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Q54PM7 (NAGK_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
N-acetyl-D-glucosamine kinase

Short name=N-acetylglucosamine kinase
EC=2.7.1.59
Alternative name(s):
GlcNAc kinase
Gene names
Name:nagk
ORF Names:DDB_G0284433
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length319 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, into GlcNAc 6-phosphate. Also has ManNAc kinase activity By similarity.

Catalytic activity

ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the eukaryotic-type N-acetylglucosamine kinase family.

Sequence caution

The sequence EAL65265.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

N-acetylglucosamine kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 319319N-acetyl-D-glucosamine kinase
PRO_0000331385

Regions

Nucleotide binding7 – 148ATP By similarity
Region137 – 1382Substrate binding By similarity
Region153 – 1553Substrate binding By similarity

Sites

Binding site371Substrate By similarity
Binding site1131Substrate By similarity
Binding site1601Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q54PM7 [UniParc].

Last modified February 8, 2011. Version 2.
Checksum: E5C017C4ED95F26F

FASTA31934,504
        10         20         30         40         50         60 
MSKEIFIGID GGGTKTSTVA VDSNGQELAR HTSPCSNYHS VGEDLAKAAI NEGIKYVIRK 

        70         80         90        100        110        120 
VKETITDDDN KEVTVGSICL GMSGVDREKD KLLVKSWVTE LLGESINYSI HNDAIVALSS 

       130        140        150        160        170        180 
GTQGKLFGVV IICGTGCISL GFNREGVSGR SGGWGPLLGD YGSGYQIGYD ILRHVLKAKD 

       190        200        210        220        230        240 
QVGPKTSLTQ VLLEKLQLTK EEDLISWAYD PKTQSWQKFA QLSPLAFEQA QLGDEISNLI 

       250        260        270        280        290        300 
LVDAANALYD LINSVIKKLG LDKEEKFPLV YTGGNIERKG ILSDLLSKKI MENYPNAEIL 

       310 
NTTCDPSMGA ALLALNSKK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000064 Genomic DNA. Translation: EAL65265.1. Different initiation.
RefSeqXP_638627.1. XM_633535.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDBDRAFT_0186012.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID8624598.
KEGGddi:DDB_G0284433.

Organism-specific databases

dictyBaseDDB_G0284433.

Phylogenomic databases

eggNOGCOG2971.
PhylomeDBQ54PM7.

Family and domain databases

InterProIPR002731. ATPase_BadF.
[Graphical view]
PfamPF01869. BcrAD_BadFG. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ54PM7.

Entry information

Entry nameNAGK_DICDI
AccessionPrimary (citable) accession number: Q54PM7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: February 8, 2011
Last modified: May 14, 2014
This is version 48 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase