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Q54PT2

- VPS4_DICDI

UniProt

Q54PT2 - VPS4_DICDI

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Protein
Vacuolar protein sorting-associated protein 4
Gene
vps4, DDB_G0284347
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in intracellular protein transport probably out of a prevacuolar endosomal compartment. May be involved in the release of components of the bilayered coat from the endosomal membrane. The association with ESCRT-III complex mediates the ATP-dependent disassembly of the ESCRT-III complex By similarity.

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi175 – 1828ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. nucleoside-triphosphatase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. endosomal transport Source: dictyBase
  2. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_216448. Endosomal Sorting Complex Required For Transport (ESCRT).

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 4 (EC:3.6.4.6)
Gene namesi
Name:vps4
ORF Names:DDB_G0284347
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 4, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0284347. vps4.

Subcellular locationi

GO - Cellular componenti

  1. endosome Source: dictyBase
  2. late endosome membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 444444Vacuolar protein sorting-associated protein 4
PRO_0000331380Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi44689.DDBDRAFT_0185960.

Structurei

3D structure databases

ProteinModelPortaliQ54PT2.
SMRiQ54PT2. Positions 124-443.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 8079MIT
Add
BLAST

Domaini

The MIT domain may serve as an adapter for the ESCRT-III complex By similarity.

Sequence similaritiesi

Belongs to the AAA ATPase family.
Contains 1 MIT domain.

Phylogenomic databases

eggNOGiCOG0464.
KOiK12196.
OMAiRPTVNTE.
PhylomeDBiQ54PT2.

Family and domain databases

Gene3Di1.20.58.280. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR007330. MIT.
IPR027417. P-loop_NTPase.
IPR015415. Vps4_C.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF04212. MIT. 1 hit.
PF09336. Vps4_C. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF116846. SSF116846. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54PT2-1 [UniParc]FASTAAdd to Basket

« Hide

MGDVNFLQKA IQIVQQATEQ DNAKNYAEAH RLYIQSLEWF TTALKYEKSE    50
RSKATIKAKT LEYLQRAEQL KEYLDKSKNK KPVAVGGNKS NSAGSANGAG 100
KSAKEDDEDM DPEDKKRNDS LSSSIVTTKP NVKWDDVAGL YQAKEYLKEA 150
VIFPIKFPQM FTGNRKPWKG ILLYGPPGTG KSYLAKAVAT EISSTFFSIS 200
PSDIVTKWLG DSEKLVKQLF EMAREKNNSV IFIDEVDSLC SSRNDQESES 250
ARRIKTEFLI QMNGVGNDSD GILVLAATNI PWGLDLAIRR RFEKRIYIGL 300
PEPQARAKMF QIHIGSTPNT LVQADYKKLA DLTEGYSGSD IGSLVKDAIM 350
QPVRAVQCAT HFKQIRAPSR EDPSVMTDYV TPCSPGDPLA QEMTWMDIDP 400
TKLKEPEITI ADCLKSLRVI KPSVNKADLD RYVEFTNDFG QDGV 444
Length:444
Mass (Da):49,605
Last modified:May 24, 2005 - v1
Checksum:i764EAB9A43A34284
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000064 Genomic DNA. Translation: EAL65222.1.
RefSeqiXP_638572.1. XM_633480.1.

Genome annotation databases

EnsemblProtistsiDDB0234037; DDB0234037; DDB_G0284347.
GeneIDi8624544.
KEGGiddi:DDB_G0284347.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000064 Genomic DNA. Translation: EAL65222.1 .
RefSeqi XP_638572.1. XM_633480.1.

3D structure databases

ProteinModelPortali Q54PT2.
SMRi Q54PT2. Positions 124-443.
ModBasei Search...

Protein-protein interaction databases

STRINGi 44689.DDBDRAFT_0185960.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0234037 ; DDB0234037 ; DDB_G0284347 .
GeneIDi 8624544.
KEGGi ddi:DDB_G0284347.

Organism-specific databases

dictyBasei DDB_G0284347. vps4.

Phylogenomic databases

eggNOGi COG0464.
KOi K12196.
OMAi RPTVNTE.
PhylomeDBi Q54PT2.

Enzyme and pathway databases

Reactomei REACT_216448. Endosomal Sorting Complex Required For Transport (ESCRT).

Family and domain databases

Gene3Di 1.20.58.280. 1 hit.
3.40.50.300. 1 hit.
InterProi IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR007330. MIT.
IPR027417. P-loop_NTPase.
IPR015415. Vps4_C.
[Graphical view ]
Pfami PF00004. AAA. 1 hit.
PF04212. MIT. 1 hit.
PF09336. Vps4_C. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
[Graphical view ]
SUPFAMi SSF116846. SSF116846. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEi PS00674. AAA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiVPS4_DICDI
AccessioniPrimary (citable) accession number: Q54PT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: September 3, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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