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Protein

Probable mitochondrial 2-oxoglutarate/malate carrier protein

Gene

ucpC

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-DDI-1614517 Sulfide oxidation to sulfate
R-DDI-428643 Organic anion transporters
R-DDI-70263 Gluconeogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Probable mitochondrial 2-oxoglutarate/malate carrier protein
Short name:
OGCP
Alternative name(s):
Mitochondrial substrate carrier family protein ucpC
Solute carrier family 25 member 11 homolog
Gene namesi
Name:ucpC
Synonyms:slc25a11
ORF Names:DDB_G0284225
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 4, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0284225 ucpC

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei28 – 48Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei79 – 99Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei125 – 145Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei185 – 205Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei225 – 245Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei281 – 301Helical; Name=6Sequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003286921 – 318Probable mitochondrial 2-oxoglutarate/malate carrier proteinAdd BLAST318

Proteomic databases

PaxDbiQ54PY7
PRIDEiQ54PY7

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0234071

Structurei

3D structure databases

ProteinModelPortaliQ54PY7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati22 – 111Solcar 1Add BLAST90
Repeati119 – 210Solcar 2Add BLAST92
Repeati219 – 309Solcar 3Add BLAST91

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0759 Eukaryota
ENOG410XQHU LUCA
InParanoidiQ54PY7
KOiK15104
PhylomeDBiQ54PY7

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q54PY7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSFNTQNKN VLQTPIPAPT PQSQLKQFVI GGLAGMLSSA FTHPIDSLKV
60 70 80 90 100
RMQLQGEGTG VGPKRGALKM LVHINQTEGF FTLYKGLSAS LLRQATYTTT
110 120 130 140 150
RFGLYDLIKD IVAKDDKPLP FTQKIMVGML SGAGGAIVGT PADLTMVRMQ
160 170 180 190 200
ADGKLPFNLR RNYKNVFDGI FRISKEEGII SLWKGCSPNL IRAMFMTAGQ
210 220 230 240 250
VSSYDQTKQL MLASGYFHDD IKTHLIASTT AAFVAAVATS PLDVIKTRIM
260 270 280 290 300
NSPKTVTGEL QYKGTFDCLS KTLRAEGFKA FYKGFNPYFM RLGPQTILTF
310
IFVEQLNILW KKSQSYFK
Length:318
Mass (Da):35,203
Last modified:May 24, 2005 - v1
Checksum:iC863FC6A4B9AAC49
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000064 Genomic DNA Translation: EAL65301.1
RefSeqiXP_638658.1, XM_633566.1

Genome annotation databases

EnsemblProtistsiEAL65301; EAL65301; DDB_G0284225
GeneIDi8624487
KEGGiddi:DDB_G0284225

Similar proteinsi

Entry informationi

Entry nameiM2OM_DICDI
AccessioniPrimary (citable) accession number: Q54PY7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: May 23, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

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