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Protein

Vacuolar protein sorting-associated protein 4

Gene

vps4

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in intracellular protein transport probably out of a prevacuolar endosomal compartment. May be involved in the release of components of the bilayered coat from the endosomal membrane. The association with ESCRT-III complex mediates the ATP-dependent disassembly of the ESCRT-III complex (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi175 – 182ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processProtein transport, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DDI-917729 Endosomal Sorting Complex Required For Transport (ESCRT)

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 4 (EC:3.6.4.6)
Gene namesi
Name:vps4
ORF Names:DDB_G0284347
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 4, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0284347 vps4

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003313801 – 444Vacuolar protein sorting-associated protein 4Add BLAST444

Proteomic databases

PaxDbiQ54PT2
PRIDEiQ54PT2

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0234037

Structurei

3D structure databases

ProteinModelPortaliQ54PT2
SMRiQ54PT2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 80MITAdd BLAST79

Domaini

The MIT domain may serve as an adapter for the ESCRT-III complex.By similarity

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Phylogenomic databases

eggNOGiKOG0739 Eukaryota
ENOG410XRHN LUCA
InParanoidiQ54PT2
KOiK12196
OMAiRAKCMQY
PhylomeDBiQ54PT2

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR003960 ATPase_AAA_CS
IPR007330 MIT
IPR036181 MIT_dom_sf
IPR027417 P-loop_NTPase
IPR015415 Vps4_C
PfamiView protein in Pfam
PF00004 AAA, 1 hit
PF04212 MIT, 1 hit
PF09336 Vps4_C, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00745 MIT, 1 hit
SUPFAMiSSF116846 SSF116846, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00674 AAA, 1 hit

Sequencei

Sequence statusi: Complete.

Q54PT2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDVNFLQKA IQIVQQATEQ DNAKNYAEAH RLYIQSLEWF TTALKYEKSE
60 70 80 90 100
RSKATIKAKT LEYLQRAEQL KEYLDKSKNK KPVAVGGNKS NSAGSANGAG
110 120 130 140 150
KSAKEDDEDM DPEDKKRNDS LSSSIVTTKP NVKWDDVAGL YQAKEYLKEA
160 170 180 190 200
VIFPIKFPQM FTGNRKPWKG ILLYGPPGTG KSYLAKAVAT EISSTFFSIS
210 220 230 240 250
PSDIVTKWLG DSEKLVKQLF EMAREKNNSV IFIDEVDSLC SSRNDQESES
260 270 280 290 300
ARRIKTEFLI QMNGVGNDSD GILVLAATNI PWGLDLAIRR RFEKRIYIGL
310 320 330 340 350
PEPQARAKMF QIHIGSTPNT LVQADYKKLA DLTEGYSGSD IGSLVKDAIM
360 370 380 390 400
QPVRAVQCAT HFKQIRAPSR EDPSVMTDYV TPCSPGDPLA QEMTWMDIDP
410 420 430 440
TKLKEPEITI ADCLKSLRVI KPSVNKADLD RYVEFTNDFG QDGV
Length:444
Mass (Da):49,605
Last modified:May 24, 2005 - v1
Checksum:i764EAB9A43A34284
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000064 Genomic DNA Translation: EAL65222.1
RefSeqiXP_638572.1, XM_633480.1

Genome annotation databases

EnsemblProtistsiEAL65222; EAL65222; DDB_G0284347
GeneIDi8624544
KEGGiddi:DDB_G0284347

Similar proteinsi

Entry informationi

Entry nameiVPS4_DICDI
AccessioniPrimary (citable) accession number: Q54PT2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: March 28, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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