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Protein

N-acetyl-D-glucosamine kinase

Gene

nagk

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Converts N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, into GlcNAc 6-phosphate. Also has ManNAc kinase activity (By similarity).By similarity

Catalytic activityi

ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei14ATP; via amide nitrogenBy similarity1
Binding sitei37SubstrateBy similarity1
Binding sitei113SubstrateBy similarity1
Binding sitei135ATPBy similarity1
Binding sitei160SubstrateBy similarity1
Binding sitei220ATP; via carbonyl oxygenBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetyl-D-glucosamine kinase (EC:2.7.1.59)
Short name:
N-acetylglucosamine kinase
Alternative name(s):
GlcNAc kinase
Gene namesi
Name:nagk
ORF Names:DDB_G0284433
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 4, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0284433.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003313851 – 319N-acetyl-D-glucosamine kinaseAdd BLAST319

Proteomic databases

PaxDbiQ54PM7.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi44689.DDB0186012.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni153 – 155Substrate bindingBy similarity3

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1794. Eukaryota.
COG2971. LUCA.
InParanoidiQ54PM7.
PhylomeDBiQ54PM7.

Family and domain databases

InterProiIPR002731. ATPase_BadF.
[Graphical view]
PfamiPF01869. BcrAD_BadFG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54PM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKEIFIGID GGGTKTSTVA VDSNGQELAR HTSPCSNYHS VGEDLAKAAI
60 70 80 90 100
NEGIKYVIRK VKETITDDDN KEVTVGSICL GMSGVDREKD KLLVKSWVTE
110 120 130 140 150
LLGESINYSI HNDAIVALSS GTQGKLFGVV IICGTGCISL GFNREGVSGR
160 170 180 190 200
SGGWGPLLGD YGSGYQIGYD ILRHVLKAKD QVGPKTSLTQ VLLEKLQLTK
210 220 230 240 250
EEDLISWAYD PKTQSWQKFA QLSPLAFEQA QLGDEISNLI LVDAANALYD
260 270 280 290 300
LINSVIKKLG LDKEEKFPLV YTGGNIERKG ILSDLLSKKI MENYPNAEIL
310
NTTCDPSMGA ALLALNSKK
Length:319
Mass (Da):34,504
Last modified:February 8, 2011 - v2
Checksum:iE5C017C4ED95F26F
GO

Sequence cautioni

The sequence EAL65265 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000064 Genomic DNA. Translation: EAL65265.1. Different initiation.
RefSeqiXP_638627.1. XM_633535.1.

Genome annotation databases

EnsemblProtistsiEAL65265; EAL65265; DDB_G0284433.
GeneIDi8624598.
KEGGiddi:DDB_G0284433.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000064 Genomic DNA. Translation: EAL65265.1. Different initiation.
RefSeqiXP_638627.1. XM_633535.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0186012.

Proteomic databases

PaxDbiQ54PM7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL65265; EAL65265; DDB_G0284433.
GeneIDi8624598.
KEGGiddi:DDB_G0284433.

Organism-specific databases

dictyBaseiDDB_G0284433.

Phylogenomic databases

eggNOGiKOG1794. Eukaryota.
COG2971. LUCA.
InParanoidiQ54PM7.
PhylomeDBiQ54PM7.

Miscellaneous databases

PROiQ54PM7.

Family and domain databases

InterProiIPR002731. ATPase_BadF.
[Graphical view]
PfamiPF01869. BcrAD_BadFG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNAGK_DICDI
AccessioniPrimary (citable) accession number: Q54PM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: February 8, 2011
Last modified: November 2, 2016
This is version 57 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.