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Q54PM7

- NAGK_DICDI

UniProt

Q54PM7 - NAGK_DICDI

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Protein
N-acetyl-D-glucosamine kinase
Gene
nagk, DDB_G0284433
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Converts N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, into GlcNAc 6-phosphate. Also has ManNAc kinase activity By similarity.

Catalytic activityi

ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei37 – 371Substrate By similarity
Binding sitei113 – 1131Substrate By similarity
Binding sitei160 – 1601Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 148ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. N-acetylglucosamine kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetyl-D-glucosamine kinase (EC:2.7.1.59)
Short name:
N-acetylglucosamine kinase
Alternative name(s):
GlcNAc kinase
Gene namesi
Name:nagk
ORF Names:DDB_G0284433
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 4, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0284433.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 319319N-acetyl-D-glucosamine kinase
PRO_0000331385Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi44689.DDBDRAFT_0186012.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni137 – 1382Substrate binding By similarity
Regioni153 – 1553Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2971.
PhylomeDBiQ54PM7.

Family and domain databases

InterProiIPR002731. ATPase_BadF.
[Graphical view]
PfamiPF01869. BcrAD_BadFG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54PM7-1 [UniParc]FASTAAdd to Basket

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MSKEIFIGID GGGTKTSTVA VDSNGQELAR HTSPCSNYHS VGEDLAKAAI    50
NEGIKYVIRK VKETITDDDN KEVTVGSICL GMSGVDREKD KLLVKSWVTE 100
LLGESINYSI HNDAIVALSS GTQGKLFGVV IICGTGCISL GFNREGVSGR 150
SGGWGPLLGD YGSGYQIGYD ILRHVLKAKD QVGPKTSLTQ VLLEKLQLTK 200
EEDLISWAYD PKTQSWQKFA QLSPLAFEQA QLGDEISNLI LVDAANALYD 250
LINSVIKKLG LDKEEKFPLV YTGGNIERKG ILSDLLSKKI MENYPNAEIL 300
NTTCDPSMGA ALLALNSKK 319
Length:319
Mass (Da):34,504
Last modified:February 8, 2011 - v2
Checksum:iE5C017C4ED95F26F
GO

Sequence cautioni

The sequence EAL65265.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000064 Genomic DNA. Translation: EAL65265.1. Different initiation.
RefSeqiXP_638627.1. XM_633535.1.

Genome annotation databases

GeneIDi8624598.
KEGGiddi:DDB_G0284433.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000064 Genomic DNA. Translation: EAL65265.1 . Different initiation.
RefSeqi XP_638627.1. XM_633535.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDBDRAFT_0186012.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8624598.
KEGGi ddi:DDB_G0284433.

Organism-specific databases

dictyBasei DDB_G0284433.

Phylogenomic databases

eggNOGi COG2971.
PhylomeDBi Q54PM7.

Miscellaneous databases

PROi Q54PM7.

Family and domain databases

InterProi IPR002731. ATPase_BadF.
[Graphical view ]
Pfami PF01869. BcrAD_BadFG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiNAGK_DICDI
AccessioniPrimary (citable) accession number: Q54PM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: February 8, 2011
Last modified: May 14, 2014
This is version 48 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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