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Protein

Porphobilinogen deaminase

Gene

hemC

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.By similarity

Miscellaneous

The porphobilinogen subunits are added to the dipyrromethane group.By similarity

Catalytic activityi

4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3.

Cofactori

dipyrromethaneBy similarityNote: Binds 1 dipyrromethane group covalently.By similarity

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes coproporphyrinogen-III from 5-aminolevulinate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Delta-aminolevulinic acid dehydratase (alad)
  2. Porphobilinogen deaminase (hemC)
  3. no protein annotated in this organism
  4. Uroporphyrinogen decarboxylase (hemE)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes coproporphyrinogen-III from 5-aminolevulinate, the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processHeme biosynthesis, Porphyrin biosynthesis

Enzyme and pathway databases

ReactomeiR-DDI-189451 Heme biosynthesis
UniPathwayiUPA00251; UER00319

Names & Taxonomyi

Protein namesi
Recommended name:
Porphobilinogen deaminase (EC:2.5.1.61)
Alternative name(s):
Heme biosynthesis protein C
Hydroxymethylbilane synthase
Short name:
HMBS
Gene namesi
Name:hemC
ORF Names:DDB_G0284697
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 4, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0284697 hemC

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003277981 – 325Porphobilinogen deaminaseAdd BLAST325

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei253S-(dipyrrolylmethanemethyl)cysteineBy similarity1

Proteomic databases

PaxDbiQ54P93

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0231417

Structurei

3D structure databases

ProteinModelPortaliQ54P93
SMRiQ54P93
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HMBS family.Curated

Phylogenomic databases

eggNOGiKOG2892 Eukaryota
COG0181 LUCA
InParanoidiQ54P93
KOiK01749
OMAiCQVPIGV
PhylomeDBiQ54P93

Family and domain databases

Gene3Di3.30.160.401 hit
HAMAPiMF_00260 Porphobil_deam, 1 hit
InterProiView protein in InterPro
IPR000860 HemC
IPR022419 Porphobilin_deaminase_cofac_BS
IPR022417 Porphobilin_deaminase_N
IPR022418 Porphobilinogen_deaminase_C
IPR036803 Porphobilinogen_deaminase_C_sf
PANTHERiPTHR11557 PTHR11557, 1 hit
PfamiView protein in Pfam
PF01379 Porphobil_deam, 1 hit
PF03900 Porphobil_deamC, 1 hit
PIRSFiPIRSF001438 4pyrrol_synth_OHMeBilane_synth, 1 hit
PRINTSiPR00151 PORPHBDMNASE
SUPFAMiSSF54782 SSF54782, 1 hit
TIGRFAMsiTIGR00212 hemC, 1 hit
PROSITEiView protein in PROSITE
PS00533 PORPHOBILINOGEN_DEAM, 1 hit

Sequencei

Sequence statusi: Complete.

Q54P93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSITKRDKV IIGSRKSQLA MLQTEWVRDR IQELNPGIIV EIKTMDTTGD
60 70 80 90 100
KVLDVSLSKI GDKGLFTKEL EDMMLNGTID LAVHSLKDIP TKLPDGLKLG
110 120 130 140 150
AITKRYNTSD AFIANAKKHG KNCKLSELPQ GAMIGSSSLR RVAQLKKAYP
160 170 180 190 200
HLQFKDIRGN LNTRFKKLED DSNGYDGMIL AVAGLERMEL TDHISEIIPD
210 220 230 240 250
SISLYAVGQG SLGIECKDGD DFIQSILNPL IHRESMYCCE AERSMLRDLE
260 270 280 290 300
GGCHVPIGVV TKLHNQSQPD ETLEINAIVL NLDGSKYIES KIIGPSIQYY
310 320
QLGKSIAQDL INKGSKDILS EFIKK
Length:325
Mass (Da):36,033
Last modified:May 24, 2005 - v1
Checksum:i2498FEF3ACA97A1D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000070 Genomic DNA Translation: EAL65118.1
RefSeqiXP_638482.1, XM_633390.1

Genome annotation databases

EnsemblProtistsiEAL65118; EAL65118; DDB_G0284697
GeneIDi8624733
KEGGiddi:DDB_G0284697

Similar proteinsi

Entry informationi

Entry nameiHEM3_DICDI
AccessioniPrimary (citable) accession number: Q54P93
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: February 28, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome