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Q54PA0 (MPI_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable mannose-6-phosphate isomerase

EC=5.3.1.8
Alternative name(s):
Phosphohexomutase
Phosphomannose isomerase
Short name=PMI
Gene names
Name:mpi
ORF Names:DDB_G0284685
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length452 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions By similarity.

Catalytic activity

D-mannose 6-phosphate = D-fructose 6-phosphate.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Pathway

Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.

Subcellular location

Cytoplasm Probable.

Sequence similarities

Belongs to the mannose-6-phosphate isomerase type 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 452452Probable mannose-6-phosphate isomerase
PRO_0000327494

Regions

Compositional bias3 – 2018Poly-Asn
Compositional bias102 – 11110Poly-Ser

Sites

Active site3141 By similarity
Metal binding1411Zinc By similarity
Metal binding1431Zinc By similarity
Metal binding1681Zinc By similarity
Metal binding2951Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q54PA0 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: FBD259EF215E6D47

FASTA45251,091
        10         20         30         40         50         60 
MENNNNNNNN NNNNNNNNNN IVLLKCVSQN YEWGKYGSNS TVAKLLKGYA KECSDIIKET 

        70         80         90        100        110        120 
IPYAELWMGD HVSAPSKVEY KNKELKLREY IDTVQKEINE KSSTSSSSSS SIRGEIVEKR 

       130        140        150        160        170        180 
FGNDFPFLFK VLSIRTALSI QAHPDSQLAQ VLFKKYPNIY KDPYHKPEIA IATTPFEALC 

       190        200        210        220        230        240 
SFRPLSEIQS FIDTIPEFKN SLPNNLIKLD DCKEYLKSIV TSLLKADGLL ISNNLKELNN 

       250        260        270        280        290        300 
RLNEKREEER DDLDRLVLKL YSQYPGDVGV FFAYILNYIV LKPGEALFLG AGEPHAYISG 

       310        320        330        340        350        360 
DCVECMAPSD NVVRAGLTPK LKDVDTLGDM LTYRTGRPDL VVPQQRPDLS LTNYRCYQPP 

       370        380        390        400        410        420 
VDEFQVEYYH LDDCCKNINV YSSKGPSIVL VYSGNLSIEN KSNQSTLNNL HTGSILFVPA 

       430        440        450 
NTDYQFIQSD SSIPVSIYVA SVSNRIFNKN NL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000070 Genomic DNA. Translation: EAL65112.1.
RefSeqXP_638475.1. XM_633383.1.

3D structure databases

ProteinModelPortalQ54PA0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDB_0231659.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0231659; DDB0231659; DDB_G0284685.
GeneID8624726.
KEGGddi:DDB_G0284685.

Organism-specific databases

dictyBaseDDB_G0284685. mpi.

Phylogenomic databases

eggNOGCOG1482.
OMAPYAEFWV.
PhylomeDBQ54PA0.

Enzyme and pathway databases

UniPathwayUPA00126; UER00423.

Family and domain databases

Gene3D2.60.120.10. 3 hits.
InterProIPR001250. Man6P_Isoase-1.
IPR016305. Mannose-6-P_Isomerase.
IPR018050. Pmannose_isomerase-type1_CS.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERPTHR10309. PTHR10309. 1 hit.
PfamPF01238. PMI_typeI. 1 hit.
[Graphical view]
PIRSFPIRSF001480. Mannose-6-phosphate_isomerase. 1 hit.
PRINTSPR00714. MAN6PISMRASE.
SUPFAMSSF51182. SSF51182. 1 hit.
TIGRFAMsTIGR00218. manA. 1 hit.
PROSITEPS00966. PMI_I_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ54PA0.

Entry information

Entry nameMPI_DICDI
AccessionPrimary (citable) accession number: Q54PA0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: July 9, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase