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Q54PM7

- NAGK_DICDI

UniProt

Q54PM7 - NAGK_DICDI

Protein

N-acetyl-D-glucosamine kinase

Gene

nagk

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 2 (08 Feb 2011)
      Previous versions | rss
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    Functioni

    Converts N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, into GlcNAc 6-phosphate. Also has ManNAc kinase activity By similarity.By similarity

    Catalytic activityi

    ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei37 – 371SubstrateBy similarity
    Binding sitei113 – 1131SubstrateBy similarity
    Binding sitei160 – 1601SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi7 – 148ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. N-acetylglucosamine kinase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-acetyl-D-glucosamine kinase (EC:2.7.1.59)
    Short name:
    N-acetylglucosamine kinase
    Alternative name(s):
    GlcNAc kinase
    Gene namesi
    Name:nagk
    ORF Names:DDB_G0284433
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 4, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0284433.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 319319N-acetyl-D-glucosamine kinasePRO_0000331385Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi44689.DDBDRAFT_0186012.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni137 – 1382Substrate bindingBy similarity
    Regioni153 – 1553Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2971.
    PhylomeDBiQ54PM7.

    Family and domain databases

    InterProiIPR002731. ATPase_BadF.
    [Graphical view]
    PfamiPF01869. BcrAD_BadFG. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q54PM7-1 [UniParc]FASTAAdd to Basket

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    MSKEIFIGID GGGTKTSTVA VDSNGQELAR HTSPCSNYHS VGEDLAKAAI    50
    NEGIKYVIRK VKETITDDDN KEVTVGSICL GMSGVDREKD KLLVKSWVTE 100
    LLGESINYSI HNDAIVALSS GTQGKLFGVV IICGTGCISL GFNREGVSGR 150
    SGGWGPLLGD YGSGYQIGYD ILRHVLKAKD QVGPKTSLTQ VLLEKLQLTK 200
    EEDLISWAYD PKTQSWQKFA QLSPLAFEQA QLGDEISNLI LVDAANALYD 250
    LINSVIKKLG LDKEEKFPLV YTGGNIERKG ILSDLLSKKI MENYPNAEIL 300
    NTTCDPSMGA ALLALNSKK 319
    Length:319
    Mass (Da):34,504
    Last modified:February 8, 2011 - v2
    Checksum:iE5C017C4ED95F26F
    GO

    Sequence cautioni

    The sequence EAL65265.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000064 Genomic DNA. Translation: EAL65265.1. Different initiation.
    RefSeqiXP_638627.1. XM_633535.1.

    Genome annotation databases

    GeneIDi8624598.
    KEGGiddi:DDB_G0284433.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000064 Genomic DNA. Translation: EAL65265.1 . Different initiation.
    RefSeqi XP_638627.1. XM_633535.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDBDRAFT_0186012.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 8624598.
    KEGGi ddi:DDB_G0284433.

    Organism-specific databases

    dictyBasei DDB_G0284433.

    Phylogenomic databases

    eggNOGi COG2971.
    PhylomeDBi Q54PM7.

    Miscellaneous databases

    PROi Q54PM7.

    Family and domain databases

    InterProi IPR002731. ATPase_BadF.
    [Graphical view ]
    Pfami PF01869. BcrAD_BadFG. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiNAGK_DICDI
    AccessioniPrimary (citable) accession number: Q54PM7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: February 8, 2011
    Last modified: October 1, 2014
    This is version 49 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3