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Protein

Frizzled and smoothened-like protein K

Gene

fslK

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Keywordsi

Molecular functionReceptor

Names & Taxonomyi

Protein namesi
Recommended name:
Frizzled and smoothened-like protein K
Gene namesi
Name:fslK
ORF Names:DDB_G0284729
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 4, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0284729. fslK.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 236ExtracellularSequence analysisAdd BLAST218
Transmembranei237 – 257Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini258 – 264CytoplasmicSequence analysis7
Transmembranei265 – 285Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini286 – 308ExtracellularSequence analysisAdd BLAST23
Transmembranei309 – 329Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini330 – 349CytoplasmicSequence analysisAdd BLAST20
Transmembranei350 – 370Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini371 – 391ExtracellularSequence analysisAdd BLAST21
Transmembranei392 – 412Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini413 – 434CytoplasmicSequence analysisAdd BLAST22
Transmembranei435 – 455Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini456 – 490ExtracellularSequence analysisAdd BLAST35
Transmembranei491 – 511Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini512 – 580CytoplasmicSequence analysisAdd BLAST69

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000037137219 – 580Frizzled and smoothened-like protein KAdd BLAST562

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi52N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi97N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi149N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi170N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi186N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ54PA5.

Expressioni

Inductioni

Down-regulated by phagocytic stimuli.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ54PA5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 154FZAdd BLAST130

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi514 – 519Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family membersBy similarity6

Domaini

Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ54PA5.
OMAiCLRIYGV.
PhylomeDBiQ54PA5.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q54PA5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVLFILFLF YFYTYTEAQQ YYPIDPTGKC EQYIGDSVIT PCNSIYVSST
60 70 80 90 100
ANQSTAMLSL NLYFSLLGGS SASCQNAYTF ATLCSTYLPE CEIFIDNSTN
110 120 130 140 150
KEIAMPKRVC LDTCNSVSKN CQITSYFDCN QLEPISKLPL FPKESSDYNL
160 170 180 190 200
TTYGGELNYR LDCYDPPKSN ETTVIGYCPF PLVFRNRTIV GKGSDSLDNS
210 220 230 240 250
ENYGYTYVSE DSYCTIPCPA PIFSEKQWDN IFDTSDAISL VSLLCSVYLF
260 270 280 290 300
ITYMVINPKR NKYDYFFSFF VLSIILMSIA GTIGFSVGGT RKLLCPEINR
310 320 330 340 350
RGVYTDPAVA AAGWIFQFAI INAILWFSIN SFELWFQIKF IKRKLHLIKF
360 370 380 390 400
YILAVLVISI ALSVPLSAIG EFNAGLGNFV VWIESGKYQN WFFWGPLGIV
410 420 430 440 450
LTVGTTFIGL VIWEIYKIVS STNKSDFFKL QLKPLMNMLL IYLTFVYLFG
460 470 480 490 500
YNFYIHNSLN GFYGSSEEFK NCIISTDGKD CRIQGPPYSS ILMFVFCLRI
510 520 530 540 550
YGVYCIALYG FSPKTRSIWS NSIVFNNSMA NKLKTLYISS GTTKGGTSST
560 570 580
DIKMSTNNNS NMDSGGGKSS SMEPDEIILR
Length:580
Mass (Da):65,458
Last modified:May 24, 2005 - v1
Checksum:i407DDC3898C207F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000070 Genomic DNA. Translation: EAL65134.1.
RefSeqiXP_638470.1. XM_633378.1.

Genome annotation databases

EnsemblProtistsiEAL65134; EAL65134; DDB_G0284729.
GeneIDi8624721.
KEGGiddi:DDB_G0284729.

Similar proteinsi

Entry informationi

Entry nameiFSLK_DICDI
AccessioniPrimary (citable) accession number: Q54PA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 24, 2005
Last modified: August 30, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  3. SIMILARITY comments
    Index of protein domains and families