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Q54PT2 (VPS4_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Vacuolar protein sorting-associated protein 4

EC=3.6.4.6
Gene names
Name:vps4
ORF Names:DDB_G0284347
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length444 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in intracellular protein transport probably out of a prevacuolar endosomal compartment. May be involved in the release of components of the bilayered coat from the endosomal membrane. The association with ESCRT-III complex mediates the ATP-dependent disassembly of the ESCRT-III complex By similarity.

Catalytic activity

ATP + H2O = ADP + phosphate.

Subcellular location

Prevacuolar compartment membrane; Peripheral membrane protein By similarity. Endosome membrane; Peripheral membrane protein By similarity.

Domain

The MIT domain may serve as an adapter for the ESCRT-III complex By similarity.

Sequence similarities

Belongs to the AAA ATPase family.

Contains 1 MIT domain.

Ontologies

Keywords
   Biological processProtein transport
Transport
   Cellular componentEndosome
Membrane
   LigandATP-binding
Nucleotide-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processendosomal transport

Inferred from sequence or structural similarity. Source: dictyBase

protein transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentendosome

Inferred from sequence or structural similarity. Source: dictyBase

late endosome membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

nucleoside-triphosphatase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 444444Vacuolar protein sorting-associated protein 4
PRO_0000331380

Regions

Domain2 – 8079MIT
Nucleotide binding175 – 1828ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q54PT2 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 764EAB9A43A34284

FASTA44449,605
        10         20         30         40         50         60 
MGDVNFLQKA IQIVQQATEQ DNAKNYAEAH RLYIQSLEWF TTALKYEKSE RSKATIKAKT 

        70         80         90        100        110        120 
LEYLQRAEQL KEYLDKSKNK KPVAVGGNKS NSAGSANGAG KSAKEDDEDM DPEDKKRNDS 

       130        140        150        160        170        180 
LSSSIVTTKP NVKWDDVAGL YQAKEYLKEA VIFPIKFPQM FTGNRKPWKG ILLYGPPGTG 

       190        200        210        220        230        240 
KSYLAKAVAT EISSTFFSIS PSDIVTKWLG DSEKLVKQLF EMAREKNNSV IFIDEVDSLC 

       250        260        270        280        290        300 
SSRNDQESES ARRIKTEFLI QMNGVGNDSD GILVLAATNI PWGLDLAIRR RFEKRIYIGL 

       310        320        330        340        350        360 
PEPQARAKMF QIHIGSTPNT LVQADYKKLA DLTEGYSGSD IGSLVKDAIM QPVRAVQCAT 

       370        380        390        400        410        420 
HFKQIRAPSR EDPSVMTDYV TPCSPGDPLA QEMTWMDIDP TKLKEPEITI ADCLKSLRVI 

       430        440 
KPSVNKADLD RYVEFTNDFG QDGV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000064 Genomic DNA. Translation: EAL65222.1.
RefSeqXP_638572.1. XM_633480.1.

3D structure databases

ProteinModelPortalQ54PT2.
SMRQ54PT2. Positions 124-443.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDBDRAFT_0185960.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0234037; DDB0234037; DDB_G0284347.
GeneID8624544.
KEGGddi:DDB_G0284347.

Organism-specific databases

dictyBaseDDB_G0284347. vps4.

Phylogenomic databases

eggNOGCOG0464.
OMARPTVNTE.
PhylomeDBQ54PT2.

Family and domain databases

Gene3D1.20.58.280. 1 hit.
3.40.50.300. 1 hit.
InterProIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR007330. MIT.
IPR027417. P-loop_NTPase.
IPR015415. Vps4_C.
[Graphical view]
PfamPF00004. AAA. 1 hit.
PF04212. MIT. 1 hit.
PF09336. Vps4_C. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMSSF116846. SSF116846. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEPS00674. AAA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameVPS4_DICDI
AccessionPrimary (citable) accession number: Q54PT2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: July 9, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase