1.

Enzyme and pathway databases

UniPathwayiUPA00618; UER00673.
ReactomeiREACT_285861. Fatty acid, triacylglycerol, and ketone body metabolism.

Miscellaneous databases

PROiQ54QC1.

Family and domain databases

InterProiIPR006076. FAD-dep_OxRdtase.
IPR000447. G3P_DH_FAD-dep.
[Graphical view]
PfamiPF01266. DAO. 1 hit.
[Graphical view]
PRINTSiPR01001. FADG3PDH.
PROSITEiPS00977. FAD_G3PDH_1. 1 hit.
PS00978. FAD_G3PDH_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiGPDM_DICDI
AccessioniPrimary (citable) accession number: Q54QC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: May 24, 2005
Last modified: June 24, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.