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Q54PT2

- VPS4_DICDI

UniProt

Q54PT2 - VPS4_DICDI

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Protein

Vacuolar protein sorting-associated protein 4

Gene

vps4

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in intracellular protein transport probably out of a prevacuolar endosomal compartment. May be involved in the release of components of the bilayered coat from the endosomal membrane. The association with ESCRT-III complex mediates the ATP-dependent disassembly of the ESCRT-III complex By similarity.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi175 – 1828ATPSequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. hydrolase activity Source: UniProtKB-KW

GO - Biological processi

  1. endosomal transport Source: dictyBase
  2. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_216448. Endosomal Sorting Complex Required For Transport (ESCRT).

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 4 (EC:3.6.4.6)
Gene namesi
Name:vps4
ORF Names:DDB_G0284347
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 4, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0284347. vps4.

Subcellular locationi

GO - Cellular componenti

  1. endosome Source: dictyBase
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 444444Vacuolar protein sorting-associated protein 4PRO_0000331380Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi44689.DDBDRAFT_0185960.

Structurei

3D structure databases

ProteinModelPortaliQ54PT2.
SMRiQ54PT2. Positions 124-443.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 8079MITAdd
BLAST

Domaini

The MIT domain may serve as an adapter for the ESCRT-III complex.By similarity

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated
Contains 1 MIT domain.Curated

Phylogenomic databases

eggNOGiCOG0464.
InParanoidiQ54PT2.
KOiK12196.
OMAiRPTVNTE.
PhylomeDBiQ54PT2.

Family and domain databases

Gene3Di1.20.58.280. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR007330. MIT.
IPR027417. P-loop_NTPase.
IPR015415. Vps4_C.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF04212. MIT. 1 hit.
PF09336. Vps4_C. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF116846. SSF116846. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54PT2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGDVNFLQKA IQIVQQATEQ DNAKNYAEAH RLYIQSLEWF TTALKYEKSE
60 70 80 90 100
RSKATIKAKT LEYLQRAEQL KEYLDKSKNK KPVAVGGNKS NSAGSANGAG
110 120 130 140 150
KSAKEDDEDM DPEDKKRNDS LSSSIVTTKP NVKWDDVAGL YQAKEYLKEA
160 170 180 190 200
VIFPIKFPQM FTGNRKPWKG ILLYGPPGTG KSYLAKAVAT EISSTFFSIS
210 220 230 240 250
PSDIVTKWLG DSEKLVKQLF EMAREKNNSV IFIDEVDSLC SSRNDQESES
260 270 280 290 300
ARRIKTEFLI QMNGVGNDSD GILVLAATNI PWGLDLAIRR RFEKRIYIGL
310 320 330 340 350
PEPQARAKMF QIHIGSTPNT LVQADYKKLA DLTEGYSGSD IGSLVKDAIM
360 370 380 390 400
QPVRAVQCAT HFKQIRAPSR EDPSVMTDYV TPCSPGDPLA QEMTWMDIDP
410 420 430 440
TKLKEPEITI ADCLKSLRVI KPSVNKADLD RYVEFTNDFG QDGV
Length:444
Mass (Da):49,605
Last modified:May 24, 2005 - v1
Checksum:i764EAB9A43A34284
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000064 Genomic DNA. Translation: EAL65222.1.
RefSeqiXP_638572.1. XM_633480.1.

Genome annotation databases

EnsemblProtistsiDDB0234037; DDB0234037; DDB_G0284347.
GeneIDi8624544.
KEGGiddi:DDB_G0284347.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000064 Genomic DNA. Translation: EAL65222.1 .
RefSeqi XP_638572.1. XM_633480.1.

3D structure databases

ProteinModelPortali Q54PT2.
SMRi Q54PT2. Positions 124-443.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDBDRAFT_0185960.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0234037 ; DDB0234037 ; DDB_G0284347 .
GeneIDi 8624544.
KEGGi ddi:DDB_G0284347.

Organism-specific databases

dictyBasei DDB_G0284347. vps4.

Phylogenomic databases

eggNOGi COG0464.
InParanoidi Q54PT2.
KOi K12196.
OMAi RPTVNTE.
PhylomeDBi Q54PT2.

Enzyme and pathway databases

Reactomei REACT_216448. Endosomal Sorting Complex Required For Transport (ESCRT).

Family and domain databases

Gene3Di 1.20.58.280. 1 hit.
3.40.50.300. 1 hit.
InterProi IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR007330. MIT.
IPR027417. P-loop_NTPase.
IPR015415. Vps4_C.
[Graphical view ]
Pfami PF00004. AAA. 1 hit.
PF04212. MIT. 1 hit.
PF09336. Vps4_C. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
[Graphical view ]
SUPFAMi SSF116846. SSF116846. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEi PS00674. AAA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiVPS4_DICDI
AccessioniPrimary (citable) accession number: Q54PT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: October 29, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3