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Q54PA0

- MPI_DICDI

UniProt

Q54PA0 - MPI_DICDI

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Protein
Probable mannose-6-phosphate isomerase
Gene
mpi, DDB_G0284685
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions By similarity.

Catalytic activityi

D-mannose 6-phosphate = D-fructose 6-phosphate.

Cofactori

Binds 1 zinc ion per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi141 – 1411Zinc By similarity
Metal bindingi143 – 1431Zinc By similarity
Metal bindingi168 – 1681Zinc By similarity
Metal bindingi295 – 2951Zinc By similarity
Active sitei314 – 3141 By similarity

GO - Molecular functioni

  1. mannose-6-phosphate isomerase activity Source: dictyBase
  2. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. GDP-mannose biosynthetic process Source: dictyBase
  2. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_201995. Synthesis of GDP-mannose.
UniPathwayiUPA00126; UER00423.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable mannose-6-phosphate isomerase (EC:5.3.1.8)
Alternative name(s):
Phosphohexomutase
Phosphomannose isomerase
Short name:
PMI
Gene namesi
Name:mpi
ORF Names:DDB_G0284685
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 4, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0284685. mpi.

Subcellular locationi

Cytoplasm Inferred

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 452452Probable mannose-6-phosphate isomerase
PRO_0000327494Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0231659.

Structurei

3D structure databases

ProteinModelPortaliQ54PA0.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi3 – 2018Poly-Asn
Add
BLAST
Compositional biasi102 – 11110Poly-Ser

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1482.
KOiK01809.
OMAiPYAEFWV.
PhylomeDBiQ54PA0.

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
InterProiIPR001250. Man6P_Isoase-1.
IPR016305. Mannose-6-P_Isomerase.
IPR018050. Pmannose_isomerase-type1_CS.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR10309. PTHR10309. 1 hit.
PfamiPF01238. PMI_typeI. 1 hit.
[Graphical view]
PIRSFiPIRSF001480. Mannose-6-phosphate_isomerase. 1 hit.
PRINTSiPR00714. MAN6PISMRASE.
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR00218. manA. 1 hit.
PROSITEiPS00966. PMI_I_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54PA0-1 [UniParc]FASTAAdd to Basket

« Hide

MENNNNNNNN NNNNNNNNNN IVLLKCVSQN YEWGKYGSNS TVAKLLKGYA    50
KECSDIIKET IPYAELWMGD HVSAPSKVEY KNKELKLREY IDTVQKEINE 100
KSSTSSSSSS SIRGEIVEKR FGNDFPFLFK VLSIRTALSI QAHPDSQLAQ 150
VLFKKYPNIY KDPYHKPEIA IATTPFEALC SFRPLSEIQS FIDTIPEFKN 200
SLPNNLIKLD DCKEYLKSIV TSLLKADGLL ISNNLKELNN RLNEKREEER 250
DDLDRLVLKL YSQYPGDVGV FFAYILNYIV LKPGEALFLG AGEPHAYISG 300
DCVECMAPSD NVVRAGLTPK LKDVDTLGDM LTYRTGRPDL VVPQQRPDLS 350
LTNYRCYQPP VDEFQVEYYH LDDCCKNINV YSSKGPSIVL VYSGNLSIEN 400
KSNQSTLNNL HTGSILFVPA NTDYQFIQSD SSIPVSIYVA SVSNRIFNKN 450
NL 452
Length:452
Mass (Da):51,091
Last modified:May 24, 2005 - v1
Checksum:iFBD259EF215E6D47
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000070 Genomic DNA. Translation: EAL65112.1.
RefSeqiXP_638475.1. XM_633383.1.

Genome annotation databases

EnsemblProtistsiDDB0231659; DDB0231659; DDB_G0284685.
GeneIDi8624726.
KEGGiddi:DDB_G0284685.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000070 Genomic DNA. Translation: EAL65112.1 .
RefSeqi XP_638475.1. XM_633383.1.

3D structure databases

ProteinModelPortali Q54PA0.
ModBasei Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0231659.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0231659 ; DDB0231659 ; DDB_G0284685 .
GeneIDi 8624726.
KEGGi ddi:DDB_G0284685.

Organism-specific databases

dictyBasei DDB_G0284685. mpi.

Phylogenomic databases

eggNOGi COG1482.
KOi K01809.
OMAi PYAEFWV.
PhylomeDBi Q54PA0.

Enzyme and pathway databases

UniPathwayi UPA00126 ; UER00423 .
Reactomei REACT_201995. Synthesis of GDP-mannose.

Miscellaneous databases

PROi Q54PA0.

Family and domain databases

Gene3Di 2.60.120.10. 3 hits.
InterProi IPR001250. Man6P_Isoase-1.
IPR016305. Mannose-6-P_Isomerase.
IPR018050. Pmannose_isomerase-type1_CS.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR10309. PTHR10309. 1 hit.
Pfami PF01238. PMI_typeI. 1 hit.
[Graphical view ]
PIRSFi PIRSF001480. Mannose-6-phosphate_isomerase. 1 hit.
PRINTSi PR00714. MAN6PISMRASE.
SUPFAMi SSF51182. SSF51182. 1 hit.
TIGRFAMsi TIGR00218. manA. 1 hit.
PROSITEi PS00966. PMI_I_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiMPI_DICDI
AccessioniPrimary (citable) accession number: Q54PA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: September 3, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi