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Protein

Kynureninase

Gene

kynu

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

Catalytic activityi

L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation
L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-kynurenine degradation

This protein is involved in step 1 of the subpathway that synthesizes L-alanine and anthranilate from L-kynurenine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Kynureninase (kynu)
This subpathway is part of the pathway L-kynurenine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-alanine and anthranilate from L-kynurenine, the pathway L-kynurenine degradation and in Amino-acid degradation.

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes quinolinate from L-kynurenine.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Kynurenine 3-monooxygenase (kmo)
  2. Kynureninase (kynu)
  3. 3-hydroxyanthranilate 3,4-dioxygenase (haao)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from L-kynurenine, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei131Pyridoxal phosphate; via amide nitrogenUniRule annotation1
Binding sitei132Pyridoxal phosphateUniRule annotation1
Binding sitei215Pyridoxal phosphateUniRule annotation1
Binding sitei244Pyridoxal phosphateUniRule annotation1
Binding sitei247Pyridoxal phosphateUniRule annotation1
Binding sitei269Pyridoxal phosphateUniRule annotation1
Binding sitei303Pyridoxal phosphateUniRule annotation1
Binding sitei331Pyridoxal phosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processPyridine nucleotide biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

ReactomeiR-DDI-71240 Tryptophan catabolism
UniPathwayiUPA00253; UER00329
UPA00334; UER00455

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
L-kynurenine hydrolaseUniRule annotation
Gene namesi
Name:kynuUniRule annotation
ORF Names:DDB_G0284203
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 4, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0284203 kynu

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003314821 – 451KynureninaseAdd BLAST451

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei270N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PaxDbiQ54Q04
PRIDEiQ54Q04

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi44689.DDB0231361

Structurei

3D structure databases

ProteinModelPortaliQ54Q04
SMRiQ54Q04
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni159 – 162Pyridoxal phosphate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the kynureninase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3846 Eukaryota
COG3844 LUCA
InParanoidiQ54Q04
KOiK01556
OMAiVCSLHAS
PhylomeDBiQ54Q04

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01970 Kynureninase, 1 hit
InterProiView protein in InterPro
IPR000192 Aminotrans_V_dom
IPR010111 Kynureninase
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR14084 PTHR14084, 1 hit
PfamiView protein in Pfam
PF00266 Aminotran_5, 1 hit
PIRSFiPIRSF038800 KYNU, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR01814 kynureninase, 1 hit

Sequencei

Sequence statusi: Complete.

Q54Q04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKFFEYIKN QNLSLEDEKL ADKLDQLDQL SSIKEEFYFP ITKDIATDLS
60 70 80 90 100
RVKDEDLDKP VIYLTGNSLG LQPKEIEKQL VCNYLNDWRK YGVEGHHKGD
110 120 130 140 150
HPFIHIDEEI QASLSKIVGA LPSEVCPMNS LSTNIHVLLS NFYKPTQTRH
160 170 180 190 200
KIIIEYGAFP SDLYVTESQI RHNSFNPETS LIKIKPRDGE YTLRTDDIIN
210 220 230 240 250
VLKEHGDSVA VVMLSGIQYF TGQFFDMKKI TEVGHEIGAI VGWDLAHAAG
260 270 280 290 300
NVELSLHDWN VDFACWCTYK YLNSGPGCIA GIFVHSKHTE SFNLSTDSRL
310 320 330 340 350
LGWFGNKLSN RFQKEKEFVA EDGALGFRMS NPSVADCTAL RASLSVFEKA
360 370 380 390 400
GGIKKLAEKS TIITGYLEYL LTHKLKTTDV QIITPSEANQ RGSQLSLLIK
410 420 430 440 450
GIKASQLKVN LSNSGIVCDV RDPDVIRVAP APLYTSFNDV KYFIQKLNEN

M
Length:451
Mass (Da):50,799
Last modified:May 24, 2005 - v1
Checksum:i99A0FA2091907172
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000064 Genomic DNA Translation: EAL65290.1
RefSeqiXP_638641.1, XM_633549.1

Genome annotation databases

EnsemblProtistsiEAL65290; EAL65290; DDB_G0284203
GeneIDi8624472
KEGGiddi:DDB_G0284203

Similar proteinsi

Entry informationi

Entry nameiKYNU_DICDI
AccessioniPrimary (citable) accession number: Q54Q04
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: May 23, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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