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Protein

Probable glycerol-3-phosphate dehydrogenase, mitochondrial

Gene

DDB_G0283951

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.

Cofactori

FADBy similarity

Pathwayi: glycerol degradation via glycerol kinase pathway

This protein is involved in step 1 of the subpathway that synthesizes glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route).
Proteins known to be involved in this subpathway in this organism are:
  1. Probable glycerol-3-phosphate dehydrogenase, mitochondrial (DDB_G0283951)
This subpathway is part of the pathway glycerol degradation via glycerol kinase pathway, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route), the pathway glycerol degradation via glycerol kinase pathway and in Polyol metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi100 – 128FADSequence analysisAdd BLAST29

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein

Enzyme and pathway databases

ReactomeiR-DDI-1483166 Synthesis of PA
R-DDI-163560 Triglyceride catabolism
UniPathwayiUPA00618; UER00673

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycerol-3-phosphate dehydrogenase, mitochondrial (EC:1.1.5.3)
Short name:
GPD-M
Short name:
GPDH-M
Gene namesi
ORF Names:DDB_G0283951
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 4, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0283951

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000355967? – 638Probable glycerol-3-phosphate dehydrogenase, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

PaxDbiQ54QC1
PRIDEiQ54QC1

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0185769

Structurei

3D structure databases

ProteinModelPortaliQ54QC1
SMRiQ54QC1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0042 Eukaryota
COG0578 LUCA
InParanoidiQ54QC1
KOiK00111
OMAiVPYYWVG
PhylomeDBiQ54QC1

Family and domain databases

Gene3Di1.10.8.870, 1 hit
3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR031656 DAO_C
IPR038299 DAO_C_sf
IPR006076 FAD-dep_OxRdtase
IPR036188 FAD/NAD-bd_sf
IPR000447 G3P_DH_FAD-dep
PANTHERiPTHR11985 PTHR11985, 1 hit
PfamiView protein in Pfam
PF01266 DAO, 1 hit
PF16901 DAO_C, 1 hit
PRINTSiPR01001 FADG3PDH
SUPFAMiSSF51905 SSF51905, 2 hits
PROSITEiView protein in PROSITE
PS00977 FAD_G3PDH_1, 1 hit
PS00978 FAD_G3PDH_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q54QC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQLLSKSFK PLVVAGVAVI GISAFSGNRA YDEYRKERES ISKKMINDLN
60 70 80 90 100
ENKITMFDYF QECKTLGRDE QLSKLNKLSK VYNKQKLNEQ ENQEELIDLD
110 120 130 140 150
LIVIGGGATG TGVALDAQSR GMKVALFEKY DFSSGTSSKS TKLVHGGIRY
160 170 180 190 200
LESAIMKLKP SELTLVKEAL RERSNLLNNA PHLSRQLPIV IPAYSIFDAS
210 220 230 240 250
KFWIGCKLYD FFYPFNDIPK SYLQTSAQTY KEFPFLREGL VSSVVYYDGQ
260 270 280 290 300
HNDSRMNVSL ALTAAQQGAL TLNYTEVVEL IKDDKINNNN KQQQLKGVVI
310 320 330 340 350
RDRLTGKKYS VPAKCVVNAT GPYCDSIRNL DDPRADPIIT ASSGVHIMLP
360 370 380 390 400
GNLIPSDKGF LNPKTKDGRV LFILPFEGKT LVGTTDDPSP IIENPQPLEK
410 420 430 440 450
DVEFILDSIK EYSNPNVKLD KSQVLACWSG IRPLVSDEPA AQGDNKKSTS
460 470 480 490 500
QVTRSHSLRM SESGLITIVG GKWTTYRSMA EATVNLVCSK HDIFTPKGCI
510 520 530 540 550
TKNLPLIGGE KYYNTLNQYL IKNFNLPEDI AEHLAHSYGD QAPFVAKLAN
560 570 580 590 600
ENGSNKRLVE GYPYIEAEVT YGVKKEYACT AEDIIGRRTR LSFLDHDKAE
610 620 630
IALPKIINIM APLLKWSNER KKEELKNSQN YLKTMTSK
Length:638
Mass (Da):71,425
Last modified:May 24, 2005 - v1
Checksum:i19DA700617840BBC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000058 Genomic DNA Translation: EAL65463.1
RefSeqiXP_638823.1, XM_633731.1

Genome annotation databases

EnsemblProtistsiEAL65463; EAL65463; DDB_G0283951
GeneIDi8624347
KEGGiddi:DDB_G0283951

Similar proteinsi

Entry informationi

Entry nameiGPDM_DICDI
AccessioniPrimary (citable) accession number: Q54QC1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: May 24, 2005
Last modified: March 28, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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