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Protein

Probable mitochondrial 2-oxoglutarate/malate carrier protein

Gene

ucpC

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-DDI-1614517. Sulfide oxidation to sulfate.
R-DDI-428643. Organic anion transporters.
R-DDI-70263. Gluconeogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable mitochondrial 2-oxoglutarate/malate carrier protein
Short name:
OGCP
Alternative name(s):
Mitochondrial substrate carrier family protein ucpC
Solute carrier family 25 member 11 homolog
Gene namesi
Name:ucpC
Synonyms:slc25a11
ORF Names:DDB_G0284225
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 4, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0284225. ucpC.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei28 – 4821Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei79 – 9921Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei125 – 14521Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei185 – 20521Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei225 – 24521Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei281 – 30121Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Probable mitochondrial 2-oxoglutarate/malate carrier proteinPRO_0000328692Add
BLAST

Proteomic databases

PaxDbiQ54PY7.
PRIDEiQ54PY7.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0234071.

Structurei

3D structure databases

ProteinModelPortaliQ54PY7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati22 – 11190Solcar 1Add
BLAST
Repeati119 – 21092Solcar 2Add
BLAST
Repeati219 – 30991Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0759. Eukaryota.
ENOG410XQHU. LUCA.
InParanoidiQ54PY7.
KOiK15104.
OMAiHINQTEG.
PhylomeDBiQ54PY7.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54PY7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSFNTQNKN VLQTPIPAPT PQSQLKQFVI GGLAGMLSSA FTHPIDSLKV
60 70 80 90 100
RMQLQGEGTG VGPKRGALKM LVHINQTEGF FTLYKGLSAS LLRQATYTTT
110 120 130 140 150
RFGLYDLIKD IVAKDDKPLP FTQKIMVGML SGAGGAIVGT PADLTMVRMQ
160 170 180 190 200
ADGKLPFNLR RNYKNVFDGI FRISKEEGII SLWKGCSPNL IRAMFMTAGQ
210 220 230 240 250
VSSYDQTKQL MLASGYFHDD IKTHLIASTT AAFVAAVATS PLDVIKTRIM
260 270 280 290 300
NSPKTVTGEL QYKGTFDCLS KTLRAEGFKA FYKGFNPYFM RLGPQTILTF
310
IFVEQLNILW KKSQSYFK
Length:318
Mass (Da):35,203
Last modified:May 24, 2005 - v1
Checksum:iC863FC6A4B9AAC49
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000064 Genomic DNA. Translation: EAL65301.1.
RefSeqiXP_638658.1. XM_633566.1.

Genome annotation databases

EnsemblProtistsiDDB0234071; DDB0234071; DDB_G0284225.
GeneIDi8624487.
KEGGiddi:DDB_G0284225.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000064 Genomic DNA. Translation: EAL65301.1.
RefSeqiXP_638658.1. XM_633566.1.

3D structure databases

ProteinModelPortaliQ54PY7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0234071.

Proteomic databases

PaxDbiQ54PY7.
PRIDEiQ54PY7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0234071; DDB0234071; DDB_G0284225.
GeneIDi8624487.
KEGGiddi:DDB_G0284225.

Organism-specific databases

dictyBaseiDDB_G0284225. ucpC.

Phylogenomic databases

eggNOGiKOG0759. Eukaryota.
ENOG410XQHU. LUCA.
InParanoidiQ54PY7.
KOiK15104.
OMAiHINQTEG.
PhylomeDBiQ54PY7.

Enzyme and pathway databases

ReactomeiR-DDI-1614517. Sulfide oxidation to sulfate.
R-DDI-428643. Organic anion transporters.
R-DDI-70263. Gluconeogenesis.

Miscellaneous databases

PROiQ54PY7.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "Mitochondrial carrier family: repertoire and peculiarities of the cellular slime mould Dictyostelium discoideum."
    Satre M., Mattei S., Aubry L., Gaudet P., Pelosi L., Brandolin G., Klein G.
    Biochimie 89:1058-1069(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiM2OM_DICDI
AccessioniPrimary (citable) accession number: Q54PY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: July 6, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.