Q54QC1 (GPDM_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable glycerol-3-phosphate dehydrogenase, mitochondrial
Short name=GPD-M
Short name=GPDH-M
EC=1.1.5.3

Gene names

ORF Names:

DDB_G0283951

Organism

Dictyostelium discoideum (Slime mold) [Reference proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	638 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.
Cofactor	FAD By similarity.
Pathway	Polyol metabolism; glycerol degradation via glycerol kinase pathway; glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route): step 1/1.
Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glycerol catabolic process Inferred from electronic annotation. Source: UniProtKB-UniPathway glycerol-3-phosphate metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	glycerol-3-phosphate dehydrogenase complex Inferred from electronic annotation. Source: InterPro mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion Potential
	Chain	? – 638		Probable glycerol-3-phosphate dehydrogenase, mitochondrial		PRO_0000355967
Regions
	Nucleotide binding	100 – 128	29	FAD Potential

Sequences

	Sequence		Length	Mass (Da)
	Q54QC1 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 19DA700617840BBC	FASTA	638	71,425
	10 20 30 40 50 60 MNQLLSKSFK PLVVAGVAVI GISAFSGNRA YDEYRKERES ISKKMINDLN ENKITMFDYF 70 80 90 100 110 120 QECKTLGRDE QLSKLNKLSK VYNKQKLNEQ ENQEELIDLD LIVIGGGATG TGVALDAQSR 130 140 150 160 170 180 GMKVALFEKY DFSSGTSSKS TKLVHGGIRY LESAIMKLKP SELTLVKEAL RERSNLLNNA 190 200 210 220 230 240 PHLSRQLPIV IPAYSIFDAS KFWIGCKLYD FFYPFNDIPK SYLQTSAQTY KEFPFLREGL 250 260 270 280 290 300 VSSVVYYDGQ HNDSRMNVSL ALTAAQQGAL TLNYTEVVEL IKDDKINNNN KQQQLKGVVI 310 320 330 340 350 360 RDRLTGKKYS VPAKCVVNAT GPYCDSIRNL DDPRADPIIT ASSGVHIMLP GNLIPSDKGF 370 380 390 400 410 420 LNPKTKDGRV LFILPFEGKT LVGTTDDPSP IIENPQPLEK DVEFILDSIK EYSNPNVKLD 430 440 450 460 470 480 KSQVLACWSG IRPLVSDEPA AQGDNKKSTS QVTRSHSLRM SESGLITIVG GKWTTYRSMA 490 500 510 520 530 540 EATVNLVCSK HDIFTPKGCI TKNLPLIGGE KYYNTLNQYL IKNFNLPEDI AEHLAHSYGD 550 560 570 580 590 600 QAPFVAKLAN ENGSNKRLVE GYPYIEAEVT YGVKKEYACT AEDIIGRRTR LSFLDHDKAE 610 620 630 IALPKIINIM APLLKWSNER KKEELKNSQN YLKTMTSK

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000058 Genomic DNA. Translation: EAL65463.1.
RefSeq	XP_638823.1. XM_633731.1.
3D structure databases
ProteinModelPortal	Q54QC1.
ModBase	Search...
Protein-protein interaction databases
STRING	44689.DDBDRAFT_0185769.
Proteomic databases
PRIDE	Q54QC1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0185769; DDB0185769; DDB_G0283951.
GeneID	8624347.
KEGG	ddi:DDB_G0283951.
Organism-specific databases
dictyBase	DDB_G0283951.
Phylogenomic databases
eggNOG	COG0578.
KO	K00111.
OMA	DSIRKMD.
ProtClustDB	CLSZ2728956.
Enzyme and pathway databases
UniPathway	UPA00618; UER00673.
Family and domain databases
InterPro	IPR006076. FAD-dep_OxRdtase. IPR000447. G3P_DH_FAD-dep. [Graphical view]
Pfam	PF01266. DAO. 1 hit. [Graphical view]
PRINTS	PR01001. FADG3PDH.
PROSITE	PS00977. FAD_G3PDH_1. 1 hit. PS00978. FAD_G3PDH_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPDM_DICDI

Accession

Primary (citable) accession number: Q54QC1

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 16, 2008
Last sequence update:	May 24, 2005
Last modified:	April 3, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)